公开(公告)号：US20150164334A1

公开(公告)日：2015-06-18

申请号：US14580705

申请日：2014-12-23

Applicant: Illumigyn Ltd.

Inventor： Lior Greenstein ,  Gilad A. Davara ,  Gad Ganon ,  David Aviv

IPC: A61B5/00 ,  A61B10/02 ,  A61B1/32

CPC classification number: A61B5/0084 ,  A61B1/00006 ,  A61B1/00009 ,  A61B1/00045 ,  A61B1/00059 ,  A61B1/00103 ,  A61B1/00105 ,  A61B1/018 ,  A61B1/042 ,  A61B1/043 ,  A61B1/045 ,  A61B1/051 ,  A61B1/0607 ,  A61B1/063 ,  A61B1/0638 ,  A61B1/0653 ,  A61B1/0684 ,  A61B1/303 ,  A61B1/32 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/0082 ,  A61B5/4836 ,  A61B5/725 ,  A61B5/7282 ,  A61B6/00 ,  A61B10/02 ,  A61B10/04 ,  A61B18/20 ,  A61B18/201 ,  A61B18/22 ,  A61B90/90 ,  A61B2017/00057 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61B2018/00982 ,  A61B2018/202 ,  A61B2018/20359 ,  A61B2018/2075 ,  A61B2018/2095

Abstract: A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets. An image analysis and control unit in communication with the image acquisition system analyzes the data sets and applies algorithms to the data sets for diagnosing abnormal cells.

公开(公告)号：US09014788B2

公开(公告)日：2015-04-21

申请号：US14182724

申请日：2014-02-18

Applicant: Vanderbilt University

Inventor： Karen Joos ,  Jin Hui Shen ,  M. Shane Hutson ,  John Kozub

IPC: A61B5/06 ,  A61B1/07 ,  A61B18/20 ,  A61B18/18 ,  A61B18/22 ,  A61B3/10 ,  A61B18/14 ,  A61B19/00

CPC classification number: A61B18/18 ,  A61B3/102 ,  A61B18/14 ,  A61B18/20 ,  A61B18/201 ,  A61B18/22 ,  A61B2090/3735

Abstract: An optical coherence tomography probe and laser combination device configured for real-time z-directional guidance of the incisional depth of a surgical procedure. It can be used alone or placed within the working channel of an endoscope. The device includes an OCT single mode fiber, and a laser fiber or laser hollow waveguide or electrical surgical wire positioned adjacent to the OCT single mode fiber. The single mode fiber is configured to move laterally when activated by an actuator to scan light data reflected from a sample that is positioned in front of a distal end of the device. The light data can be processed to generate a B-scan image. The device can collect data in real-time during lasing, or immediately prior to and following the cutting. The surgical tool, when coupled to a processor, can deactivate when the B-scan image identifies that the incision is within a predefined tolerance.

Abstract translation: 光学相干断层扫描探针和激光组合装置被配置成用于实时z方向引导外科手术切口深度。 它可以单独使用或放置在内窥镜的工作通道内。 该装置包括OCT单模光纤以及邻近OCT单模光纤定位的激光光纤或激光中空波导或电手术线。 单模光纤被配置为在由致动器激活时横向移动以扫描从位于设备的远端前方的样品反射的光数据。 可以处理光数据以生成B扫描图像。 该设备可以在激光期间或切割之前或之后立即采集数据。 当B扫描图像识别出切口在预定义的公差内时，手术工具当耦合到处理器时可以停用。

公开(公告)号：US20140276771A1

公开(公告)日：2014-09-18

申请号：US14211039

申请日：2014-03-14

Applicant: VOLCANO CORPORATION

Inventor： David G. Miller ,  John W. Goodnow

IPC: A61B18/12

CPC classification number: A61B18/1233 ,  A61B18/082 ,  A61B18/1492 ,  A61B18/1815 ,  A61B18/201 ,  A61B2018/00357 ,  A61B2018/00577 ,  A61B2018/00875 ,  A61B2034/2063

Abstract: The invention describes methods for safely delivering ablation energy to a tissue, e.g., thrombus, in need of ablation therapy. The method uses a catheter adapted for IVUS imaging, ablation, and impedance measurements to monitor the impedance of a tissue receiving ablation energy. In an embodiment, a user may view an IVUS image of the tissue with impedance measurements to determine if it is safe to deliver additional energy. In another embodiment, a processor is configured to determine if it is safe to deliver additional ablation energy based upon the impedance measurement.

