公开(公告)号：US09885862B2

公开(公告)日：2018-02-06

申请号：US14267762

申请日：2014-05-01

Applicant: BIO-RAD LABORATORIES, INC.

Inventor： Frank Hsiung ,  Kelly Kroeger ,  Robert Archer ,  Veronika Kortisova ,  Teresa Rubio

IPC: G02B21/24 ,  G02B21/36

CPC classification number: G02B21/368 ,  G02B21/241 ,  G02B21/365

Abstract: The present invention relates in general to microscopy systems. In particular, the present invention relates to microscopes rendering digital images of samples, with the capability to digitally control the focus of the microscope system, and the software used to control the operation of the digital microscope system. Further, the present invention relates to a microscope structure that allows for compact and multi-functional use of a microscope, providing for light shielding and control with samples that require specific light wavelength characteristics, such as fluorescence, for detection and imaging. The microscope is adjustable, with a structure that can move along range(s) of motion and degree(s) of freedom to allow for ease of access to samples, shielding of samples, and manipulation of a display apparatus.

公开(公告)号：US09840697B2

公开(公告)日：2017-12-12

申请号：US14562396

申请日：2014-12-05

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yan Wang ,  Man Cheng

IPC: C12N9/12 ,  C12Q1/68 ,  C12N9/22

CPC classification number: C12N9/1252 ,  C07K2319/80 ,  C12N9/22 ,  C12Q1/686

Abstract: Fusion polypeptides having a heterologous 5′-3′ exonuclease domain linked to a polymerase that does not naturally have 5′-3′ exonuclease activity, as well as methods of their use are provided. Other aspects are also disclosed.

公开(公告)号：US09816931B2

公开(公告)日：2017-11-14

申请号：US14008990

申请日：2012-03-28

Applicant: Adam Abate ,  John Lawrence Emhoff ,  Tony Hung ,  Adnan Moez Esmail ,  Sepehr Kiani ,  Pascaline Mary

Inventor： Adam Abate ,  John Lawrence Emhoff ,  Tony Hung ,  Adnan Moez Esmail ,  Sepehr Kiani ,  Pascaline Mary

IPC: G01J3/30 ,  G01N21/64 ,  C12Q1/68 ,  G01N21/25 ,  G01N21/76

CPC classification number: G01N21/6486 ,  C12Q1/6806 ,  G01N21/255 ,  G01N21/76 ,  G01N2201/06113 ,  G01N2201/062 ,  C12Q2545/101 ,  C12Q2563/107 ,  C12Q2563/159 ,  C12Q2563/161 ,  C12Q2565/629

Abstract: The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.

公开(公告)号：US09810703B2

公开(公告)日：2017-11-07

申请号：US14883395

申请日：2015-10-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Adam Darmstadt ,  Michael Waite ,  Theresa Forni

IPC: G01N35/00 ,  G01N30/04

CPC classification number: G01N35/00693 ,  G01N35/0095 ,  G01N2030/047 ,  G01N2035/00702

Abstract: An improved calibration process for a medical testing machine. The machine automatically recognizes that a package of calibration material has been inserted into it, and performs a calibration sequence to ascertain a calibration parameter to be used in performing future tests with the medical testing machine. The calibration package may include machine-readable indicators that the package is to be used for calibration, and of a calibration setpoint of a calibration material in the package. A calibration material may be stored in a lyophilized state in the package, and the medical testing machine may automatically reconstitute the lyophilized material.

公开(公告)号：US09792548B2

公开(公告)日：2017-10-17

申请号：US13625753

申请日：2012-09-24

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Todd Yeck ,  Niels Kirk Thomsen ,  John Clopton Dunaway

IPC: G06N5/02 ,  G06F19/26 ,  G06F19/28

CPC classification number: G06N5/02 ,  G06F19/26 ,  G06F19/28

Abstract: Methods and systems for biochemical data analysis are provided. A dataset can be received and a selection of a compare field can be used for creation of sub-groups of data to run statistical analysis on. The sub-groups of the dataset can be created based on the selection of the compare field. Statistical information about each sub-group of data can be calculated and displayed on a user display. Other information can be provided for further dataset refinements. A user may supply a control group selection, and such a selection may then result in an indication on the display of which population represents the control group. A user may supply information for further dataset filtering. Such information may be used to filter data, prior to creating the sub-groups for statistical analysis.

公开(公告)号：US20170264828A1

公开(公告)日：2017-09-14

申请号：US15449786

申请日：2017-03-03

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Evelio Perez ,  Evan P. Thrush ,  Stephen L.R. Swihart ,  Brian D. Hall

IPC: H04N5/232 ,  G02B7/02 ,  H04N5/225

CPC classification number: H04N5/2254 ,  G03B17/02 ,  G03B17/55 ,  G03B17/561 ,  G03B43/00 ,  H04N5/2252 ,  H04N5/2253

Abstract: Techniques and systems for implementing fast, fixed-focal-length lens imaging systems for molecular biology or genetics applications are provided. In particular, techniques and structures are provided for allowing for precise alignment of the optical and imaging components of such imaging systems during assembly with a minimal amount of adjustment.

公开(公告)号：US09752177B2

公开(公告)日：2017-09-05

申请号：US14256861

申请日：2014-04-18

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yanhong Kong ,  Steven T. Okino ,  Xiangdong Meng

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q2521/125 ,  C12Q2521/301 ,  C12Q2527/156

Abstract: Filtering small nucleic acids using permeabilized cells and methods for using the filtering to detect genomic DNA accessibility are described.

公开(公告)号：US20170205345A9

公开(公告)日：2017-07-20

申请号：US14099750

申请日：2013-12-06

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Yann Jouvenot ,  Serge Saxonov ,  Simant Dube ,  John Frederick Regan

IPC: G01N21/64

CPC classification number: G01N21/64 ,  G01N21/6428 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441 ,  G06F19/12 ,  G06F19/18

Abstract: System, including methods and apparatus, for performing a multiplexed digital assay.

公开(公告)号：US09702822B2

公开(公告)日：2017-07-11

申请号：US13973940

申请日：2013-08-22

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Claudia Litterst ,  Austin P. So ,  Duc Do

IPC: C12Q1/68 ,  C12P19/34 ,  G01N21/64

CPC classification number: G01N21/6486 ,  C12Q1/6846 ,  C12Q1/6851 ,  C12Q1/6858 ,  C12Q2525/204 ,  C12Q2563/159

Abstract: Digital assay system, includes methods, apparatus, and compositions, for distinguishing and measuring different types of templates according to the different lengths of corresponding amplicons, which may be amplified by the same pair of primers. The system may include a length-sensitive reporter generating luminescence that varies according to amplicon length. The system may, for example, be utilized to identify, distinguish, and/or quantify wild-type and mutant/variant templates, processed and unprocessed template, a target template and a primer dimer, or the like.

公开(公告)号：US09688969B2

公开(公告)日：2017-06-27

申请号：US14845234

申请日：2015-09-03

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Peter B. Vander Horn ,  Yan Wang

IPC: C12N9/12

CPC classification number: C12N9/1252 ,  C07K2319/00 ,  C12N9/1241 ,  C12Y207/07007

Abstract: The invention provides novel compositions with polymerase activity and methods of using the compositions.