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371 条记录 (耗时 0.025 秒)

    Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine
    111.
    发明授权
    Methods and compositions for treating allergic asthma and dermatitis using descarboethoxyloratadine 失效
    使用去甲氧基乙酰氨喋呤治疗过敏性哮喘和皮炎的方法和组合物

    公开(公告)号：US5900421A

    公开(公告)日：1999-05-04

    申请号：US799605

    申请日：1997-02-11

    申请人： Dean A. Handley ,  Paul D. Rubin

    发明人： Dean A. Handley ,  Paul D. Rubin

    IPC分类号： A61K31/445 ,  A61K31/4545 ,  A61K45/06 ,  A61P11/06 ,  A61P37/08 ,  A61P43/00 ,  A61K31/44

    CPC分类号： A61K45/06 ,  A61K31/445 ,  A61K31/4545 ,  Y10S514/826 ,  Y10S514/864

    摘要： Methods utilizing descarboethoxyloratadine ("DCL"), for the treatment of allergic disorders, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. Also included are methods for the treatment of allergic asthma using DCL and either a decongestant or a leukotriene inhibitor, while avoiding the concomitant liability of adverse side-effects associated with other non-sedating antihistamines. The invention also encompasses the administration of DCL in a nasal or oral spray.

    摘要翻译： 利用去甲氧基吡咯烷（“DCL”）治疗过敏性疾病的方法，同时避免与其他非镇静性抗组胺药相关的不利副作用的伴随责任。 还包括使用DCL和减充血剂或白三烯抑制剂治疗过敏性哮喘的方法，同时避免与其它非镇静性抗组胺药相关的副作用的伴随的责任。 本发明还包括以鼻腔或口腔喷雾剂施用DCL。

    Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine
    114.
    发明授权
    Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine 失效
    使用光学纯的（ - ）尼群地平治疗高血压，心绞痛和其他疾病的方法和组合物

    公开(公告)号：US5571827A

    公开(公告)日：1996-11-05

    申请号：US259930

    申请日：1994-06-15

    申请人： Timothy J. Barberich ,  James W. Young

    发明人： Timothy J. Barberich ,  James W. Young

    IPC分类号： A61K31/44 ,  A61K45/06

    CPC分类号： A61K45/06 ,  A61K31/44

    摘要： Methods and compositions are disclosed utilizing the optically pure S(-) isomer of nitrendipine. This compound is a potent drug for the treatment of hypertension while avoiding the concomitant liability of adverse effects associated with the administration of the racemic mixture of nitrendipine. The S(-) isomer of nitrendipine is also useful for the treatment of angina and such other conditions as may be related to the activity of S(-) nitrendipine as a calcium channel antagonist without the concomitant liability of adverse effects associated with the racemic mixture of nitrendipine.

    摘要翻译： 公开利用尼群地平的光学纯的S（ - ）异构体的方法和组合物。 该化合物是用于治疗高血压的有效药物，同时避免与施用尼群地平的外消旋混合物相关的副作用的伴随责任。 尼群地平的S（ - ）异构体也可用于治疗心绞痛和其他可能与作为钙通道拮抗剂的S（ - ）尼群地平的活性有关的其他病症，而与外消旋混合物有关的不良反应的伴随责任 尼群地平。

    Antipyretic and analgesic methods of using optically pure R-etodolac
    115.
    发明授权
    Antipyretic and analgesic methods of using optically pure R-etodolac 失效
    使用光学纯的R-乙哚乙酸的解热镇痛方法

    公开(公告)号：US5561151A

    公开(公告)日：1996-10-01

    申请号：US368735

    申请日：1995-01-04

    申请人： James W. Young ,  Nancy M. Gray ,  William J. Wechter

    发明人： James W. Young ,  Nancy M. Gray ,  William J. Wechter

    IPC分类号： C07D491/052 ,  A61K31/40 ,  A61P25/04

    CPC分类号： A61K31/40

    摘要： Methods are disclosed utilizing optically pure R(-) etodolac for the treatment of pain, including but not limited to pain associated with toothaches, headaches, sprains, joint pain and surgical pain, for example dental pain and ophthalmic pain, while substantially reducing adverse effects which are associated with the administration of the racemic mixture of etodolac. The optically pure R(-) etodolac is also useful in treating pyrexia while substantially reducing the adverse effects associated with the administration of the racemic mixture of etodolac.

