公开(公告)号：US20140141526A1

公开(公告)日：2014-05-22

申请号：US14072336

申请日：2013-11-05

Applicant: Xing SU ,  Kai WU ,  David J LIU

Inventor： Xing SU ,  Kai WU ,  David J LIU

IPC: G01N27/74

CPC classification number: G01N27/74 ,  B01J2219/00576 ,  B01J2219/00648 ,  B01J2219/00655 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/043 ,  B01L2400/0439 ,  B03C1/032 ,  B03C1/0335 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N27/745 ,  G01R33/1269

Abstract: An embodiment of the invention relates to a device for detecting an analyte in a sample. The device comprises a fluidic network and an integrated circuitry component. The fluidic network comprises multiple zones such as a sample zone, a cleaning zone and a detection zone. The fluidic network contains a magnetic particle and/or a signal particle. A sample containing an analyte is introduced, and the analyte interacts with the magnetic particle and/or the signal particle through affinity agents. A microcoil array or a mechanically movable permanent magnet is functionally coupled to the fluidic network, which are activatable to generate a magnetic field within a portion of the fluidic network, and move the magnetic particle from the sample zone to the detection zone. A detection element is present which detects optical or electrical signals from the signal particle, thus indicating the presence of the analyte.

Abstract translation: 本发明的一个实施例涉及用于检测样品中的分析物的装置。 该装置包括流体网络和集成电路部件。 流体网络包括多个区域，例如样品区域，清洁区域和检测区域。 流体网络包含磁性颗粒和/或信号颗粒。 引入含有分析物的样品，并且分析物通过亲和试剂与磁性颗粒和/或信号颗粒相互作用。 微线圈阵列或机械可移动永磁体在功能上耦合到流体网络，流体网络可激活以在流体网络的一部分内产生磁场，并将磁性颗粒从样品区域移动到检测区域。 存在检测元件，其检测来自信号颗粒的光学或电信号，从而指示分析物的存在。

公开(公告)号：US20140140804A1

公开(公告)日：2014-05-22

申请号：US14057538

申请日：2013-10-18

Applicant: QIAGEN GMBH

Inventor： Maximilian FOCKE ,  Lothar BREITKOPF ,  Karen KOWALEWSKI ,  Thorsten SINGER

IPC: B01L9/06

CPC classification number: B01L9/06 ,  B01L2200/028 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/043 ,  B01L2300/0829 ,  B01L2300/12 ,  B01L2400/043 ,  B03C1/0332 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N35/0098

Abstract: Magnetic rack system comprising a holder having trough-holes for receiving tubes, a base having a plurality of receptacles with at least one magnet, wherein trough-holes in the holder are arranged relative to the base such that each tube can be positioned in a respective receptacle in a pre-determined position relative to the magnet, and an adapter, wherein the adapter is designed to allow transmission of motion to the tubes (2) positioned in the holder (1).

Abstract translation: 磁性架系统包括具有用于接纳管的槽孔的支架，具有多个具有至少一个磁体的容器的底座，其中保持器中的槽孔相对于基座布置，使得每个管子可以位于相应的 接收器相对于磁体处于预定位置，以及适配器，其中适配器被设计成允许将运动传递到位于保持器（1）中的管（2）。

公开(公告)号：US08728296B2

公开(公告)日：2014-05-20

申请号：US13643385

申请日：2011-04-27

Applicant: Dazhao Gu ,  Yinshan Jiang ,  Cundi Wei ,  Jianguo Han ,  Deli Yu ,  Zhaohua Guo ,  Yixin Zhao ,  Ping Zou ,  Chunbin Guo

Inventor： Dazhao Gu ,  Yinshan Jiang ,  Cundi Wei ,  Jianguo Han ,  Deli Yu ,  Zhaohua Guo ,  Yixin Zhao ,  Ping Zou ,  Chunbin Guo

IPC: C25C1/22 ,  C22B58/00

CPC classification number: C25C1/22 ,  B03C1/03 ,  B03C1/032 ,  B03C1/0335 ,  B03C1/034 ,  B03C2201/18 ,  C22B3/42 ,  C22B7/007 ,  C22B58/00 ,  C25C7/02 ,  Y02P10/234

