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124 条记录 (耗时 0.042 秒)

    Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage
    113.
    发明授权
    Method for determining whether a compound is capable of inhibiting the interaction of a peptide with rage 失效
    用于确定化合物是否能够抑制肽与愤怒的相互作用的方法

    公开(公告)号：US06753150B2

    公开(公告)日：2004-06-22

    申请号：US09166649

    申请日：1998-10-05

    申请人： Ann Marie Schmidt ,  David Stern

    发明人： Ann Marie Schmidt ,  David Stern

    IPC分类号： G01N3353

    CPC分类号： C07K14/705 ,  G01N33/566 ,  G01N33/68 ,  G01N33/6842 ,  G01N2500/00

    摘要： The present invention provides a method for determining whether a compound is capable of inhibiting the interaction of a peptide with receptor for advanced glycation end product (RAGE), which comprises: (a) admixing: (i) the peptide, wherein amino groups of the peptide are inactivated by derivitization, (ii) RAGE or a fragment thereof, and (iii) the compound; (b) determining the amount of the peptide bound to RAGE or the fragment thereof, and (c) comparing the amount of bound peptide determined in step (b) with the amount determined when the peptide is admixed with RAGE or a fragment thereof in the absence of the compound, thereby determining whether the compound is capable of inhibiting the interaction of the peptide with RAGE or a fragment thereof, wherein a reduction in the amount of binding in the presence of the compound indicates that the compound is capable of inhibiting the interaction. The present invention also provides a method for inhibiting the interaction of an advanced glycation endproduct (AGE) with a receptor for advanced glycation endproduct (RAGE) in a subject which comprises administering to the subject a pharmaceutically acceptable amount of the compound identified in aforementioned screening method effective to inhibit the interaction between the AGE and the RAGE in the subject. The present invention also provides for a compound identified by the screening method and which is useful for the treatment of diabetes in a subject.

    摘要翻译： 本发明提供了一种用于确定化合物是否能够抑制肽与晚期糖基化终产物（RAGE）的受体相互作用的方法，其包括：（a）混合：（i）所述肽，其中所述肽 肽通过衍生而失活，（ii）RAGE或其片段，和（iii）化合物; （b）确定与RAGE或其片段结合的肽的量，和（c）将步骤（b）中测定的结合肽的量与当肽与RAGE或其片段中的片段混合时测定的量进行比较 不存在化合物，从而确定化合物是否能够抑制肽与RAGE或其片段的相互作用，其中在化合物存在下结合量的减少表明该化合物能够抑制相互作用 。 本发明还提供一种用于抑制晚期糖基化终末产物（AGE）与受试者晚期糖基化终末产物（RAGE）受体的相互作用的方法，其包括向受试者施用药学上可接受量的上述筛选方法鉴定的化合物 有效地抑制受试者中AGE和RAGE之间的相互作用。 本发明还提供了通过筛选方法鉴定的化合物，其可用于治疗受试者的糖尿病。

    Systems and methods for high performance scanning
    117.
    发明授权
    Systems and methods for high performance scanning 有权
    高性能扫描的系统和方法

    公开(公告)号：US06545264B1

    公开(公告)日：2003-04-08

    申请号：US09383986

    申请日：1999-08-26

    申请人： David Stern

    发明人： David Stern

    IPC分类号： H01J314

    CPC分类号： G02B21/0084 ,  G02B21/0048 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/26

    摘要： The present invention provides a scanning confocal microscope image detection system having a simple and inexpensive objective lens and a high acceleration/high speed voice coil driven translation system. The objective lens provides high light collection efficiency at low cost. The voice coil provides improved acceleration for fast scanning of at least one axis (scanning direction; fast scan axis) of a polymer array that can be used effectively with the inexpensive objective lens having high light collection efficiency. In one embodiment the translation stage includes a voice coil, a linear slide, and a light weight bracket connecting the voice coil to the linear slide. The bracket is rigid and designed to support a polymer array to be scanned or a turning prism and objective lens. Thus, the present invention provides systems and methods for high speed low cost scanning of, for example, polymer arrays, i.e., high performance cost effective polymer array scanning using a voice coil driven translation stage.

    摘要翻译： 本发明提供了一种具有简单廉价的物镜和高加速/高速音圈驱动的翻转系统的扫描共焦显微镜图像检测系统。 物镜以低成本提供高的光采集效率。 音圈提供改进的加速度，用于快速扫描聚合物阵列的至少一个轴（扫描方向;快速扫描轴），其可以有效地与具有高光采集效率的廉价物镜有效地使用。 在一个实施例中，平移台包括音圈，线性滑块和将音圈连接到线性滑块的轻量级支架。 支架是刚性的，设计用于支撑待扫描的聚合物阵列或转向棱镜和物镜。 因此，本发明提供了用于例如聚合物阵列的高速低成本扫描的系统和方法，即使用音圈驱动的平移级的高性能成本有效的聚合物阵列扫描。

    Methods involving direct write optical lithography
    119.
    发明授权
    Methods involving direct write optical lithography 失效
    涉及直写光刻的方法

    公开(公告)号：US06271957B1

    公开(公告)日：2001-08-07

    申请号：US09318775

    申请日：1999-05-26

    申请人： Calvin F. Quate ,  David Stern

    发明人： Calvin F. Quate ,  David Stern

    IPC分类号： G02B2608

    CPC分类号： G03F7/70291 ,  B01J19/0046 ,  B01J2219/00353 ,  B01J2219/00439 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00725 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G03F7/70283 ,  G03F7/704

    摘要： An improved optical photolithography system and method provides predetemined light patterns generated by a direct write system without the use of photomasks. The Direct Write System provides predetermined light patterns projected on the surface of a substrate (e.g., a wafer) by using a computer controlled component for dynamically generating the predetermined light pattern, e.g., a spatial light modulator. Image patterns are store in computer and through electronic control of the spatial light modulator directly illuminate the wafer to define a portion of the polymer array, rather than being defined by a pattern on a photomask. Thus, in the Direct Write System each pixel is illuminated with an optical beam of suitable intensity and the imaging (printing) of an individual feature is determined by computer control of the spatial light modulator at each photolithographic step without the use of a photomask. The Direct Write System including a spatial light modulator is particularly useful in the synthesis of DNA arrays and provides an efficient element for polymer array synthesis by using spatial light modulators to generate a predetermined light pattern that defines the image patterns of a polymer array to be deprotected.

    摘要翻译： 改进的光学光刻系统和方法提供由直接写入系统产生的预先设定的光图案，而不使用光掩模。 直接写入系统通过使用用于动态生成预定光图案的计算机控制部件（例如空间光调制器）来提供投影在基板（例如，晶片）的表面上的预定光图案。 图像图案存储在计算机中，并且通过空间光调制器的电子控制直接照亮晶片以限定聚合物阵列的一部分，而不是由光掩模上的图案限定。 因此，在直写系统中，每个像素用适当强度的光束照射，并且通过在每个光刻步骤的计算机控制空间光调制器而不使用光掩模来确定单个特征的成像（打印）。 包括空间光调制器在内的直接写入系统在DNA阵列的合成中特别有用，并且通过使用空间光调制器产生限定要去保护的聚合物阵列的图像图案的预定光图案，为聚合物阵列合成提供有效元素 。