公开(公告)号：US20050249748A1

公开(公告)日：2005-11-10

申请号：US11021441

申请日：2004-12-23

Applicant: Thomas Dubensky ,  Daniel Portnoy ,  William Luckett ,  David Cook

Inventor： Thomas Dubensky ,  Daniel Portnoy ,  William Luckett ,  David Cook

IPC: A61K39/00 ,  A61K39/02 ,  A61K48/00 ,  C07H21/04 ,  C07K14/195 ,  C12N1/21 ,  C12N15/74

CPC classification number: C07K14/195 ,  A61K39/00 ,  A61K2039/523 ,  C07K2319/02 ,  Y02A50/464

Abstract: The present invention provides recombinant nucleic acid molecules, expression cassettes, and vectors useful for expression of polypeptides, including heterologous polypeptides, such as antigens, in bacteria. Some of the recombinant nucleic acid molecules, expression cassettes and vectors comprise codon-optimized sequences encoding the polypeptides and/or signal peptides. Some of the recombinant nucleic acid molecules, expression cassettes, and expression vectors comprise sequences encoding non-Listerial and/or non-secA1 signal peptides for secretion of the polypeptides. The invention also provides bacteria comprising the nucleic acid molecules, expression cassettes, and expression vectors, as well as compositions such as vaccines comprising the bacteria. Methods of making and using the bacteria, recombinant nucleic acid molecules, and expression cassettes are also provided.

Abstract translation: 本发明提供了可用于在细菌中表达多肽的重组核酸分子，表达盒和载体，包括异源多肽，例如抗原。 一些重组核酸分子，表达盒和载体包含编码多肽和/或信号肽的密码子优化的序列。 一些重组核酸分子，表达盒和表达载体包含编码用于分泌多肽的非赖斯特和/或非secA1信号肽的序列。 本发明还提供了包含核酸分子，表达盒和表达载体的细菌，以及包含细菌的疫苗的组合物。 还提供了制备和使用细菌，重组核酸分子和表达盒的方法。

公开(公告)号：US06938448B2

公开(公告)日：2005-09-06

申请号：US09946574

申请日：2001-09-05

Applicant: Steven Kennerknecht ,  David Cook

Inventor： Steven Kennerknecht ,  David Cook

IPC: B21D11/08 ,  B21D31/06 ,  B64C1/12 ,  B64C3/26 ,  C21D7/06 ,  B21J5/00

CPC classification number: B24C1/10 ,  B21D11/08 ,  B21D31/06 ,  B64C1/12 ,  B64C3/26 ,  C21D7/06 ,  Y10T29/479

Abstract: A panel, such as is intended for an aircraft wing panel, has continuous ribs extending on one surface. The panel is formed, or given a dihedral bend, by shot peening the ribs at a V-shaped section to expand the V-shaped sections and thus deform the panel. A strong formed panel is thus provided with continuous ribs. Further shot peening steps can be carried out on the panel for further shaping.

Abstract translation: 诸如用于飞行器翼板的面板具有在一个表面上延伸的连续肋。 通过在V形截面处对肋条进行喷丸硬化来形成或给予二面体弯曲，以扩大V形部分，从而使面板变形。 因此，强形成的面板设置有连续的肋。 可以在面板上进行进一步的喷丸硬化步骤以进一步成型。

公开(公告)号：US20050131826A1

公开(公告)日：2005-06-16

申请号：US10994973

申请日：2004-11-23

Applicant: David Cook

Inventor： David Cook

IPC: G06Q20/00 ,  G06F17/60

CPC classification number: G06Q20/04 ,  G06Q20/027 ,  G06Q20/085 ,  G06Q20/0855 ,  G06Q20/108 ,  G06Q20/12 ,  G06Q20/3674 ,  G06Q20/382 ,  G06Q20/3821 ,  G06Q20/3825 ,  G06Q20/383 ,  G06Q20/40 ,  G06Q20/401 ,  G06Q20/4012 ,  G06Q20/4016

Abstract: A system and method for authorizing certain aspects of network based transactions between a customer and a merchant is disclosed. At a credit card authorization system, merchant information, transaction information, and a credit card number of a customer is received from an e-commerce merchant. An authorization form at the credit card authorization system that contains the transaction information is created. An internet browser associated with the customer is caused to display the authorization form. A signature phrase is received from the customer via the authorization form. The received signature phrase is verified that it corresponds to a signature phrase stored in a credit card account associated with the credit card number. The internet browser associated with the customer is caused to be transferred to a web site associated with the e-commerce merchant.

