公开(公告)号：US11655395B2

公开(公告)日：2023-05-23

申请号：US16263525

申请日：2019-01-31

Applicant: TOPPAN PRINTING CO., LTD. ,  HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Koji Sakairi ,  Atsushi Matsushima ,  Tomohiro Shinoda ,  Atsushi Sonobe

IPC: C09J7/29 ,  C09J201/02 ,  B32B27/40 ,  C09J201/00

CPC classification number: C09J7/29 ,  B32B27/40 ,  C09J201/00 ,  C09J201/02 ,  C09J2301/162 ,  C09J2400/12 ,  C09J2471/001 ,  C09J2475/001 ,  C09J2475/006

Abstract: A support film for a tape material, includes a film-shaped support formed of polyurethane; and a barrier layer containing an aromatic isocyanate-based polyurethane and a layered inorganic compound and formed on one surface of the support.

公开(公告)号：US11607394B2

公开(公告)日：2023-03-21

申请号：US16954627

申请日：2018-12-14

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Hiroyuki Araki ,  Yuka Takagi ,  Yoko Fujiwara ,  Hiroaki Kobayashi ,  Takao Kurokawa

IPC: A61P25/16 ,  A61K47/32 ,  A61K31/381 ,  A61K9/70

Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof,
the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and
in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.

公开(公告)号：US20230077669A1

公开(公告)日：2023-03-16

申请号：US17796723

申请日：2021-02-09

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Koji OKAWA ,  Kuniaki OTAKA ,  Hiroyuki SATO ,  Hiroshi INAKURA ,  Masaaki KURIKI

IPC: A61K9/70 ,  A61K31/196 ,  A61K47/20 ,  A61K47/14 ,  A61K47/34

Abstract: Disclosed is a patch for alleviating cancerous pain. The patch is provided with a support layer and an adhesive layer laminated on the support layer. The adhesive layer contains an adhesive base and 150-225 mg of diclofenac sodium. One patch is used by being attached once per day.

公开(公告)号：US20230074629A1

公开(公告)日：2023-03-09

申请号：US17796921

申请日：2021-02-09

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Koji OKAWA ,  Kuniaki OTAKA ,  Hiroyuki SATO ,  Hiroshi INAKURA ,  Masaaki KURIKI

IPC: A61K31/196 ,  A61P29/00 ,  A61K9/70 ,  A61K47/12 ,  A61K47/20 ,  A61K47/44

Abstract: Disclosed is a patch for relieving cancer pain, the patch comprising a support layer, and an adhesive layer laminated on the support layer, wherein the adhesive layer contains an adhesive base and diclofenac sodium. The patch is applied once a day, and is used such that the dosage of the diclofenac sodium is 150-225 mg per dose.

公开(公告)号：US20220409524A1

公开(公告)日：2022-12-29

申请号：US17902303

申请日：2022-09-02

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryota HORI ,  Toshihiro KOGURE ,  Seiji TOKUMOTO ,  Shinpei NISHIMURA

IPC: A61K9/00 ,  A61K31/4174 ,  A61K31/135 ,  A61K47/20 ,  A61K47/02 ,  A61M37/00

Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles, wherein the coating comprising dexmedetomidine or a pharmaceutically acceptable salt thereof and isoproterenol or a pharmaceutically acceptable salt thereof. Using said microneedle device, a fast increase rate of dexmedetomidine concentration in plasma after application of the microneedle device is achieved.

公开(公告)号：US20220362214A1

公开(公告)日：2022-11-17

申请号：US17761019

申请日：2020-09-11

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoyuki UCHIDA ,  Satoshi AMANO

IPC: A61K31/4045 ,  A61K9/70 ,  A61K47/14

Abstract: A ropinirole-containing patch comprising an adhesive agent layer and a backing layer, wherein the adhesive agent layer containing: at least one selected from the group consisting of ropinirole and a pharmaceutically acceptable salt thereof; a fatty acid metal salt having 7 or more carbon atoms; and an adhesive agent.

公开(公告)号：US20220257528A1

公开(公告)日：2022-08-18

申请号：US17617991

申请日：2020-06-05

Applicant: Hisamitsu Pharmaceutical Co., Inc.

Inventor： Hiroyuki ARAKI ,  Yuka TAKAGI ,  Yoko FUJIWARA ,  Hiroaki KOBAYASHI ,  Takao KUROKAWA

IPC: A61K9/70 ,  A61K31/381

Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof, and the adhesive agent layer further contains an alicyclic saturated hydrocarbon resin and at least one aliphatic alcohol selected from the group consisting of lauryl alcohol, octyldodecanol, oleyl alcohol, and myristyl alcohol.

公开(公告)号：US20220133643A1

公开(公告)日：2022-05-05

申请号：US17426796

申请日：2020-01-30

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takao KUROKAWA ,  Hidekazu KUMA ,  Masaki YUKUHIRO

IPC: A61K9/70 ,  A61K31/573 ,  A61K31/407 ,  A61K31/381 ,  A61K31/27 ,  A61K31/13 ,  A61K31/4422 ,  A61K31/403

Abstract: The present invention provides a patch comprising an adhesive layer on a backing, wherein the adhesive layer contains a adhesive base, a skin irritant drug or a pharmaceutically acceptable salt thereof, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0009 to 0.08% by mass based on the total mass of the adhesive layer.

公开(公告)号：US20220079879A1

公开(公告)日：2022-03-17

申请号：US17536295

申请日：2021-11-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shinya MATSUMURA ,  Toshihiro NAKANISHI ,  Yasuhisa KOSE

IPC: A61K9/06 ,  A61K9/107 ,  A61K31/196 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38 ,  A61K47/44

Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.

公开(公告)号：US11130148B2

公开(公告)日：2021-09-28

申请号：US14894397

申请日：2014-05-29

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Eiji Hashimoto ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto

IPC: B05C15/00 ,  F24F3/16 ,  F24F3/14 ,  B05C21/00 ,  B05C3/00 ,  B81C99/00 ,  A61M37/00 ,  F24F8/10 ,  B05D3/04

Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.