公开(公告)号：US20170165424A1

公开(公告)日：2017-06-15

申请号：US15440951

申请日：2017-02-23

Applicant: MERIAL INC.

Inventor： Robert William Lachlan Holmes ,  Rodney Gordon Walker ,  Todd Donald Ebbett ,  Colin Anthony Standing ,  Peter Robert Williams ,  Giovanni Ciampa ,  Michael Rossignuolo ,  Robert John Smith

IPC: A61M5/178 ,  A61M5/31 ,  A61M5/24

CPC classification number: A61M5/178 ,  A61D17/00 ,  A61M5/00 ,  A61M5/24 ,  A61M5/2425 ,  A61M5/2459 ,  A61M5/3129 ,  A61M5/31511 ,  A61M5/3158 ,  A61M5/3204 ,  A61M2005/005 ,  A61M2005/2414 ,  A61M2005/2481 ,  A61M2005/31516 ,  A61M2250/00

Abstract: A trigger operated syringe (100) for intramammary injection of antibiotics has a fluid containing syringe cartridge (203) activated by a plunger (206) which is inserted into the syringe cartridge (203A) and expels fluid when the trigger (205) is pulled. A syringe cartridge holding mechanism (223) holds the syringe cartridge in place until the trigger (205) is released and the plunger (206) retracted. Single syringe cartridge (203) and multiple syringe cartridge (204) versions are disclosed. The plunger moves in a direction which is effectively perpendicular to the direction of movement of the trigger, allowing for ease of injection to a cow's teats, and ejection of the spent cartridges.

公开(公告)号：US20170143819A1

公开(公告)日：2017-05-25

申请号：US15353727

申请日：2016-11-16

Applicant: MERIAL INC.

Inventor： Jean-Christophe Audonnet ,  Frédéric Reynard ,  Natalia Bomchil ,  Cécile Sigoillot-Claude

IPC: A61K39/135 ,  C07K14/005 ,  C12N7/00 ,  A61K39/385

CPC classification number: A61K39/135 ,  A61K39/385 ,  A61K2039/5258 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/6075 ,  C07K14/005 ,  C07K14/32 ,  C07K2319/40 ,  C07K2319/735 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/32122 ,  C12N2770/32134 ,  C12N2770/32171

Abstract: The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV. The invention further encompasses methods of making or producing antigenic polypeptides or antigens.

公开(公告)号：US20170087242A1

公开(公告)日：2017-03-30

申请号：US15233013

申请日：2016-08-10

Applicant: MERIAL, INC.

Inventor： Jean-Christophe Audonnet ,  Jules Maarten Minke ,  Teshome Mebatsion ,  Catherine Charreyre

IPC: A61K39/155 ,  C12N7/00

CPC classification number: A61K39/155 ,  A61K39/12 ,  A61K2039/505 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2710/24043 ,  C12N2760/18222 ,  C12N2760/18234 ,  C12N2799/023

Abstract: The present invention provides vectors that contain and express in vivo or in vitro one or more Hendra virus polypeptides or antigens that elicit an immune response in animal or human against Hendra virus and Nipah virus, compositions comprising said vectors and/or Hendra virus polypeptides, methods of vaccination against Hendra virus and Nipah virus, and kits for use with such methods and compositions.

公开(公告)号：US20170023570A1

公开(公告)日：2017-01-26

申请号：US15215106

申请日：2016-07-20

Applicant: MERIAL INC.

Inventor： Jean Reyes

IPC: G01N33/569 ,  G01N15/14

Abstract: This invention relates to high throughput methods of determining a viral titer. The instant invention addresses the need for a more rapid and cost effective method of quantitating infectious viral particles in a sample.

Abstract translation: 本发明涉及确定病毒滴度的高通量方法。 本发明解决了对样品中感染性病毒颗粒进行定量的更快速和成本有效的方法的需要。

公开(公告)号：US20170021004A1

公开(公告)日：2017-01-26

申请号：US15050155

申请日：2016-02-22

Applicant: MERIAL, INC. ,  CALIXAR ,  GENOSTAR ,  VETAGRO-SUP ,  INSTITUT PASTEUR

Inventor： Natalia Ines Bomchil ,  Jean-Baptiste Claude ,  Lionel Pierre Christian Cupillard ,  Célia Fontana ,  Anass Jawhari ,  Elodie Mandon ,  Angeli Kodjo ,  Mathieu Picardeau ,  Azad Eshghi

IPC: A61K39/02 ,  C12N15/74 ,  A61K9/00

CPC classification number: A61K39/0208 ,  A61K9/0019 ,  A61K39/0225 ,  A61K2039/54 ,  A61K2039/545 ,  A61P31/04 ,  C07K14/20 ,  C12N15/74 ,  Y02A50/48

Abstract: The present invention provides compositions and methods for eliciting heterologous protective immunity in animals against Leptospira spp. The Leptospira spp. immunoprotective peptides disclosed herein elicit protective immunity against subsequent challenge or exposure to at least two Leptospira spp. serovars.

