公开(公告)号：US20230228715A1

公开(公告)日：2023-07-20

申请号：US18154348

申请日：2023-01-13

申请人： REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Jan P. Stegemann ,  Cheri X. Deng ,  Eric C. Hobson

IPC分类号： G01N29/02 ,  G01N29/04 ,  G01N33/02 ,  G01N33/487 ,  G01N33/483

CPC分类号： G01N29/02 ,  G01N29/04 ,  G01N33/02 ,  G01N33/487 ,  G01N33/4833 ,  G01N2291/106 ,  G01N2291/022 ,  G01N2291/023

摘要： Techniques for performing an acoustic rheology measurement of a sample are provided. A first set of acoustic pulses is provided by a focused ultrasound transducer to induce surface oscillations of the sample. A second set of acoustic pulses is provided by a detection transducer to interrogate the sample and detect the echo pulses reflected by the sample surface as a function of time. The detection ultrasound transducer system converts the echo signals to an electrical signal associated with the detected echo pulses, and a processor determines a dynamic displacement of the interface of the sample as a function of time. The processor also determines the spectrum, resonant surface oscillation frequency, and damping coefficient. Viscoelastic properties of the material are determined from these measurements, with applications for the characterization of the blood clotting process, the identification of a blood clot, gelation process, tumor, or fibrosis based on the viscoelastic properties.

公开(公告)号：US20230225839A1

公开(公告)日：2023-07-20

申请号：US17996565

申请日：2021-04-15

申请人： The Regents of the University of Michigan

发明人： Junying Li ,  Hom-Lay Wang ,  Zhaozhao Chen

IPC分类号： A61C9/00 ,  A61C11/02 ,  A61C19/045 ,  A61C19/05 ,  A61C7/00

CPC分类号： A61C9/0053 ,  A61C11/02 ,  A61C19/045 ,  A61C19/05 ,  A61C7/002

摘要： The present invention relates to methods and systems for generating a 3-D dental impression with a corresponding hinge axis position and, in certain embodiments, a condylar guide inclination. In some embodiments, an intraoral scanner and a computer processing system are employed to: i) generate upper and lower jaw models, and first and second occlusal 3-D models with different mouth openings (MOs) or functional positions (FPs), ii) align the models to generate a composite 3-D model, iii) calculate a hinge axis position from the composite 3-D model based on the difference in said MOs or FPs, and iv) mount the 3-D dental impression on a virtual articulator (VA) by aligning the hinge axis position to the hinge axis position of the VA.

公开(公告)号：US20230212123A1

公开(公告)日：2023-07-06

申请号：US17920794

申请日：2021-04-20

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Scott D. Larsen ,  James A. Shayman ,  Michael William Wilson ,  Neil Moss

IPC分类号： C07D213/64 ,  C07D213/65 ,  C07D213/40 ,  C07D213/68 ,  C07D401/06 ,  C07D213/61 ,  A61K45/06

CPC分类号： C07D213/64 ,  A61K45/06 ,  C07D213/40 ,  C07D213/61 ,  C07D213/65 ,  C07D213/68 ,  C07D401/06

摘要： Glucosylceramide synthase inhibitors and compositions containing the same are disclosed. Methods of using the glucosylceramide synthase inhibitors in the treatment of diseases and conditions wherein inhibition of glucosylceramide synthase provides a benefit, like Gaucher disease and Fabry disease, also are disclosed.

公开(公告)号：US11691989B2

公开(公告)日：2023-07-04

申请号：US17047423

申请日：2019-11-20

申请人： ASCENTAGE PHARMA (SUZHOU) CO., LTD. ,  THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  ASCENTAGE PHARMA GROUP CORP LIMITED

发明人： Hao Chen ,  Wenming Chen ,  Chao Li ,  Dongbo Li ,  Yu Jing ,  Guozhi Tang ,  Yunlong Zhou ,  Shaomeng Wang ,  Chao-Yie Yang

IPC分类号： C07D497/22 ,  C07D515/22 ,  C07D231/12 ,  A61K31/395 ,  A61P35/00

CPC分类号： C07D515/22 ,  A61P35/00

摘要： Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R1a, R1b, R1h, L2, L3, #, #, # are as defined as set forth in the re) specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

公开(公告)号：US20230201354A1

公开(公告)日：2023-06-29

申请号：US17998761

申请日：2021-05-14

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Hakan Demirci ,  Nicholas Kotov ,  Yichun Wang

IPC分类号： A61K47/52 ,  A61K9/00 ,  A61K45/06 ,  A61K49/00 ,  A61K47/69 ,  C01B32/159

CPC分类号： A61K47/52 ,  A61K9/0019 ,  A61K45/06 ,  A61K9/0092 ,  A61K49/0095 ,  A61K49/0017 ,  A61K47/6929 ,  C01B32/159 ,  C01B2202/36 ,  C01B2202/34 ,  B82Y5/00

摘要： Disclosed herein are compositions and methods for injecting compounds into a vitreous body. Carbon nanotubes can be functionalized with a variety of agents, such as therapeutic agents and/or diagnostic agents, which can be injected into a vitreous body for treatment or detection of ocular tumors such as retinoblastoma. The carbon nanotubes can effectively penetrate the ocular tumor, making them effective carriers for the therapeutic and/or diagnostic agents.

