公开(公告)号：US20080175863A1

公开(公告)日：2008-07-24

申请号：US11780627

申请日：2007-07-20

Applicant: Hong Jin ,  Bin Liu

Inventor： Hong Jin ,  Bin Liu

IPC: A61K39/145 ,  C12N15/01 ,  C12N7/00 ,  A61P31/20

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/005 ,  C12N2760/16121 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: In certain aspects, the present invention provides methods for increasing the replication capacity of influenza viruses in hens' eggs and/or cell culture, recombinant and/or reassortant influenza viruses with increased replication capacity, and immunogenic and vaccine compositions comprising such recombinant and/or reassortant influenza viruses. In other aspects, the invention further provides nucleic acids encoding influenza genes associated with increased replication capacity, expression vectors comprising the nucleic acids of the invention, methods for making influenza viruses with increased replication capacity, and kits useful for practice of the methods.

Abstract translation: 在某些方面，本发明提供了增加在具有增加的复制能力的母鸡卵和/或细胞培养物，重组和/或重配流感病毒中的流感病毒的复制能力的方法，以及包含这种重组和/或 重配流感病毒。 在其它方面，本发明还提供编码与增加的复制能力相关的流感基因的核酸，包含本发明的核酸的表达载体，具有增加的复制能力的制备流感病毒的方法，以及可用于实施该方法的试剂盒。

公开(公告)号：US07366532B2

公开(公告)日：2008-04-29

申请号：US10682772

申请日：2003-10-09

Applicant: Charbel Khawand ,  Bin Liu ,  Jianping W. Miller

Inventor： Charbel Khawand ,  Bin Liu ,  Jianping W. Miller

IPC: H04B7/01

CPC classification number: H04B7/269 ,  H04W56/002 ,  H04W56/0035 ,  H04W92/18

Abstract: A method of communicating with a transceiver (120). In one arrangement, the method of communicating with the transceiver can be performed in a systemless group environment. Synchronization information (150) can be received from a mobile transceiver (110) and used to synchronize to the mobile transceiver. The synchronization information can include a timing offset and a frequency offset. Synchronization can be maintained until a predetermined condition is met, for example, a predetermined amount of group inactivity.

Abstract translation: 一种与收发器（120）进行通信的方法。 在一种布置中，可以在无系统的组环境中执行与收发器通信的方法。 可以从移动收发机（110）接收同步信息（150）并用于与移动收发信机同步。 同步信息可以包括定时偏移和频率偏移。 可以保持同步，直到满足预定条件，例如，预定量的组不活动。

公开(公告)号：US07313163B2

公开(公告)日：2007-12-25

申请号：US10462853

申请日：2003-06-17

Applicant: Bin Liu ,  Charbel Khawand ,  Jianping W. Miller

Inventor： Bin Liu ,  Charbel Khawand ,  Jianping W. Miller

IPC: H04B1/713 ,  H04L7/00

CPC classification number: H04B1/7156 ,  H04B2001/71563 ,  H04B2001/71566

Abstract: Half duplex, Frequency Hopped-Spread Spectrum wireless transceivers (102), operating without a central controller, maintain time synchronization with the frequency hopping sequence for a period after transmission of a half duplex signal ceases. The wireless transceiver (102) operates their receivers (308) according to the RF frequency hopping sequence and schedule (200). The wireless transceiver (102) is then able to send a short transmission request to signal that it will start transmitting on the Frequency Hopping schedule (200) of the previously ceased transmission. A wireless transceiver (102) that was either the original transmitter or the original receiver is able to transmit this transmission request. A subset of time slots within the hopping schedule (200) can be optionally assigned to the original transmitter and original receiver to obviate collisions of the transmit request transmissions from both device at the same time.

Abstract translation: 半双工，跳频扩频无线收发器（102）在没有中央控制器的情况下运行，在半双工信号传输停止之后的一段时间内保持与跳频序列的时间同步。 无线收发器（102）根据RF跳频序列和时间表（200）操作其接收机（308）。 无线收发器（102）然后能够发送短的传输请求，以发信号通过先前停止的传输的跳频计划（200）开始发送。 作为原始发送器或原始接收器的无线收发器（102）能够发送该发送请求。 可以可选地将跳频计划（200）内的时隙的子集分配给原始发射机和原始接收机，以同时消除来自两个装置的发射请求传输的冲突。

公开(公告)号：US20070088130A1

公开(公告)日：2007-04-19

申请号：US11561893

申请日：2006-11-21

Applicant: Guillermo Bazan ,  Bin Liu

Inventor： Guillermo Bazan ,  Bin Liu

IPC: C08F297/02

CPC classification number: H01B1/122 ,  C08G61/02 ,  C08G61/10 ,  C08G61/123 ,  C08G61/126 ,  C08G73/02 ,  C08G73/08 ,  C40B40/04

Abstract: Methods, compositions and articles of manufacture involving cationic conjugated conformationally flexible polymers are provided. A method for the synthesis of cationic water-soluble polymers with linkages along the polymer main chain structure which disrupt the ability of the polymers to form extended-rod structures is provided. Such polymers may serve in the fabrication of novel optoelectronic devices and in the development of highly efficient biosensors. The invention further relates to the application of these polymers in assay methods.

