公开(公告)号：US09955881B2

公开(公告)日：2018-05-01

申请号：US14196520

申请日：2014-03-04

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Xinyan Cui ,  Nicolas Alexander Alba ,  Mingui Sun

IPC分类号： A61B5/04 ,  A61N1/04 ,  A61B5/0408 ,  A61B5/0478 ,  A61B5/0492

CPC分类号： A61B5/04 ,  A61B5/04087 ,  A61B5/0478 ,  A61B5/0492 ,  A61B2562/0215 ,  A61B2562/0217 ,  A61B2562/125 ,  A61N1/0408 ,  A61N1/0472 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/0496

摘要： An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q′ ratio of at least 5 as defined by the equation Q ′ = W W W G wherein WG is the dry weight of the hydrophilic polymer and WW is weight of water in the sample after absorption of the electrolyte fluid comprising water and an electrolyte salt. The surface contact element can consist essentially of the hydrophilic polymer swollen by the electrolyte fluid. Another electrode system includes a contact element including a crosslinked hydrophilic polymer matrix. The contact element has a Q′ ratio of at least 5 as defined by the equation Q ′ = W W W G . The contact elements can also have a Q′ ratio of at least 6, at least 7, at least 10 or even at least 11.

公开(公告)号：US09914870B2

公开(公告)日：2018-03-13

申请号：US14762332

申请日：2014-01-22

申请人： CARNEGIE MELLON UNIVERSITY

发明人： Newell R. Washburn ,  Hoyong Chung

IPC分类号： C09K8/588 ,  C08K3/04 ,  C08H7/00 ,  C08F251/02 ,  C08F291/04 ,  C08F293/00 ,  C08G81/02

CPC分类号： C09K8/588 ,  C08F251/02 ,  C08F291/04 ,  C08F293/005 ,  C08F2438/01 ,  C08G81/02 ,  C08H6/00 ,  C08K3/04 ,  C08L97/005

摘要： A composition includes an agent formed by grafting at least a first polymer with lignin and a component other than the agent, lignin or the at least a first polymer, wherein lignin has an affinity for the component. A method of dispersing a component in a matrix includes adding an agent to the matrix. The agent is formed by grafting at least a first polymer with lignin. The first polymer has an affinity for the matrix. Lignin has an affinity for the component. The component is other than the agent, lignin or the at least a first polymer. The method for includes contacting the matrix with the component.

公开(公告)号：US09855341B2

公开(公告)日：2018-01-02

申请号：US14625873

申请日：2015-02-19

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Song Li ,  Yixian Huang ,  Xiaolan Zhang ,  Xiang Gao

IPC分类号： A61K47/48 ,  A61K31/337 ,  A61K31/235 ,  A61K31/704 ,  A61K9/00 ,  A61K9/107 ,  C08G65/331 ,  C08G65/333 ,  C08G65/334

CPC分类号： A61K47/60 ,  A61K9/0019 ,  A61K9/1075 ,  A61K31/235 ,  A61K31/337 ,  A61K31/704 ,  C08G65/331 ,  C08G65/3311 ,  C08G65/33306 ,  C08G65/33396 ,  C08G65/334 ,  C08G65/3344 ,  C08L2203/02

摘要： A method of forming or creating a formulation for a compound to be delivered includes creating a carrier agent by conjugating at least one hydrophobic domain or hydrophobic compound with at least one hydrophilic domain or hydrophilic compound and associating the compound to be delivered with the carrier agent to create the formulation. The at least one hydrophobic compound has the formula: wherein R1 is a farnesyl group, a geranyl group or geranyl-geranyl group, X is O, S, SO, SO2, NH or Se, Z is C—R2 or N, R2 is H, CN, CO2R7, SO3R7, CONR7R8 or SO2NR7R8, wherein R7 and R8 are each independently H, an alkyl group, an alkenyl group, CO2M or SO3M, wherein M is a cation and R3, R4, and R5 are independently H, a carboxyl group, an alkyl group, an alkenyl group, an aminoalkyl group, a nitroalkyl group, a nitro group, a halo atom, an amino group, a mono-alkylamino group, a di-alkylamino group, mercapto group, a mercaptoalkyl group, an azido group or a thiocyanato group. A plurality of the carrier agents are adapted to assemble into a structure. The hydrophobic compound is cleavably conjugated to the at least one hydrophilic compound via a linkage which is labile in vivo.