Abstract translation: 公开了一种用于授权客户和商家之间基于网络的交易的某些方面的系统和方法。 在信用卡授权系统中，从电子商务商家接收到顾客的商家信息，交易信息和信用卡号。 创建包含交易信息的信用卡授权系统的授权表单。 导致与客户相关联的互联网浏览器显示授权表单。 从客户通过授权表收到签名短语。 验证所接收的签名短语，其对应于存储在与信用卡号码相关联的信用卡帐户中的签名短语。 将与客户相关联的互联网浏览器转移到与电子商务商家相关联的网站。

公开(公告)号：US20050072399A1

公开(公告)日：2005-04-07

申请号：US10681056

申请日：2003-10-07

Applicant: Aleksandar Kojic ,  Jean-Pierre Hathout ,  David Cook ,  Jasim Ahmed

Inventor： Aleksandar Kojic ,  Jean-Pierre Hathout ,  David Cook ,  Jasim Ahmed

IPC: F02B1/12 ,  F02B5/00 ,  F02B19/02 ,  F02B77/08 ,  F02D41/30 ,  F02B19/14

CPC classification number: F02B19/02 ,  F02B1/12 ,  F02B5/00 ,  F02B77/085 ,  F02D41/3041 ,  Y02T10/125

Abstract: A method and system of controlling auto-ignition timing in an internal combustion engine cylinder in which the timing of auto-ignition in prechambers that are coupled to the cylinder is precisely controlled. The auto-ignition in the prechambers produces hot gas jets that are introduced into the charge space of the cylinder and rapidly induce a second auto-ignition of the mixture in the cylinder. By precisely controlling the timing of the auto-ignitions within the prechambers, the timing of the auto-ignition within the cylinders can, in turn, be precisely controlled.

Abstract translation: 在内燃机气缸中控制自动点火正时的方法和系统，其中精确地控制联接到气缸的预燃烧器中的自动点火定时。 前燃烧室中的自动点火产生引入气缸充气空间的热气体射流，并迅速引起气缸中混合物的第二次自动点火。 通过精确地控制预燃室内自动点火的时间，可以精确地控制气缸内自动点火的时间。

公开(公告)号：US20050011189A1

公开(公告)日：2005-01-20

申请号：US10885325

申请日：2004-07-06

Applicant: David Cook ,  Ben Covell

Inventor： David Cook ,  Ben Covell

IPC: B66F9/065 ,  B66F9/22 ,  E02F9/22 ,  F16D31/02

CPC classification number: E02F9/2203 ,  B66F9/0655 ,  B66F9/22 ,  E02F9/2207 ,  E02F9/2217 ,  E02F9/2221

Abstract: A method of operating a hydraulic system of a loader arm carrying a working implement, the system having a ride improvement system and a selection valve connected to first and second chambers of a ram which operates the loader arm. A check valve assembly is provided, with the check valve assembly being responsive to pressure changes in the second chamber. The check valve assembly, when closed, prevents fluid from passing between the first chamber to the selection valve. Means are provided communicating the fluid pressure in the second chamber to the check valve, with the means responsive to pressure changes in the second chamber to open the check valve. The selection valve is operable to raise the loader arm with the system arranged to permit passage of fluid between the first chamber and the accumulator while permitting fluid to pass from the second chamber to a low pressure region.

Abstract translation: 一种操作承载工作工具的装载臂的液压系统的方法，该系统具有行驶改进系统和连接到操作装载臂的压头的第一和第二室的选择阀。 提供止回阀组件，其中止回阀组件响应于第二室中的压力变化。 止回阀组件在关闭时防止流体在第一室与选择阀之间通过。 提供了将第二室中的流体压力传递到止回阀的装置，其中响应于第二室中的压力变化的装置打开止回阀。 选择阀可操作以升高装载臂，该系统布置成允许流体在第一室和蓄液器之间通过，同时允许流体从第二室传递到低压区域。

公开(公告)号：US06546297B1

公开(公告)日：2003-04-08

申请号：US09378509

申请日：1999-08-20

Applicant: Michael T. Gaston ,  David Cook ,  Goutam Gandhi ,  Gary D. Hedrick ,  Victor L. Potter ,  Carl J. Lecheler ,  Timothy S. Matt

Inventor： Michael T. Gaston ,  David Cook ,  Goutam Gandhi ,  Gary D. Hedrick ,  Victor L. Potter ,  Carl J. Lecheler ,  Timothy S. Matt

IPC: G05B1942

CPC classification number: G05B19/0426 ,  G05B2219/23446 ,  G05B2219/2633 ,  G05B2219/32129

Abstract: A control system for a device, such as an appliance, is designed by storing software representations of pre-existing control panel components (2005) and pre-existing control processes (2010) on a computer, using the computer to develop a control panel for the device by selecting and placing software representations of pre-existing control panel objects in a software representation of the control panel (2015), and using the computer to develop control software for the device by selecting software representations of pre-existing control processes and associating the selected control processes with the selected control panel objects (2020). The control software then is downloaded from the computer to control hardware to be included in the device (2025). Finally, the device is tested using the control software running on the control hardware and under the control of the computer (2030). A system (2100) for designing a control system for a device (2105) includes a computer (2110) having an input unit (2115), an output unit (2120), a processor (2125), a storage device (2130) on which the software representations (2140) are stored, and a display (2135) on which a representation of the control panel is presented. The system also includes control hardware (2145) connected to active components (2150) of the device (2105) and operable to receive data from the output unit (2120) of the computer (2110). The processor (2125) is programmed to generate the control system in the manner discussed above.