Abstract translation: 本发明提供了用于在动物体内产生针对钩端螺旋体属（Leptospira spp）的异源保护性免疫的组合物和方法。 钩端螺旋体属 本文公开的免疫保护肽引起针对随后的攻击或暴露于至少两种钩端螺旋体属的保护性免疫。 血清型

公开(公告)号：US20170020955A1

公开(公告)日：2017-01-26

申请号：US15089282

申请日：2016-04-01

Applicant: MERIAL, INC.

Inventor： Brenda Bondesen ,  Lance Hammerland

IPC: A61K38/15 ,  A61K31/55 ,  A61K31/4985 ,  A61K31/365 ,  A61K9/00

CPC classification number: A61K38/15 ,  A61K9/0056 ,  A61K31/365 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/7048 ,  A61K2300/00

Abstract: The present invention relates to a veterinary composition comprising an effective amount of at least one cyclic depsipeptide and at least one macrocyclic lactone; and a pharmaceutically acceptable carrier, for the treatment or prophylaxis of parasitic infection in a mammal wherein the parasite shows resistance to treatment or prophylaxis with the macrocyclic lactone alone.

Abstract translation: 本发明涉及一种兽用组合物，其包含有效量的至少一种环状缩肽和至少一种大环内酯; 和药学上可接受的载体，用于治疗或预防哺乳动物的寄生虫感染，其中寄生虫对单独的大环内酯显示出对治疗或预防的抵抗力。

公开(公告)号：US20160375122A1

公开(公告)日：2016-12-29

申请号：US15190740

申请日：2016-06-23

Applicant: MERIAL INC.

Inventor： Teshome Mebatsion ,  Aemro Kassa ,  Taejoong Kim

IPC: A61K39/12 ,  C12N7/00

CPC classification number: A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  C07K14/082 ,  C07K2319/03 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12N2770/10034 ,  C12N2770/10051 ,  C12N2840/203

Abstract: The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.

Abstract translation: 本发明包括重组猪繁殖与呼吸综合征病毒（PRRSV）疫苗或组合物。 特别地，本发明包括编码和表达PRRSV gp2，gp3，gp4，gp5a，gp5和/或E抗原，蛋白质，表位或免疫原的重组腺病毒载体。 这样的疫苗或组合物可用于保护动物免于PRRSV。

公开(公告)号：US20160374994A1

公开(公告)日：2016-12-29

申请号：US14977680

申请日：2015-12-22

Applicant: MERIAL INC.

Inventor： Mark David Soll ,  Diane Larsen ,  Susan Mancini Cady ,  Peter Cheifetz ,  Izabela Galeska ,  Saijun Gong

IPC: A61K31/42 ,  A61K45/06 ,  A61K47/42 ,  A61K31/325 ,  A61K31/365 ,  A61K31/7048 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/36

CPC classification number: A61K31/42 ,  A01N43/80 ,  A23K20/00 ,  A61K9/0056 ,  A61K9/0068 ,  A61K31/194 ,  A61K31/27 ,  A61K31/325 ,  A61K31/365 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/7048 ,  A61K45/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61K47/36 ,  A61K47/42 ,  A61K47/44 ,  C07D261/04 ,  A61K2300/00

Abstract: This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.

公开(公告)号：US20150374808A1

公开(公告)日：2015-12-31

申请号：US14699296

申请日：2015-04-29

Applicant: MERIAL INC.

Inventor： Laurent Bernard Fischer

IPC: A61K39/00

CPC classification number: A61K39/0011 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/545

Abstract: The application discloses therapeutic vaccines based upon the “pING” DNA plasmid vector expressing the gene encoding the rat Her2 protein. Vaccines according to the instant disclosure are used as an adjunct treatment for surgery, radiation and/or chemotherapy for dogs and cats with cancers that over express the Her2 antigen, and prolong the post-surgical disease free interval and/or survival time. Also included are therapeutically effective methods of immunization using said vaccines.

Abstract translation: 该申请公开了基于表达编码大鼠Her2蛋白的基因的“pING”DNA质粒载体的治疗性疫苗。 根据本公开的疫苗被用作用于具有过表达Her2抗原的癌症的狗和猫的手术，放射和/或化学疗法的辅助治疗，并且延长了手术后无疾病间隔和/或存活时间。 还包括使用所述疫苗的治疗有效的免疫方法。

公开(公告)号：US20150283225A1

公开(公告)日：2015-10-08

申请号：US14747419

申请日：2015-06-23

Applicant: MERIAL INC.

Inventor： Michel Bublot ,  Teshome Mebatsion ,  Joyce Pritchard ,  Perry Linz

IPC: A61K39/17 ,  C12N7/00 ,  A61K39/12

CPC classification number: A61K39/17 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134 ,  C12N2760/18171 ,  C12N2800/22

Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors, polyvalent vaccines comprising the recombinant HVT vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.

Abstract translation: 本发明提供含有和表达禽类病原体抗原的火鸡（HVT）载体的重组疱疹病毒，包含重组HVT载体的组合物，包含重组HVT载体和一种或多种野生型病毒或重组载体的多价疫苗。 本发明进一步提供针对各种禽类病原体的疫苗接种方法和生产重组HVT载体的方法。