公开(公告)号：US09814821B2

公开(公告)日：2017-11-14

申请号：US14405038

申请日：2013-06-15

申请人： University of Pittsburgh—Of The Commonwealth System of Higher Education

发明人： William J. Federspiel ,  David T. Arazawa ,  Jeremy D. Kimmel

IPC分类号： B01D11/00 ,  B01D63/00 ,  B01D53/22 ,  B01D71/70 ,  A61M1/34 ,  A61M1/16 ,  B01D61/00 ,  B01D63/02 ,  B01D67/00 ,  B01D69/14 ,  B01D71/26 ,  B01D63/04 ,  B01D69/08 ,  A61M1/36

CPC分类号： A61M1/34 ,  A61M1/1698 ,  A61M1/3403 ,  A61M1/3687 ,  A61M2202/0225 ,  A61M2202/0275 ,  A61M2202/0283 ,  B01D61/00 ,  B01D63/02 ,  B01D63/04 ,  B01D67/0093 ,  B01D69/08 ,  B01D69/144 ,  B01D71/26 ,  B01D2311/13

摘要： A method for removal of at least a portion of carbon dioxide from an aqueous fluid such as a blood fluid includes placing a first surface of at least one membrane through which carbon dioxide and at least one acid gas other than carbon dioxide can pass in fluid in contact with the fluid. The membrane limits or prevent passage of the fluid therethrough. A carrier or sweep gas including the acid gas other than carbon dioxide is passed over a second surface (which is typically opposite the first surface) of the membrane so that the acid gas other than carbon dioxide can pass through the membrane into the fluid, and carbon dioxide from the fluid can pass from the liquid, through the membrane, and into the sweep gas.

公开(公告)号：US09808560B2

公开(公告)日：2017-11-07

申请号：US14194188

申请日：2014-02-28

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Yi Hong ,  William R Wagner ,  Sang-Ho Ye

IPC分类号： A61K31/74 ,  A61L33/06 ,  A61L27/18 ,  A61L27/58 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L33/068 ,  A61L27/18 ,  A61L27/58 ,  A61L31/10 ,  A61L31/148 ,  A61L31/16 ,  A61L33/064 ,  A61L2300/402 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/416 ,  C08L67/04

摘要： A method of forming an implantable article includes providing a biodegradable polymer including anti-thrombogenic groups along the length of the biodegradable polymer, biodegradable groups in the backbone of the biodegradable polymer and a plurality of functional groups adapted to react with reactive functional groups on a surface of the implantable article, and reacting at least a portion of the plurality of functional groups with the reactive functional groups on the surface of the implantable article.

公开(公告)号：US09625406B2

公开(公告)日：2017-04-18

申请号：US14454119

申请日：2014-08-07

申请人： MSA TECHNOLOGY, LLC.

发明人： Mark Flori Zanella, Sr.

IPC分类号： G01N27/16 ,  G01N33/00

CPC分类号： G01N27/16 ,  G01N33/0016 ,  G01N33/0027 ,  G01N33/0031 ,  G01N33/0073

摘要： A combustible gas sensor includes at least a first sensing element comprising a first conductive element having, for example, an average diameter less than 20 μm in electrical connection with electronic circuitry. The combustible gas sensor further includes a first support element having a first anchored end, a second anchored end and an extending intermediate section between the first anchored end and the second anchored end, the extending intermediate section providing support for the first conductive element. Another combustible gas sensor includes a first sensing element and a second sensing element. The first sensing element includes a first catalyst support member having a volume less than a sphere having a diameter of 500 μm. The second sensing element includes a second catalyst support member having a volume less than a sphere having a diameter of 500 μm. The combustible gas sensor further includes electronic circuitry that is adapted to cycle between a first mode in which the first sensing element is operated in a higher power mode and the second sensing element is operated in a lower power mode and a second mode in which the second sensing element is operated in a higher power mode and the first sensing element is operated in a lower power mode.

