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公开(公告)号：US20200277406A1
公开(公告)日：2020-09-03
申请号：US16821537
申请日：2020-03-17
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Andreas Gallusser , Dieter Heindl , Michael Schraeml , Christoph Seidel , Herbert von der Eltz
Abstract: A binding agent of the Formula A-a′:a-S-b:b′-B:X(n), wherein A as well as B is a monovalent binder, a′:a as well as b:b′ is a binding pair wherein a′ and a do not interfere with the binding of b to b′ and vice versa, S is a spacer of at least 1 nm in length, :X denotes a functional moiety bound either covalently or via a binding pair to at least one of a′, a, b, b′ or S, (n) is an integer and at least 1, — represents a covalent bond, and the linker a-S-b has a length of 6 to 100 nm. Also disclosed are methods of producing such binding agent and certain uses thereof.
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公开(公告)号：US20200263160A1
公开(公告)日：2020-08-20
申请号：US16865487
申请日：2020-05-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Werner Hoelke , Michaela Fischer , Johann-Peter Thalhofer , Markus Weber
Abstract: Described are compositions, in particular lyophilizates, containing proteolytic enzymes, and methods for producing the compositions. Typically these compositions contain one or more proteases with collagenase activity and a neutral protease, for example, thermolysin. The compositions are free of acetate salts. Surprisingly, such compositions can be dissolved in water more rapidly than lyophilized protease mixtures of the state of the art.
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公开(公告)号：US10677809B2
公开(公告)日：2020-06-09
申请号：US15807802
申请日：2017-11-09
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Boehm , Sascha Lutz , Thomas Keller
Abstract: A method and cartridge for determining an amount of at least two analytes in a biological sample and an automatic analyzer are disclosed. The cartridge may comprise a cartridge inlet, a sample holding chamber fluidically connected to the inlet, and two or more metering chambers. Each metering chamber may comprise a sample inlet, a sample outlet, and a metered outlet for dispensing a predetermined volume. At least one sample distribution channel is connected between the sample outlet of a metering chamber with a sample inlet of another metering chamber. For each metering chamber, a connecting tube fluidically connects the sample inlet with the sample holding chamber, a microfluidic structure for processing the sample into a processed sample connects to the sample outlet, and a measurement structure fluidically connects to the microfluidic structure and enables measurement of the processed sample to determine the amount of the analyte in the processed sample.
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公开(公告)号：US20200156075A1
公开(公告)日：2020-05-21
申请号：US16672869
申请日：2019-11-04
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Robert Enck
Abstract: A method to handle tubes in a diagnostic laboratory automation system comprising a control device and a tube-analyzing device is presented. The tube-analyzing device comprises a tube identification reader, a tube type recognition unit, a sample color determination unit, and a tube consistence unit. The tube identification reader reads tube identification device. The tube type recognition unit identifies tube type. The sample color determination unit determines sample color. The tube consistence unit determines sample consistency. The sample tube type, the tube type, the sample color, the sample consistency are send to the control device. The control device determines a construed tube type from one or more of the information of the tube type, the sample color, and the sample consistency. The control device checks whether the tube type matches the construed tube type and changes a used tube type from the tube type to the construed tube type.
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公开(公告)号：US20200150140A1
公开(公告)日：2020-05-14
申请号：US16743026
申请日：2020-01-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Hans Schneider , Eugen Lusser , Marcel Kaeppeli , Tobias Huber , Hermann Pius , Matthias Edelmann
Abstract: A transport device unit for a transport device assembled using a plurality of transport device units is presented. The transport device unit comprises a base plate module with a base plate for fixing the transport device unit to a support frame, an actuator module with a plurality of electro-magnetic actuators, where the actuator module is supported by the base plate module, and a driving surface module with a driving surface element, where the driving surface element is arranged above the actuator module covering the actuators and configured to carry sample container carriers. A transport device, a system for at least partially disassembling the transport device, and a laboratory sample distribution system comprising a transport device are also presented. In addition, a laboratory automation system comprising a laboratory sample distribution system is also presented.
