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    FIRST AND SECOND ORDER FOCUSING USING FIELD FREE REGIONS IN TIME-OF-FLIGHT
    111.
    发明申请
    FIRST AND SECOND ORDER FOCUSING USING FIELD FREE REGIONS IN TIME-OF-FLIGHT 有权
    第一和第二个订单在时间飞行中使用现场免费区域聚焦

    公开(公告)号：US20150014522A1

    公开(公告)日：2015-01-15

    申请号：US14367234

    申请日：2012-12-06

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Robert E. Haufler ,  William Morgan Loyd

    IPC: H01J49/40 ,  H01J49/02 ,  H01J49/00

    CPC classification number: H01J49/405 ,  H01J49/0027 ,  H01J49/02 ,  H01J49/406

    Abstract: In some embodiments, a time of flight mass spectrometer can comprise an input orifice for receiving ions, a first ion accelerator stage for accelerating the ions along a first path, at least one ion reflector for receiving said accelerated ions and redirecting said ions along a second path different than the first path, a detector for detecting at least a portion of the ions redirected by said at least one ion reflector, and at least first and second field free drift regions disposed between said first acceleration stage and said detector, wherein said second field free region is disposed in proximity of the detector. In some embodiments, the lengths of the field free drift regions can be selected so as to provide 1st and 2nd order corrections of the time of flight of the ions with respect to variation in their initial positions.

    Abstract translation: 在一些实施例中，飞行时间质谱仪可以包括用于接收离子的输入孔，用于沿着第一路径加速离子的第一离子加速器级，用于接收所述加速离子的至少一个离子反射器，并沿着第二路径重定向所述离子 用于检测由所述至少一个离子反射器重定向的离子的至少一部分的检测器，以及设置在所述第一加速级与所述检测器之间的至少第一和第二场自由漂移区，其中所述第二 无场区设置在检测器附近。 在一些实施例中，可以选择场自由漂移区的长度，以便提供离子相对于其初始位置变化的飞行时间的1次和2次校正。

    QUANTIFICATION OF AN ANALYTE IN SERUM AND OTHER BIOLOGICAL MATRICES
    112.
    发明申请
    QUANTIFICATION OF AN ANALYTE IN SERUM AND OTHER BIOLOGICAL MATRICES 有权
    分析血清和其他生物学基础的分析数据

    公开(公告)号：US20140291505A1

    公开(公告)日：2014-10-02

    申请号：US14354313

    申请日：2012-10-26

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD. ,  PHYTRONIX TECHNOLOGIES INC.

    Inventor： Serge Auger ,  Gregory Blachon ,  Hesham Ghobarah ,  Michael Jarvis ,  Pierre Picard

    IPC: H01J49/00 ,  H01J49/04

    CPC classification number: H01J49/0031 ,  G01N27/624 ,  G01N33/82 ,  H01J49/0431 ,  H01J49/0445 ,  H01J49/0463 ,  H01J49/168

    Abstract: Methods and systems for quantifying analytes in a biological sample are provided comprising preparing a biological sample for mass spectrometric analysis, utilizing an ionization source to ionize at least a portion of the prepared biological sample to generate an ionized analyte flow, introducing the ionized analyte flow into a differential mobility spectrometer set at a compensation voltage selected to extract ionized analyte molecules from the ionized analyte flow, introducing an output analyte flow of the differential mobility spectrometer into a mass spectrometer to detect and quantify analyte ions in the output analyte flow.

    Abstract translation: 提供了用于量化生物样品中分析物的方法和系统，包括制备用于质谱分析的生物样品，利用电离源将至少一部分制备的生物样品电离以产生电离的分析物流，将电离的分析物流引入 差示迁移率光谱仪设置在选择的电压分析物流中的离子化分析物分子的选择补偿电压，将差分迁移率光谱仪的输出分析物流引入质谱仪中，以检测和量化输出分析物流中的分析物离子。

    DIFFERENTIAL MOBILITY SPECTROMETER AND METHODS THEREOF
    113.
    发明申请
    DIFFERENTIAL MOBILITY SPECTROMETER AND METHODS THEREOF 有权
    差分移动光谱仪及其方法

    公开(公告)号：US20140264009A1

    公开(公告)日：2014-09-18

    申请号：US14361378

    申请日：2012-11-21

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： John Lawrence Campbell ,  Yves LeBlanc

    IPC: G01N27/62

    CPC classification number: G01N27/624 ,  G01N27/622 ,  G01N33/6848 ,  H01J49/0072

    Abstract: An apparatus and method are provided for analyzing samples of molecules. The apparatus comprises a mass analysis system including a differential mobility spectrometer, which includes at least three filter electrodes defining two ion flow paths where the filter electrodes generate electric fields for passing through selected portions of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, a first and a second ion inlet that receive sample ions, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.