公开(公告)号：US11680143B2

公开(公告)日：2023-06-20

申请号：US16738872

申请日：2020-01-09

申请人： The Regents of the University of Michigan ,  The Regents of the University of California

发明人： Mark H. Tuszynski ,  Jeffrey S. Sakamoto ,  Kendell M. Pawelec ,  Yacov M. Koffler ,  Michael Sailor ,  Jonathan Zuidema

IPC分类号： C08J5/18 ,  A61F2/02 ,  A61M31/00 ,  C08K3/36 ,  C08K3/04 ,  C08K3/32 ,  A61F2/30

CPC分类号： C08J5/18 ,  A61F2/02 ,  A61M31/002 ,  C08K3/36 ,  A61F2002/30316 ,  C08J2367/04 ,  C08K3/042 ,  C08K2003/325 ,  C08K2201/011

摘要： Provided herein is technology relating to materials having microscale and/or nanoscale features and particularly, but not exclusively, to porous materials comprising microscale features, methods for producing porous materials comprising microscale features, drug delivery vehicles, and related kits, systems, and uses.

公开(公告)号：US20230179182A1

公开(公告)日：2023-06-08

申请号：US18077759

申请日：2022-12-08

申请人： The Regents of the University of Michigan

发明人： Xin Zan ,  Al-Thaddeus Avestruz

IPC分类号： H03K3/01 ,  H03K5/01

CPC分类号： H03K3/01 ,  H03K5/01

摘要： A pulse shaping device includes an inductor that is selectively output-coupled to a first port of a capacitor. The inductor is charged to a selected current throughput and then coupled to the first port to generate a first characteristic within the current flowing at a second port of the capacitor. The capacitor is charged until reaching a clamping voltage at the first port. A voltage clamp of the shaping device clamps the first port of the capacitor at the clamping voltage to generate a second characteristic within the current flowing at a second port of the capacitor.

公开(公告)号：US20230173768A1

公开(公告)日：2023-06-08

申请号：US17870418

申请日：2022-07-21

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： Fengchao LIU ,  Pingsha DONG

IPC分类号： B29C65/00 ,  B29C65/14 ,  B29C65/44

CPC分类号： B29C66/742 ,  B29C65/1429 ,  B29C65/44 ,  B29C66/022 ,  B29C66/43 ,  B29C66/30326

摘要： A method of directly joining a polymer to a metal along a joint interface through the formation of C—O—M chemical bonds, where M represents an element in the metal to be joined. The method includes heating the metal to a predetermined temperature above a glass transition temperature of the polymer and less than a flash ignition temperature of the polymer and less than a metal melting temperature of the metal; and applying force to the joint interface of the metal and the polymer to generate intimate atomic contact between the metal and the polymer to create C—O—M chemical bonds between the metal and the polymer.

公开(公告)号：US20230172706A1

公开(公告)日：2023-06-08

申请号：US18103128

申请日：2023-01-30

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

发明人： David A. ZOPF ,  Scott J. HOLLISTER

IPC分类号： A61F2/18 ,  B33Y70/00 ,  A61F2/00

CPC分类号： A61F2/18 ,  B33Y70/00 ,  A61F2/0059 ,  A61F2002/183 ,  A61L27/18

摘要： Ear implants for auricular tissue reconstruction in a patient are provided. The ear implant may be a tissue scaffold multicomponent assembly for reconstruction of auricular tissue. Thus, the assembly may include both a first and a second tissue scaffold component. Each comprises a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The first tissue scaffold component defines a central void region and at least a portion of an outer ear framework of the patient after implantation. The second tissue scaffold component defines a base portion. After implantation into the patient, the second tissue scaffold component seats within the central void region of the first tissue scaffold component, so that the second tissue scaffold component is secured to the first tissue scaffold component. Methods for reconstructing auricular tissue in a patient using such ear implant tissue scaffolds are also provided.

公开(公告)号：US11665968B2

公开(公告)日：2023-05-30

申请号：US17180193

申请日：2021-02-19

申请人： The Regents of the University of Michigan ,  VESPER TECHNOLOGIES INC.

发明人： Karl Grosh ,  Robert J. Littrell

IPC分类号： H01L41/083 ,  H01L41/187 ,  H01L41/113 ,  H04R17/00 ,  H04R17/02 ,  B81B7/00 ,  B81B7/02 ,  B81B3/00

CPC分类号： H01L41/083 ,  B81B3/0021 ,  B81B7/0032 ,  B81B7/02 ,  H01L41/1132 ,  H01L41/1136 ,  H01L41/1138 ,  H01L41/187 ,  H04R17/00 ,  H04R17/02 ,  B81B2201/0257 ,  B81B2203/0127 ,  B81B2203/0315 ,  B81B2203/04 ,  B81B2207/09 ,  H04R2201/003

摘要： A microphone including a casing having a front wall, a back wall, and a side wall joining the front wall to the back wall, a transducer mounted to the front wall, the transducer including a substrate and a transducing element, the transducing element having a transducer acoustic compliance dependent on the transducing element dimensions, a back cavity cooperatively defined between the back wall, the side wall, and the transducer, the back cavity having a back cavity acoustic compliance. The transducing element is dimensioned such that the transducing element length matches a predetermined resonant frequency and the transducing element width, thickness, and elasticity produces a transducer acoustic compliance within a given range of the back cavity acoustic compliance.