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101.发明申请Modulation of Stat 6 Expression for the Treatment of Airway Hyperresponsiveness 审中-公开调节Stat 6表达用于治疗气道高反应性公开(公告)号：US20100202977A9
公开(公告)日：2010-08-12
申请号：US11914131
申请日：2006-05-12
IPC分类号： A61K9/12 , C07H21/04 , A61P11/00 , A61K31/711 , A61K48/00
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节STAT6在细胞，组织或动物中的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗与STAT6表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：US20100035964A1
公开(公告)日：2010-02-11
申请号：US12011761
申请日：2008-01-28
申请人： William Gaarde , Andrew T. Watt , Brett P. Monia , Mausumee Guha
发明人： William Gaarde , Andrew T. Watt , Brett P. Monia , Mausumee Guha
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding connective tissue growth factor. Methods of using these compounds for modulation of connective tissue growth factor expression and for treatment of diseases associated with expression of connective tissue growth factor are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节结缔组织生长因子的表达。 组合物包含靶向编码结缔组织生长因子的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节结缔组织生长因子表达和治疗与结缔组织生长因子表达相关的疾病的方法。
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公开(公告)号：US20090036355A1
公开(公告)日：2009-02-05
申请号：US11665423
申请日：2005-10-13
IPC分类号： A61K38/28 , A61K31/711 , A61P3/10 , A61P3/04 , A61P9/10
CPC分类号： A61K31/175 , A61K31/155 , A61K31/425 , A61K31/426 , A61K31/64 , A61K31/70 , A61K31/7105 , A61K31/7125 , A61K38/22 , A61K38/2278 , A61K38/28 , A61K45/06 , A61K2300/00
摘要： Compositions and methods are provided for decreasing blood glucose levels in an animal or for preventing or de-laying the onset of a rise in blood glucose levels in an animal, comprising administering to said animal an antisense inhibitor of PTP1B expression in combination with at least one glucose-lowering drug. The present invention is also directed to compositions and methods for improving insulin sensitivity in an animal or for preventing or delaying the onset of insulin resistance in an animal. Also provided are compositions and methods for treating or preventing a metabolic condition in an animal. The metabolic condition may be, e.g., diabetes or obesity.
摘要翻译： 提供组合物和方法用于降低动物体内的血糖水平或用于预防或消除动物体内血糖水平升高的发作，包括向所述动物施用PTP1B表达的反义抑制剂与至少一种 葡萄糖降低药物。 本发明还涉及用于改善动物体内胰岛素敏感性或预防或延迟动物体内胰岛素抵抗发作的组合物和方法。 还提供了用于治疗或预防动物代谢状况的组合物和方法。 代谢病症可以是例如糖尿病或肥胖症。
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公开(公告)号：US20080311052A1
公开(公告)日：2008-12-18
申请号：US11914131
申请日：2006-05-12
IPC分类号： A61K9/12 , C07H21/04 , A61P11/00 , A61K31/711
CPC分类号： C12N15/113 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of STAT 6 in a cell, tissue, or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders related to expression of STAT 6, airway hyperresponsiveness, and/or pulmonary inflammation.
摘要翻译： 本文公开了用于调节STAT6在细胞，组织或动物中的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗与STAT6表达，气道高反应性和/或肺部炎症相关的疾病和病症的药物中的用途。
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公开(公告)号：US06607915B1
公开(公告)日：2003-08-19
申请号：US09624945
申请日：2000-07-25
申请人： Brett P. Monia , Edward Wancewicz
发明人： Brett P. Monia , Edward Wancewicz
IPC分类号： C07H2104
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for inhibiting E2A-Pbx1 mediated transformation. The compositions comprise antisense compounds targeted to nucleic acids encoding E2A-Pbx1. Methods of using these antisense compounds for inhibition of E2A-Pbx1 expression and for treatment of diseases, particularly cancers, associated with overexpression or constitutive activation of E2A-Pbx1 are provided.
