公开(公告)号：US11913070B2

公开(公告)日：2024-02-27

申请号：US17184201

申请日：2021-02-24

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Stuart Lindsay

IPC: C12Q1/6869 ,  C12Q1/00 ,  G16B30/20 ,  G16B40/10 ,  G01N33/487 ,  G01N27/12

CPC classification number: C12Q1/6869 ,  C12Q1/005 ,  G01N33/48721 ,  G16B30/20 ,  G16B40/10 ,  G01N27/125

Abstract: The present disclosure provides devices, systems, and methods related to sequencing a biopolymer. In particular, the present disclosure provides methods of obtaining a bioelectronic signature based on current fluctuations that correspond to the activity of an enzyme-of-interest. As described herein, certain aspects of the bioelectronic signature can be used to determine the sequence of a biopolymer.

公开(公告)号：US20240062548A1

公开(公告)日：2024-02-22

申请号：US18236842

申请日：2023-08-22

Applicant: Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Kavan Hazeli ,  Bahram Jalali ,  Janet Roveda

IPC: G06V20/50 ,  G08B7/00 ,  G06V10/82 ,  G01S17/08 ,  G01S17/86

CPC classification number: G06V20/50 ,  G08B7/00 ,  G06V10/82 ,  G01S17/08 ,  G01S17/86

Abstract: A life-assisting system to enhance the quality of life for people with visual impairment. The system integrates state-of-the-art sensing and sensory stimulation with light detection and ranging (LiDAR), machine learning, and advanced haptic navigation to provide the visually impaired population with a real-time haptic map of the three-dimensional environment and auditory descriptions of objects within that environment. By allowing the visually impaired population to sense objects in the surrounding environment through haptic and auditory feedback, the disclosed system has the potential to promote individual independence, reduce anxiety and stress, facilitate access to educational and employment opportunities, and reduce social and economic gaps. To provide those benefits, the system uses multi-modal learning to convert higher dimensional (e.g., four-dimensional) scene data into lower dimensional (e.g., one-dimensional) auditory data and (e.g., two- or three-dimensional) haptic data.

公开(公告)号：US20240061085A1

公开(公告)日：2024-02-22

申请号：US18235617

申请日：2023-08-18

Applicant: Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Yuzuru TAKASHIMA ,  Jeff Ching-Wen CHAN ,  Xianyue DENG

IPC: G01S7/481 ,  G01S7/4865

CPC classification number: G01S7/4817 ,  G01S7/4814 ,  G01S7/4816 ,  G01S7/4865

Abstract: A LIDAR system includes a laser source configured to generate laser light pulses, a first DMD, a second DMD and a two-dimensional (2D) sensor array. The first DMD is configured to receive the laser light pulses and diffractively steer the light pulses to sequentially illuminate different sub-regions within the extended region. The second DMD is configured to receive reflected light pulses from the different sub-regions in a sequential manner as each of the different sub-regions is illuminated by the light pulses. The 2D sensor array configured to receive reflected light pulses from the second DMD and form an image of the different sub-regions as the reflected light pulses from each of the different sub-regions is sequentially received from the second DMD.

公开(公告)号：US11904054B2

公开(公告)日：2024-02-20

申请号：US16963043

申请日：2019-01-18

Applicant: Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Heidi M. Mansour ,  Stephen Black ,  Maria Acosta

IPC: A61K9/16 ,  A61K9/00 ,  A61K9/51 ,  A61K31/366 ,  A61K31/047 ,  A61K31/221 ,  A61K45/06 ,  B82Y5/00

CPC classification number: A61K9/1682 ,  A61K9/0075 ,  A61K9/5192 ,  A61K31/366 ,  A61K31/047 ,  A61K31/221 ,  A61K45/06 ,  B82Y5/00

Abstract: Provided herein are compositions and methods for treating respiratory and pulmonary vascular disease. In particular, provided herein are spray dried simvastatin for delivery to the lung.

公开(公告)号：US20240052400A1

公开(公告)日：2024-02-15

申请号：US18453129

申请日：2023-08-21

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Alexander Green ,  Duo Ma ,  Anli Tang

IPC: C12Q1/6825 ,  C12Q1/6816

CPC classification number: C12Q1/6825 ,  C12Q1/6816 ,  Y02A50/30

Abstract: Methods and compositions for detecting the presence of a pathogen are described. In particular, this document provides a method of detecting a pathogen-associated nucleic acid in a biological sample of a subject, where the method comprises using one or more unimolecular aptamer-based sensors comprising an aptamer-fluorophore complex and an amplification step to detect the pathogen-associated nucleic acid. Methods specific for detecting the presence of malaria and other mosquito-borne virus infections are also provided.