Abstract translation: 本发明描述了将消融能量安全地递送到需要消融治疗的组织例如血栓的方法。 该方法使用适于IVUS成像，消融和阻抗测量的导管来监测接收消融能量的组织的阻抗。 在一个实施例中，用户可以利用阻抗测量来查看组织的IVUS图像，以确定是否安全地递送额外的能量。 在另一个实施例中，处理器被配置为基于阻抗测量来确定是否安全地递送额外的消融能量。

公开(公告)号：US20140275982A1

公开(公告)日：2014-09-18

申请号：US13799664

申请日：2013-03-13

Applicant: THE SPECTRANETICS CORPORATION

Inventor： Brandon Thomas Hendrick ,  Blaine Andrew Schneider

IPC: A61M25/01 ,  A61B5/00 ,  A61M25/06 ,  A61B5/06

CPC classification number: A61B34/20 ,  A61B5/062 ,  A61B5/064 ,  A61B18/201 ,  A61B90/98 ,  A61B2017/00075 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2034/301 ,  A61B2090/3954 ,  A61M25/0108 ,  A61M25/0113 ,  A61M25/0116 ,  A61M25/0662 ,  A61M2205/502

Abstract: An endovascular device monitoring system is provided that determines, based on movement of the endovascular device past a selected reference location, at least one of a movement rate of a endovascular device and position of a distal end of a endovascular device in a body of a patient.

Abstract translation: 提供一种血管内装置监测系统，其基于血管内装置经过所选择的参考位置的运动确定血管内装置的移动速率和血管内装置的远端在患者体内的位置中的至少一个 。

公开(公告)号：US20140188111A1

公开(公告)日：2014-07-03

申请号：US13760042

申请日：2013-02-05

Applicant: Paul Joseph Weber

Inventor： Paul Joseph Weber

IPC: A61B18/14

CPC classification number: A61B18/14 ,  A61B18/082 ,  A61B18/1402 ,  A61B18/148 ,  A61B18/1482 ,  A61B18/149 ,  A61B18/1815 ,  A61B18/201 ,  A61B34/30 ,  A61B90/98 ,  A61B2017/00106 ,  A61B2017/00221 ,  A61B2018/00023 ,  A61B2018/00303 ,  A61B2018/00589 ,  A61B2018/00601 ,  A61B2018/00619 ,  A61B2018/00642 ,  A61B2018/0066 ,  A61B2018/00666 ,  A61B2018/00708 ,  A61B2018/00714 ,  A61B2018/0072 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/00982 ,  A61B2018/1807 ,  A61B2018/2211 ,  A61B2090/3945 ,  A61B2218/002 ,  A61B2218/007 ,  A61N7/00 ,  A61N2007/0047

Abstract: Methods, apparatus and systems for tissue dissection and modification are disclosed herein. A method for tissue dissection and modification may comprise inserting a tissue dissecting and modifying wand (TDM) through an incision in a patient's body. The TDM may comprise a tip having a plurality of protrusions with lysing segments positioned between the protrusions to dissect and/or modify tissue. The TDM may also comprise an energy window positioned on top of the TDM that is configured to deliver energy to modify tissues. After separating tissue using the lysing segment(s) to define a target region, the energy window may be activated and moved around within the target region to modify tissues. In some implementations, the energy window may be activated prior to and/or during dissection of the tissue such that the tissue is separated while tissue is modified within the target region.

Abstract translation: 本文公开了用于组织解剖和修饰的方法，装置和系统。 用于组织解剖和修饰的方法可以包括通过患者体内的切口插入组织解剖和修改棒（TDM）。 TDM可以包括具有多个突起的末端，其中裂解段定位在突起之间以解剖和/或修饰组织。 TDM还可以包括位于TDM顶部的能量窗口，其被配置为递送能量以修改组织。 在使用裂解段分离组织以限定目标区域之后，能量窗口可以被激活并在目标区域内移动以修改组织。 在一些实施方案中，能量窗口可以在组织解剖之前和/或期间激活，使得组织在组织在目标区域内被修饰时被分离。

