公开(公告)号：US20180147558A1

公开(公告)日：2018-05-31

申请号：US15798233

申请日：2017-10-30

Applicant: Medtronic, Inc.

Inventor： Christopher M. Hobot ,  Bryantl J. Pudil

IPC: B01J20/34 ,  A61M1/16 ,  B01D15/00 ,  A61L2/00 ,  C01G25/02 ,  C01B25/37 ,  B01J20/06 ,  B01J20/02

CPC classification number: B01J20/3475 ,  A61L2/0088 ,  A61L2202/17 ,  A61L2202/24 ,  A61M1/168 ,  A61M1/1696 ,  A61M2205/3324 ,  A61M2205/3331 ,  B01D15/00 ,  B01J20/0211 ,  B01J20/0292 ,  B01J20/06 ,  B01J20/28052 ,  B01J20/3433 ,  B01J49/07 ,  B01J49/08 ,  B01J49/57 ,  C01B25/372 ,  C01G25/02

Abstract: The invention relates to devices, systems, and methods for conditioning a zirconium oxide sorbent module for use in dialysis after recharging. The devices, systems, and methods can provide for conditioning and recharging of zirconium oxide in a single system, or in separate systems.

公开(公告)号：US20180098704A1

公开(公告)日：2018-04-12

申请号：US15837388

申请日：2017-12-11

Applicant: Medtronic, Inc.

Inventor： Orhan Soykan ,  VenKatesh R. Manda ,  Martin T. Gerber ,  Christopher M. Hobot ,  Linda L. Ruetz ,  Carl Schu

IPC: A61B5/0205 ,  A61B5/0452 ,  A61B5/00 ,  A61B5/0488 ,  A61B5/145 ,  A61B5/20 ,  B01D61/24 ,  B01D61/32 ,  B01D65/02

CPC classification number: A61B5/0205 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/0488 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/201 ,  A61B5/4836 ,  A61B5/6866 ,  A61B5/7275 ,  A61B2560/0223 ,  A61M1/14 ,  A61M1/1601 ,  A61M1/3609 ,  A61M2205/18 ,  A61M2205/3523 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2230/20 ,  A61M2230/207 ,  A61M2230/208 ,  A61M2230/30 ,  B01D61/243 ,  B01D61/32 ,  B01D65/02 ,  B01D2321/12 ,  B01D2321/40 ,  G16H50/30

Abstract: A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

公开(公告)号：US09848778B2

公开(公告)日：2017-12-26

申请号：US13844257

申请日：2013-03-15

Applicant: Medtronic, Inc.

Inventor： Orhan Soykan ,  VenKatesh R. Manda ,  Martin T. Gerber ,  Christopher M. Hobot ,  Linda L. Ruetz ,  Carl Schu

IPC: A61B5/0205 ,  A61B5/0452 ,  A61B5/0488 ,  A61B5/00 ,  A61B5/145 ,  B01D61/32 ,  B01D65/02 ,  A61B5/20 ,  B01D61/24 ,  A61M1/14 ,  A61B5/053 ,  A61M1/16 ,  A61M1/36

CPC classification number: A61B5/0205 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/0488 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/201 ,  A61B5/4836 ,  A61B5/6866 ,  A61B5/7275 ,  A61B2560/0223 ,  A61M1/14 ,  A61M1/1601 ,  A61M1/3609 ,  A61M2205/18 ,  A61M2205/3523 ,  A61M2205/52 ,  A61M2205/70 ,  A61M2230/20 ,  A61M2230/207 ,  A61M2230/208 ,  A61M2230/30 ,  B01D61/243 ,  B01D61/32 ,  B01D65/02 ,  B01D2321/12 ,  B01D2321/40 ,  G06F19/00

Abstract: A medical monitoring device for monitoring electrical signals from the body of a subject is described. The medical monitoring device monitors electrical signals originating from a cardiac cycle of the subject and associates each cardiac cycle with a time index. The medical monitoring device applies a forward computational procedure to generate a risk score indicative of hyperkalemia, hypokalemia or arrhythmia of the subject. The medical monitoring device can adjust the forward computational procedure based upon clinical data obtained from the subject.

