公开(公告)号：US20150239859A1

公开(公告)日：2015-08-27

申请号：US14416026

申请日：2013-07-19

Applicant: The Regents of the University of California ,  RESEARCH TRIANGLE INSTITUTE

Inventor： Igor Spigelman ,  Herbert H. Seltzman ,  Craig Shiner

IPC: C07D307/52 ,  C07D295/03 ,  C07D295/096 ,  C07C13/465 ,  C07D295/073 ,  C07C43/215 ,  C07C49/788 ,  C07C39/04 ,  C07D209/12 ,  C07D215/14

CPC classification number: C07D333/20 ,  C07C13/465 ,  C07C39/04 ,  C07C43/215 ,  C07C49/788 ,  C07C49/84 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D215/12 ,  C07D215/14 ,  C07D217/02 ,  C07D295/03 ,  C07D295/037 ,  C07D295/073 ,  C07D295/096 ,  C07D307/52

Abstract: Peripherally acting cannabinoid agonist compounds, pharmaceutical compositions, and methods of using them are presented.

Abstract translation: 提出了外周作用大麻素激动剂化合物，药物组合物及其使用方法。

公开(公告)号：US20150211358A1

公开(公告)日：2015-07-30

申请号：US14417674

申请日：2013-08-01

Applicant: RESEARCH TRIANGLE INSTITUTE, INTERNATIONAL

Inventor： Scott Goodwin

IPC: E21B47/09 ,  E21B47/12

CPC classification number: E21B47/09 ,  E21B47/122 ,  E21B47/124

Abstract: Systems and methods for determining the location of sensors embedded in material surrounding a well. In an example system, at least one seismic signal generator is configured to generate a seismic wave signal to communicate information that enables the determination of the sensor location to the sensor. A sensor location apparatus is provided and configured to lower the at least one seismic signal generator into the subsurface structure. A sensor location controller is provided in the sensor location apparatus and configured to actuate generation of the seismic wave signal as the at least one seismic signal generator is lowered into the well.

Abstract translation: 用于确定嵌入在井周围的材料中的传感器的位置的系统和方法。 在示例系统中，至少一个地震信号发生器被配置为产生地震波信号以传送能够确定传感器位置的信息。 传感器定位装置被提供和配置成将至少一个地震信号发生器降低到地下结构中。 传感器位置控制器设置在传感器位置设备中，并被配置为当至少一个地震信号发生器降到井中时致动地震波信号的产生。

公开(公告)号：US20150190777A1

公开(公告)日：2015-07-09

申请号：US14415283

申请日：2013-07-19

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Jian-Ping Shen ,  Luke James Ivor Coleman ,  Marty Alan Lail ,  Raghubir Prasad Gupta ,  Brian Scott Turk

IPC: B01J20/04 ,  B01D53/96 ,  B01J20/30 ,  B01D53/62 ,  B01J20/34

CPC classification number: B01J20/043 ,  B01D53/02 ,  B01D53/0462 ,  B01D53/0476 ,  B01D53/62 ,  B01D53/82 ,  B01D53/96 ,  B01D2251/304 ,  B01D2251/402 ,  B01D2251/602 ,  B01D2251/606 ,  B01D2253/1124 ,  B01D2257/504 ,  B01D2258/01 ,  B01D2258/0241 ,  B01D2258/025 ,  B01D2258/0283 ,  B01J20/04 ,  B01J20/041 ,  B01J20/28011 ,  B01J20/3078 ,  B01J20/3085 ,  B01J20/3433 ,  B01J20/3483 ,  B01J20/3491 ,  B01J2220/42 ,  C10K1/005 ,  C10K1/26 ,  Y02C10/04 ,  Y02C10/08 ,  Y02C20/20 ,  Y02P20/152

Abstract: A mixed salt composition adapted for use as a sorbent for carbon dioxide removal from a gaseous stream is provided, the composition being in solid form and including magnesium oxide, an alkali metal carbonate, and an alkali metal nitrate, wherein the composition has a molar excess of magnesium characterized by a Mg:X atomic ratio of at least about 3:1, wherein X is the alkali metal. A process for preparing the mixed salt is also provided, the process including mixing a magnesium salt with a solution comprising alkali metal ions, carbonate ions, and nitrate ions to form a slurry or colloid including a solid mixed salt including magnesium carbonate; separating the solid mixed salt from the slurry or colloid to form a wet cake; drying the wet cake to form a dry cake including the solid mixed salt; and calcining the dry cake to form a mixed salt sorbent.

