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    REAGENT FOR IMAGING INTRACELLULAR ACETYLATION
    111.
    发明申请
    REAGENT FOR IMAGING INTRACELLULAR ACETYLATION 审中-公开
    用于成像细胞内乙酰化的试剂

    公开(公告)号：US20150276751A1

    公开(公告)日：2015-10-01

    申请号：US14434270

    申请日：2013-10-10

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Motomu Kanai ,  Hirokazu Komatsu

    IPC: G01N33/58 ,  C07D311/90

    CPC classification number: G01N33/582 ,  A61K49/0041 ,  C07D311/90 ,  C12Q1/48 ,  G01N2333/91051 ,  G01N2440/10

    Abstract: A reagent for imaging an advancing intracellular acetylation, for example, an acetylation that is advanced by the action of acetyl-CoA in the mitochondria, at high sensitivity and high efficiency, which comprises a combination of a rhodamine derivative that is substantially non-fluorescent before being acetylated, and emits strong fluorescence after being acetylated, and an acylation catalyst and/or an acylation reaction-promoting agent.

    Abstract translation: 用于成像前进的细胞内乙酰化的试剂，例如在线粒体中通过乙酰辅酶A的作用促进的乙酰化，其具有高灵敏度和高效率，其包括基本上不荧光的罗丹明衍生物的组合 乙酰化，乙酰化后发出强荧光，酰化催化剂和/或酰化反应促进剂。

    Method for manufacturing monocrystalline thin film and monocrystalline thin film device manufactured thereby
    112.
    发明授权
    Method for manufacturing monocrystalline thin film and monocrystalline thin film device manufactured thereby 有权
    由此制造单晶薄膜和单晶薄膜器件的方法

    公开(公告)号：US09130111B2

    公开(公告)日：2015-09-08

    申请号：US12963168

    申请日：2010-12-08

    Applicant: Suguru Noda

    Inventor： Suguru Noda

    IPC: C30B1/04 ,  H01L31/18 ,  C30B25/02 ,  C30B29/06 ,  C30B33/00 ,  H01L31/0392 ,  H01L21/02

    CPC classification number: H01L31/1804 ,  C30B25/02 ,  C30B29/06 ,  C30B33/00 ,  H01L21/02381 ,  H01L21/0245 ,  H01L21/02532 ,  H01L21/02634 ,  H01L21/02664 ,  H01L31/03921 ,  Y02E10/547 ,  Y02P70/521

    Abstract: The present invention provides a method for manufacturing a monocrystalline film and a device formed by the above method, and according to the method mentioned above, lift-off of the monocrystalline silicon film is preferably performed and a high-purity monocrystalline silicon film can be obtained. A monocrystalline silicon substrate (template Si substrate) 201 is prepared, and on this monocrystalline silicon substrate 201, an epitaxial sacrificial layer 202 is formed. Subsequently, on this sacrificial layer 202, a monocrystalline silicon thin film 203 is rapidly epitaxially-grown using a RVD method, followed by etching of the sacrificial layer 202, whereby a monocrystalline silicon thin film 204 used as a photovoltaic layer of solar cells is formed.

    Abstract translation: 本发明提供一种制造单晶膜的方法和通过上述方法形成的器件，并且根据上述方法，优选进行单晶硅膜的剥离，并且可以获得高纯度单晶硅膜 。 制备单晶硅衬底（模板Si衬底）201，并且在该单晶硅衬底201上形成外延牺牲层202。 随后，在该牺牲层202上，使用RVD方法快速地外延生长单晶硅薄膜203，然后蚀刻牺牲层202，由此形成用作太阳能电池的光伏层的单晶硅薄膜204 。

    Channel device and sample treatment apparatus including the same
    114.
    发明授权
    Channel device and sample treatment apparatus including the same 有权
    通道装置和包括其的样品处理装置

    公开(公告)号：US09114402B2

    公开(公告)日：2015-08-25

    申请号：US13513331

    申请日：2010-07-26

    Applicant: Takatoki Yamamoto

    Inventor： Takatoki Yamamoto

    IPC: B03C5/02 ,  B01L3/00 ,  G01N15/10

    CPC classification number: B03C5/026 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2300/0645 ,  B01L2300/0864 ,  B01L2300/0896 ,  B01L2400/0415 ,  B03C2201/26 ,  G01N15/1031 ,  G01N15/1056

