公开(公告)号：US20150160217A1

公开(公告)日：2015-06-11

申请号：US14376837

申请日：2011-04-12

Applicant: Chi-Huey Wong ,  Chung-Yi Wu ,  Chi-Hui Liang ,  An-Suei Yang

Inventor： Chi-Huey Wong ,  Chung-Yi Wu ,  Chi-Hui Liang ,  An-Suei Yang

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N33/53 ,  G01N33/54346 ,  G01N2333/11 ,  G01N2400/00 ,  G01N2400/38 ,  G01N2458/00

Abstract: Glycan arrays that can detect and distinguish between various sub-types and strains of influenza virus are provided. Methods for using the glycan arrays with assays using nanoparticle amplification technique are disclosed. Sandwich assays using gold nanoparticles conjugated to phage particles comprising influenza virus-specific antibodies for detecting multiple serotypes using a single reaction are provided. Plurality of glycans directed to specific target HA of influenza virus comprises the array. Detector molecules comprising noble metals conjugated to (a) phage display particles expressing antibodies against hemagglutinin and (b) neuraminidase binding agents are disclosed.

Abstract translation: 提供了可以检测和区分各种亚型和流感病毒株的糖阵列。 公开了使用纳米颗粒扩增技术的测定法使用聚糖阵列的方法。 提供使用与包含用于使用单个反应检测多种血清型的流感病毒特异性抗体的噬菌体颗粒缀合的金纳米颗粒的三明治测定。 针对流感病毒的特定目标HA的多种聚糖包括阵列。 公开了包含与（a）噬菌体缀合的贵金属的检测分子，其显示表达针对血凝素的抗体的颗粒和（b）神经氨酸酶结合剂。

公开(公告)号：US20150148403A1

公开(公告)日：2015-05-28

申请号：US14405085

申请日：2013-05-31

Applicant: Chi-Ming LIANG ,  ACADEMIA SINICA

Inventor： Hsiu-Ming Shih ,  Wei-Chih Yang

IPC: C12Q1/68 ,  G01N33/50 ,  C12N15/113

CPC classification number: C12Q1/6897 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q2600/136 ,  G01N33/5008 ,  G01N2333/948 ,  G01N2500/10

Abstract: Method of regulating the stability and/or the level of the fusion protein PLZF/RARA are disclosed. Also disclosed are methods for identifying an agent as a regulator of the stability and/or the level of the fusion protein PLZF/RARA. Methods for identifying a therapeutic agent for treating PLZF/RARA-associated acute promyelocytic leukemia (APL) is also disclosed.

Abstract translation: 公开了调节融合蛋白PLZF / RARA的稳定性和/或水平的方法。 还公开了用于鉴定作为融合蛋白PLZF / RARA的稳定性和/或水平的调节剂的试剂的方法。 还公开了用于鉴定治疗PLZF / RARA相关急性早幼粒细胞白血病（APL）的治疗剂的方法。

公开(公告)号：US09029190B2

公开(公告)日：2015-05-12

申请号：US14028760

申请日：2013-09-17

Applicant: Academia Sinica

Inventor： Shih-Yen Lin ,  Meng-Yu Lin

IPC: H01L21/00 ,  H01L21/02 ,  H01L29/66 ,  H01L29/778 ,  H01L29/16

CPC classification number: H01L21/02527 ,  H01L21/02425 ,  H01L21/02631 ,  H01L21/02664 ,  H01L29/1606 ,  H01L29/66045 ,  H01L29/7781

Abstract: The present invention provides a method for manufacturing a graphene film and a graphene channel of transistor. The graphene film is prepared at a low temperature by using molecular beam epitaxy technique, and the graphene channel is able to fit into a transistor. The excellent characteristic of current modulation within graphene transistors is observed.

Abstract translation: 本发明提供一种用于制造石英烯膜和晶体管的石墨烯通道的方法。 通过使用分子束外延技术在低温下制备石墨烯膜，并且石墨烯通道能够装配到晶体管中。 观察石墨烯晶体管内电流调制的优异特性。

公开(公告)号：US09006650B2

公开(公告)日：2015-04-14

申请号：US14274707

申请日：2014-05-10

Applicant: Academia Sinica

Inventor： Chung-Hsuan Chen ,  Jung-Lee Lin ,  Huan Chang Lin

IPC: H01J49/26 ,  H01J49/42 ,  H01J49/36 ,  G01N27/66 ,  G01N33/483

CPC classification number: H01J49/36 ,  G01N33/4833 ,  H01J49/164 ,  H01J49/4225 ,  H01J49/424

Abstract: Apparatus and methods for performing mass spectrometry of a nanoparticle or virus analyte. Apparatus may include a laser desorption plate, a mass analyzer configured to measure mass over the range of m/z from 105 to 1010, an electrical shield surrounding the mass analyzer, and a charge sensitive detector, wherein the laser firing is phase lock synchronized with the applied radiofrequency voltages.