Abstract translation: 提供涉及阳离子共轭构象柔性聚合物的方法，组合物和制品。 提供了一种用于合成阳离子水溶性聚合物的方法，所述聚合物具有沿聚合物主链结构的连接，其破坏聚合物形成延伸棒结构的能力。 这种聚合物可用于制造新的光电器件和开发高效生物传感器。 本发明还涉及这些聚合物在测定方法中的应用。

公开(公告)号：US20060178438A1

公开(公告)日：2006-08-10

申请号：US10546906

申请日：2004-03-12

Applicant: Jennifer Allen ,  Stephen Hitchcock ,  William Turner ,  Bin Liu

Inventor： Jennifer Allen ,  Stephen Hitchcock ,  William Turner ,  Bin Liu

IPC: A61K31/165 ,  C07C257/18

CPC classification number: C07C323/41 ,  C07B2200/07 ,  C07C257/14 ,  C07C257/18 ,  C07C271/24 ,  C07C2601/02 ,  C07C2602/08 ,  C07D213/64 ,  C07D213/70 ,  C07D295/125 ,  C07D295/13

Abstract: The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

公开(公告)号：US20060079647A1

公开(公告)日：2006-04-13

申请号：US11221123

申请日：2005-09-06

Applicant: Guillermo Bazan ,  Bin Liu

Inventor： Guillermo Bazan ,  Bin Liu

IPC: C08F297/02

CPC classification number: C08G61/123 ,  C08F8/44 ,  C08F257/00 ,  C08F279/02 ,  C08F287/00 ,  C08F289/00 ,  C08F291/00 ,  C08G61/02 ,  C08G61/124 ,  C08G61/125 ,  C08G61/126 ,  C08G73/00 ,  C08G73/06 ,  C08G73/08 ,  C08L51/006 ,  C08L51/04 ,  H01L51/0034 ,  H01L51/0035 ,  H01L51/0036 ,  H01L51/0037 ,  H01L51/0038 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/5048 ,  C08L2666/02

Abstract: Methods, compositions and articles of manufacture involving soluble conjugated polymers are provided. The conjugated polymers have a sufficient density of polar substituents to render them soluble in a polar medium, for example water and/or methanol. The conjugated polymer may desirably comprise monomers which alter its conductivity properties. In some embodiments, the inventors have provided cationic conjugated polymers (CCPs) comprising both solubilizing groups and conductive groups, resulting in conductive conjugated polymers soluble in polar media. The different solubility properties of these polymers allow their deposition in solution in multilayer formats with other conjugated polymers. Also provided are articles of manufacture comprising multiple layers of conjugated polymers having differing solubility characteristics. Embodiments of the invention are described further herein.

公开(公告)号：US06828866B2

公开(公告)日：2004-12-07

申请号：US10679839

申请日：2003-10-06

Applicant: Bin Liu

Inventor： Bin Liu

IPC: H03B532

CPC classification number: H03F3/45183 ,  H03F3/4565 ,  H03F3/72 ,  H03F2203/7203 ,  H03K3/0231 ,  H03K3/0322 ,  H03K5/133 ,  H03K2005/00208 ,  H03L7/0995

Abstract: A ring oscillator circuit, such as a VCO, with a relatively high level of noise rejection for noise originating from both the voltage supply and ground. The ring oscillator circuit is composed of a plurality of differential delay circuits, each differential delay circuit generating a differential output signal that is a delayed (and preferably inverted) version of a differential input signal. ‘Each differential delay circuit includes first and second input transistors for receiving the differential input signal. Each differential delay circuit also includes first and second load transistors coupled in parallel with the respective first and second input transistors. Each differential delay circuit further includes a first current source coupled between the first input transistor and a first power supply terminal (e.g., a voltage supply terminal), a second current source coupled between the second input transistor and the first power supply terminal and a third current source coupled between the first and second input transistors and a second power supply terminal (e.g., a ground terminal). The first and second current sources reduce the coupling of noise from the first power supply terminal to the output. The third current source reduces the coupling of noise from the second power supply terminal to the output.