    摘要翻译： 公开了利用光学纯的R（ - ）依托度酸治疗疼痛的方法，包括但不限于与牙痛，头痛，扭伤，关节疼痛和手术疼痛相关的疼痛，例如牙痛和眼痛，同时显着降低不良反应 其与依托度酸的外消旋混合物的施用相关联。 光学纯的R（ - ）依托度酸也可用于治疗发热，同时显着减少与依托度酸的外消旋混合物的施用相关的不利影响。

    Methods and compositions for treating bacterial infection using optically pure (R)-lomefloxacin
    118.
    发明授权
    Methods and compositions for treating bacterial infection using optically pure (R)-lomefloxacin 失效
    使用光学纯（R） - 洛美沙星治疗细菌感染的方法和组合物

    公开(公告)号：US5476854A

    公开(公告)日：1995-12-19

    申请号：US312682

    申请日：1994-09-27

    申请人： James W. Young

    发明人： James W. Young

    IPC分类号： A61K31/495

    CPC分类号： A61K31/495

    摘要： Methods and compositions are disclosed utilizing the optically pure (R)-isomer of lomefloxacin. This compound is a potent drug for the treatment of infection or other diseases requiring antibiotics while avoiding the concomitant liability of adverse effects that are associated with the racemic mixture of lomefloxacin.

    摘要翻译： 公开了使用洛美沙星的光学纯的（R） - 异构体的方法和组合物。 该化合物是治疗需要抗生素的感染或其他疾病的有效药物，同时避免与洛美沙星的外消旋混合物相关的副作用的伴随责任。

    Methods for treating emesis and nausea using optically pure R(+) ondansetron
    119.
    发明授权
    Methods for treating emesis and nausea using optically pure R(+) ondansetron 失效
    使用光学纯的R（+）昂丹司琼治疗呕吐和恶心的方法

    公开(公告)号：US5470868A

    公开(公告)日：1995-11-28

    申请号：US164734

    申请日：1993-12-07

    申请人： James W. Young

    发明人： James W. Young

    IPC分类号： A61K9/08 ,  A61K9/48 ,  A61K31/415 ,  A61K31/4178

    CPC分类号： A61K31/4178 ,  A61K31/415 ,  Y10S514/872

    摘要： Methods are disclosed utilizing the optically pure R(+) isomer of ondansetron. This compound is a potent drug for the treatment of nausea and vomiting associated with chemotherapy and radiation therapy, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ondansetron. The R(+) isomer of ondansetron is also useful for the treatment of behavioral disorders such as mood anxiety and schizophrenia, and such other conditions as may be related to R(+) ondansetron's activity as a competitive antagonist of serotonin receptor subtype 5-HT.sub.3 such as disorders of gastrointestinal motility, depression, migraine, and as an aid for alcohol withdrawal, nicotine withdrawal, and drug (benzodiazepine et al.) withdrawal, without the concomitant liability of adverse effects associated with the racemic mixture of ondansetron. Furthermore, the R(+) isomer of ondansetron is also useful for the treatment of cognitive disorders such as dementia or age-associated memory impairment, while avoiding the concomitant liability of adverse effects associated with the racemic mixture of ondansetron.

    摘要翻译： 公开利用昂丹司琼的光学纯的R（+）异构体的方法。 该化合物是用于治疗与化疗和放射治疗相关的恶心和呕吐的有效药物，同时避免与昂丹司琼外消旋混合物相关的副作用的伴随责任。 昂丹司琼的R（+）异构体也可用于治疗诸如情绪焦虑和精神分裂症等行为障碍，以及可能与R（+）昂丹司琼活性相关的其他条件，作为5-羟色胺受体亚型5-HT3的竞争性拮抗剂 例如消化道运动障碍，抑郁症，偏头痛，以及用于酒精戒断，尼古丁戒断和药物（苯并二氮杂类等）撤离的辅助，而不伴随昂丹司琼外消旋混合物的不良反应。 此外，昂丹司琼的R（+）异构体也可用于治疗诸如痴呆或年龄相关记忆障碍的认知障碍，同时避免与昂丹司琼的外消旋混合物相关的副作用的伴随责任。