Abstract translation: 用于进行纳米颗粒或病毒分析物的质谱分析的装置和方法。 设备可以包括激光解吸板，质量分析器，被配置为测量从105到1010的m / z范围内的质量，围绕质量分析器的电屏蔽，以及电荷敏感检测器，其中激光点火与 应用的射频电压。

公开(公告)号：US20150086558A1

公开(公告)日：2015-03-26

申请号：US14395572

申请日：2013-03-14

Applicant: Academia Sinica

Inventor： Tse Wen Chang ,  Jiun-Bo Chen ,  Chien-Jen Lin ,  Nien-Yi Chen

IPC: C07K16/42

CPC classification number: C07K16/4291 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732

Abstract: Antibodies binding to junction regions between the CH4 and CεmX domains of membrane-bound IgE and uses thereof in treating IgE-mediated diseases such as allergic diseases.

Abstract translation: 抗体结合于膜结合IgE的CH4和Cγ区域之间的结合区域的抗体及其在治疗IgE介导的疾病如过敏性疾病中的用途。

公开(公告)号：US08980281B2

公开(公告)日：2015-03-17

申请号：US12704928

申请日：2010-02-12

Applicant: Pei-Wen Hsiao ,  Chia-Ying Wu ,  Yi-Chun Yeh

Inventor： Pei-Wen Hsiao ,  Chia-Ying Wu ,  Yi-Chun Yeh

IPC: A61K39/42 ,  C12P21/00 ,  C12N9/26 ,  C07K16/08 ,  C12N5/07 ,  C12N15/00 ,  A61P31/16 ,  A61K39/215 ,  A61K39/145 ,  C07K14/005 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/215 ,  A61K2039/5258 ,  C07K14/005 ,  C07K16/1018 ,  C12N2760/16034 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2830/006 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2469/10 ,  G01N2469/20

Abstract: Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described.

Abstract translation: 从Vero细胞重组产生哺乳动物宿主病毒（如SARS-CoV和流感病毒）的病毒样颗粒（VLP）。 VLP密切模仿真实病毒颗粒的外观，具有高度的免疫原性。 它们可以引起哺乳动物体液，但也可引起细胞免疫反应。 还描述了与VLP相关的组合物和方法。

公开(公告)号：US08969530B2

公开(公告)日：2015-03-03

申请号：US13644311

申请日：2012-10-04

Applicant: Academia Sinica

Inventor： Han-Chung Wu ,  Kuo-Hua Tung

IPC: C07K16/00 ,  C12P21/08 ,  G01N33/53 ,  A61K39/395 ,  A61K39/00 ,  C07K16/18 ,  C07K16/30

CPC classification number: C07K16/18 ,  C07K16/303 ,  C07K2317/73

Abstract: A purified monoclonal antibody, or an. antigen-binding portion thereof, which specifically binds to human clathrin heavy chain (CHC) is disclosed. The antibody, or antigen-binding portion, thereof, exhibits at least one, two, three, four, five, six, seven, or all eight of the following properties: (a) specifically binds to pancreatic adenocarcinoma cells; (b) binding to the cell surface and cytosol of cancer cells and tumor blood vessels; (c) internalized by CHC-expressing cells; (d) inhibiting tumor growth, invasion ability, migration, and angiogenesis; (e) inducing apoptosis in cancer cells and human umbilical vein endothelial cells; (f) inhibiting tumor growth and tumor blood vessels in pancreatic cancer in vivo; (g) suppressing epidermal growth factor, transferrin, and VEGF internalizations by cancer cells; and (h) suppressing hypoxia-inducible factor-1α expression and vascular endothelial growth factor secretion. Methods for inhibiting tumor cell growth and/or angiogenesis, and detecting cancer in a subject is also disclosed.

