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公开(公告)号：US20240265941A1
公开(公告)日：2024-08-08
申请号：US18568250
申请日：2022-06-08
Applicant: UNIVERSITY OF SOUTH AUSTRALIA
Inventor： Nicolas Noel RIESEN , Hans Albert RIESEN
IPC: G11B7/0045 , G11B7/005 , G11B7/2533
CPC classification number: G11B7/00455 , G11B7/0052 , G11B7/2533
Abstract: A data storage medium for storing digital data. The medium includes a mixture of different nano-sized materials, each of the nano-sized materials having a respective optical transition profile characterizing an optical transition of the nano-sized material and covering a respective wavelength range, wherein a combined optical transition profile of the mixture covers an extended wavelength range as compared to the respective wavelength ranges of the respective optical transition profiles of the different nano-sized materials, and wherein one or more of the different nano-sized materials is photo-reactive to selectively vary a respective absorption/emission band upon irradiation to encode digital data in the combined optical transition profile of the mixture.
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公开(公告)号：US20230405593A1
公开(公告)日：2023-12-21
申请号：US18248175
申请日：2021-10-08
Applicant: UNIVERSITY OF SOUTH AUSTRALIA
Inventor： Craig Priest , Aliaa Shallan , Michael Breadmore , Moein Navvab Kashani
CPC classification number: B01L3/502753 , B01L3/502707 , B01L3/502761 , G01N33/24 , B01L2200/0668 , B01L2300/04 , B01L2300/0874
Abstract: The present invention relates generally to devices able to manipulate, process, treat, sort, measure and/or analyse samples at a micro level, commonly referred to as microfluidic devices. In particular, the present invention relates to a microfluidic device that can be used for the analysis of particulate samples, such as by the leaching at a micro level of a crushed rock particulate sample from a mineral ore body and the subsequent analysis of the leachate. The present invention also relates to a method for the use of a microfluidic device for the analysis of a particulate sample.
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公开(公告)号：US20230390316A1
公开(公告)日：2023-12-07
申请号：US18031762
申请日：2021-10-13
Applicant: University of South Australia
Inventor： Chelsea Thorn , Nicky Thomas , Clive Prestidge
CPC classification number: A61K31/7036 , A61K38/12 , A61K9/1274 , A61P31/04 , A61K47/14 , A61K47/10 , A61P17/02
Abstract: The present invention relates to antimicrobial compositions and methods for their use. In particular, the compositions comprise an antimicrobial agent and a nanostructured liquid crystal carrier, wherein the antimicrobial agent is contained within the nanostructured liquid crystal carrier, and wherein the nanostructured liquid crystal carrier potentiates the activity of the antimicrobial agent. Antimicrobial agents encompassed by the present invention include cationic antibiotics, antimicrobial peptides, and antifungal agents. Nanostructured liquid crystal carriers encompassed by the present invention include those formed from an amphiphilic lipid such as monoolein and phytantriol. Antimicrobial compositions encompassed by the present invention can be used for the treatment or prevention of a microbial infection, such as that caused by a Gram-negative bacterium, including where the microbial infection forms part of a biofilm. The present invention also relates to methods for reducing the viability of a microorganisms, for potentiating the activity of an antimicrobial agent, for reducing the dose of an antimicrobial agent required to treat or prevent a microbial infection, or for increasing the potency of an antimicrobial agent required to treat or prevent a microbial infection, by administering an antimicrobial composition described herein. Kits comprising the antimicrobial compositions are also encompassed by the present invention.
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公开(公告)号：US20230305590A1
公开(公告)日：2023-09-28
申请号：US18011003
申请日：2021-03-11
Applicant: UNIVERSITY OF SOUTH AUSTRALIA
Inventor： Russell Brinkworth , Anthony Finn , Daniel Griffiths , Phillip Stanley Martin Skelton
CPC classification number: G06F1/022 , G06F11/002 , G16Z99/00
Abstract: A computer-implemented data processing method to improve information quality in data sequences by attenuating noise in the data sequences, the method including: receiving input data sequences, having a plurality of elements, from one or more sensors, each of the elements having at least one dimensional component; performing a spectral analysis on the dimensional component of each of the elements, independently, to estimate a signal profile of the input data sequences; estimating a noise profile of the input data sequences using calibration data associated with the sensor; dynamically calculating a time-constant for a noise attenuation filter, and adapting the time-constant over time, for each one of the elements in the input data sequences, based on the relationship between the noise profile and the signal profile; applying the noise attenuation filter for each one of the elements to each one of the elements, respectively, to filter the input data sequences to derive filtered data sequences; and outputting the filtered data sequences.