公开(公告)号：US09833548B2

公开(公告)日：2017-12-05

申请号：US14968305

申请日：2015-12-14

Applicant: Warsaw Orthopedic, Inc. ,  Medtronic, Inc.

Inventor： William F. McKay ,  Amira Wohabrebbi ,  Vanja Margareta King ,  Phillip Edward McDonald ,  Christopher M. Hobot ,  Troy Carter

IPC: A61K31/415 ,  A61L31/16 ,  A61K9/00 ,  A61K9/20 ,  A61K31/4162 ,  A61K47/34 ,  A61K31/4168 ,  A61L31/06

CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

公开(公告)号：US09775800B2

公开(公告)日：2017-10-03

申请号：US14851906

申请日：2015-09-11

Applicant: Warsaw Orthopedic, Inc. ,  Medtronic, Inc.

Inventor： Phillip E. McDonald ,  Amira Wohabrebbi ,  Christopher M. Hobot ,  Vanja M. King

IPC: A61K51/00 ,  A61M36/14 ,  A61K9/00 ,  A61K9/20 ,  A61K31/4168 ,  A61K31/445 ,  A61K45/06

CPC classification number: A61K9/0024 ,  A61K9/204 ,  A61K31/4168 ,  A61K31/445 ,  A61K45/06

Abstract: Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.

公开(公告)号：US20160243299A1

公开(公告)日：2016-08-25

申请号：US15143458

申请日：2016-04-29

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot ,  David B. Lura ,  Kanjimpuredathil Muralikrishna Menon ,  Kaustubh R. Patil ,  Mahesh Parameswaran ,  Rohit Kumar Narula ,  Ramkumar Jeyachandran

IPC: A61M1/16 ,  B01J39/12 ,  B01J41/10 ,  B01J49/00

CPC classification number: A61M1/1696 ,  A61M1/169 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3368 ,  B01J20/0211 ,  B01J20/3475 ,  B01J20/3483 ,  B01J39/09 ,  B01J39/12 ,  B01J41/10 ,  B01J49/53 ,  B01J49/57 ,  B01J49/60

Abstract: Systems and methods for recharging zirconium phosphate and zirconium oxide in reusable sorbent modules are provided. The systems and methods provide for recharging any combination of zirconium phosphate and/or zirconium oxide sorbent modules. The systems and methods also provide for linkage of multiple rechargers for sharing of infrastructure.

Abstract translation: 提供了在可重复使用的吸附剂模块中为磷酸锆和氧化锆再充电的系统和方法。 该系统和方法提供了对磷酸锆和/或氧化锆吸附剂模块的任何组合的再充电。 这些系统和方法还提供了用于共享基础设施的多个充电器的连接。

公开(公告)号：US20160236188A1

公开(公告)日：2016-08-18

申请号：US15143482

申请日：2016-04-29

Applicant: Medtronic, Inc.

Inventor： Kanjimpuredathil Muralikrishna Menon ,  Ramkumar Jeyachandran ,  Sukalyan Dutta ,  Christopher M. Hobot ,  David B. Lura

IPC: B01J49/00 ,  B01J39/12 ,  A61M1/34 ,  B01J41/10

CPC classification number: B01J49/0078 ,  A61M1/169 ,  A61M1/1696 ,  A61M2205/3317 ,  A61M2205/3324 ,  B01J20/0211 ,  B01J20/3475 ,  B01J20/3483 ,  B01J39/09 ,  B01J39/12 ,  B01J41/10 ,  B01J49/53 ,  B01J49/57 ,  B01J49/60

Abstract: Systems and methods for managing effluent from recharging zirconium phosphate and/or zirconium oxide are provided. The systems and methods control the pH of the zirconium phosphate and zirconium oxide effluent to allow for safe disposal. The systems and methods provide for management of the recharger effluent pH while recharging zirconium phosphate and zirconium oxide either independently or concurrently.

