公开(公告)号：US20210049883A1

公开(公告)日：2021-02-18

申请号：US16964799

申请日：2019-01-24

Applicant: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Ben NASSI ,  Adi SHAMIR ,  Yuval ELOVICI

IPC: G08B13/196 ,  G06F21/83 ,  G06F21/62

Abstract: A system and method for identifying if a drone is illegitimately video streaming a location, object or person. An interceptor intercepts radio transmissions and identifies if a radio transmission is an FPV video transmission. A watermarker is used for emitting a periodic physical stimulus at a given frequency for a given duration. The system then verifies if there is a correlation between the video transmission and the periodic physical stimulus; and issues a privacy invasion attack notification if such a correlation is determined between the video transmission and the periodic physical stimulus.

公开(公告)号：US20210002283A1

公开(公告)日：2021-01-07

申请号：US16969224

申请日：2019-02-13

Applicant: JIANGSU NHWALUOKANG PHARMACEUTICAL RESEARCH AND DEVELOPMENT CO., LTD.

Inventor： Qingeng Li ,  Chen Duan ,  Tao Wang ,  Jian Liao ,  Changwen LI ,  Chao Hao

IPC: C07D487/04

Abstract: The present invention provides a crystalline form of a benzodiazepine derivative hydrochloride of Formula I or its ethanolate, wherein R is methyl or ethyl. The present invention also provides a method of preparing the crystal form of the compound of Formula I and a pharmaceutical composition comprising the crystal form.

公开(公告)号：US20200382100A1

公开(公告)日：2020-12-03

申请号：US16473630

申请日：2017-12-27

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD.

Inventor： Reshef TENNE ,  Ernesto JOSELEVICH ,  Yiftach DIVON ,  Roi LEVI ,  Assaf YAAKOBOVITZ ,  Dan YUDILEVICH

IPC: H03H9/24 ,  H03H9/02 ,  B82B1/00

Abstract: This invention provides electromechanical resonators based on metal chalcogenide nanotubes. The invention further provides methods of fabrication of electromechanical resonators and methods of use of such electromechanical resonators.

公开(公告)号：US10849985B2

公开(公告)日：2020-12-01

申请号：US15573550

申请日：2016-05-19

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Valery Krizhanovsky ,  Yossi Ovadya

IPC: A61K47/68 ,  A61P35/00 ,  A61K45/06 ,  C07K16/18 ,  C12N15/113

Abstract: A method of targeting a pharmaceutical agent to a senescent cell is disclosed. The method comprises administering the pharmaceutical agent to the subject, wherein said pharmaceutical agent is attached to an affinity moiety, said affinity moiety being capable of binding specifically to a polypeptide selected from the group consisting of HSP90B1, DNAJB4, PI4K2A, DBN1, PRKCSH, SPTBN1, NPM1, ITGA3 and a polypeptide set forth in Table 1. The targeting may be for therapeutics or diagnostics.

公开(公告)号：US20200368322A1

公开(公告)日：2020-11-26

申请号：US16986473

申请日：2020-08-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Benjamin GEIGER ,  Eran ELINAV ,  Inna GROSHEVA

IPC: A61K38/20 ,  A61K38/19 ,  A61K38/18 ,  A61K38/08

Abstract: A method of treating a disease associated with intestinal barrier dysfunction in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which downregulates the amount of glucose in intestinal cells, with the proviso that the disease is not Diabetes or obesity. Other agents for treating diseases associated with intestinal barrier dysfunction are also disclosed.

公开(公告)号：US10829561B2

公开(公告)日：2020-11-10

申请号：US15961928

申请日：2018-04-25

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah Fass ,  Iris Grossman ,  Tal Ilani

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18 ,  A61K39/00 ,  A61P35/00

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.

公开(公告)号：US20200332011A1

公开(公告)日：2020-10-22

申请号：US16852508

申请日：2020-04-19

Applicant: ImmunoBrain Checkpoint, Inc. ,  Yeda Research and Development Co. Ltd.

Inventor： Ester Yoles ,  Berit Olsen Krogh ,  Allan Jensen ,  Jan Egebjerg ,  Carol David ,  Kuti Baruch ,  Michal Eisenbach-Schwartz

IPC: C07K16/28

Abstract: The present specification discloses modified anti-PD-L1 antibodies that abolishes Fc-related effector function and enhances clearance rate while maintaining therapeutic efficacy for neurodegenerative disease modification. The present specification also discloses nucleic acid sequences and expression constructs encoding such modified anti-PD-L1 antibodies as well as methods of making such modified anti-PD-L1 antibodies. In addition, the present specification discloses methods of treatment and uses that employ an administration regime of the disclosed anti-PD-L1 antibodies that ensures the antibodies are present for only a specific period of time and then are sufficiently cleared from the body to ensure treatment efficacy is maintained.

公开(公告)号：US20200297796A1

公开(公告)日：2020-09-24

申请号：US16899647

申请日：2020-06-12

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Sharon ,  Maria Gabriella Fuzesi-Levi

IPC: A61K38/10 ,  C12N15/113

Abstract: A method of treating a condition associated with aberrant protein degradation is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent, which reduces the amount of CSN Acidic Protein (CSNAP) which is incorporated into the COP9 signalosome complex (CSN) of the cell.

公开(公告)号：US20200289582A1

公开(公告)日：2020-09-17

申请号：US16885331

申请日：2020-05-28

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yair REISNER ,  Chava ROSEN ,  Elias SHEZEN ,  Irit MILMAN KRENTSIS

IPC: A61K35/42 ,  A61K45/06 ,  A61K31/015 ,  A61K35/12 ,  A61K35/28 ,  C12N5/071 ,  A61K9/00 ,  A61K31/255 ,  A61K31/675 ,  A61N5/10

Abstract: A method of conditioning a subject in need of transplantation of progenitor cells in suspension of a tissue of interest is disclosed. The method comprising: (a) administering to a subject a therapeutically effective amount of an agent capable of inducing damage to the tissue of interest, wherein the damage results in proliferation of resident stem cells in the tissue; and subsequently (b) subjecting the subject to an agent which ablates the resident stem cells in the tissue. A method of transplanting progenitor cells in suspension of a tissue of interest to a subject in need thereof is also disclosed.

公开(公告)号：US20200225223A1

公开(公告)日：2020-07-16

申请号：US16748001

申请日：2020-01-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Irun R. COHEN ,  Eytan DOMANY ,  Francisco Javier QUINTANA ,  Guy HED ,  Gad GETZ

IPC: G01N33/564 ,  G16B20/00 ,  G01N33/68

Abstract: Method, system and an article of manufacture for clustering and thereby identifying predefined antigens reactive with undetermined immunoglobulins of sera derived from patient subjects in need of diagnosis of disease or monitoring of treatment.