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公开(公告)号：US20240242953A1
公开(公告)日：2024-07-18
申请号：US18563569
申请日：2022-05-26
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Brett M. Marsh
CPC classification number: H01J49/065 , H01J49/16
Abstract: The invention generally relates to systems and methods for focusing ions using counter flows of opposite or like charged ions. In certain embodiments, oppositely charged ions are introduced in a counter flow to a target ion beam within an atmospheric ion guide.
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公开(公告)号：US20240219410A1
公开(公告)日：2024-07-04
申请号：US18394339
申请日：2023-12-22
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Livia Schiavinato Eberlin , Christina Ramires Ferreira , Allison Lisa Dill , Demian R. Ifa
CPC classification number: G01N33/92 , H01J49/0036 , H01J49/165 , H01J49/0004 , H01J49/142
Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.
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公开(公告)号：US11854781B2
公开(公告)日：2023-12-26
申请号：US17979121
申请日：2022-11-02
Applicant: Purdue Research Foundation , AMGEN INC.
Inventor： Robert Graham Cooks , Tawnya Flick
IPC: H01J49/04 , H01J49/16 , G01N27/44 , G01N27/447 , G01N30/72
CPC classification number: H01J49/0431 , G01N27/4473 , G01N27/44717 , H01J49/165 , G01N30/7266
Abstract: The invention generally relates to electrophoretic mass spectrometry probes and systems and methods of uses thereof. In certain aspects, the invention provides a mass spectrometry probe having a hollow body with a distal tip, an electrically conductive hollow conduit, and an electrode. The electrically conductive hollow conduit may be operably coupled to a reservoir and a power source, and the electrically conductive hollow conduit may be configured to transport a liquid sample into the hollow body and polarize the liquid sample as it flows through the electrically conductive hollow conduit and into in the hollow body. The electrode and the electrically conductive hollow conduit are disposed within the hollow body (e.g., at different heights within the hollow body).
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公开(公告)号：US20230238233A1
公开(公告)日：2023-07-27
申请号：US18130474
申请日：2023-04-04
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Brett M. Marsh
CPC classification number: H01J49/24 , H01J49/4225 , H01J49/0031 , H01J49/16
Abstract: The invention generally relates to mass spectrometers that utilize ionic wind and methods of use thereof.
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125.发明授权公开(公告)号：US11676805B2
公开(公告)日：2023-06-13
申请号：US17159407
申请日：2021-01-27
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Dalton Snyder
IPC: H01J49/00
CPC classification number: H01J49/0027 , H01J49/004 , H01J49/0081 , H01J49/0013
Abstract: The invention generally relates to systems and methods for performing multiple precursor, neutral loss and product ion scans in a single ion trap. In certain aspects, the invention provides systems including a mass spectrometer having a single ion trap, and a central processing unit (CPU), and storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to apply at least one of the following ion scans to a single ion population in the single ion trap: multiple precursor ion scans, a plurality of segmented neutral loss scans, or multiple simultaneous neutral loss scans.
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Patent Agency Ranking
公开(公告)号：US11635415B2
公开(公告)日：2023-04-25
申请号：US17395909
申请日：2021-08-06
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zheng Ouyang
Abstract: The invention generally relates to ion generation using modified wetted porous materials. In certain aspects, the invention generally relates to systems and methods for ion generation using a wetted porous substrate that substantially prevents diffusion of sample into the substrate. In other aspects, the invention generally relate to ion generation using a wetted porous material and a drying agent. In other aspects, the invention generally relates to ion generation using a modified wetted porous substrate in which at least a portion of the porous substrate includes a material that modifies an interaction between a sample and the substrate.
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公开(公告)号：US11531005B2
公开(公告)日：2022-12-20
申请号：US17846923
申请日：2022-06-22
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Nicolás M. Morato , Dylan T. Holden
IPC: G01N27/64 , G01N27/622 , G01N27/626 , H01J49/04
Abstract: The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS).
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公开(公告)号：US20220326180A1
公开(公告)日：2022-10-13
申请号：US17846923
申请日：2022-06-22
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Nicolás M. Morato , Dylan T. Holden
IPC: G01N27/622 , G01N27/64 , G01N27/626 , H01J49/04
Abstract: The invention generally relates to high-throughput label-free enzymatic bioassays using desorption electrospray ionization-mass spectrometry (DESI-MS).
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公开(公告)号：US20220265172A1
公开(公告)日：2022-08-25
申请号：US17692613
申请日：2022-03-11
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks , Zheng Ouyang , Chien-hsun Chen , Ziqing Lin , Livia Schiavinato Eberlin
IPC: A61B5/1477 , A61B10/00 , H01J49/04 , A61M11/00 , A61M25/00 , H01J49/00 , H01J49/16 , H01J49/34 , G01N33/483
Abstract: The invention generally relates to enclosed desorption electrospray ionization probes, systems, and methods. In certain embodiments, the invention provides a source of DESI-active spray, in which a distal portion of the source is enclosed within a transfer member such that the DESI-active spray is produced within the transfer member.
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公开(公告)号：US11361954B2
公开(公告)日：2022-06-14
申请号：US16494973
申请日：2018-03-22
Applicant: Purdue Research Foundation
Inventor： Robert Graham Cooks
Abstract: The invention generally relates to systems and methods for conducting reactions and screening for reaction products.
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