摘要翻译： 提供化合物，组合物和方法用于抑制E2A-Pbx1介导的转化。 组合物包含靶向编码E2A-Pbx1的核酸的反义化合物。 提供了使用这些反义化合物抑制E2A-Pbx1表达和治疗与E2A-Pbx1的过度表达或组成型激活相关的疾病，特别是癌症的方法。
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106.发明授权Antisense inhibition of ras gene with chimeric and alternating oligonucleotides 有权用嵌合和交替寡核苷酸反义ras基因的抑制公开(公告)号：US06359124B1
公开(公告)日：2002-03-19
申请号：US09248386
申请日：1999-02-12
IPC分类号： C07H2102
CPC分类号： C12N15/1135 , C07H21/00 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Q1/6876 , C12Q2600/158 , C12N2310/3525
摘要： Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided that have methylene(methylimino) linkages alternating with phosphorothioate or phosphodiester linkages. Further oligonucleotides are provide that have a first region having a methylene(methylimino) linkage alternating with a phosphorothioate or phosphodiester linkage and a second region having phosphorothioate linkages. Such oligonucleotides can be used for diagnostics as well as for research purposes including methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene.
摘要翻译： 提供组合物和方法用于调节正常和活化形式的人ras基因的表达。 提供了具有与硫代磷酸酯或磷酸二酯键交替的亚甲基（甲基亚氨基）键的寡核苷酸。 提供另外的寡核苷酸，其具有与硫代磷酸酯或磷酸二酯键交替的亚甲基（甲基亚氨基）键的第一区域和具有硫代磷酸酯键的第二区域。 这样的寡核苷酸可用于诊断以及研究目的，包括用于诊断，检测和治疗由H-ras基因激活产生的病症的方法。
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公开(公告)号：US06300132B1
公开(公告)日：2001-10-09
申请号：US09467642
申请日：1999-12-17
申请人： Brett P. Monia , Lex M. Cowsert
发明人： Brett P. Monia , Lex M. Cowsert
IPC分类号： A61K317115
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Telomeric repeat binding factor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Telomeric repeat binding factor 2. Methods of using these compounds for modulation of Telomeric repeat binding factor 2 expression and for treatment of diseases associated with expression of Telomeric repeat binding factor 2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节端粒重复结合因子2的表达。该组合物包含靶向编码端粒重复结合因子2的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节端粒重复的方法 提供了结合因子2表达和用于治疗与端粒重复结合因子2的表达相关的疾病。
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公开(公告)号：US06238921B1
公开(公告)日：2001-05-29
申请号：US09048810
申请日：1998-03-26
申请人： Loren J. Miraglia , Pamela Nero , Mark J. Graham , Brett P. Monia
发明人： Loren J. Miraglia , Pamela Nero , Mark J. Graham , Brett P. Monia
IPC分类号： C12N1585
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/335 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
摘要翻译： 提供化合物，组合物和方法用于抑制人mdm2的表达。 组合物包含靶向编码mdm2的核酸的反义寡核苷酸。 提供了使用这些寡核苷酸抑制mdm2表达和治疗诸如与mdm2过度表达相关的癌症的疾病的方法。
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公开(公告)号：US6165789A
公开(公告)日：2000-12-26
申请号：US428696
申请日：1999-10-27
申请人： Brett P. Monia , Lex M. Cowsert
发明人： Brett P. Monia , Lex M. Cowsert
IPC分类号： A61K38/00 , C07H21/00 , C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/04 , C12N15/00 , C12N15/85
CPC分类号： C12N15/113 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of hnRNP A1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding hnRNP A1. Methods of using these compounds for modulation of hnRNP A1 expression and for treatment of diseases associated with expression of hnRNP A1 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节hnRNP A1的表达。 组合物包含靶向编码hnRNP A1的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节hnRNP A1表达和治疗与hnRNP A1表达有关的疾病的方法。
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公开(公告)号：US6146829A
公开(公告)日：2000-11-14
申请号：US144611
申请日：1998-08-31
申请人： Phillip Dan Cook , Brett P. Monia
发明人： Phillip Dan Cook , Brett P. Monia
IPC分类号： A61K31/70 , A61K31/7125 , A61K38/00 , A61K48/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07H19/04 , C07H21/00 , C07H21/04 , C07K9/00 , C07K14/00 , C07K14/82 , C12N15/09 , C12N15/113 , C12Q1/68
CPC分类号： C12Q1/6813 , C07H21/00 , C07H21/04 , C07K14/003 , C07K14/82 , C12N15/1135 , C12Q1/6816 , C12Q1/6832 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q2525/125
摘要： Oligonucleotides and other macromolecules are provided that have increased nuclease resistance, substituent groups for increasing binding affinity to complementary strand, and sub-sequences of 2'-deoxy-erythro-pentofuranosyl nucleotides that activate RNase H enzyme. Such oligonucleotides and macromolecules are useful for diagnostics and other research purposes, for modulating protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to antisense therapeutics.
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