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119 条记录 (耗时 0.073 秒)

    Chimeric peptides for the regulation of GTPases
    101.
    发明授权
    Chimeric peptides for the regulation of GTPases 有权
    嵌合肽用于调节GTP酶

    公开(公告)号：US08242246B2

    公开(公告)日：2012-08-14

    申请号：US13036964

    申请日：2011-02-28

    申请人： Yi Zheng ,  David A. Williams

    发明人： Yi Zheng ,  David A. Williams

    IPC分类号： C07K14/00 ,  A61K38/00

    CPC分类号： C07K14/4706 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/03 ,  C12N9/14 ,  C12Y306/05002

    摘要： Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene.

    摘要翻译： 公开了嵌合肽或融合蛋白，其包括RhoGAP活性结构域和至少一个靶向特异性Rho蛋白的特异性结构域。 融合蛋白可用于抑制细胞内的任何GTP酶活性。 融合蛋白对癌症的治疗特别有利。 本发明一般涉及能够调节GTP酶的嵌合肽，更具体地，涉及通过使用GTP酶活化蛋白靶向各种GTP酶的方法。 这些蛋白质可用于治疗癌症和其它与GTP酶有关的疾病。 本发明涉及核酸分子和编码的GTP酶活化蛋白及其变体，以及这些分子在表征，诊断，预防和治疗细胞信号传导，免疫和细胞增殖性疾病，特别是癌症中的用途。 本文公开了用于调节所选基因转录的化合物和方法。

    Mobilization of hematopoietic cells
    103.
    发明授权
    Mobilization of hematopoietic cells 有权
    动员造血细胞

    公开(公告)号：US07417026B2

    公开(公告)日：2008-08-26

    申请号：US10918328

    申请日：2004-08-12

    申请人： David A. Williams ,  Yi Zheng

    发明人： David A. Williams ,  Yi Zheng

    IPC分类号： A61K38/00

    CPC分类号： A61K31/522 ,  A61K31/04 ,  A61K31/7088 ,  A61K35/28 ,  A61K38/193 ,  C07K14/4706 ,  C07K2319/01 ,  C12N5/0647 ,  C12N2500/40 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/26

    摘要： Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. The subject's blood can be processed and used to repopulate the destroyed lymphohematopoietic system of a recipient and may in the future be utilized to repair a variety of non-hematopoietic tissues. Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. They can also be used for increasing white blood cell survival and for chemotherapy.

    摘要翻译： 本文提供了改进的方法和药物组合物，用于将造血祖细胞从骨髓移入外周血中，包括单独或组合施用有效量的GTP酶抑制剂，例如Rac1和Rac2。 具体地，公开了将造血干细胞移入受试者的外周血中的方法。 特别地，该方法的实施方案涉及抑制Rac1和Rac2GTP酶以将造血干细胞的数量增加到受试者的受试者的外周血中。 受试者的血液可以被处理并用于重建受体的破坏的淋巴造血系统，并且将来可以用于修复各种非造血组织。 因此，通过本发明的方法动员到受试者的外周血中的造血干细胞可用作骨髓移植中的供体细胞来源，用于治疗各种疾病，包括癌症，贫血，自身免疫和免疫缺陷。 它们也可用于增加白细胞的存活和化疗。

    AC coupled bias circuit for power converters
    104.
    发明授权
    AC coupled bias circuit for power converters 有权
    电源转换器的交流耦合偏置电路

    公开(公告)号：US07274575B2

    公开(公告)日：2007-09-25

    申请号：US11198601

    申请日：2005-08-05

    申请人： Ramanujam Ramabhadran ,  David A. Williams

    发明人： Ramanujam Ramabhadran ,  David A. Williams

    IPC分类号： H02M3/335 ,  H02M5/42

    CPC分类号： H02M3/33507 ,  H02M2001/0006

    摘要： A switching power system for converting an input voltage to an output voltage across a transformer is disclosed. The system includes a control circuit. The control circuit has a control input coupled for receiving the output voltage and an output coupled to a primary winding of the transformer. The system includes a bias circuit for supplying an operating voltage to the control circuit. The bias circuit includes a capacitor. The capacitor has a first terminal coupled to a first terminal of a first secondary winding of the transformer. A first diode is coupled between a second terminal of the first secondary winding and a second terminal of the first capacitor. A second diode is coupled between the second terminal of the capacitor and a bias input of the control circuit. A method of making the same is disclosed.