Abstract translation: 提供了一种混合盐组合物，适用于从气态物流中除去二氧化碳的吸附剂，该组合物为固体形式，包括氧化镁，碱金属碳酸盐和碱金属硝酸盐，其中组合物具有摩尔过量 的Mg：X原子比为至少约3:1，其中X为碱金属。 还提供了制备混合盐的方法，该方法包括将镁盐与包含碱金属离子，碳酸根离子和硝酸根离子的溶液混合以形成包括含有碳酸镁的固体混合盐的浆料或胶体; 将固体混合盐与浆料或胶体分离以形成湿饼; 干燥湿饼以形成包括固体混合盐的干饼; 并煅烧干饼形成混合盐吸附剂。

公开(公告)号：US20150152119A1

公开(公告)日：2015-06-04

申请号：US14616313

申请日：2015-02-06

Applicant: Research Triangle Institute

Inventor： Frank Ivy Carroll ,  Pauline Wanjiku Ondachi

IPC: C07D487/08

CPC classification number: C07D487/08 ,  A61K31/407 ,  C07D401/14 ,  C07D409/14

Abstract: Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence.

Abstract translation: 本文提供了能够作为烟碱受体的激动剂或拮抗剂起作用的化合物的化合物和方法。 还提供了包含一种或多种这些化合物的药物组合物，其可进一步包含一种或多种另外的治疗剂。 还提供了治疗可能对烟碱受体上的这种活性有反应的各种病症的方法，例如尼古丁依赖性。

公开(公告)号：US20150064654A1

公开(公告)日：2015-03-05

申请号：US14395242

申请日：2013-04-18

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Jeffrey Robert Piascik ,  Brian R. Stoner

IPC: A61C8/00 ,  A01N55/02 ,  A01N25/08 ,  A61K6/083 ,  A61K6/02

CPC classification number: A61C8/0015 ,  A01N25/08 ,  A01N55/02 ,  A61K6/0067 ,  A61K6/0094 ,  A61K6/0215 ,  A61K6/0225 ,  A61K6/0235 ,  A61K6/024 ,  A61K6/025 ,  A61K6/0255 ,  A61K6/0835 ,  A61L27/10 ,  A61L27/446 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/106 ,  A61L2300/206 ,  A61L2300/406 ,  A61L2400/18 ,  A61L2430/12 ,  Y10T29/49885 ,  A61K6/083 ,  C08L43/04 ,  C08L33/14 ,  C08L33/068 ,  C08L33/10

Abstract: A fluoride treated ceramic material is provided, the ceramic material comprising fluorinated metal oxide on its surface. A method for the preparation of such treated ceramics is also provided, the method involving exposure of the ceramic to a fluorine-containing reagent. The ceramic materials can be further functionalized so as to bond to functional ligands and/or resins. The ceramic materials can be, for example, ceramic medical implants or particulate ceramic, which can be incorporated within dental and/or orthopedic composites.

Abstract translation: 提供氟化物处理的陶瓷材料，陶瓷材料在其表面上包含氟化金属氧化物。 还提供了制备这种经处理的陶瓷的方法，该方法涉及将陶瓷暴露于含氟试剂。 陶瓷材料可以进一步官能化以便键合到官能配体和/或树脂上。 陶瓷材料可以是例如陶瓷医疗植入物或颗粒陶瓷，其可以掺入牙齿和/或矫形复合材料中。

公开(公告)号：US20150057268A1

公开(公告)日：2015-02-26

申请号：US14363079

申请日：2012-12-06

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Scott Runyon ,  Yanan Zhang ,  Carla Hassler ,  Brian Gilmour

IPC: C07D491/048 ,  C07D491/107

CPC classification number: C07D491/048 ,  C07D491/04 ,  C07D491/10 ,  C07D491/107

Abstract: Neuropeptide S receptor antagonists are provided that bind in functional assays to neuropeptide S receptors; methods are provided for use of these antagonists in treatment of conditions or disease states that are ameliorated by blocking of the neuropeptide S receptor, including substance abuse and substance abuse relapse; and for use of neuropeptide S receptor antagonists in the manufacture of therapeutics and pro-drugs for therapeutics useful in disease states and conditions sensitive to binding of the neuropeptide S receptor.

Abstract translation: 提供神经肽S受体拮抗剂，其在功能测定中与神经肽S受体结合; 提供了这些拮抗剂用于治疗通过阻断神经肽S受体而改善的病症或疾病状态的方法，包括药物滥用和药物滥用复发; 并且用于神经肽S受体拮抗剂在制备用于治疗疾病状态和治疗神经肽S受体结合敏感的疾病状态的治疗剂的前药中的用途。

公开(公告)号：US20150008390A1

公开(公告)日：2015-01-08

申请号：US14216296

申请日：2014-03-17

Applicant: Research Triangle Institute

Inventor： John Lewis ,  Ethan Klem

IPC: H01L27/32 ,  H01L31/032 ,  H01L31/0296 ,  H01L51/00 ,  H01L31/18 ,  H01L51/56 ,  H01L51/05 ,  H01L27/28 ,  H01L31/0352

CPC classification number: H01L31/12 ,  H01L25/167 ,  H01L27/288 ,  H01L27/3227 ,  H01L31/167 ,  H01L51/0046 ,  H01L51/0081 ,  H01L2924/0002 ,  H01L2924/00

Abstract: Integrated upconversion devices capable of upconverting incident visible to short wavelength infrared photons to visible photons are disclosed. The device may include a quantum dot-based photodiode and a light-emitting diode. The device may further include a gain element such as a thin-film transistor.

