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公开(公告)号:US20200299632A1
公开(公告)日:2020-09-24
申请号:US16893464
申请日:2020-06-05
Applicant: DSM IP Assets B.V.
Inventor: John E. NASH , William T. FISHER , Gino BRADICA
IPC: C12M1/00
Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
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公开(公告)号:US20200288753A1
公开(公告)日:2020-09-17
申请号:US16084032
申请日:2017-03-15
Applicant: DSM IP ASSETS B.V.
Inventor: Markus BECK , Elger FUNDA , Simone KÖNIG-GRILLO
Abstract: The present patent application relates to novel red-orange coated particles, which are mainly used in (dry) formulations for instant beverages. The advantage of these coated particles is that they are red to orange as such (also in the formulations for instant beverages, wherein they can be identified by the naked eye as individual discrete coloured particles), but upon dissolution of the instant beverage powder these particles will dissolve as well and will not interfere with or change the intended color of the ready-to drink instant beverages made from the instant beverage dry powders.
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公开(公告)号:US20200283805A1
公开(公告)日:2020-09-10
申请号:US16649284
申请日:2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor: Paulus Petrus DE WAAL , Ingrid Maria VUGT - VAN LUTZ , Jozef Petrus Johannes SCHMITZ , Hans Marinus Charles Johannes DE BRUIJN
IPC: C12P7/10 , C12N9/10 , C12N9/02 , C12N9/04 , C07K14/395
Abstract: The invention relates to a process for the production of ethanol from a composition comprising at least glucose comprising fermenting said composition in the presence of a recombinant yeast; and recovering the ethanol, wherein said yeast comprises one or more genes coding for an enzyme having glycerol dehydrogenase activity, one or more genes coding for an enzyme having dihydroxyacetone kinase activity (E.C. 2.7.1.28 and/or E.C. 2.7.1.29); one or more genes coding for an enzyme in an acetyl-CoA-production pathway and one or more genes coding for an enzyme having at least NAD+ dependent acetylating acetaldehyde dehydrogenase activity (EC 1.2.1.10 or EC 1.1.1.2), and optionally one or more genes coding for a glycerol transporter, wherein the composition comprises an amount of undissociated acetic acid of 10 mM or less. A recombinant yeast having the genes as described above is particularly sensitive towards acetic acid, and the ethanol yield rapidly decreases when the composition contains more than 10 mM undissociated acetic acid.
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公开(公告)号:US10767206B2
公开(公告)日:2020-09-08
申请号:US16012653
申请日:2018-06-19
Applicant: DSM IP ASSETS B.V.
Inventor: Jie Zhao , Zhihui Gao , Wouter Adrianus Van Winden , Rogier Meulenberg
IPC: C12P19/04
Abstract: The invention provides a new fermentation process for producing gellan gum, which can control the feeding amount and feeding speed of the nitrogen sources accurately and quantitatively, and control the growth and gum production of the strains, so as to significantly improve the controllability, stability and yield of the fermentation process for producing gellan gum.
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公开(公告)号:US10757959B2
公开(公告)日:2020-09-01
申请号:US16132992
申请日:2018-09-17
Applicant: DSM IP Assets B.V.
Inventor: Kirk E. Apt , Joseph W. Pfeifer, III , Jon Milton Hansen , Paul Warren Behrens , Ross Zirkle , Tracey Lynn Stahl
IPC: A61K31/232 , A23K20/158 , A61K31/20 , C12P7/64 , C12R1/89 , A23L33/115 , A23L33/135 , A23K50/80 , A23D9/00 , A23K50/00 , A23L33/12 , A61K8/99 , A61K31/202 , A61K36/02 , A61Q19/00 , A61K35/00
Abstract: The present invention is directed to isolated thraustochytrid microorganisms as well as strains and mutants thereof. The invention is further directed to biomasses, microbial oils, compositions, cultures, methods of producing microbial oils, and methods of using the isolated thraustochytrids, biomasses, and microbial oils.
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公开(公告)号:US20200255877A1
公开(公告)日:2020-08-13
申请号:US16614563
申请日:2018-05-17
Applicant: DSM IP ASSETS B.V.
