公开(公告)号：US11967410B2

公开(公告)日：2024-04-23

申请号：US15902597

申请日：2018-02-22

Applicant: Meso Scale Technologies, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/53 ,  G01N27/327 ,  G01N33/68 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02 ,  G16H20/40

CPC classification number: G16H20/40 ,  G01N27/3273 ,  G01N33/6893 ,  G01N35/00 ,  G01T1/00 ,  G01T1/02 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60

Abstract: Methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. Also, algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US11892455B2

公开(公告)日：2024-02-06

申请号：US17061095

申请日：2020-10-01

Applicant: Meso Scale Technologies, LLC

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC: G01N35/10 ,  B67B7/00 ,  G01N33/58 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  B01L3/00 ,  G01N35/04

CPC classification number: G01N33/582 ,  B01L3/5085 ,  B01L3/50255 ,  B67B7/24 ,  G01N21/6452 ,  G01N21/66 ,  G01N33/5302 ,  G01N35/028 ,  G01N35/1011 ,  G01N35/1079 ,  G01N35/1081 ,  G01N35/1002 ,  G01N35/109 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/1025 ,  Y10T83/9314

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20220390469A1

公开(公告)日：2022-12-08

申请号：US17890782

申请日：2022-08-18

Applicant: Meso Scale Technologies, LLC.

Inventor： Jeffrey Debad ,  Eli N. Glezer ,  Sudeep Kumar

IPC: G01N33/68 ,  G01N33/574

Abstract: The present invention relates to methods of diagnosing an inflammatory disorder in a patient, as well as methods of monitoring the progression of an inflammatory disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20220283157A1

公开(公告)日：2022-09-08

申请号：US17531868

申请日：2021-11-22

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Mikayla Higgins ,  John Kenten ,  George Sigal

IPC: G01N33/564

Abstract: The present disclosure relates to multiplexed assay formats configured to measure the level of a plurality of biomarkers that include a protein array for detecting autoreactive antibody levels against autoantigens.

公开(公告)号：US20220196668A1

公开(公告)日：2022-06-23

申请号：US17693918

申请日：2022-03-14

Applicant: Meso Scale Technologies, LLC.

Inventor： Simone Barbero ,  Eli N. Glezer ,  Anu Mathew ,  Mingyue Wang

IPC: G01N33/574 ,  A61K31/44 ,  A61K31/404 ,  C12Q1/48

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11320366B2

公开(公告)日：2022-05-03

申请号：US16219030

申请日：2018-12-13

Applicant: Meso Scale Technologies, LLC.

Inventor： Nicholas Anderson ,  Jeffery Debad ,  Eli N. Glezer ,  Sudeep Kumar ,  Noel Lawrence ,  Kenneth Page ,  George Sigal ,  Sharon West

IPC: B01L9/00 ,  G01N21/05 ,  G01N21/69 ,  G01N21/76 ,  B01L3/00 ,  G01N21/03 ,  G01F23/02 ,  G01F23/292 ,  G01N1/10 ,  B01L7/00

Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US11156801B2

公开(公告)日：2021-10-26

申请号：US16360257

申请日：2019-03-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Ian Chamberlin ,  Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Manish Kochar ,  Sandor Kovacs ,  D. T. Le ,  Aaron Leimkuehler ,  George Sigal ,  Leo Tabakin ,  Jon Willoughby

IPC: G02B7/36 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

Abstract: Apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation are described. They are particularly well suited for conducting automated analysis in a multi-well plate assay format.

公开(公告)号：US20210109100A1

公开(公告)日：2021-04-15

申请号：US16937500

申请日：2020-07-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Michael Tsionsky ,  Eli N. Glezer ,  Selen Stromgren ,  George Sigal ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Svetlana Leytner ,  Mark Martin ,  Larry Helms

IPC: G01N33/573 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/58 ,  G01N21/76 ,  G01N33/53

Abstract: The invention relates to improved electrochemiluminescence assay methods for phosphorylated peptides or proteins employing phospho-specific antibodies and buffer compositions that are substantially free of inorganic phosphate.

公开(公告)号：US20210060567A1

公开(公告)日：2021-03-04

申请号：US17032524

申请日：2020-09-25

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Stephen Higgins ,  Sandor Kovacs ,  Sudeep Kumar ,  Kenneth Page ,  Kristian Roth ,  George Sigal

IPC: B01L7/00 ,  B01L3/00

Abstract: Assay cartridges are described that have purification, reaction, and detection zones and other fluidic components which can include sample chambers, waste chambers, conduits, vents, reagent chambers, reconstitution chambers and the like. The assay cartridges are used to conduct multiplexed nucleic acid measurements. Also described are kits including such cartridges, methods of using the same, and a reader configured to analyze an assay conducted using an assay cartridge.

公开(公告)号：US20210055287A1

公开(公告)日：2021-02-25

申请号：US17090367

申请日：2020-11-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Jonathan K. Leland ,  Mark A. Billadeau ,  Joseph M. Leginus ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Koustubh A. Phalnikar ,  Sriram Jambunathan

IPC: G01N33/543 ,  B01L3/00 ,  B01L9/00 ,  C12Q1/00 ,  G01N27/30 ,  G01N21/76 ,  B01J19/00

Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.