    摘要翻译： 公开了一种用于将输入电压转换成变压器两端的输出电压的开关电源系统。 该系统包括一个控制电路。 控制电路具有耦合用于接收输出电压的控制输入和耦合到变压器的初级绕组的输出。 该系统包括用于向控制电路提供工作电压的偏置电路。 偏置电路包括电容器。 电容器具有耦合到变压器的第一次级绕组的第一端子的第一端子。 第一二极管耦合在第一次级绕组的第二端子和第一电容器的第二端子之间。 第二二极管耦合在电容器的第二端子和控制电路的偏置输入端之间。 公开了制造该方法的方法。

    Feline pancreatic lipase composition and method of preparing and using such composition
    105.
    发明授权
    Feline pancreatic lipase composition and method of preparing and using such composition 失效
    猫胰脂肪酶组合物及其制备和使用方法

    公开(公告)号：US06855506B2

    公开(公告)日：2005-02-15

    申请号：US10428546

    申请日：2003-05-02

    申请人： Jörg M. Steiner ,  David A. Williams

    发明人： Jörg M. Steiner ,  David A. Williams

    IPC分类号： C12N9/18 ,  C12N9/20 ,  G01N33/573 ,  G01N33/567

    CPC分类号： G01N33/573 ,  C12N9/18 ,  C12N9/20 ,  C12Y301/01003 ,  G01N2333/918

    摘要： A novel form of lipase, namely feline pancreatic lipase (also termed feline classical pancreatic lipase) has an N-terminal amino acid sequence as shown in SEQ ID NO. 1. A method of purifying this lipase includes collecting pancreatic tissue from cats, delipidating the pancreatic tissue to produce a delipidated pancreatic extract, extracting pancreatic lipase from the delipidated pancreatic extract, and eluting the extracted pancreatic lipase through various columns. This lipase can be used for measuring pancreatic lipase immunoreactivity in serum thereby diagnosing pancreatitis in cats. To do so, antiserum against feline pancreatic lipase is prepared, and immunoassays are then performed in serum samples using this antiserum. In the event that increased concentration of pancreatic lipase immunoreactivity above the control range is detected in the serum, the cat might have pancreatitis.

    摘要翻译： 脂肪酶的新型形式，即猫胰脂肪酶（也称为猫经典胰脂肪酶）具有如SEQ ID NO：1所示的N-末端氨基酸序列。 1.一种纯化该脂肪酶的方法，包括从猫收集胰腺组织，使胰腺组织脱脂以产生脱脂胰腺提取物，从脱脂胰腺提取物中提取胰脂肪酶，并通过各种柱洗脱提取的胰脂肪酶。 该脂肪酶可用于测量血清中的胰脂肪酶免疫反应性，从而诊断猫的胰腺炎。 为此，制备抗猫胰脂肪酶的抗血清，然后使用该抗血清在血清样品中进行免疫测定。 在血清中检测到高于对照范围的胰脂肪酶免疫反应性浓度增加的情况下，猫可能患有胰腺炎。

    Safety jacket and harness system
    107.
    发明授权
    Safety jacket and harness system 失效
    安全护套和线束系统

    公开(公告)号：US5738046A

    公开(公告)日：1998-04-14

    申请号：US695682

    申请日：1996-07-22

    申请人： Tommie Ann Williams ,  David A. Williams

    发明人： Tommie Ann Williams ,  David A. Williams

    IPC分类号： A41D13/00 ,  A62B35/00

    CPC分类号： A62B35/0025 ,  A41D13/0007 ,  A62B35/0068 ,  Y10S119/907

    摘要： A safety jacket and harness system including a body harness formed by a pair of torso bands and a pair of shoulder straps. The torso bands form an upper torso band and a lower torso band. Each torso band has a fastening member that is attached to end portions. The pair of shoulder straps each have a first shoulder strap portion and a second shoulder strap portion. Each shoulder strap portion is coupled together by a fastening member when each shoulder strap is attached to the pair of torso bands. Included is a center strap that is fixedly attached to the pair of torso bands and has a locking member at a top end. A safety strap has a first safety strap end that can couple with the locking member of the center strap, and a second safety strap end that can be looped and fastened around a tree trunk. An escape strap is attached to the safety strap. Lastly, a jacket receives the body harness when worn by a hunter using a tree stand with the center strap of the harness coupled to the safety strap looped around the tree trunk.