    Abstract: A channel device including a nanosize channel through which single molecule flows, at least one electrode pair arranged near the nanosize channel, and an AC power source that applies an AC voltage to the electrodes. This channel device is useful for identifying molecules one by one. Furthermore, a channel device including a nanosize channel through which single molecule flows, a branching portion, and a plurality of branching channels, wherein (i) an electrode pair is arranged near the nanosize channel so as to sandwich the nanosize channel between the electrodes, or (ii) one electrode of the electrode pair is located near the nanosize channel, whereas the other is arranged near the branching channels. This channel device is useful for separating single molecule. The present channel device achieves identification or separation at an accuracy of 100% in principle. A sample treatment apparatus according to present invention includes a channel device, a measurement section, and an arithmetic processing section. The measurement section applies a voltage (DC or AC) to between electrodes of an electrode pair installed in the nanosize channel, and measures an electric signal when single molecule passes between the electrodes to identify the molecule (see FIG. 1B).

    Abstract translation: 包括单分子流过的纳米尺寸通道，配置在纳米尺寸通道附近的至少一个电极对的通道器件以及向电极施加AC电压的AC电源。 该通道装置可用于逐个识别分子。 此外，包括单分子流过的纳米尺寸通道，分支部分和多个分支通道的通道器件，其中（i）电极对布置在纳米尺寸通道附近，以将纳米尺寸通道夹在电极之间， 或（ii）电极对的一个电极位于纳米尺寸通道附近，而另一个设置在分支通道附近。 该通道装置可用于分离单分子。 本通道装置原则上以100％的精度实现识别或分离。 根据本发明的样品处理装置包括通道装置，测量部和运算处理部。 测量部分在安装在纳米尺寸通道中的电极对的电极之间施加电压（DC或AC），并且当单分子通过电极之间测量电信号以识别分子（参见图1B）。

    ORGANIC POLYMER THIN MEMBRANE, AND METHOD FOR PRODUCING SAME
    115.
    发明申请
    ORGANIC POLYMER THIN MEMBRANE, AND METHOD FOR PRODUCING SAME 有权
    有机聚合物薄膜及其制造方法

    公开(公告)号：US20150224452A1

    公开(公告)日：2015-08-13

    申请号：US14426508

    申请日：2013-09-06

    Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY

    Inventor： Takahiko Hariyama ,  Yasuharu Takaku ,  Hiroshi Suzuki ,  Masatsugu Shimomura ,  Daisuke Ishii ,  Isao Ohta ,  Yoshinori Muranaka

    IPC: B01D71/38 ,  B01D69/12 ,  B01D69/02 ,  B01D67/00

    CPC classification number: B01D71/38 ,  B01D67/009 ,  B01D69/02 ,  B01D69/127 ,  B01D2323/30 ,  B01D2325/36 ,  C09D4/00 ,  C09D4/06

    Abstract: Provided is a technique for fabricating a novel thin membrane with a starting material such as a biocompatible compound that is not easily processible into a membrane, particularly a technique for fabricating a novel thin membrane of a composition that is gradually polymerized from a membrane surface into the membrane in the cross sectional direction of the membrane, and having, for example, different structures on the front and back of the membrane. The technique includes the steps of preparing a solution of a starting material compound; forming a thin membrane of the solution on a base material surface; and forming the organic polymer thin membrane through a polymerization reaction caused by irradiating the exposed surface of the thin membrane with a plasma or an electron beam.