公开(公告)号：US20240049981A1

公开(公告)日：2024-02-15

申请号：US18266563

申请日：2021-12-09

Applicant: Arizona Board of Regents on behalf of Arizona State University ,  Aural Analytics, Inc.

Inventor： Visar Berisha ,  Julie Liss ,  Shira Hahn ,  Gabriela Stegmann ,  Jeremy Shefner

IPC: A61B5/08 ,  G10L25/66 ,  G10L15/22 ,  G10L15/02 ,  A61B5/00 ,  G16H10/20 ,  G16H10/60 ,  G16H20/30

CPC classification number: A61B5/08 ,  G10L25/66 ,  G10L15/22 ,  G10L15/02 ,  A61B5/4803 ,  A61B5/7267 ,  A61B5/6898 ,  G16H10/20 ,  G16H10/60 ,  G16H20/30 ,  A61B2562/0204

Abstract: Described are platforms, systems, media, and methods for maintaining a database of items associated with one or more skill requirements and a visit duration; maintaining a database of experts associated with one or more skill proficiencies, a location, and a schedule; receiving a request from a consumer for delivery by an expert of one or more items in the database to a consumer address; identifying experts in the database having skill proficiencies matching the skill requirements of the one or more items and available in a timeslot for the visit duration of the one or more items; presenting timeslots for which one or more experts are identified to the consumer and allowing the consumer to select a timeslot; and selecting an expert from among the identified experts in the selected timeslot based on shortest travel time; provided that utilization of the selected expert exceeds a predetermined utilization threshold.

公开(公告)号：US20240043853A1

公开(公告)日：2024-02-08

申请号：US18311587

申请日：2023-05-03

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Alexander Green ,  Fan Hong

IPC: C12N15/67 ,  C12Q1/6825 ,  C12Q1/6897

CPC classification number: C12N15/67 ,  C12Q1/6825 ,  C12Q1/6897

Abstract: Provided herein are highly sensitive compositions and methods for detection of at least one specific nucleic acid molecule in a sample. The presence of a specific nucleic acid provides a positive indicator of a pathogenic agent, contaminant, non-canonical bases, and/or wild-type or mutated genes in a sample or a cell. Applications for which the compositions and methods are particularly well suited include point-of-care disease diagnosis or cellular RNA imaging.

公开(公告)号：US20240039237A1

公开(公告)日：2024-02-01

申请号：US18245841

申请日：2021-09-17

Applicant: Arizona Board of Regents on Behalf of the University of Arizona

Inventor： Yushi Kaneda

IPC: H01S3/23 ,  H01S3/10

CPC classification number: H01S3/2341 ,  H01S3/10061 ,  H01S2301/02

Abstract: The described methods and devices minimize or reduce the effects of the leading amplified spontaneous emission component of an optical pulse in optical multi-pass amplifier systems. One multi-pass optical amplifier includes a gain medium positioned to receive a pump laser, and to receive an optical pulse having a main component and one or both of a leading or a trailing component. The optical amplifier also includes one or more reflectors positioned at a first side or at a second side of the gain medium that allow multi-pass propagation of the optical pulse through the gain medium. The one or more reflectors are positioned to allow the main component of the optical pulse to traverse through the gain medium in a first pass before the leading component of the optical pulse reaches the gain medium in a second pass through the gain medium.

公开(公告)号：US11875910B2

公开(公告)日：2024-01-16

申请号：US17350464

申请日：2021-06-17

Applicant: Arizona Board of Regents on Behalf Of Arizona State University

Inventor： William Graves

IPC: G21K1/06

CPC classification number: G21K1/06 ,  G21K2201/064 ,  G21K2201/067

Abstract: An optical apparatus is provided for manipulating light from x-ray sources (e.g., free electron lasers). In some embodiments, the optical apparatus includes a first capillary optic having a first longitudinal axis and a second capillary optic having a second longitudinal axis that is angled with respect to the first longitudinal axis. The second capillary optic is positioned to receive light directly from the first capillary optic.

公开(公告)号：US20240011065A1

公开(公告)日：2024-01-11

申请号：US18327434

申请日：2023-06-01

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： Nicholas Stephanopoulos ,  Minghui Liu

IPC: C12P19/34 ,  C12N15/11

CPC classification number: C12P19/34 ,  C12N15/111 ,  C12N2310/122 ,  B82Y40/00

Abstract: A photocaged DNA nano-tweezer and methods of using said photocaged DNA nano-tweezer are described. In particular, provided herein is a DNA nano-tweezer comprising a hairpin with a single-stranded loop that comprises a first arm and a second arm; and a trigger strand complementary to the single-stranded loop and comprising at least one photocaged residue with a protecting group.