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公开(公告)号：US09808488B2
公开(公告)日：2017-11-07
申请号：US14479385
申请日：2014-09-08
Inventor： Benjamin Dekel , Orit Harari-Steinberg
CPC classification number: A61K35/22 , C12N5/0686 , C12N5/0687 , C12N5/0696 , C12N15/85 , C12N2500/90 , C12N2501/06 , C12N2501/065 , C12N2501/415 , C12N2506/25
Abstract: Isolated populations of fetal renal stem cells and progenitor cells are provided. Also provided are methods of generating and using these isolated populations of cells.
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公开(公告)号：US20170273906A1
公开(公告)日：2017-09-28
申请号：US15505464
申请日：2015-06-18
Applicant: Ramot at Tel-Aviv University Ltd. , Tel Hashomer Medical Research Infrastructure and Services Ltd.
Inventor： Jonathan LEOR , Tamar BEN-MORDECHAI , Radka HOLBOVA-GELKOFF , Olga YARENCHYK , Rimona MARGALIT , Inbar ELRON-GROSS , Yifat GLUCKSAM-GALNOY
IPC: A61K9/127 , A61K31/555
CPC classification number: A61K9/1271 , A61K31/555
Abstract: Provided are liposomes including a lipid membrane enclosing an intraliposomal compartment. The liposomes may encapsulate an iron complex, including an iron moiety and a macromolecule, in the intraliposomal compartment. The liposomes may additionally have a targeting moiety associated with the liposomal membranes. The targeting moiety may be exposed at the liposome's outer surface. The liposomes exhibit an immunomodulatory effect or anti-cancer effect depending on the molar ratio between the lipids forming the lipid membrane and the iron complex. As such, the liposomes can be used to treat types of inflammation, particularly inflammations that are not associated or caused by infection or be used to treat cancer. Further provided are compositions including the disclosed liposomes, methods of using and kits including the liposomes.
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公开(公告)号：US20170239333A1
公开(公告)日：2017-08-24
申请号：US15506496
申请日：2015-08-30
Inventor： Dror MEIROW , Hadassa RONESS
IPC: A61K38/22
CPC classification number: A61K38/22 , A61B17/435 , A61K35/54 , A61K45/06 , A61P15/00 , A61P15/18 , A61K2300/00
Abstract: Provided are compositions and methods for preventing premature follicle activation and loss induced by acute insults, such as, medical treatment, a disease or a disorder, thereby preserving fertility in a subject.
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公开(公告)号：US20170020529A1
公开(公告)日：2017-01-26
申请号：US15302190
申请日：2015-04-14
Applicant: Tel HaShomer Medical Research Infrastructure and Servies Ltd. , The Trendlines Group Ltd.
Inventor： Abraham TSUR , Sharon FARBER , Roy MASHIACH , Yosef HAZAN , David SHASHAR , Avshalom SHENHAV
IPC: A61B17/122 , A61B5/00 , A61M31/00 , A61B17/42
CPC classification number: A61B17/122 , A61B5/435 , A61B5/4356 , A61B5/6846 , A61B5/6847 , A61B5/6882 , A61B5/6885 , A61B17/1227 , A61B17/42 , A61B2017/00221 , A61B2017/00535 , A61B2017/00734 , A61B2017/00893 , A61B2017/4225 , A61B2090/065 , A61B2090/0811 , A61F6/08 , A61M31/00
Abstract: A device for retarding birth including an upper ring for surrounding a cervix, an anchoring component for anchoring the device, and an elastic component for attaching the upper ring to the anchoring component, wherein the elastic component pushes the upper ring and the anchoring component apart. A device for retarding birth including a sleeve for surrounding a cervix along a greater portion of a length of the cervix, a support strip on the sleeve directed along an axis of the sleeve, and a ring at least partially around the sleeve, in which when a top of the sleeve is pushed to expand radially, the support strip pivots on the ring, such that an end of the support strip near the top of the sleeve moves radially outward, and an end of the support strip near the bottom of the sleeve moves radially inward. Related apparatus and methods are also described.
Abstract translation: 一种用于延迟出生的装置，包括用于包围子宫颈的上环，用于锚定装置的锚固部件，以及用于将上环连接到锚固部件的弹性部件，其中弹性部件将上部环和锚定部件分开。 一种用于延缓出生的装置，包括用于围绕子宫颈的较大部分围绕子宫颈的套筒，沿套筒的轴线引导的套筒上的支撑条和至少部分围绕套筒的环，其中当 套筒的顶部被推动以径向膨胀，支撑带在环上枢转，使得靠近套筒顶部的支撑条的端部径向向外移动，并且支撑条的端部靠近套筒的底部 径向向内移动。 还描述了相关装置和方法。
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公开(公告)号：US09528979B2
公开(公告)日：2016-12-27
申请号：US13678126
申请日：2012-11-15
Applicant: Technion Research and Development Foundation Ltd. , Tel Hashomer Medical Research, Infrastructure and Services Ltd.
Inventor： Hossam Haick , Nir Peled
IPC: G01N33/497 , G01N33/00
CPC classification number: G01N33/497 , G01N33/0034 , G01N2800/7028
Abstract: The present invention provides a unique profile of volatile organic compounds as breath biomarkers for lung cancer. The present invention further provides the diagnosis, prognosis and monitoring of lung cancer or predicting the response to an anti-cancer treatment through the detection of the unique profile of volatile organic compounds indicative of lung cancer at its various stages.