Abstract: Disclosed is a method for extracting gallium from fly ash, which comprises the following steps: crushing the fly ash and removing Fe by magnetic separation; then dissolving it by using hydrochloric acid to obtain hydrochloric acid leachate; adsorbing gallium contained in the hydrochloric acid leachate with macro-porous cationic resin, followed by eluting to obtain an eluent containing gallium; adding masking agent to mask ferric ion to obtain an eluent containing gallium after masking; adsorbing gallium in the eluent containing gallium after masking with macro-porous cationic resin, followed by eluting to obtain a secondary eluent; adding sodium hydroxide solution into the secondary eluent to react; filtering and removing precipitates after reaction, and then concentrating the filtrate and electrolyzing to obtain metal gallium. The method simplifies the process and improves extraction efficiency of gallium.

Abstract translation: 本发明公开了一种从粉煤灰中提取镓的方法，包括以下步骤：粉碎飞灰并通过磁选除去Fe; 然后用盐酸溶解得到盐酸浸出液; 用大孔阳离子树脂吸附盐酸浸出液中的镓，然后洗脱得到含镓的洗脱液; 加入掩蔽剂掩蔽铁离子，得到掩蔽后含镓的洗脱液; 用大孔阳离子树脂掩蔽后，在含镓的洗脱液中吸附镓，然后洗脱得到二次洗脱液; 将氢氧化钠溶液加入二次洗脱液中反应; 反应后过滤除去沉淀物，然后浓缩滤液并电解，得到金属镓。 该方法简化了工艺，提高了镓的提取效率。

公开(公告)号：US20140099658A1

公开(公告)日：2014-04-10

申请号：US14001301

申请日：2012-02-22

Applicant: Jukka Tuunanen

Inventor： Jukka Tuunanen

IPC: G01N1/40

CPC classification number: G01N1/4077 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/284 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  G01N33/5434 ,  G01N35/0098

Abstract: The invention concerns a method for processing magnetic particles, which selectively interact with a substance present in a liquid medium. The particles are collected with a probe (2) comprising a hollow shield (4) and a probe magnet (3) moveable up and down. The lower end of the probe with the collected particles is placed on a release location (7) of a plate (6), below which release location there is a release magnet (8). The surface of the release location is dry or has a liquid film or a drop on it. In accordance with the invention, very high concentration ratios can be achieved.

Abstract translation: 本发明涉及一种处理磁性颗粒的方法，磁性颗粒选择性地与存在于液体介质中的物质相互作用。 用包括中空屏蔽（4）和探头磁体（3）上下移动的探针（2）收集颗粒。 具有收集的颗粒的探针的下端被放置在板（6）的释放位置（7）上，在该位置下方具有释放磁体（8）。 释放位置的表面是干燥的或具有液体膜或其上的液滴。 根据本发明，可以实现非常高的浓缩比。

公开(公告)号：US08691087B1

公开(公告)日：2014-04-08

申请号：US14051963

申请日：2013-10-11

Applicant: Mosnic Corporation

Inventor： Kazumi Asada ,  Shuichi Mogi

IPC: B01D21/18 ,  B01D33/06 ,  B01D33/073 ,  B01D33/70 ,  B01D35/06 ,  B03C1/30 ,  B23Q11/00

CPC classification number: B01D21/18 ,  B01D33/06 ,  B01D33/067 ,  B01D33/073 ,  B01D33/50 ,  B01D33/70 ,  B01D33/76 ,  B01D35/06 ,  B03C1/12 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B23Q11/00 ,  B23Q11/0067 ,  B23Q11/1069 ,  Y02P70/171

Abstract: A filtration apparatus that removes chips from a chip-containing machining fluid is applied which effectively prevents clogging of a filtration filter that makes up the apparatus. A filtration apparatus 1 is provided with a magnet 9 attached to an outer wall surface of a drum housing chamber 5, the magnet 9 functions as means for fixing chips in the machining fluid that flows into the drum housing chamber 5 from an inlet 16 on a bottom surface 5B or a slope 5A of the drum housing chamber 5 by a magnetic force, and the periphery of the inlet 16 is configured as a magnet non-existent section 17 where the magnet 9 does not exist so as to suppress a phenomenon that chips in the machining fluid are fixed near a top edge of the slope 5A of the drum housing chamber 5 by the magnetic force of the magnet 9.