Abstract translation: 纯化的单克隆抗体，或 公开了与人网格蛋白重链（CHC）特异性结合的抗原结合部分。 抗体或其抗原结合部分显示出以下性质中的至少一种，二种，三种，四种，五种，六种，七种或全部八种：（a）特异性结合胰腺腺癌细胞; （b）结合癌细胞和肿瘤血管的细胞表面和细胞溶质; （c）通过表达CHC的细胞内化; （d）抑制肿瘤生长，侵袭能力，迁移和血管生成; （e）诱导癌细胞和人脐静脉内皮细胞凋亡; （f）体内抑制胰腺癌肿瘤生长和肿瘤血管; （g）抑制癌细胞的表皮生长因子，转铁蛋白和VEGF内化; 和（h）抑制低氧诱导因子-1α表达和血管内皮生长因子分泌。 还公开了抑制肿瘤细胞生长和/或血管发生以及检测受试者中的癌症的方法。

公开(公告)号：US20150046473A1

公开(公告)日：2015-02-12

申请号：US14455384

申请日：2014-08-08

Applicant: ACADEMIA SINICA

Inventor： De-Nian YANG ,  Chih-Ya SHEN ,  Hong-Han SHUAI ,  Ming-Syan CHEN

IPC: G06F17/30

CPC classification number: G06Q50/01 ,  G06Q10/109

Abstract: A social activity planning method includes the following operation. A database storing multiple candidate invitees with their geographical locations and interest scores towards a topic, and a social graph including vertices representing the candidate invitees and edges connecting two vertices representing mutual acquaintance of the associated candidate invitees is accessed. A social activity request including an invitation number, information about a social activity, and a familiarity condition for the social activity request is received. At least one feasible solution including the invitation number of the candidate invitees and meeting the familiarity condition is generated. A group of selected invitees are found based on the feasible solution and the information about the social activity.

Abstract translation: 社会活动规划方法包括以下操作。 数据库，存储有多个候选受邀者及其与主题相关的地理位置和兴趣分数，以及包括表示候选受邀者的顶点和连接表示相关候选被邀请者相互认识的两个顶点的边缘的社交图。 收到社会活动请求，包括邀请号码，有关社会活动的信息以及社交活动请求的熟悉条件。 生成至少一个可行的解决方案，包括候选人的邀请号和满足熟悉条件。 根据可行的解决方案和有关社会活动的信息，找到一组被选中的被邀请者。

公开(公告)号：US08951961B2

公开(公告)日：2015-02-10

申请号：US13938761

申请日：2013-07-10

Applicant: Academia Sinica

Inventor： Tsung-Lin Li ,  Yu-Chen Liu ,  Yi-Shan Li ,  Syue-Yi Lyu

IPC: A01N37/18 ,  A61K38/04 ,  C07K9/00 ,  A61K38/14

CPC classification number: C07K9/008 ,  A61K38/14

Abstract: A novel pharmaceutical composition comprising a compound of formula (I) is disclosed. The novel compound can include a pharmaceutically acceptable carrier. The invention further comprises methods for making compounds of formula (I) using Dbv29, and to the use of compound of formula (I) to treat bacterial infections.

Abstract translation: 公开了包含式（I）化合物的新型药物组合物。 该新化合物可包括药学上可接受的载体。 本发明还包括使用Dbv29制备式（I）化合物的方法，以及式（I）化合物用于治疗细菌感染的方法。

公开(公告)号：US20140363372A1

公开(公告)日：2014-12-11

申请号：US14223800

申请日：2014-03-24

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY ,  CHANG GUNG MEMORIAL HOSPITAL ,  ACADEMIA SINICA

Inventor： Alice L. Yu ,  John Yu ,  Ya-Hui Wang ,  Chuan-Lung Hsu ,  Yi-Chang Chen ,  Ying-Yung Lok

IPC: C07K16/30 ,  G01N33/574 ,  C12Q1/68 ,  A61K51/10

CPC classification number: C07K16/3015 ,  A61K39/39558 ,  C07K16/30 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57496

Abstract: A method for treating cancer includes administering to a subject in need thereof an antibody against a transmembrane and coiled-coil domains protein 3 (TMCC3), wherein the antibody binds to an epitope in an extracellular domain of TMCC3. The antibody binds to an epitope in an intercoil domain of TMCC3. A method of diagnosing or assessing a cancer condition includes assessing a level of expression or activity of a transmembrane and coiled-coil domains protein 3 (TMCC3) in a sample, wherein an increase in the level of expression of activity of TMCC3 as compared to a standard indicates the presence of cancer stem cells in the sample.

Abstract translation: 治疗癌症的方法包括向有需要的受试者施用针对跨膜和卷曲螺旋结构域蛋白3（TMCC3）的抗体，其中所述抗体结合TMCC3的细胞外结构域中的表位。 抗体结合TMCC3的线粒体结构域中的表位。 一种诊断或评估癌症病症的方法包括评估样品中跨膜和卷曲螺旋结构域蛋白3（TMCC3）的表达或活性水平，其中TMCC3的活性表达水平与 标准表明样品中存在癌干细胞。