公开(公告)号：US09615964B2

公开(公告)日：2017-04-11

申请号：US14347800

申请日：2012-09-29

申请人： Robert Rogers

发明人： Robert Rogers

IPC分类号： A61F5/56 ,  A61C7/08

CPC分类号： A61F5/566 ,  A61C7/08 ,  A61C7/36 ,  A61F5/56 ,  Y10T29/49567

摘要： A method of forming oral orthotic systems (100) to position and/or stabilize a mandible of a patient includes providing an upper dental member (20) adapted to be placed in connection with upper dentition of the patient, providing a lower dental member (30) adapted to be placed in connection with lower dentition of the patient and providing a plurality of posterior mounting structures (40). Each of the posterior mounting structure is adapted to be attached to one of the upper dental member or the lower dental member at a posterior, buccal position thereon. Each of the posterior mounting structures includes an extending member (42) which includes a plurality of positions (44) at which one of a plurality of connectors (50) is attachable to the extending member. Force may be applied to the mandible of the patient via at least one of a plurality of different mechanisms via attachment of a component of the mechanism (120) to at least one of the posterior mounting structures. The upper dental member and the lower dental member are formed, independently, from at least one polymeric material.

公开(公告)号：US09611841B2

公开(公告)日：2017-04-04

申请号：US13773720

申请日：2013-02-22

申请人： Gregory S. Antoun

发明人： Gregory S. Antoun

IPC分类号： F04B17/00 ,  F04B23/02

CPC分类号： F04B23/02 ,  Y10T137/0379 ,  Y10T137/86035

摘要： A system includes at least one fluid volume in which pressure varies, a retention volume for collecting a liquid used in operating the system; and a pump device in fluid connection with the retention volume and in operative connection with the fluid volume. The pump device includes a housing, a movable pressurizing mechanism within the housing and in fluid connection with the fluid volume, a biasing mechanism in operative connection with the pressurizing mechanism to bias the pressurizing mechanism in a first direction, and a pump volume within the housing. The volume of the pump volume is defined by a position of the pressurizing mechanism, wherein the position of the pressurizing mechanism is controlled by pressure within the fluid volume and the biasing mechanism. The pump device further includes an inlet port in fluid connection with the pump volume and an outlet port in fluid connection with the pump volume.

公开(公告)号：US09410020B2

公开(公告)日：2016-08-09

申请号：US14373553

申请日：2013-01-28

申请人： CARNEGIE MELLON UNIVERSITY

发明人： Krzysztof Matyjaszewski ,  Michael Bockstaller

IPC分类号： C08L33/12 ,  C08J3/02 ,  B81C1/00 ,  C08J3/00 ,  C08L25/06 ,  C08G83/00 ,  C08L101/00 ,  B82Y30/00

CPC分类号： C08J3/02 ,  B81B2207/056 ,  B81C1/00031 ,  B81C2201/0149 ,  B82Y30/00 ,  C08G83/003 ,  C08J3/005 ,  C08J2325/06 ,  C08J2333/12 ,  C08L25/06 ,  C08L33/12 ,  C08L101/005 ,  C08L2205/025

摘要： A method of forming a composition includes adding together a plurality of particle brush systems wherein each of the particle brush systems includes a particle and a polymer brush including a plurality of polymer chains attached to the particle. The plurality of polymer chains of the polymer brush exhibit two chain conformations as the degree of polymerization of the polymer chains increases so that the polymer brush includes a concentrated polymer brush region with stretched polymer chains and a semi-dilute polymer brush region with relaxed chains that is radially outside of the concentrated polymer brush region. The degree of polymerization of the polymer brush is no less than 10% less than a critical degree of polymerization and no more than 20% greater than the critical degree of polymerization. The critical degree of polymerization is defined as the degree of polymerization required to achieve a transition from the concentrated polymer brush region to the semi-dilute polymer brush region.

摘要翻译： 形成组合物的方法包括将多个颗粒刷系统加入到其中，其中每个颗粒刷系统包括颗粒和包含附着到颗粒上的多个聚合物链的聚合物刷。 当聚合物链的聚合度增加时，聚合物刷的多个聚合物链表现出两个链构象，使得聚合物刷包括具有拉伸聚合物链的浓缩聚合物刷区域和具有松弛链的半稀释聚合物刷区域 位于浓缩聚合物刷区域的径向外侧。 聚合物刷的聚合度不低于临界聚合度的10％且不低于临界聚合度的20％以上。 临界聚合度定义为实现从浓缩聚合物刷区域到半稀释聚合物刷涂区域的转变所需的聚合度。

公开(公告)号：USD703526S1

公开(公告)日：2014-04-29

申请号：US29441175

申请日：2013-01-02

申请人： John F. Quinn ,  Debbie Skatell-Wehner ,  Peter Everett

设计人： John F. Quinn ,  Debbie Skatell-Wehner ,  Peter Everett