公开(公告)号：US06174815B1

公开(公告)日：2001-01-16

申请号：US08957813

申请日：1997-10-27

Applicant: Fu-Liang Yang ,  Chau-Jen Kuo ,  Bin Liu

Inventor： Fu-Liang Yang ,  Chau-Jen Kuo ,  Bin Liu

IPC: H01L21311

CPC classification number: H01L21/31055 ,  H01L21/316 ,  H01L21/31625 ,  H01L27/10852

Abstract: A method for planarizing DRAM cells comprising the steps of providing a silicon substrate having a field oxide layer, an oxide layer and a capacitor formed thereon, then forming a first dielectric layer over the substrate. Next, portions of the first dielectric layer is etched back to form a spacer layer, and then a second dielectric layer is formed over the spacer layer. Thereafter, an insulating layer is formed over the second dielectric layer. Finally, the insulating layer is fully etched back to form a third dielectric layer.

Abstract translation: 一种用于平坦化DRAM单元的方法，包括以下步骤：提供具有场氧化物层，氧化物层和形成在其上的电容器的硅衬底，然后在衬底上形成第一介电层。 接下来，将第一电介质层的部分进行回蚀以形成间隔层，然后在隔离层上形成第二电介质层。 此后，在第二电介质层上形成绝缘层。 最后，绝缘层被完全回蚀以形成第三电介质层。

公开(公告)号：US06066732A

公开(公告)日：2000-05-23

申请号：US138354

申请日：1998-08-21

Applicant: Edward C. Taylor ,  Bin Liu

Inventor： Edward C. Taylor ,  Bin Liu

IPC: C07D487/04 ,  C07D239/47 ,  C07D239/48

CPC classification number: C07D487/04

Abstract: 4(3H)-X-7H-Pyrrolo[2,3-d]pyrimidines in which X is .dbd.O or .dbd.NH are prepared by treating a 6-amino-4(3H)-X-pyrimidine with a unsubstituted or substituted 1-nitroalk-1-ene to yield a 6-amino-4(3H)-X-pyrimidine which is substituted in the 5-position by a 1-nitroalk-2-yl group; (ii) converting the 5-(1-nitroalk-2-yl)-6-amino-4(3H)-X-pyrimidine to the corresponding 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyr-imidine; and (iii) removing the elements of water from the 5-(1-oxoalk-2-yl)-6-amino-4(3H)-X-pyrimidine to effect cyclization. A typical embodiment involves treating 2,6-diamino-4(3H)-pyrimidone with 1-nitro-4-(4-ethoxycarbonylphenyl)-1-butene to yield 1 -nitro-2-(2,6-diamino-4(3H)-oxopyrimidin-5-yl)-4-(4-ethoxy-carbonylphenyl)butane which is then treated sequentially with base and acid, without isolation of the intermediate aldehyde, to form 4-[2-(2-amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid, a valuable known chemical intermediate for the preparation of N-[4-{2-(2-hydroxy-4-amino-7H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl}benzoyl]glutamic acid.

Abstract translation: 通过用未取代的或取代的1位的6-氨基-4（3H） - 嘧啶处理制备X（= O或= NH）的4（3H） - 7H-吡咯并[2,3-d] - 硝基-1-烯，得到6-位氨基-4（3H） - 嘧啶，其在5-位被1-硝基烷基-2-基取代; （ii）将5-（1-硝基烷基-2-基）-6-氨基-4（3H） - 嘧啶转化成相应的5-（1-氧代-2-基）-6-氨基-4（ 3H）-X-吡啶亚胺; 和（iii）从5-（1-氧代-2-基）-6-氨基-4（3H）-X-嘧啶中除去水元素以进行环化。 典型的实施方案涉及用1-硝基-4-（4-乙氧基羰基苯基）-1-丁烯处理2,6-二氨基-4（3H） - 嘧啶酮，得到1-硝基-2-（2,6-二氨基-4 3H） - 氧代嘧啶-5-基）-4-（4-乙氧基 - 羰基苯基）丁烷，然后用碱和酸依次处理，而不分离中间体醛，形成4- [2-（2-氨基-4 （3H） - 氧代-7H-吡咯并[2,3-d]嘧啶-5-基）乙基]苯甲酸是一种有价值的已知化学中间体，用于制备N- [4- {2-（2-羟基-4 - 氨基-7H-吡咯并[2,3-d] - 嘧啶-5-基）乙基}苯甲酰基]谷氨酸。

公开(公告)号：US20250121246A1

公开(公告)日：2025-04-17

申请号：US18379664

申请日：2023-10-13

Applicant: Bin Liu

Inventor： Bin Liu

IPC: A63B21/00 ,  A63B21/062

Abstract: The present invention discloses a fitness equipment comprising frame assembly, drive assembly, slide trolley and a smith system. Two base frames set opposite to each other are connected by connecting rod, and the first column and the second column are set in the vertical direction of the connecting rod which are connected by gantry frame, and the first cross beam and the second cross beam are set vertically on the connecting rod and the gantry frame, respectively, and the third column is set between them, thus forming the structure of fitness equipment, and pulley assembly is cooperated with the first wire rope, the second wire rope, and the third wire rope so that it can drive the slide car moves, realizing the alignment from the middle, which can reduce friction and increase the service life of the multifunctional fitness equipment when in use.