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公开(公告)号：US20190128909A1
公开(公告)日：2019-05-02
申请号：US16227041
申请日：2018-12-20
Applicant: Meso Scale Technologies, LLC.
Inventor： Craig P. Lovell , Thomas Lucas Hampton, III
Abstract: A flexible instrument control and data storage/management system and method for representing and processing assay plates having one or more predefined plate locations is disclosed. The system utilizes a graph data structure, layer objects and data objects. The layer objects map the graph data structure to the data objects. The graph data structure can comprise one node for each of the one or more predefined plate locations, wherein the nodes can be hierarchically defined according to a predefined plate location hierarchy. Each node can be given a unique node identifier, a node type and a node association that implements the predefined plate location hierarchy. The layer objects can include an index that maps the node identifiers to the data objects.
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公开(公告)号：US10201812B2
公开(公告)日：2019-02-12
申请号：US15784399
申请日：2017-10-16
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Sudeep Kumar , Pankaj Oberoi , George Sigal , Michael Tsionsky
IPC: C12Q1/68 , B01L3/00 , C12Q1/6876 , G01N33/543 , C12Q1/6804 , G01N33/68 , C12Q1/6816
Abstract: The invention relates to methods for conducting solid-phase binding assays. One example is an assay method having improved analyte specificity where specificity is limited by the presence of non-specific binding interactions.
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公开(公告)号：US10184947B2
公开(公告)日：2019-01-22
申请号：US15468734
申请日：2017-03-24
Applicant: Meso Scale Technologies, LLC.
Inventor： Craig P. Lovell , Thomas Lucas Hampton, III
Abstract: A flexible instrument control and data storage/management system and method for representing and processing assay plates having one or more predefined plate locations is disclosed. The system utilizes a graph data structure, layer objects and data objects. The layer objects map the graph data structure to the data objects. The graph data structure can comprise one node for each of the one or more predefined plate locations, wherein the nodes can be hierarchically defined according to a predefined plate location hierarchy. Each node can be given a unique node identifier, a node type and a node association that implements the predefined plate location hierarchy. The layer objects can include an index that maps the node identifiers to the data objects.
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公开(公告)号：US20180341708A1
公开(公告)日：2018-11-29
申请号：US16052711
申请日：2018-08-02
Applicant: Meso Scale Technologies, LLC.
Inventor： Xinri Cong , Jerome Jackson , Carl Stevens , Michael Vock , Jacob N. Wohlstadter
IPC: G06F17/30 , G07C9/00 , G16H10/40 , G06Q30/02 , G06Q10/10 , G06Q10/06 , G06Q30/06 , G01N35/00 , G01N35/04 , G06F19/00 , G01N35/10 , G06F19/28
Abstract: The present invention relates to methods, devices and systems for associating consumable data with an assay consumable used in a biological assay. Provided are assay systems and associated consumables, wherein the assay system adjusts one or more steps of an assay protocol based on consumable data specific for that consumable. Various types of consumable data are described, as well as methods of using such information in the conduct of an assay by an assay system.
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公开(公告)号：US20180246100A1
公开(公告)日：2018-08-30
申请号：US15902597
申请日：2018-02-22
Applicant: Meso Scale Technologies, LLC. , THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Inventor： William F. Blakely , Eli N. Glezer , John Kenten , Sudeep Kumar , Anu Mathew , Natalia I. Ossetrova , George Sigal
IPC: G01N33/569 , G01N33/566 , G01N33/68
CPC classification number: G01N33/56972 , G01N33/566 , G01N33/6893 , G01N2333/70535 , G01N2333/70578 , G01N2800/40 , G01N2800/60 , G01T1/00 , G01T1/02
Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.
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Patent Agency Ranking
公开(公告)号：US20180074061A1
公开(公告)日：2018-03-15
申请号：US15813418
申请日：2017-11-15
Applicant: Meso Scale Technologies, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , Sudeep Kumar , Galina Nikolenko , Martin Stengelin , Srikant Vaithilingam
IPC: G01N33/574
CPC classification number: G01N33/57423 , G01N2800/52
Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.
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117.发明授权公开(公告)号：US09804173B2
公开(公告)日：2017-10-31
申请号：US14478221
申请日：2014-09-05
Applicant: Meso Scale Technologies, LLC
Inventor： Jeff D. Debad , Eli N. Glezer , Sudeep M. Kumar
IPC: G01N33/68
CPC classification number: G01N33/6893 , G01N33/6863 , G01N2333/523 , G01N2333/525 , G01N2333/70578 , G01N2800/065 , G01N2800/52
Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.
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公开(公告)号：US20170168047A1
公开(公告)日：2017-06-15
申请号：US15440191
申请日：2017-02-23
Applicant: Meso Scale Technologies, LLC.
Inventor： Anahit Aghvanyan , Eli N. Glezer , John Kenten , George Sigal , Martin Stengelin
CPC classification number: G01N33/54393 , C12Q1/6804 , G01N21/66 , G01N21/76 , G01N21/77 , G01N33/5306 , G01N33/5308 , G01N33/533 , G01N33/54306 , G01N33/56988 , G01N33/582 , G01N2021/7786 , C12Q2537/125 , C12Q2563/179
Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.
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119.发明申请公开(公告)号：US20160245799A1
公开(公告)日：2016-08-25
申请号：US15146293
申请日：2016-05-04
Applicant: Meso Scale Technologies, LLC.
Inventor： Eli N. Glezer , Kent Johnson , Michael Tsionsky , John H. Kenten , Jeff D. Debad , Robert M. Umek , Paula Denney Eason , Hans Biebuyck , Jacob N. Wohlstadter , James Wilbur , George Sigal , Niranjan Y. Sardesai
IPC: G01N33/53 , G01N33/573 , G01N33/68 , G01N33/569
CPC classification number: G01N33/5304 , C12Q1/485 , G01N33/54366 , G01N33/54373 , G01N33/5438 , G01N33/54386 , G01N33/56944 , G01N33/56983 , G01N33/56988 , G01N33/573 , G01N33/68 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2333/11 , G01N2333/135 , G01N2333/16 , G01N2333/525 , G01N2333/5412 , G01N2333/545 , G01N2333/57 , G01N2333/71 , G01N2333/9121 , Y10S436/807
Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.
Abstract translation: 使用具有多个测定域的测定模块进行多重测试测量。 在优选实施方案中，这些测量在具有集成电极的测定模块中进行，所述测量模块具有适于接收测定模块的读取器装置，在测定模块的孔或测定区域中诱导发光，优选电极诱导的发光并测量诱导的发光。
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公开(公告)号：US09404881B2
公开(公告)日：2016-08-02
申请号：US14170721
申请日：2014-02-03
Applicant: Meso Scale Technologies, LLC
Inventor： Eli N. Glezer , Jonathan K. Leland , Mark A. Billadeau , Joseph M. Leginus , Bandele Jeffrey-Coker , Jeffery D. Debad , Koustubh A. Phalnikar , Sriram Jambunathan
CPC classification number: G01N21/76 , B01J19/0046 , B01J2219/00653 , B01J2219/00725 , B01J2219/0074 , B01L3/5027 , B01L3/502715 , B01L3/5029 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/049 , B01L2400/0688 , B33Y80/00 , C12Q1/001 , C40B40/10 , G01N27/30 , G01N33/5438 , G01N2458/30 , Y10T436/25 , Y10T436/25375 , Y10T436/255
Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
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