Inventor: Adam LAWRENCE , Celine VIAROUGE
Abstract: The present invention is directed to microbial production of nicotinamide riboside and/or nicotinamide mononucleotide using a genetically modified fungus.
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167.
公开(公告)号:US20200253229A1
公开(公告)日:2020-08-13
申请号:US16084591
申请日:2016-03-16
Applicant: DSM IP ASSETS B.V.
Inventor: Mariya Alexeevna TARAZANOVA , Thom HUPPERTZ , Herwig BACHMANN , Jan KOK , Marke BEERTHUYZEN
IPC: A23C9/123 , A23L33/135 , C12R1/46 , C07K14/195
Abstract: The present invention relates to the field of microbiology, specifically the field of production of a dairy food product using fermentation and the field of gene transfer by conjugation.
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公开(公告)号:US20200231896A1
公开(公告)日:2020-07-23
申请号:US16644443
申请日:2018-08-30
Applicant: EVONIK OPERATIONS GMBH , DSM IP ASSETS B.V.
Inventor: Michael BAHL , Marc BEISER , Jochen LEBERT , Holger PFEIFER , Christian RABE
Abstract: The current invention relates to a method of separating polyunsaturated fatty acids containing lipids from a lipids containing biomass by using acetone.
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169.
公开(公告)号:US20200224223A1
公开(公告)日:2020-07-16
申请号:US16837637
申请日:2020-04-01
Applicant: DSM IP ASSETS B.V.
Inventor: Bertus NOORDAM , Michael Petrus Jozef BERKHOUT , Aida HISENI
IPC: C12P7/10 , C12P19/14 , C12P19/02 , C12P5/02 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/40 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/54 , C12P7/56 , C12P17/10 , C12P35/00
Abstract: The invention relates to a process for the preparation of a sugar product from lignocellulosic material, comprising the following steps: a) optionally pre-treatment of the ligno-cellulosic material; b) optionally washing of the optionally pre-treated ligno-cellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pre-treated ligno-cellulosic material using an enzyme composition comprising at least two cellulase and whereby the enzyme composition at least comprises GH61; and d) optionally recovery of a sugar product; wherein during part of the time of the enzymatic hydrolysis, oxygen is added to the ligno-cellulosic material and during part of the time of the enzymatic hydrolysis less oxygen is added to the ligno-cellulosic material compared to the other part of the time of the enzymatic hydrolysis, preferably no oxygen is added to the ligno-cellulosic material.
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公开(公告)号:US10711375B2
公开(公告)日:2020-07-14
申请号:US16353993
申请日:2019-03-14
Applicant: DSM IP ASSETS B.V.
Inventor: Joseph Arnold Paul Maria Simmelink , Jacobus Johannes Mencke , Martinus Johannes Nicolaas Jacobs , Roeloef Marissen
IPC: D01F6/04 , D01D4/02 , D02G3/02 , D01D5/18 , C08F10/02 , C08L23/06 , C08L53/02 , D07B1/02 , A61L17/04 , A61L27/16 , F41H5/04
Abstract: Processes for making high-performance polyethylene multi-filament yarn are disclosed which include the steps of a) making a solution of ultra-high molar mass polyethylene in a solvent; b) spinning of the solution through a spinplate containing at least 5 spinholes into an air-gap to form fluid filaments, while applying a draw ratio DRfluid; c) cooling the fluid filaments to form solvent-containing gel filaments; d) removing at least partly the solvent from the filaments; and e) drawing the filaments in at least one step before, during and/or after said solvent removing, while applying a draw ratio DRsolid of at least 4, wherein in step b) each spinhole comprises a contraction zone of specific dimension and a downstream zone of diameter Dn and length Dn with Ln/Dn of from 0 to at most 25, to result in a draw ratio DRfluid=DRsp*DRag of at least 150, wherein DRsp is the draw ratio in the spinholes and DRag is the draw ratio in the air-gap, with DRsp being greater than 1 and DRag at least 1. High-performance polyethylene multifilament yarn, and semi-finished or end-use products containing said yarn, especially to ropes and ballistic-resistant composites, are also disclosed.
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