Abstract translation: 公开了能够将对短波长红外光子可见的入射上变频到可见光子的集成上变频装置。 该器件可以包括量子点基光电二极管和发光二极管。 该器件还可以包括诸如薄膜晶体管的增益元件。

公开(公告)号：US20140318593A1

公开(公告)日：2014-10-30

申请号：US14359817

申请日：2012-11-21

Applicant: RESEARCH TRIANGLE INSTITUTE ,  NORTH CAROLINA STATE UNIVERSITY

Inventor： Rama Venkatasubramanian ,  Judy Stuart ,  Ryan Wiitala ,  Peter Thomas ,  Carl C. Koch ,  Tsungta Ethan Chan

IPC: H01L35/16 ,  H01L35/18 ,  H01L35/28

CPC classification number: H01L35/16 ,  H01L35/18 ,  H01L35/28 ,  Y10T428/268

Abstract: A thermoelectric composite and a thermoelectric device and a method of making the thermoelectric composite. The thermoelectric composite is a semiconductor material formed from mechanically-alloyed powders of elemental constituents of the semiconductor material to produce nano-particles of the semiconductor material, and compacted to have at least a bifurcated grain structure. The bifurcated grain structure has at least two different grain sizes including small size grains in a range of 2-200 nm and large size grains in a range of 0.5 to 5 microns. The semiconductor material has a figure of merit ZT, defined as a ratio of the product of square of Seebeck coefficient, S2, and electrical conductivity σ divided by the thermal conductivity k, which varies from greater than 1 at 300 K to 2.5 at temperatures of 300 to 500K.

Abstract translation: 热电复合材料和热电元件以及制造热电复合材料的方法。 热电复合体是由半导体材料的元素成分的机械合金化粉末形成的半导体材料，以制造半导体材料的纳米颗粒，并且被压制成具有至少一个分叉的晶粒结构。 分叉晶粒结构具有至少两种不同的晶粒尺寸，包括在2-200nm范围内的小尺寸晶粒和0.5至5微米范围内的大尺寸晶粒。 半导体材料具有品质因数ZT，定义为塞贝克系数的平方乘积，S2和电导率的乘积比; 除以热导率k，其在300至500K的温度下在300K下从大于1变化至2.5。

公开(公告)号：US20040097477A1

公开(公告)日：2004-05-20

申请号：US10699885

申请日：2003-11-04

Applicant: Research Triangle Institute

Inventor： C. Edgar Cook ,  John A. Kepler ,  Yue-Wei Lee ,  Mansukh C. Wani

IPC: A61K031/58 ,  A61K031/573

CPC classification number: C07J1/00

Abstract: An androgenic steroid compound of the formula: 1 wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.

Abstract translation: 下式的雄激素类固醇化合物：其中：X，Y，Z，R 1，R 2，R 3，R 5和R 6如本文所定义。

公开(公告)号：US20040049517A1

公开(公告)日：2004-03-11

申请号：US10232372

申请日：2002-09-03

Applicant: Research Triangle Institute

Inventor： Avinash C. Singh

IPC: G06F007/00

CPC classification number: G06F21/6254 ,  G06F17/30303 ,  Y10S707/99945

Abstract: A method and system for ensuring statistical disclosure limitation (SDL) of categorical or continuous micro data, while maintaining the analytical quality of the micro data. The new SDL methodology exploits the analogy between (1) taking a sample (instead of a census,) along with some adjustments, including imputation, for missing information, and (2) releasing a subset, instead of the original data set, along with some adjustments for records still at disclosure risk. Survey sampling reduces monetary cost in comparison to a census, but entails some loss of information. Similarly, releasing a subset reduces disclosure cost in comparison to the full database, but entails some loss of information. Thus, optimal survey sampling methods can be used for statistical disclosure limitation. The method includes partitioning the database into risk strata, optimal probabilistic substitution, optimal probabilistic subsampling, and optimal sampling weight calibration.

Abstract translation: 一种确保分类或连续微数据统计公开限制（SDL）的方法和系统，同时保持微数据的分析质量。 新的SDL方法利用（1）采样（而不是普查）之间的类比，以及对缺失信息的一些调整，包括插补，以及（2）发布一个子集，而不是原始数据集，以及 一些调整记录仍处于披露风险。 调查抽样与普查相比降低了货币成本，但却导致信息丢失。 类似地，释放子集可以减少与完整数据库相比的披露成本，但会导致信息丢失。 因此，最佳调查抽样方法可用于统计披露限制。 该方法包括将数据库划分为风险层次，最优概率替代，最优概率子抽样和最优抽样权重校准。