    Abstract translation: 提供了用于分析分子样品的装置和方法。 该装置包括质量分析系统，其包括差动迁移谱仪，其包括限定两个离子流动路径的至少三个过滤器电极，其中过滤电极基于样品离子的迁移率特性产生用于穿过样本离子的选定部分的电场 。 差动迁移谱仪还包括电压源，其向至少一个滤波电极提供DC和RF电压以产生电场;接收样品离子的第一和第二离子入口;以及输出所选部分的离子出口 的样品离子。 质谱仪接收样品离子的部分或全部选定部分。

    Simplification of method or system using scout MRM
    116.
    发明授权
    Simplification of method or system using scout MRM 有权

    公开(公告)号：US12300478B2

    公开(公告)日：2025-05-13

    申请号：US17999569

    申请日：2021-05-21

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： David M. Cox ,  Chang Liu

    IPC: H01J49/00 ,  H01J49/04 ,  H01J49/16

    Abstract: Each sample of a series of samples is ejected at an ejection time and according to a sample order. Each ejected sample of the series is ionized, producing ion beam. A list of different sets of MRM transitions is received. Each set of the list corresponds to a different sample. A group of one or more different sets is selected from the list. Initially, each set selected for the group corresponds to a different sample of one or more first samples of the series. A mass spectrometer is instructed to execute each transition of each set of the group on the ion beam until a transition of a set of the group is detected, upon which, one or more next sets are selected from the list to be monitored using the set of the detected transition and the sample order.

    DISCRETE PEG MOLECULES AS ANALYTES FOR MS CALIBRATION AND TUNING IN POSITIVE AND NEGATIVE MODES
    117.
    发明申请
    DISCRETE PEG MOLECULES AS ANALYTES FOR MS CALIBRATION AND TUNING IN POSITIVE AND NEGATIVE MODES 有权

    公开(公告)号：US20250136810A1

    公开(公告)日：2025-05-01

    申请号：US18683343

    申请日：2022-08-11

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Subhasish Purkayastha ,  Subhakar Dey

    IPC: C08L71/02 ,  H01J49/00

    Abstract: The disclosure provides compositions, methods, and kits that find use in calibrating a mass spectrometer, and can include one or more predetermined concentration(s) of one or more calibrant molecule(s) that comprise a polyethylene glycol (PEG) compounds that have a single functional group that can be ionized by an ion source, and a solvent for dissolving the calibrant molecule(s). The calibrant molecule(s) and compositions including them can be used in either positive or negative ionization mode, and can be used for calibrating a variety of mass spectrometers (e.g., APCI, ESI) operating in a variety of acquisition modes (e.g., MRM, MS/MS, etc.).

    Low Noise Bipolar High Voltage Regulator
    118.
    发明申请
    Low Noise Bipolar High Voltage Regulator 有权

    公开(公告)号：US20250036151A1

    公开(公告)日：2025-01-30

    申请号：US18792786

    申请日：2024-08-02

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Manuel FAUR ,  Ernesto GRADIN

    IPC: G05F1/595 ,  G05F1/575

    Abstract: In one aspect, a voltage regulator is disclosed, which comprises a first voltage regulator unit configured for regulating a voltage generated by a positive high voltage source, a second voltage regulator unit configured for regulating a voltage generated by a negative high voltage source, a polarity switch for connecting said first and second voltage regulator units to said positive and negative high voltage sources, respectively, and an output voltage port for receiving a regulated positive and negative high voltage from said first and said second voltage regulator units, respectively.

    Background reduction in top-down antibody analysis
    120.
    发明授权
    Background reduction in top-down antibody analysis 有权

    公开(公告)号：US12188944B2

    公开(公告)日：2025-01-07

    申请号：US17440130

    申请日：2020-05-13

    Applicant: DH Technologies Development PTE. LTD.

    Inventor： Takashi Baba ,  Pavel Ryumin

    IPC: G01N33/68 ,  H01J49/42

    Abstract: Method and devices for performing top down analysis of an antibody are described which involve utilizing an ion source to generate a plurality of ions from a sample containing at least one intact antibody. Further, transmitting said plurality of ions through a quadrupole rod set while applying an RF signal thereto and in the absence of a resolving DC voltage so as to preferentially transmit precursor ions having an m/z value greater than a low mass cutoff of about 1500 m/z from the quadrupole rod set to an ECD cell. The method and device can also performing an ECD reaction in the ECD cell on said precursor ions and also detect reaction products from the ECD reaction.

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