公开(公告)号：US20230279067A1

公开(公告)日：2023-09-07

申请号：US18057604

申请日：2022-11-21

Applicant: Genentech, Inc.

Inventor： Yichin LIU ,  Christine Carine MOUSSION ,  Travis William BAINBRIDGE ,  lraj HOSSEINI ,  Gregory Alan LAZAR ,  Sivan COHEN ,  Christopher Charles KEMBALL ,  Jill M. SCHARTNER

IPC: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/395 ,  C07K16/28

CPC classification number: C07K14/475 ,  A61K31/713 ,  A61K38/18 ,  A61K39/39541 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/505

Abstract: The invention provides an effectorless immunoglobulin Fc protein, fusions of the effectorless Fc protein to a Flt3 ligand, and methods of using the same.

公开(公告)号：US11732054B2

公开(公告)日：2023-08-22

申请号：US16790656

申请日：2020-02-13

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark S. Dennis ,  Allen J. Ebens, Jr. ,  Teemu T. Junttila ,  Robert F. Kelley ,  Mary A. Mathieu

IPC: C07K16/28 ,  C07K16/32 ,  A61K39/395 ,  C07K16/30 ,  A61K45/06 ,  A61K31/573 ,  A61K47/68 ,  A61K39/00

CPC classification number: C07K16/32 ,  A61K31/573 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6881 ,  C07K16/283 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/92

Abstract: The invention provides anti-cluster of differentiation 3 (CD3) antibodies and methods of using the same.

公开(公告)号：US20230257430A1

公开(公告)日：2023-08-17

申请号：US18309003

申请日：2023-04-28

Applicant: Genentech, Inc.

Inventor： Jason LIANG ,  Avinashnarayan VENKATANARAYAN ,  Lai Man Phu YEE ,  Donald Scott KIRKPATRICK

IPC: C07K14/47 ,  G01N33/68 ,  C12N9/12

CPC classification number: C07K14/4702 ,  G01N33/6848 ,  C12Y207/12002 ,  C12N9/12 ,  G01N2458/15

Abstract: Provided herein are recombinant proteins comprising sets of polypeptides that may be used for measurement of protein levels.

公开(公告)号：US20230250103A1

公开(公告)日：2023-08-10

申请号：US18299622

申请日：2023-04-12

Applicant: Genentech, Inc.

Inventor： Danial BEAUDRY ,  Theresa CRAVILLION ,  Francis GOSSELIN ,  Ngiap-Kie LIM ,  Sushant MALHOTRA ,  Qingping TIAN ,  Haiming ZHANG ,  Alexander GMEHLING ,  Alec FETTES ,  Stephan BACHMANN

IPC: C07D487/04 ,  B01J31/24

CPC classification number: C07D487/04 ,  B01J31/2409 ,  B01J31/2414 ,  B01J2231/40 ,  B01J2531/824 ,  C07B2200/09

Abstract: Methods for preparing the Bruton's Tyrosine Kinase (“BTK”) inhibitor compound 2-{3′-hydroxymethyl-1-methyl-5-[5-((S)-2-methyl-4-oxetan-3-yl-piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-[3,4′]bipyridinyl-2′-yl}-7,7-dimethyl-3,4,7,8-tetrahydro-2H,6H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1-one are provided. Methods for preparing tricyclic lactam compounds are also provided.

公开(公告)号：US20230250074A1

公开(公告)日：2023-08-10

申请号：US18164302

申请日：2023-02-03

Applicant: Genentech, Inc. ,  Hoffmann-La Roche Inc.

Inventor： Rene LEBL ,  Ngiap Kie LIM ,  Roland Christoph MEIER ,  Ugo Jonathan ORCEL ,  Joerg SEDELMEIER ,  Jeff SHEN ,  Lauren Elizabeth SIROIS ,  Jacob C. TIMMERMAN ,  Etienne TRACHSEL ,  Nicholas Andrew WHITE ,  Jie XU ,  Haiming ZHANG ,  Stephan BACHMANN ,  Thomas Michael BASS ,  Raphael BIGLER ,  Johannes Adrian BURKHARD ,  Kyle Bradley Pascual CLAGG ,  Francis GOSSELIN ,  Chong HAN ,  Dainis KALDRE ,  Sean M. KELLY ,  Sebastian HEROLD ,  Christian LEITNER

IPC: C07D401/04 ,  B01J23/44 ,  B01J23/755

CPC classification number: C07D401/04 ,  B01J23/44 ,  B01J23/755

Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

公开(公告)号：US20230233567A1

公开(公告)日：2023-07-27

申请号：US17999799

申请日：2021-05-17

Applicant: Hanmi Pharm. Co., Ltd. ,  Genentech, Inc.