Abstract translation: 本发明提供挥发性有机化合物作为肺癌呼吸生物标志物的独特特征。 本发明还通过检测其各种阶段的指示肺癌的挥发性有机化合物的独特特征，进一步提供对肺癌的诊断，预后和监测或预测对抗癌治疗的反应。
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Patent Agency Ranking
公开(公告)号：US20160143776A1
公开(公告)日：2016-05-26
申请号：US14903350
申请日：2014-08-01
Inventor： Ygal ROTENSTREICH
CPC classification number: A61F9/009 , A61F9/0008 , A61F9/0017 , A61F9/00825 , A61F9/00836 , A61F2009/00853 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872
Abstract: The present invention discloses a device suitable for delivery of a fluid composition to an eye, especially therapeutic compositions, comprising: a hollow needle with a bore having a proximal end and a distal end, said distal end configured to pass into a passage in a sclera of an eye, said bore configured to function as a conduit for a fluid from said proximal end to said distal end, and a solid separator having a distal tip, configured to move inside said bore of said hollow needle allowing said distal tip of said separator to protrude from said distal end of said needle.
Abstract translation: 本发明公开了一种适用于将流体组合物输送到眼睛，特别是治疗组合物的装置，包括：具有孔的中空针，所述孔具有近端和远端，所述远端配置成进入巩膜中的通道 所述孔构造成用作用于从所述近端到所述远端的流体的导管，以及具有远端的固体分离器，其构造成在所述中空针的所述孔内移动，允许所述分离器的所述远端 从所述针的所述远端突出。
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127.发明授权Microrna patterns for the diagnosis, prognosis and treatment of melanoma 有权Microrna模式用于诊断，预后和治疗黑色素瘤公开(公告)号：US09238838B2
公开(公告)日：2016-01-19
申请号：US14265337
申请日：2014-04-29
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY
Inventor： Gal Markel , Eyal Greenberg , Jacob Schachter
IPC: C12Q1/68 , C07H21/02 , C07H21/04 , A61K48/00 , A61K31/7105
CPC classification number: C12Q1/6886 , A61K31/7105 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178
Abstract: The present invention relates to methods for diagnosing, staging, prognosticating and treating melanoma based on evaluating the expression of specific patterns of oncogenic or suppressive microRNA (miR) molecules in a patient in need thereof.
Abstract translation: 本发明涉及用于诊断，分期，预后和治疗黑素瘤的方法，其基于评价有需要的患者中致癌或抑制性微小RNA（miR）分子的特异性模式的表达。
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128.发明申请公开(公告)号：US20150315646A1
公开(公告)日：2015-11-05
申请号：US14703942
申请日：2015-05-05
Inventor： Anat ACHIRON , Michael GUREVICH
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/166
Abstract: Provided are methods and kits for classifying a subject as being more likely to have benign multiple sclerosis (BMS) or as being more likely to have typical relapsing remitting multiple sclerosis (RRMS). Classification of multiple sclerosis disease course is performed by comparing a level of expression of at least one gene involved in the RNA polymerase I pathway in a cell of the subject to a reference expression data of said at least one gene obtained from a cell of at least one subject pre-diagnosed as having BMS and/or from a cell of at least one subject pre-diagnosed as having typical RRMS, thereby classifying the subject as being more likely to have BMS or as being more likely to have typical RRMS. Also provided are methods of diagnosing and treating multiple sclerosis and methods of monitoring treatment efficiency.
Abstract translation: 提供了用于将受试者分类为更可能具有良性多发性硬化（BMS）或更可能具有典型的复发性多发性硬化症（RRMS）的方法和试剂盒。 通过将受试者细胞中涉及的RNA聚合酶I途径中的至少一个基因的表达水平与从至少一个细胞获得的所述至少一种基因的参考表达数据进行比较来进行多发性硬化症病程的分类 一个被预先诊断为患有BMS的受试者和/或来自预先诊断为具有典型RRMS的至少一个受试者的细胞，从而将受试者分类为更可能具有BMS或更可能具有典型的RRMS。 还提供诊断和治疗多发性硬化症的方法以及监测治疗效率的方法。
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公开(公告)号：US20150209078A1
公开(公告)日：2015-07-30
申请号：US14421170
申请日：2013-08-13
Inventor： Avinoam Nevler , Chaya Schwartz , Nir Horesh , Gil Har-Zahav
CPC classification number: A61B17/3474 , A61B17/3415 , A61B17/3417 , A61B17/3439 , A61B90/06 , A61B2017/00867 , A61B2017/3441 , A61B2090/064 , A61B2562/0247 , A61M13/003
Abstract: A Veress needle includes an outer needle having a shaft and a sharp distal point. The sharp distal point and a distal portion of the shaft are configured to penetrate tissue. A spring-loaded, inner cannula is disposed in the outer needle. The cannula has a dull tip and a gas exit aperture is formed near a distal end of the cannula. The outer needle has an outwardly expandable portion located on the distal portion of the shaft.
Abstract translation: 止血针包括具有轴和尖锐远端点的外针。 尖锐的远端点和轴的远端部分构造成穿透组织。 弹簧加载的内套管设置在外针中。 套管具有钝的尖端，并且在套管的远端附近形成气体出口孔。 外针具有位于轴的远端部分上的可向外扩张的部分。
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130.发明申请公开(公告)号：US20150182169A1
公开(公告)日：2015-07-02
申请号：US14658930
申请日：2015-03-16
Inventor： Genady KOSTENICH , Arie ORENSTEIN
IPC: A61B5/00
CPC classification number: A61B5/6861 , A61B1/041 , A61B5/0059 , A61B5/0084 , A61B5/42 , A61B5/4255
Abstract: Disclosed are methods useful for providing information useful in the diagnosis of gastrointestinal abnormalities as well as ingestible devices useful for providing information useful in the diagnosis of gastrointestinal abnormalities.
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