Abstract translation: 用于设备（​​例如设备）的控制系统是通过在计算机上存储预先存在的控制面板组件（2005）和预先存在的控制过程（2010）的软件表示来设计的，使用该计算机开发用于 该设备通过在控制面板（2015）的软件表示中选择和放置预先存在的控制面板对象的软件表示，并且使用计算机通过选择预先存在的控制过程的软件表示和关联来开发设备的控制软件 所选择的控制面板对象的控制处理（2020）。 然后从计算机下载控制软件以控制要包括在设备中的硬件（2025）。 最后，使用在控制硬件上运行的控制软件和计算机的控制（2030）测试设备。 一种用于设计用于设备（​​2105）的控制系统的系统（2100），包括具有输入单元（2115），输出单元（2120），处理器（2125），存储设备（2130） 存储软件表示（2140）的显示器（2135），其上呈现控制面板的表示。 该系统还包括连接到设备（2105）的有源组件（2150）并且可操作以从计算机（2110）的输出单元（2120）接收数据的控制硬件（2145）。 处理器（2125）被编程为以上述方式产生控制系统。

公开(公告)号：US06410219B1

公开(公告)日：2002-06-25

申请号：US09539226

申请日：2000-03-30

Applicant: David Cook ,  Susan Wollowitz ,  Aileen Nerio

Inventor： David Cook ,  Susan Wollowitz ,  Aileen Nerio

IPC: A01N102

CPC classification number: C07D493/04 ,  A61K35/16 ,  A61L2/0088 ,  A61L2/18 ,  C07D219/12 ,  C12N7/00 ,  C12N7/04 ,  C12N2730/10163 ,  C12N2740/16063 ,  C12N2795/18163

Abstract: Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.

Abstract translation: 描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。 该技术处理大量人血清而不损害检测结果。 还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

公开(公告)号：US06177441B1

公开(公告)日：2001-01-23

申请号：US09012702

申请日：1998-01-23

Applicant: David Cook ,  Susan Wollowitz ,  Aileen Nerio

Inventor： David Cook ,  Susan Wollowitz ,  Aileen Nerio

IPC: A61K3144

CPC classification number: A61K31/473 ,  A61K31/37 ,  A61K31/396 ,  A61K31/4025 ,  A61K31/496 ,  A61K31/5415 ,  A61L2/0082 ,  A61M1/3687

Abstract: Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results.

Abstract translation: 描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。 该技术处理大量人血清而不损害检测结果。

公开(公告)号：US06171777B2

公开(公告)日：2001-01-09

申请号：US08486821

申请日：1995-06-07

Applicant: David Cook ,  Susan Wollowitz ,  Aileen Nerio

Inventor： David Cook ,  Susan Wollowitz ,  Aileen Nerio

IPC: A01N102

CPC classification number: C07D493/04 ,  A61K35/16 ,  A61L2/0088 ,  A61L2/18 ,  C07D219/12 ,  C12N7/00 ,  C12N7/04 ,  C12N2730/10163 ,  C12N2740/16063 ,  C12N2795/18163

Abstract: Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.

Abstract translation: 描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。 该技术处理大量人血清而不损害检测结果。 还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

公开(公告)号：US5691132A

公开(公告)日：1997-11-25

申请号：US338040

申请日：1994-11-14

Applicant: Susan Wollowitz ,  David Cook ,  Aileen Nerio

Inventor： Susan Wollowitz ,  David Cook ,  Aileen Nerio

IPC: C12Q1/00 ,  A61K31/47 ,  A61K31/473 ,  A61K35/16 ,  A61L2/00 ,  A61P31/12 ,  C07D219/12 ,  C07D219/14 ,  C07D493/04 ,  C12N1/20 ,  C12N5/06 ,  C12N5/08 ,  C12N7/04 ,  C12N7/06 ,  C12Q1/68 ,  A01N1/02 ,  A01N63/00 ,  A01N43/42

CPC classification number: C07D493/04 ,  A61L2/0088 ,  C07D219/12 ,  C12N7/00 ,  C12N2730/10163 ,  C12N2740/16063 ,  C12N2795/18163

Abstract: Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes. In particular, quinacrine mustard is used to inactivate pathogens in red cell compositions with retention of red cell function.

Abstract translation: 描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。 该技术处理大量人血清而不损害检测结果。 还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。 特别地，奎纳克林芥末用于灭活具有红细胞功能的红细胞组合物中的病原体。