    摘要翻译： 一种安全护套和线束系统，包括由一对躯干带和一对肩带形成的身体线束。 躯干带形成上躯干带和下躯干带。 每个躯干带具有附接到端部的紧固构件。 一对肩带各具有第一肩带部分和第二肩带部分。 当每个肩带附接到一对躯干带时，每个肩带部分通过紧固构件联接在一起。 包括固定地连接到该对躯干带上并且在顶端具有锁定构件的中心带。 安全带具有可以与中心带的锁定构件联接的第一安全带端部，以及能够环绕并围绕树干固定的第二安全带端部。 安全带上安装有逃生吊带。 最后，一个外套在猎人使用树架上时收到身体线束，其中线束的中心带与环绕树干的安全带相连。

    Self-adhesive wallcoverings
    110.
    发明授权
    Self-adhesive wallcoverings 失效
    自粘墙纸

    公开(公告)号：US5413829A

    公开(公告)日：1995-05-09

    申请号：US50091

    申请日：1993-07-21

    申请人： Kenneth D. Brown ,  David A. Williams

    发明人： Kenneth D. Brown ,  David A. Williams

    IPC分类号： B44C7/00 ,  B65D85/671 ,  D06N7/00 ,  D21H17/00 ,  D21H19/16 ,  D21H27/20 ,  E04F13/07 ,  E04F13/08

    CPC分类号： B65D85/671 ,  D06N3/0097 ,  D06N7/0002 ,  D21H17/00 ,  D21H27/20 ,  D06N2201/042 ,  D06N2203/048 ,  D06N2205/026 ,  D06N2209/141 ,  D06N2211/12 ,  Y10S428/906 ,  Y10T156/1989 ,  Y10T428/1424 ,  Y10T428/249995 ,  Y10T428/2813 ,  Y10T428/2839 ,  Y10T428/2848 ,  Y10T428/2852 ,  Y10T428/31895 ,  Y10T428/31906

    摘要： A package comprising a sealed container containing a roll of wall covering material which comprises a hydrophilic substrate layer, a pressure sensitive adhesive layer on one surface and, on the other surface, a decorative layer, usually including a layer of PVC or other plastics material. The wallcovering material is preferably self-wound on a roll. The moisture content of the wallcovering material is controlled in the package so as to provide a desired area of the product which falls between the area of the product where it is soaked in water under predetermined conditions and the area of the product when it is preconditioned under relatively dry, predetermined conditions. The moisture content is generally above the equilibrium content under normal ambient conditions so that any problems caused by expansion of the product in use under humid conditions, such as bubbling and raising of the edges of the material at seams, are minimised. In a process for producing the product the moisture content is monitored during the process, usually downstream from a drying stage, for instance the drying stage following application of an aqueous adhesive.

    摘要翻译： PCT No.PCT / GB92 / 01685 Sec。 371日期：1993年7月21日 102（e）日期1993年7月21日PCT提交1992年9月14日PCT公布。 公开号WO93 / 06301 日本公报1993年4月1日。一种包含密封容器的包装，该容器包含一层壁覆盖材料，其包括亲水基底层，一个表面上的压敏粘合剂层，另一个表面上具有通常包括层 的PVC或其他塑料材料。 墙纸材料优选在卷上自行缠绕。 包装材料的含水量被控制在包装中，以便提供在预定条件下浸泡在水中的产品的区域之间的产品的期望区域，以及在预处理时产品的面积 相对干燥，预定条件。 在正常环境条件下，水分含量通常高于平衡含量，使得在潮湿条件下使用中的产品膨胀所引起的任何问题（例如在接缝处的材料的边缘起泡和升高）都被最小化。 在生产产品的过程中，在该过程中通常在干燥阶段的下游监测水分含量，例如在施加水性粘合剂之后的干燥阶段。