Abstract translation: 提供了用于管理从磷酸氢锆和/或氧化锆充电的流出物的系统和方法。 系统和方法控制磷酸锆和氧化锆流出物的pH值，以便安全处置。 这些系统和方法提供了对充电器流出物pH的管理，同时独立地或同时地补充磷酸锆和氧化锆。

公开(公告)号：US20160022704A1

公开(公告)日：2016-01-28

申请号：US14846067

申请日：2015-09-04

Applicant: Warsaw Orthopedic, Inc. ,  Medtronic, Inc.

Inventor： William F. McKay ,  Christopher M. Hobot ,  Danielle L. Biggs ,  Katara Shaw ,  John Myers Zanella ,  Vanja Margareta King ,  Stephen Mark Cox ,  Kathy L. Remsen

IPC: A61K31/58 ,  A61K47/34

CPC classification number: A61K31/58 ,  A61K9/0024 ,  A61K9/1647 ,  A61K31/585 ,  A61K47/34

Abstract: Effective treatments of pain and inflammation are provided. Through the administration of an effective amount of fluocinolone at or near a target site, one can reduce, prevent or treat inflammation and pain and autoimmune disorders. In various embodiments, fluocinolone formulations may be provided within biodegradable polymers to reduce, prevent or treat sciatic pain and/or inflammation. In various embodiments, prevent transplant rejection for at least twenty-five days. In some embodiments, the pain relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

公开(公告)号：US20150367059A1

公开(公告)日：2015-12-24

申请号：US14641673

申请日：2015-03-09

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot

IPC: A61M1/34 ,  B01D15/08 ,  B01D61/24 ,  A61M1/14

CPC classification number: B01D15/08 ,  A61M1/1696 ,  A61M2202/0057 ,  A61M2202/0498 ,  A61M2205/12 ,  A61M2205/3337 ,  B01D61/243

Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The system is configured to allow insertion of a urease pouch, injection of a urease solution, or addition of a urease cartridge, into a dialysis cabinet containing a dialysis flow loop. The urease can be dissolved and the resulting urease solution added to the sorbent cartridge in the flow loop to replenish the urease within the sorbent cartridge. The sorbent cartridge can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.

Abstract translation: 用于补充用于吸附剂透析的吸附剂盒中的脲酶的装置和方法。 该系统被配置为允许将尿素酶袋插入，脲酶溶液的注射或尿素酶盒的添加到包含透析流动回路的透析柜中。 可以溶解尿素酶，并将所得脲酶溶液加入到流动回路中的吸附剂筒中，以补充吸附剂盒内的脲酶。 吸附剂盒还可以包含用于从废透析液中去除尿素以外的毒素的其它可再充电的吸附剂材料。

公开(公告)号：US20150367058A1

公开(公告)日：2015-12-24

申请号：US14645394

申请日：2015-03-11

Applicant: Medtronic, Inc.

Inventor： Martin T. Gerber ,  Christopher M. Hobot

IPC: A61M1/34 ,  B01J20/28

CPC classification number: B01J20/28052 ,  A61M1/1696 ,  B01J20/0211 ,  B01J20/06 ,  B01J20/20 ,  B01J20/22 ,  B01J2220/66

Abstract: A stacked sorbent assembly for use in sorbent dialysis. The stacked sorbent assembly contains two or more interchangeable sorbent pouches that allow for fluid to freely pass into and through the sorbent materials, while keeping the sorbent materials inside the sorbent pouches. Any of the pouches in the sorbent cartridge can be reused and/or recharged.

Abstract translation: 用于吸附剂透析的堆叠式吸附剂组件。 堆叠的吸附剂组件包含两个或更多个可互换的吸附剂袋，其允许流体自由地进入和穿过吸附剂材料，同时将吸附剂材料保持在吸附剂袋内。 吸附剂盒中的任何袋可以重复使用和/或再充电。