公开(公告)号：US20140188107A1

公开(公告)日：2014-07-03

申请号：US13760028

申请日：2013-02-05

Applicant: Paul Joseph Weber

Inventor： Paul Joseph Weber

IPC: A61B18/14

CPC classification number: A61B18/14 ,  A61B18/082 ,  A61B18/1402 ,  A61B18/148 ,  A61B18/1482 ,  A61B18/149 ,  A61B18/1815 ,  A61B18/201 ,  A61B34/30 ,  A61B90/98 ,  A61B2017/00106 ,  A61B2017/00221 ,  A61B2018/00023 ,  A61B2018/00303 ,  A61B2018/00589 ,  A61B2018/00601 ,  A61B2018/00619 ,  A61B2018/00642 ,  A61B2018/0066 ,  A61B2018/00666 ,  A61B2018/00708 ,  A61B2018/00714 ,  A61B2018/0072 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00863 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/00982 ,  A61B2018/1807 ,  A61B2018/2211 ,  A61B2090/3945 ,  A61B2218/002 ,  A61B2218/007 ,  A61N7/00 ,  A61N2007/0047

Abstract: Methods and systems for tissue dissection and modification are disclosed herein. A method for tissue dissection and modification may comprise inserting a tissue dissecting and modifying wand (TDM) through an incision in a patient's body. The TDM may comprise a tip having a plurality of protrusions with lysing segments positioned between the protrusions to dissect and/or modify tissue. The TDM may also comprise an energy window positioned on top of the TDM that is configured to deliver energy to modify tissues. After separating tissue using the lysing segment(s) to define a target region, the energy window may be activated and moved around within the target region to modify tissues. In some implementations, the energy window may be activated prior to and/or during dissection of the tissue such that the tissue is separated while tissue is modified within the target region.

Abstract translation: 本文公开了用于组织解剖和修饰的方法和系统。 用于组织解剖和修饰的方法可以包括通过患者体内的切口插入组织解剖和修改棒（TDM）。 TDM可以包括具有多个突起的末端，其中裂解段定位在突起之间以解剖和/或修饰组织。 TDM还可以包括位于TDM顶部的能量窗口，其被配置为递送能量以修改组织。 在使用裂解段分离组织以限定目标区域之后，能量窗口可以被激活并在目标区域内移动以修改组织。 在一些实施方案中，能量窗口可以在组织解剖之前和/或期间激活，使得组织在组织在目标区域内被修饰时被分离。

公开(公告)号：US20140163537A1

公开(公告)日：2014-06-12

申请号：US14182724

申请日：2014-02-18

Applicant: VANDERBILT UNIVERSITY

Inventor： Karen Joos ,  Jin Hui Shen ,  M. Shane Hutson ,  John Kozub

IPC: A61B18/22 ,  A61B18/18

CPC classification number: A61B18/18 ,  A61B3/102 ,  A61B18/14 ,  A61B18/20 ,  A61B18/201 ,  A61B18/22 ,  A61B2090/3735

Abstract: An optical coherence tomography probe and laser combination device configured for real-time z-directional guidance of the incisional depth of a surgical procedure. It can be used alone or placed within the working channel of an endoscope. The device includes an OCT single mode fiber, and a laser fiber or laser hollow waveguide or electrical surgical wire positioned adjacent to the OCT single mode fiber. The single mode fiber is configured to move laterally when activated by an actuator to scan light data reflected from a sample that is positioned in front of a distal end of the device. The light data can be processed to generate a B-scan image. The device can collect data in real-time during lasing, or immediately prior to and following the cutting. The surgical tool, when coupled to a processor, can deactivate when the B-scan image identifies that the incision is within a predefined tolerance.

Abstract translation: 光学相干断层扫描探针和激光组合装置被配置成用于实时z方向引导外科手术切口深度。 它可以单独使用或放置在内窥镜的工作通道内。 该装置包括OCT单模光纤以及邻近OCT单模光纤定位的激光光纤或激光中空波导或电手术线。 单模光纤被配置为在由致动器激活时横向移动以扫描从位于设备的远端前方的样品反射的光数据。 可以处理光数据以生成B扫描图像。 该设备可以在激光期间或切割之前或之后立即采集数据。 当B扫描图像识别出切口在预定义的公差内时，手术工具当耦合到处理器时可以停用。

公开(公告)号：US20140107629A1

公开(公告)日：2014-04-17

申请号：US14027997

申请日：2013-09-16

Applicant: Katalyst Surgical, LLC

Inventor： Gregg D. Scheller ,  Matthew N. Zeid

IPC: A61F9/008

CPC classification number: A61F9/008 ,  A61B18/201 ,  A61B18/22 ,  A61F9/00821 ,  A61F2009/00863

Abstract: A steerable laser probe may include a handle, an actuation structure having an actuation structure distal end and an actuation structure proximal end, a flexible housing tube, and an optic fiber disposed within an inner bore of the handle and the flexible housing tube. An extension of the actuation structure distal end relative to the actuation structure proximal end may be configured to gradually curve the flexible housing tube and the optic fiber. A retraction of the actuation structure distal end relative to the actuation structure proximal end may be configured to gradually straighten the flexible housing tube and the optic fiber.

