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    Receiver plate with multiple cross-sections
    161.
    发明授权
    Receiver plate with multiple cross-sections 有权

    公开(公告)号：US09138742B2

    公开(公告)日：2015-09-22

    申请号：US14514853

    申请日：2014-10-15

    Applicant: EMD Millipore Corporation

    Inventor： Christopher A. Scott ,  Brian Foley

    IPC: B01L3/00

    CPC classification number: B01L3/50255 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/0678 ,  B01L2200/0684 ,  B01L2200/141 ,  B01L2300/0681 ,  B01L2300/0829 ,  B01L2300/0858

    Abstract: A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.

    Biomaterial freezing
    162.
    发明授权
    Biomaterial freezing 有权
    生物材料冷冻

    公开(公告)号：US09046292B2

    公开(公告)日：2015-06-02

    申请号：US13654595

    申请日：2012-10-18

    Applicant: EMD Millipore Corporation

    Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

    IPC: F25D25/00 ,  F25D21/00 ,  F25D3/08 ,  F25B49/00 ,  F25D29/00 ,  A01N1/02

    CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

    Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

    Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。

    Biomaterial freezing
    164.
    发明授权
    Biomaterial freezing 有权

    公开(公告)号：US09027356B2

    公开(公告)日：2015-05-12

    申请号：US13654593

    申请日：2012-10-18

    Applicant: EMD Millipore Corporation

    Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

    IPC: F25D25/00 ,  F25D21/00 ,  F25D3/08 ,  F25B49/00 ,  F25D29/00 ,  A01N1/02

    CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

    Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

    Device For A Biological Liquid Treatment Installation
    167.
    发明申请
    Device For A Biological Liquid Treatment Installation 有权
    生物液体处理装置

    公开(公告)号：US20150013773A1

    公开(公告)日：2015-01-15

    申请号：US14493858

    申请日：2014-09-23

    Applicant: EMD Millipore Corporation

    Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

    IPC: F17D1/00

    CPC classification number: F17D1/00 ,  B01D61/18 ,  B01D61/20 ,  B01D61/30 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/58 ,  B30B7/00 ,  B30B9/22 ,  C12M47/12 ,  F04B43/08 ,  Y10T137/0318 ,  Y10T137/8593

    Abstract: The invention concerns a device comprising: a base (2); a moveable or removable door (20), said device having a closed door position; and in the closed door position, a circuit (8) comprising a bag comprising two flexible films and conveying network connectors, and a press (9) comprising a first shell (16) disposed on said front face (5) of said base (2) and a second shell (17) disposed in said door (20); said bag being clamped between said first shell (16) and said second shell (17) in a state in which conduits of said network for conveying liquid are formed between said films.

    Abstract translation: 本发明涉及一种装置，包括：基座（2）; 一个可移动或可拆卸的门（20），所述装置具有一个闭合的门位置; 并且在关闭的门位置，包括包括两个柔性膜和传送网络连接器的袋的电路（8）和包括设置在所述基座（2）的所述前表面（5）上的第一壳体（16）的压力机（9） ）和设置在所述门（20）中的第二壳（17）; 所述袋被夹在所述第一壳体（16）和所述第二壳体（17）之间，在所述薄膜之间形成用于输送液体的所述网络的导管的状态。

    Apparatus and method for increasing collection efficiency in capillary based flowcytometry
    168.
    发明授权
    Apparatus and method for increasing collection efficiency in capillary based flowcytometry 有权
    基于毛细血管的流式细胞术提高收集效率的装置和方法

    公开(公告)号：US08922778B2

    公开(公告)日：2014-12-30

    申请号：US14065136

    申请日：2013-10-28

    Applicant: EMD Millipore Corporation

    Inventor： Fedor Ilkov

    IPC: G01N21/00 ,  G01N21/01 ,  G01N21/53 ,  G01N21/64 ,  G02B19/00

    CPC classification number: G01N21/01 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/53 ,  G01N21/6486 ,  G01N2015/1006 ,  G02B19/0028 ,  G02B19/0076

    Abstract: In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths.

    Abstract translation: 在包括用于通过含有待分析颗粒的流体的毛细管的颗粒分析装置中，使用光学系统来收集从标记到颗粒的颗粒或物质发射的荧光，并且具有改善的收集效率，从而保持仪器的分辨率。 光学系统可以包括附接到毛细管的第一收集透镜和布置成与第一收集透镜相邻布置成反射一个或多个波长的荧光的第一反射元件。 光学系统可以包括附接到毛细管的第二收集透镜，以及被配置成反射一个或多个波长的荧光的与第二收集透镜相邻的第二反射元件。

    Device for spraying a reagent for fast microbiological analysis
    170.
    发明授权
    Device for spraying a reagent for fast microbiological analysis 有权
    用于喷雾用于快速微生物分析的试剂的装置

    公开(公告)号：US08852884B2

    公开(公告)日：2014-10-07

    申请号：US13868263

    申请日：2013-04-23

    Applicant: EMD Millipore Corporation

    Inventor： Christian Schann ,  Bruno Duquet ,  Abdel Hajila ,  Frederic Olivieri

    IPC: G01N21/76 ,  C12Q1/24 ,  B05B15/04

    CPC classification number: C12Q1/24 ,  B05B12/20 ,  G01N21/763

    Abstract: The device for spraying a reagent onto a support (81) adapted to retain microorganisms on a predetermined surface (82), comprises a spraying bell (3) as well as a nozzle (71) for emitting a jet of droplets of said reagent into a spraying chamber (34) comprised by said bell (3), said device also comprising an absorbent pad (5) mounted against said bell (3) transversely to said jet and closing said chamber (34) from the opposite side to said nozzle (71) with the exception of a circular central opening (51) provided in said pad (5), the diameter of said central opening (51) being adapted to enable a portion of said jet, when said device faces said support (81) and is at a predetermined distance therefrom, to pass through said central opening (51) over its entire area and be deposited on the whole of said predetermined surface (82) of said support (81).

    Abstract translation: 用于将试剂喷洒到适于将微生物保留在预定表面（82）上的支撑体（81）上的装置包括喷雾钟（3）以及喷嘴（71），用于将所述试剂的液滴喷射到 喷雾室（34），所述装置还包括一个吸收垫（5），该吸收垫（5）横向于所述射流安装在所述钟形（3）上，并从所述喷嘴（71）的相对侧关闭所述腔室 ），除了设置在所述垫（5）中的圆形中心开口（51）之外，所述中心开口（51）的直径适于使所述装置的一部分当所述装置面向所述支撑件（81）并且是 在其预定距离处穿过所述中心开口（51）遍及其整个区域并且沉积在所述支撑件（81）的整个所述预定表面（82）上。

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