Abstract translation: 应用从含有芯片的机械加工液中除去芯片的过滤装置，其有效地防止构成该装置的过滤器的堵塞。 过滤装置1设置有附接到鼓容纳室5的外壁表面的磁体9，磁体9用作将芯片固定在加工流体中的装置，该加工流体从入口16流入滚筒容纳室5 底部表面5B或鼓容纳室5的斜面5A，并且入口16的周边被构造为不存在磁体9的磁体不存在部分17，以便抑制芯片 在加工流体中，通过磁体9的磁力固定在鼓容纳室5的斜面5A的上边缘附近。

公开(公告)号：US08678640B2

公开(公告)日：2014-03-25

申请号：US13755991

申请日：2013-01-31

Applicant: Drexel University

Inventor： Benjamin B. Yellen ,  Gennady Friedman

IPC: B01F13/08

CPC classification number: B03C1/02 ,  B01F13/0809 ,  B03C1/288 ,  B03C1/30 ,  B03C1/32 ,  B03C2201/18

Abstract: Device and methods for use of these devices to manipulate substantially non-magnetic particles dispersed inside a magnetic fluid by employing a changeable pattern of local magnetic field maxima and minima are provided.

Abstract translation: 提供了使用这些装置通过采用局部磁场最大值和最小值的可变图案来操纵分散在磁性流体内部的基本上非磁性颗粒的装置和方法。

公开(公告)号：US20140069855A1

公开(公告)日：2014-03-13

申请号：US13990856

申请日：2011-12-01

Applicant: Matthew Taylor

Inventor： Matthew Taylor

IPC: B03C1/30

CPC classification number: B03C1/30 ,  B01D21/0009 ,  B01D21/0036 ,  B01D21/2483 ,  B01D2221/02 ,  B03C1/02 ,  B03C1/284 ,  B03C1/286 ,  B03C2201/18 ,  B03C2201/28 ,  C02F1/488 ,  C02F2103/02 ,  C02F2201/48 ,  C02F2209/40 ,  C02F2301/024 ,  C02F2303/22 ,  C02F2307/14 ,  F24D19/0092

Abstract: A separator (10) comprises a housing (12) and a separator chamber (24) contained within the housing, an inlet (26) and outlet (28) to the separator chamber and a dividing member (34) for substantially dividing the separator chamber into a first chamber (30) and a second chamber (32). A flow path (38) is provided between the first and second chambers for allowing flow to circulate between the first and second chambers, and guide means (56) for creating opposing flow paths in the second chamber (32) for slowing flow through the second chamber (32).

Abstract translation: 分离器（10）包括壳体（12）和容纳在壳体内的分离器室（24），到分离器室的入口（26）和出口（28）以及分隔构件（34），用于将分隔器室 进入第一腔室（30）和第二腔室（32）。 流动路径（38）设置在第一和第二腔室之间，用于允许流动在第一和第二腔室之间循环;以及引导装置（56），用于在第二腔室（32）中产生相反的流动通道，用于减缓通过第二腔室 室（32）。

公开(公告)号：US20140038259A1

公开(公告)日：2014-02-06

申请号：US13984016

申请日：2012-03-13

Applicant: Yong Chen

Inventor： Yong Chen

IPC: C12N13/00

CPC classification number: C12N13/00 ,  B03C1/0332 ,  B03C1/0335 ,  B03C1/035 ,  B03C1/288 ,  B03C2201/18 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/149

Abstract: Fluidic sorting systems configured to immobilize, and optionally concentrate and/or analyze, one or more particles within the system are provided. Aspects of the systems include a flow-through chamber and an immobilization component configured to immobilize, preferably reversibly, a particle within the flow-through chamber. Optionally, the systems include an analysis component configured to optically analyze an immobilized particle within the flow-through chamber. In certain aspects, the systems are configured to collect one or more particles from the flow-through chamber for subsequent analysis, experimentation, and/or use. Also provided are methods, components and kits for reversibly immobilizing, and optionally analyzing, one or more particles within a fluidic sorting system.

