公开(公告)号：US09686969B2

公开(公告)日：2017-06-27

申请号：US14517184

申请日：2014-10-17

Applicant: Merial, Inc. ,  Agri Advanced Technologies GmbH

Inventor： Sven Meissner ,  Stefan Geissler ,  Toni Frohnert ,  Doreen Goehler ,  Bjoern Fischer

IPC: A01K45/00 ,  A01K43/00 ,  A01K43/04 ,  G01B11/00 ,  G01N33/08 ,  G02B3/00

CPC classification number: A01K45/007 ,  A01K43/00 ,  A01K43/04 ,  A01K45/00 ,  G01B11/002 ,  G01N33/085 ,  G02B3/0081

Abstract: The present disclosure relates to a device for delivering substances to specific embryonic structures, including heart and blood vessels, within a developing avian egg. The disclosure also relates to methods of using the device to produce enhanced avian embryos. Methods include administering to chicken embryos various substances, including vaccines, nutrients, and stem cells. Chickens resulting from enhanced avian embryos have advantages, including greater growth potential and resistance to pathogen infection/infestation.

公开(公告)号：US20170173146A1

公开(公告)日：2017-06-22

申请号：US15378147

申请日：2016-12-14

Applicant: Merial, Inc.

Inventor： Francois Xavier LE GROS

IPC: A61K39/23 ,  C12N7/00

CPC classification number: A61K39/23 ,  A61K2039/5254 ,  A61K2039/552 ,  C07K14/005 ,  C12N7/00 ,  C12N2750/14122 ,  C12N2750/14134 ,  C12N2750/14322 ,  C12N2750/14334

Abstract: This disclosure provides an attenuated palmiped parvovirus that affords heterologous protection for both Muscovy duck parvovirus and goose parvovirus (i.e., Derzsy's Disease). The disclosure further provides compositions comprising the same, and methods of production and use thereof.

公开(公告)号：US20170137843A1

公开(公告)日：2017-05-18

申请号：US15410588

申请日：2017-01-19

Applicant: MERIAL, INC.

Inventor： Teshome Mebatsion ,  Jules Maarten Minke ,  Frederic David

IPC: C12N15/86 ,  A61K39/205

CPC classification number: C12N15/86 ,  A61K39/008 ,  A61K39/12 ,  A61K39/205 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55516 ,  C12N15/8633 ,  C12N2710/24043 ,  C12N2760/20134

Abstract: The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus

公开(公告)号：US20170118955A1

公开(公告)日：2017-05-04

申请号：US15292950

申请日：2016-10-13

Applicant: MERIAL INC.

Inventor： Christopher Davis Leslie ,  Francisco Javier Rojo Barrañón ,  Hector Valdemar Garcia Espinosa

IPC: A01K13/00 ,  B05B9/04 ,  A01K39/012 ,  A01K45/00 ,  A01K5/02 ,  A01K31/00

CPC classification number: A01K13/003 ,  A01K5/02 ,  A01K31/002 ,  A01K39/012 ,  A01K45/00 ,  A01K45/002 ,  A61D1/025 ,  A61D7/00 ,  B05B9/04

Abstract: The disclosure relates to a spray applicator system for accurately and precisely dosing liquid formulations, including vaccines and probiotic formulations, to caged avian animals. In particular, the disclosure relates to spray applicators, having improved acceptance by the avian animals, relative to more disruptive prior spray applicators. The disclosed automated caged spray applicator system is designed to attach to and function with automated poultry feeding systems, routinely used in poultry house settings.

公开(公告)号：US09623105B2

公开(公告)日：2017-04-18

申请号：US14977485

申请日：2015-12-21

Applicant: Merial Inc.

Inventor： Benjamin M. Hause

IPC: A61K39/145 ,  A61K39/02 ,  A61K39/21 ,  A61K39/12 ,  C12N7/04 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/0241 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N7/00 ,  C12N7/04 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16161

Abstract: This disclosure provides attenuated swine influenza strains, particularly those produced via a reverse genetics approach, compositions comprising same, and methods of production and use thereof. The attenuated strains are engineered to encode HA proteins having additional glycosylation sites, relative to the HA proteins encoded by the corresponding virulent parental viruses. Advantageously, the attenuated influenza strains may be administered.

公开(公告)号：US09592283B2

公开(公告)日：2017-03-14

申请号：US14668656

申请日：2015-03-25

Applicant: MERIAL, INC.

Inventor： Tammy Kolander ,  Paulraj Lawrence ,  Russell Bey

IPC: A61K39/102 ,  A61K45/06 ,  C12N1/36 ,  C12N1/38 ,  A61K39/00

CPC classification number: A61K39/102 ,  A61K45/06 ,  A61K2039/522 ,  A61K2039/543 ,  A61K2039/552 ,  A61K2039/70 ,  C12N1/36 ,  C12N1/38

Abstract: This disclosure provides attenuated Histophilus somni strains, compositions comprising same, and methods of production and use thereof. The attenuated strains may express lower or no levels of various virulence-associated genes, relative to the corresponding pathogenic bacteria Advantageously, the attenuated Histophilus somni strains may be administered orally, intranasally, intra-tracheally, or subcutaneously.