Abstract translation: 可操纵的激光探针可以包括手柄，具有致动结构远端和致动结构近端的致动结构，柔性外壳管和布置在手柄和柔性外壳管的内孔内的光纤。 致动结构远端相对于致动结构近端的延伸可以被配置为逐渐弯曲柔性外壳管和光纤。 驱动结构远端相对于致动结构近端的缩回可被构造成逐渐拉直柔性外壳管和光纤。

公开(公告)号：US20140005646A1

公开(公告)日：2014-01-02

申请号：US14015270

申请日：2013-08-30

Applicant: OmniGuide, Inc.

Inventor： Burak Temelkuran ,  Charalambos Anastassiou ,  David Torres ,  Gil Shapira ,  Max Shurgalin ,  Gregor Dellemann ,  Ori Weisberg ,  Steven A. Jacobs ,  Tairan Wang ,  Uri Kolodny ,  Jesse Rusk ,  Robert Payne ,  Yoel Fink

IPC: A61B18/20

CPC classification number: A61B18/24 ,  A61B18/201 ,  A61B18/22 ,  A61B2018/00017 ,  A61B2018/2288 ,  G02B6/02304 ,  G02B6/02385 ,  G02B6/032 ,  G02B6/42

Abstract: In general, in one aspect, the disclosure features a system that includes a flexible waveguide having a hollow core extending along a waveguide axis and a region surrounding the core, the region being configured to guide radiation from the CO2 laser along the waveguide axis from an input end to an output end of the waveguide. The system also includes a handpiece attached to the waveguide, wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient and the handpiece includes a tip extending past the output end that provides a minimum standoff distance between the output end and the target location.

Abstract translation: 通常，在一个方面，本发明的特征在于一种系统，其包括柔性波导，该柔性波导具有沿着波导轴线延伸的中空芯和围绕该芯的区域，该区域被配置为沿着波导轴线从CO 2激光器引导辐射 输入端到波导的输出端。 该系统还包括附接到波导的手持件，其中手持件允许操作者控制输出端的取向以将辐射引导到患者的目标位置，并且手持件包括延伸穿过输出端的尖端， 输出端与目标位置之间的最小间隔距离。

公开(公告)号：US20130267889A1

公开(公告)日：2013-10-10

申请号：US13790144

申请日：2013-03-08

Applicant: Aquabeam, LLC

Inventor： Nikolai ALJURI ,  Rodney C. PERKINS

IPC: A61B17/3203 ,  A61B18/18 ,  A61B18/14 ,  A61B18/20

CPC classification number: A61B17/3203 ,  A61B17/32037 ,  A61B18/04 ,  A61B18/14 ,  A61B18/1485 ,  A61B18/18 ,  A61B18/201 ,  A61B18/24 ,  A61B2017/00274 ,  A61B2017/22079 ,  A61B2018/00196 ,  A61B2018/00285 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/00583 ,  A61B2018/00946 ,  A61B2018/00952 ,  A61B2018/046 ,  A61B2018/1472 ,  A61B2018/1497 ,  A61B2018/1861 ,  A61B2218/002 ,  A61B2218/007 ,  A61F9/007 ,  A61F9/00736

Abstract: Methods and systems for resecting and debulking prostatic tissue to utilize a shaft carrying an energy source. The shaft is anchored by a balloon or other structure expanded in the bladder, and the energy source is capable of directing ablative energy radially outwardly from the urethra, where the energy source will be moved in order to remove a pre-defined volume of prostatic tissue.

Abstract translation: 用于切除和减压前列腺组织以利用承载能量源的轴的方法和系统。 轴由气囊或其他在膀胱中膨胀的结构锚定，能量源能够从尿道径向向外引导消融能量，其中能量源将被移动以去除预定体积的前列腺组织 。