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公开(公告)号：US11319343B2
公开(公告)日：2022-05-03
申请号：US16624367
申请日：2018-06-29
Applicant: ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY , UNIVERSITY OF SOUTH AUSTRALIA , THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN , MONASH UNIVERSITY
Inventor： Stavros Selemidis , Doug A. Brooks , John O'Leary
Abstract: The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation. Pharmaceutical compositions are also enabled herein.
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Patent Agency Ranking
公开(公告)号：US20210118525A1
公开(公告)日：2021-04-22
申请号：US17253833
申请日：2019-06-20
Applicant: Jamie Evan Craig , The Flinders University of South Australia , The Council of the Queensland Institute of Medical Research , University of Tasmania , Southern Adelaide Local Health Network
Inventor： Jamie Evan Craig , Stuart MacGregor , Alex William Hewitt
Abstract: The present disclosure relates to methods and systems for assessing the risk of glaucoma in a subject. In certain embodiments, the present disclosure provide a method of assessing the risk of primary open angle glaucoma in a subject, the method comprises determining a risk score for primary open angle glaucoma in the subject on the basis of the genetic content of the subject at a plurality of selected genetic loci or markers and thereby assessing the risk of primary open angle glaucoma in the subject, wherein the selected genetic loci or markers comprise (i) genetic loci or markers having an association with glaucoma, and/or (ii) genetic loci or markers having an association with increased intraocular pressure, and/or (iii) genetic loci or markers having an association with an increased vertical cup to disk ratio, and/or (iv) genetic loci or markers having an association with a multi-trait test of glaucoma, intraocular pressure and vertical cup to disc ratio. Other embodiments are described.
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公开(公告)号：US20210000751A1
公开(公告)日：2021-01-07
申请号：US16758792
申请日：2018-10-26
Applicant: UNIVERSITY OF SOUTH AUSTRALIA
Inventor： Ivan Mark KEMPSON , Tyron James TURNBULL
IPC: A61K9/51 , A61K41/00 , A61K33/242 , A61P35/00
Abstract: Methods of potentiating chemotherapy or radiotherapy are disclosed. The methods comprise administering to a subject in need of chemotherapeutic or radiotherapeutic treatment an effective amount of a composition comprising biocompatible nanoparticles, particularly gold nanoparticles, under conditions in which the nanoparticles alter one or more cell regulatory mechanisms in cells in which the nanoparticles are localised or other cells. Then one or more doses of a chemotherapeutic or radiotherapeutic treatment are administered to the subject either concurrently with or after the nanoparticles have altered the one or more cell regulatory mechanisms in the cells in which the nanoparticles are localised or other cells. Also disclosed are methods of enhancing the effects of chemotherapy or radiotherapy on a cell population, methods of increasing the amount of strand breaks in DNA in a cell, and methods of inducing cancer cell death.
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公开(公告)号：US10814012B2
公开(公告)日：2020-10-27
申请号：US15570504
申请日：2016-04-29
Applicant: University of South Australia
Inventor： Nicolas Hans Voelcker , Steven James Peter McInnes , Christopher Travis Turner , Allison June Cowin
IPC: A61K47/69 , C07K16/18 , C07K16/24 , A61K9/14 , A61K47/52 , A61P17/02 , A61K47/42 , A61L15/32 , A61L15/42 , A61L15/44 , A61K39/00
Abstract: The present invention relates to a drug delivery system and uses thereof. Specifically, a system that can be used to deliver therapeutic proteins, including antibodies, to proteolytic environments is disclosed. In one form of the invention the drug delivery system is a composition which comprises a porous substrate and an antibody bound to the substrate. In one embodiment, the composition comprises nanoporous silicon and can be used to deliver antibodies for the treatment, or for improving the repair, of a wound.
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119.发明申请公开(公告)号：US20200283431A1
公开(公告)日：2020-09-10
申请号：US16599354
申请日：2019-10-11
Applicant: UNIVERSITY OF SOUTH AUSTRALIA
Inventor： Shudong WANG , Solomon Tadesse ZELEKE , Mingfeng YU
IPC: C07D417/14 , A61P35/02
Abstract: A novel class of inhibitors of protein kinases that are useful in the treatment of cell proliferative diseases and conditions, and especially those characterised by over-expression of CDK4, CDK6 and/or cyclin D, including certain cancers of lung, breast, brain central nervous system, colorectal cancer and leukaemias. The inhibitors have the general structure I:
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公开(公告)号：US20200029519A1
公开(公告)日：2020-01-30
申请号：US16539696
申请日：2019-08-13
Applicant: The Flinders University of South Australia
Abstract: The present invention relates to methods for enhancing at least one growth parameter of a leguminous plant via co-inoculation of a leguminous plant with at least one rhizobial microorganism together with at least one actinobacterial microorganism. In further aspects, the present invention also relates to leguminous plants co-inoculated with at least one rhizobial microorganism together with at least one actinobacterial microorganism, as well as specific actinobacterial strains and inoculant compositions which are useful in accordance with the present invention.
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