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Patent Agency Ranking
公开(公告)号：US10573443B2
公开(公告)日：2020-02-25
申请号：US15170251
申请日：2016-06-01
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Christoph Seidel , Jens Christian Bolle , Sandra Recklies
IPC: H01F1/44 , C08F257/00 , C08K9/10
Abstract: Disclosed is a simplified process for producing magnetic polymer particles. The process comprises: (a) providing a composition having a liquid monomer which is radical polymerizable, a radical initiator soluble in the monomer, a steric stabilizer, and a ferrofluid comprising surfactant-coated colloidal magnetic particles in a carrier fluid which is miscible with the monomer; (b) preparing an emulsion from a polar solvent which is immiscible with the monomer, and the composition of step (a); (c) adding seed polymer particles to the emulsion, mixing to form a seeded emulsion, and incubating the seeded emulsion, thereby swelling the seed polymer particles; and (d) activating the radical initiator and polymerizing the monomer in the swollen seed polymer particles; thereby producing the magnetic polymer particles. The process forms monodisperse magnetic particles. The particles are characterized by a uniform distribution of magnetic material, and an absence of magnetite bleeding.
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公开(公告)号：US20200003666A1
公开(公告)日：2020-01-02
申请号：US16569700
申请日：2019-09-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Eloisa Lopez-Calle , Ewelina Hegel , Thomas Fischer , Caroline Bylda , Hans-Peter Josel , Josef Roedl
Abstract: The present disclosure relates to an in vitro method for releasing analytes from a sample involving contacting the sample with (i) a chaotropic agent, (ii) an organic solvent, (iii) a detergent, and (iv) at least one agent providing bicarbonate ions. The present disclosure further relates to a release agent for releasing analytes from a sample having the aforesaid compounds. Moreover, the present disclosure relates to uses, kits, methods and devices related to the method and the release agent of the present disclosure.
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128.发明授权公开(公告)号：US10508267B2
公开(公告)日：2019-12-17
申请号：US16014355
申请日：2018-06-21
Inventor： Peter Kratzsch , Mara Boenitz-Dulat , Daniela Beck , Thomas Streidl , Stacy Hunt DuVall
Abstract: The present disclosure relates to a mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) with improved performance relative to the wild-type 3-HBDH, a nucleic acid encoding the mutant 3-HBDH, a cell having the mutant 3-HBDH or the nucleic acid, and/or a method of determining the amount or concentration of 3-hydroxybutyrate in a sample. Also disclosed is the use of the mutant 3-HBDH for determining the amount or concentration of 3-hydroxybutyrate in a sample, and a device for determining the amount or concentration of 3-hydroxybutyrate in a sample.
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公开(公告)号：US10478817B2
公开(公告)日：2019-11-19
申请号：US15943093
申请日：2018-04-02
Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
Inventor： Christoph Boehm , Sascha Lutz , Juergen Spinke
Abstract: An automatic analyzer cartridge, spinnable about a rotational axis, has fluid and aliquoting chambers, a metering chamber connected to a vent that is nearer to the rotational axis than the metering chamber, first and second ducts connecting the fluid and aliquoting chambers, and the metering and aliquoting chambers, respectively. Metering chamber side walls taper away from a central region, wherein capillary action next to the walls is greater than in the central region. Fluid flows to the metering chamber using capillary action via the second duct that has an entrance and exit in the aliquoting and metering chambers, respectively; the exit being closer to the rotational axis than the entrance. A downstream fluidic element connects to the metering chamber via a valve. A fluidic structure receives and processes a biological sample into the processed biological sample and has a measurement structure that enables measurement of the processed biological sample.
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公开(公告)号：US20190324025A1
公开(公告)日：2019-10-24
申请号：US16450181
申请日：2019-06-24
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Michael Gerg , Dieter Heindl , Lars Hillringhaus , Klaus Hirzel , Caroline Dorothea Hojer , Florian Huber , Hans-Peter Josel , Thomas Meier , Michael Schraeml , Edgar Voss
IPC: G01N33/543 , C07K16/44
Abstract: The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as disclosed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.
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