Abstract translation: 本公开提供减毒的嗜热索氏杆菌菌株，包含其的组合物，及其生产和使用方法。 相对于相应的致病菌，减毒菌株可以表达较低或没有各种毒力相关基因的水平。有利的是，减毒的Histophilus somni菌株可以口服，鼻内，气管内或皮下给药。

公开(公告)号：US20170067873A1

公开(公告)日：2017-03-09

申请号：US14849446

申请日：2015-09-09

Applicant: MERIAL, INC. ,  SANOFI

Inventor： Lance Hammerland ,  Brenda Bondesen ,  Jean-Marie Chambard ,  Thierry Vermat ,  Werner Dittrich ,  Michel Partiseti ,  Qing Zhou-Liu ,  Cathy Cojean ,  Rachid Boukaiba ,  Eric Tagat

IPC: G01N33/50 ,  C07K14/47 ,  G01N33/68 ,  C07K14/435

CPC classification number: G01N33/502 ,  C07K14/4354 ,  C07K14/4705 ,  C07K14/70571 ,  C12N5/0602 ,  C12N2503/02 ,  C12N2510/00 ,  G01N33/6872 ,  G01N2333/4353 ,  G01N2333/4706 ,  G01N2500/10

Abstract: The following discloses mammalian cells lines that stably express functional nematode acetylcholine receptor subunits. The resulting expression of functional ion channels has been made possible by the stable co-expression of the chaperone protein, RIC3. These cell lines are extremely useful for the high throughput screening (HTS) of compounds, to identify new candidate parasiticidal, including nematocidal, active ingredients.

Abstract translation: 以下公开了稳定表达功能性线虫乙酰胆碱受体亚基的哺乳动物细胞系。 所产生的功能性离子通道的表达已经通过伴侣蛋白RIC3的稳定共表达而成为可能。 这些细胞系对化合物的高通量筛选（HTS）非常有用，以鉴定新的候选杀寄生虫，包括杀线虫活性成分。

公开(公告)号：US20170027899A1

公开(公告)日：2017-02-02

申请号：US15304018

申请日：2015-04-17

Applicant: MERIAL INC. ,  BASF, SE

Inventor： Charles Meng ,  Christian Miculka ,  Mark Soll ,  Ralph Paulini ,  Matthias Pohlman ,  Sebastian Sorgel ,  Henricus Maria Martinus Bastiaans ,  Sarah Thompson ,  Cecille Ebuenga Doyog ,  Anna Malveda Umali ,  Rhoel Suiza Cosare ,  Christopher Palmer ,  Takeo Hokama

IPC: A61K31/277 ,  A61D7/00 ,  A01K11/00 ,  A61K9/00 ,  A61K31/357

Abstract: The present invention provides uses of aryl alkyl malononitrile compounds of formula (I), or veterinarily acceptable salts thereof, for controlling and preventing parasite infestations in animals. The invention also provides methods for controlling and preventing parasite infestation in animals comprising administering an effective amount of at least one aryl alkyl malononitrile compound of formulae (I), or a veterinarily acceptable salt thereof, to the animal.

Abstract translation: 本发明提供式（I）的芳基烷基丙二腈化合物或其兽医学上可接受的盐用于控制和预防动物中的寄生虫感染的用途。 本发明还提供了用于控制和预防动物中寄生虫侵袭的方法，包括向动物施用有效量的至少一种式（I）的芳基烷基丙二腈化合物或其兽医学上可接受的盐。

公开(公告)号：US09555096B2

公开(公告)日：2017-01-31

申请号：US14747419

申请日：2015-06-23

Applicant: Merial Inc.

Inventor： Michel Bublot ,  Teshome Mebatsion ,  Joyce Pritchard ,  Perry Linz

IPC: A61K39/17 ,  A61K39/12 ,  C12N7/00 ,  C12N15/86 ,  A61K39/00

CPC classification number: A61K39/17 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10034 ,  C12N2720/10071 ,  C12N2760/18134 ,  C12N2760/18171 ,  C12N2800/22

Abstract: The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors, polyvalent vaccines comprising the recombinant HVT vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.

Abstract translation: 本发明提供含有和表达禽类病原体抗原的火鸡（HVT）载体的重组疱疹病毒，包含重组HVT载体的组合物，包含重组HVT载体和一种或多种野生型病毒或重组载体的多价疫苗。 本发明进一步提供针对各种禽类病原体的疫苗接种方法和生产重组HVT载体的方法。

公开(公告)号：US20170022253A1

公开(公告)日：2017-01-26

申请号：US15160577

申请日：2016-05-20

Applicant: MERIAL INC.

Inventor： Loic Le Hir de Fallois ,  Greg Pacofsky ,  Alan Long ,  Charles Meng ,  Hyoung Ik Lee ,  Cyprian O. Ogbu

IPC: C07K11/02

CPC classification number: C07K11/02 ,  A01N43/72 ,  A61K38/00 ,  C07D273/00 ,  A01N37/46 ,  A01N43/90

Abstract: The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasites in or on mammals and birds. The invention also provides for an improved method for eradicating, controlling and preventing parasite infestation in birds and mammals.

Abstract translation: 本发明提供式（I）的环状缩肽化合物和包含有效对抗伤害动物的寄生虫的化合物的组合物。 化合物和组合物可用于对抗哺乳动物和鸟类中或哺乳动物上的寄生虫。 本发明还提供了用于消除，控制和预防鸟类和哺乳动物中的寄生虫感染的改进方法。