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403 条记录 (耗时 0.149 秒)

    Antibodies to HNFIP24 polypeptides
    102.
    发明授权
    Antibodies to HNFIP24 polypeptides 失效
    HNFIP24多肽的抗体

    公开(公告)号：US08106165B2

    公开(公告)日：2012-01-31

    申请号：US11745580

    申请日：2007-05-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng

    IPC分类号： C07K16/26 ,  C07K16/00 ,  C12N5/12

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Human G-Protein Chemokine Receptor (CCR5) HDGNR10
    103.
    发明申请
    Human G-Protein Chemokine Receptor (CCR5) HDGNR10 审中-公开
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US20110081360A1

    公开(公告)日：2011-04-07

    申请号：US12943722

    申请日：2010-11-10

    申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/00 ,  A61P37/04 ,  A61P9/00 ,  A61P17/06 ,  A61P17/00 ,  A61P11/00

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/2866 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.

    摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

    Antibodies to HWHGU54 polypeptides
    104.
    发明授权
    Antibodies to HWHGU54 polypeptides 有权
    HWHGU54多肽的抗体

    公开(公告)号：US07838636B1

    公开(公告)日：2010-11-23

    申请号：US11760578

    申请日：2007-06-08

    申请人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    发明人： Steven M. Ruben ,  Craig A. Rosen ,  Ying-Fei Wei

    IPC分类号： C07K16/40 ,  C12P21/08 ,  C12P21/06 ,  C12N15/09

    CPC分类号： C07K14/47

    摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

    摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

    Antibodies that specifically bind to neurokinin B
    106.
    发明授权
    Antibodies that specifically bind to neurokinin B 失效
    特异性结合神经激肽B的抗体

    公开(公告)号：US07514079B2

    公开(公告)日：2009-04-07

    申请号：US10981692

    申请日：2004-11-05

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C07K16/26

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  Y10S424/80 ,  Y10S424/804 ,  Y10S424/806 ,  Y10S424/809 ,  Y10S435/975

    摘要： The present invention relates to antibodies and related molecules that specifically bind to neurokinin B. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including pre-eclampsia, hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain. The invention also relates to nucleic acid molecules encoding anti-neurokinin B antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially pre-eclampsia, as well as hypertension, inflammation, asthma, gastrointestinal disorders, anxiety, depression, addiction, or pain, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to neurokinin B.

    摘要翻译： 本发明涉及与神经激肽B特异性结合的抗体和相关分子。这样的抗体具有例如用于预防和治疗癌症以及免疫系统疾病和病症，包括先兆子痫，高血压，炎症，哮喘， 胃肠道疾病，焦虑症，抑郁症，成瘾症或疼痛。 本发明还涉及编码抗神经激肽B抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是先兆子痫以及高血压，炎症，哮喘，胃肠道疾病，焦虑，抑郁，成瘾或疼痛的方法和组合物，其包括 向动物，优选人施用有效量的一种或多种特异性结合神经激肽B的抗体或其片段或变体或相关分子。

    Antibodies that specifically bind to chemokine beta-4
    109.
    发明授权
    Antibodies that specifically bind to chemokine beta-4 失效
    特异性结合趋化因子β-4的抗体

    公开(公告)号：US07375192B2

    公开(公告)日：2008-05-20

    申请号：US10513705

    申请日：2003-04-30

    申请人： Craig A. Rosen ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K16/00

    CPC分类号： C07K16/24 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention relates to antibodies and related molecules that specifically bind to CK-B4. Such antibodies have uses, for example, in the prevention and treatment of cancer as well as immune system diseases and disorders including cancers, as well as immune system diseases and disorders including autoimmune diseases, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease. The invention also relates to nucleic acid molecules encoding anti-CK-B4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancers, as well as immune system diseases and disorders including autoimmune disease, inflammatory disorders, immunodeficiencies, infections, HIV, arthritis, allergy, psoriasis, dermatitis, and inflammatory bowel disease, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to CK-B4.

    摘要翻译： 本发明涉及特异性结合CK-B4的抗体和相关分子。 这样的抗体具有例如用于预防和治疗癌症以及包括癌症在内的免疫系统疾病和病症，以及免疫系统疾病和病症，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 ，牛皮癣，皮炎和炎性肠病。 本发明还涉及编码抗CK-B4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于预防，检测，诊断，治疗或改善疾病或病症，特别是癌症以及免疫系统疾病和病症的方法和组合物，包括自身免疫性疾病，炎症性疾病，免疫缺陷，感染，HIV，关节炎，过敏 牛皮癣，皮炎和炎性肠病，包括向动物，优选人类施用有效量的与CK-B4特异性结合的一种或多种抗体或其片段或变体或相关分子。

    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors
    110.
    发明授权
    Methods of treating cancer using antibodies that immunospecifically bind to trail receptors 有权
    使用免疫特异性结合尾静脉受体的抗体治疗癌症的方法

    公开(公告)号：US07361341B2

    公开(公告)日：2008-04-22

    申请号：US11391384

    申请日：2006-03-29

    申请人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    发明人： Theodora W. Salcedo ,  Steven M. Ruben ,  Craig A. Rosen ,  Vivian R. Albert ,  Claire Dobson ,  Tristan Vaughan

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/04 ,  C12P21/08 ,  C07K16/00 ,  C07H21/04

    CPC分类号： C07K16/2878 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/73

    摘要： The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR4. Such antibodies have uses, for example, in the treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding anti-TR4 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorders, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR4.

    摘要翻译： 本发明涉及免疫特异性结合TRAIL受体TR4的抗体和相关分子。 这样的抗体具有例如用于治疗癌症和其它增殖性疾病的用途。 本发明还涉及编码抗TR4抗体的核酸分子，含有这些核酸的载体和宿主细胞及其制备方法。 本发明涉及用于检测，诊断，治疗或改善疾病或病症，特别是癌症和其它过度增殖性疾病的方法和组合物，包括向动物，优选人类施用有效量的一种或多种抗体或片段或变体 或相关分子，其免疫特异性结合TRAIL受体TR4。