    Abstract translation: 本发明提供一种制备具有不容易加工成膜的生物相容性化合物等起始材料的新型薄膜的技术，特别是制造从膜表面逐渐聚合的新型薄膜的技术， 膜在膜的横截面方向上，并且在膜的前后具有例如不同的结构。 该技术包括制备原料化合物溶液的步骤; 在基材表面上形成薄膜溶液; 以及通过用等离子体或电子束照射薄膜的暴露表面而引起的聚合反应形成有机聚合物薄膜。

    Method for screening toxin neutralizing peptide, STX2 inhibiting peptide and verotoxin neutralizing agent
    116.
    发明授权
    Method for screening toxin neutralizing peptide, STX2 inhibiting peptide and verotoxin neutralizing agent 有权
    毒素中和肽，STX2抑制肽和毒素中和剂的筛选方法

    公开(公告)号：US09103820B2

    公开(公告)日：2015-08-11

    申请号：US11631008

    申请日：2005-06-28

    Applicant: Kiyotaka Nishikawa

    Inventor： Kiyotaka Nishikawa

    IPC: C40B30/04 ,  C07K7/00 ,  G01N33/50 ,  A61K38/00

    CPC classification number: G01N33/5014 ,  A61K38/00 ,  Y02A50/471

    Abstract: A screening method directed towards; (1) specifying a receptor binding site by introduction of mutation, and (2) specifying a binding site-specific peptide motif on the basis of an amino acid selection ratio by contrast between a peptide motif bound to a wild-type subunit and a peptide motif bound to a mutant functionally deficient in the binding site according to a peptide library method. A peptide which inhibits a toxin whose receptor binding portion has a subunit structure is screened. Accordingly, an STX2 inhibitor in which an STX2 inhibiting peptide is incorporated in a molecular nuclear structure portion having three molecules of lysine (Lys) peptide-linked thereto and which is easy to synthesize and can inhibit verotoxin is provided.

    Abstract translation: 针对的筛选方法 （1）通过引入突变来指定受体结合位点，和（2）通过与野生型亚基结合的肽基序与肽之间的对比来指定基于氨基酸选择比的结合位点特异性肽基序 根据肽文库方法结合到结合位点功能缺陷突变体的基序。 筛选受体结合部分具有亚基结构的毒素的肽。 因此，提供了STX2抑制肽，其中STX2抑制肽被结合到具有三分子赖氨酸（Lys）肽的分子核结构部分中，并且易于合成并且可以抑制verotoxin。

    IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, PROGRAM, PRINTING MEDIUM, AND RECORDING MEDIUM
    118.
    发明申请
    IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, PROGRAM, PRINTING MEDIUM, AND RECORDING MEDIUM 有权
    图像处理设备，图像处理方法，程序，打印介质和记录介质

    公开(公告)号：US20150131906A1

    公开(公告)日：2015-05-14

    申请号：US14400440

    申请日：2013-05-13

    Applicant: National Institute of Japan Science and Technology Agency

    Inventor： Hitoshi Arai ,  Shinobu Arai

    IPC: G06T5/00 ,  G06T5/20

    CPC classification number: G06T5/003 ,  G06T5/002 ,  G06T5/10 ,  G06T5/20 ,  G06T7/13 ,  G06T7/168 ,  G06T2207/10024 ,  G06T2207/20016 ,  G06T2207/20024 ,  G06T2207/20064 ,  G06T2207/20182

    Abstract: When obtaining subband signals by performing multiresolution decomposition on image data using a broad-sense pinwheel framelet or a pinwheel wavelet frame, having a degree, that is a set of an approximate filter with no orientation and a plurality of detail filters with respective orientations, and acquiring processed image data by the subband signals in a decomposition phase of the multiresolution decomposition, or processed image data that has been reconstructed into an image by summing the subband signals in a synthesis phase of the multiresolution decomposition, the present invention performs attenuation or amplification of the subband signals in the decomposition phase of the multiresolution decomposition that correspond to at least one of the filters.

    Abstract translation: 通过使用具有一定程度的广义感知风车框架或风轮小波框架对图像数据进行多分辨率分解来获得子带信号，即具有不定向的近似滤波器的集合和具有各个取向的多个细节滤波器，以及 本发明通过在多分辨率分解的分解阶段中通过子带信号获取处理后的图像数据，或者通过在多分辨率分解的合成阶段中对子带信号进行求和而将其重构为图像的处理图像数据进行衰减或放大 多分辨率分解的分解阶段中的子带信号对应于至少一个滤波器。

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