Abstract translation: 提供了配置成固定并且可选地浓缩和/或分析系统内的一种或多种颗粒的流体分选系统。 系统的方面包括流通室和固定部件，其被配置为固定，优选地可逆地在流通室内的颗粒。 可选地，所述系统包括配置成光学分析所述流通室内的固定化颗粒的分析组件。 在某些方面，系统被配置为从流通室收集一个或多个颗粒，用于随后的分析，实验和/或使用。 还提供了用于可逆地固定和任选地分析流体分选系统内的一种或多种颗粒的方法，组件和试剂盒。

公开(公告)号：US08637324B2

公开(公告)日：2014-01-28

申请号：US13081927

申请日：2011-04-07

Applicant: Michael G. Pollack ,  Vamsee K. Pamula ,  Ramakrishna Sista ,  Arjun Sudarsan

Inventor： Michael G. Pollack ,  Vamsee K. Pamula ,  Ramakrishna Sista ,  Arjun Sudarsan

IPC: G01N15/06

CPC classification number: G01N33/54333 ,  B01F11/0071 ,  B01F13/0071 ,  B01F13/0076 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/502784 ,  B01L3/502792 ,  B01L7/52 ,  B01L7/525 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0668 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/089 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0415 ,  B01L2400/0421 ,  B01L2400/0424 ,  B01L2400/0427 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0442 ,  B03C1/02 ,  B03C1/288 ,  B03C1/30 ,  B03C5/005 ,  B03C2201/18 ,  B03C2201/26 ,  C12N15/1013 ,  G01N33/561 ,  G01N2035/1046 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

Abstract: The present invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte), and secondary reporter antibodies on a magnet, on and off a magnet, and completely off a magnet are provided. Also provided are methods for washing magnetically responsive beads using shape-assisted merging of droplets. Also provided are methods for shape-mediated splitting, transporting, and dispensing of a sample droplet that contains magnetically responsive beads. The apparatuses and methods of the invention provide for rapid time to result and optimum detection of an analyte in an immunoassay.

Abstract translation: 本发明涉及在液滴致动器上的珠孵化和洗涤。 提供了用于将用一抗标记的磁响应珠，样品（即分析物）和二次报告基因抗体孵育在磁体上，磁铁上和从磁体上离开并完全离开磁体的方法。 还提供了使用形状辅助的液滴合并来洗涤磁响应珠的方法。 还提供了用于形状介导的分离，输送和分配含有磁响应珠的样品液滴的方法。 本发明的装置和方法提供了免疫测定中分析物的快速结果和最佳检测的时间。

公开(公告)号：US20140021105A1

公开(公告)日：2014-01-23

申请号：US13809091

申请日：2011-07-07

Applicant: Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

Inventor： Gil Lee ,  Peng Li ,  Mark Platt ,  Gemma Cannon

IPC: B03C1/02

CPC classification number: B03C1/02 ,  B03C1/032 ,  B03C1/24 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/24 ,  B03C2201/26 ,  G01N27/44756

Abstract: A flow enhanced method and system for flow non-linear magnetophoresis (F-NLM) is described. By tuning an external field frequency and the flow rate the migration velocities of different bead types may be caused to differ by several orders of magnitude over an extended range of frequencies to allow for separation of particles. Use of such efficiency in separation in bio-separation and similar assays is described.

Abstract translation: 描述了用于流动非线性磁电泳（F-NLM）的流动增强方法和系统。 通过调整外场频率和流速，可以使不同珠粒类型的迁移速度在扩展的频率范围内相差几个数量级以允许分离颗粒。 描述了在生物分离中的这种效率的使用和类似的测定。