Inventor： Tae Won KIM ,  Yoon-hee HONG ,  Young Su NOH ,  Matthew Tsn-Wei CHANG ,  Shiva MALEK ,  Yibing YAN ,  Ivana Yen Yen YEN

IPC: A61K31/519 ,  A61P35/00 ,  A61P17/00

CPC classification number: A61K31/519 ,  A61P35/00 ,  A61P17/00

Abstract: Provided are methods for the use of belvarafenib to treat cancer having at least one mutation selected from a BRAFV600E mutation, a KRASG12V mutation, a KRASG12D mutation, a KRASG12C mutation, a KRASG12R mutation, a KRASG13D mutation, a KRASQ61H mutation, a NRASG12D mutation, a NRASG13D mutation, a NRASQ61K mutation, a NRASQ61L mutation, a NRASQ61R mutation, and a NRASG12C mutation.

公开(公告)号：US20230226180A1

公开(公告)日：2023-07-20

申请号：US18154581

申请日：2023-01-13

Applicant: Genentech, Inc.

Inventor： Jane L. GROGAN

IPC: A61K39/395 ,  A61K31/7088 ,  A61K45/06 ,  C07K16/28 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K47/68 ,  A61P35/00 ,  A61K39/00 ,  A61K38/00 ,  C07K16/30 ,  C12N15/113 ,  C12N15/115

CPC classification number: A61K39/39558 ,  A61K31/7088 ,  A61K45/06 ,  C07K16/2803 ,  A61K38/193 ,  A61K38/20 ,  A61K38/217 ,  A61K47/6803 ,  A61K47/6851 ,  A61P35/00 ,  A61K39/00117 ,  A61K39/001113 ,  A61K39/001124 ,  A61K39/001129 ,  A61K39/001106 ,  A61K39/001128 ,  A61K39/001138 ,  A61K39/001104 ,  A61K39/001119 ,  A61K39/00114 ,  A61K39/001141 ,  A61K39/001166 ,  A61K39/001109 ,  A61K38/00 ,  A61K39/0011 ,  C07K16/30 ,  C12N15/1138 ,  C12N15/115 ,  Y02A50/30 ,  A61K2039/505 ,  A61K2039/5158 ,  A61K2039/545 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/76 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/14

Abstract: The present disclosure provides methods comprising administering to the individual an effective amount of an agent that decreases or inhibits TIGIT expression and/or activity and an anti-cancer agent and/or an anti-cancer therapy. Further provided are kits comprising an anti-cancer agent, an agent that decreases or inhibits TIGIT expression and/or activity, or both, as well as instructions for use thereof.

公开(公告)号：US20230226179A1

公开(公告)日：2023-07-20

申请号：US18149972

申请日：2023-01-04

Applicant: Genentech, Inc.

Inventor： Jakob Dupont ,  Cornelia Irl ,  Amreen Husain ,  Mika A. Sovak ,  Jing Yi ,  Hoa Nguyen

IPC: A61K39/395 ,  A61K31/282 ,  A61K31/337 ,  G06Q99/00 ,  C07K16/22 ,  A61K31/7068 ,  A61K9/00 ,  C07K16/30

CPC classification number: A61K39/39558 ,  A61K31/282 ,  A61K31/337 ,  G06Q99/00 ,  C07K16/22 ,  A61K31/7068 ,  A61K39/3955 ,  A61K9/0019 ,  C07K16/3069 ,  A61K2039/54

Abstract: This invention concerns in general treatment of diseases and pathological conditions with anti-VEGF antibodies. More specifically, the invention concerns the treatment of human patients susceptible to or diagnosed with cancer using an anti-VEGF antibody, preferably in combination with one or more additional anti-tumor therapeutic agents for the treatment of ovarian cancer.

公开(公告)号：US11702479B2

公开(公告)日：2023-07-18

申请号：US16872631

申请日：2020-05-12

Applicant: Genentech, Inc.

Inventor： Christian W. Siebel ,  Yan Wu

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  C07K16/28 ,  C07K16/30 ,  A61K47/68 ,  C07K16/24 ,  A61K39/00

CPC classification number: C07K16/2896 ,  A61K39/3955 ,  A61K47/6849 ,  C07K16/18 ,  C07K16/24 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K2039/505 ,  C07K16/22 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides anti-Jagged antibodies and methods of using the same.

公开(公告)号：US11702452B2

公开(公告)日：2023-07-18

申请号：US17517103

申请日：2021-11-02

Applicant: Genentech, Inc.

Inventor： Filip Petronijevic ,  Ngiap-Kie Lim ,  Nicholas Wong ,  Allen Hong ,  Haiyun Hou ,  Xin Linghu ,  Francis Gosselin

IPC: C07K7/64 ,  C07K1/06

CPC classification number: C07K7/64 ,  C07K1/061

Abstract: Methods for making an arylomycin ring of formula t




or salts or solvates thereof, wherein R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R5, R10 and Pg1 are as defined herein.