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公开(公告)号：US20190069837A1
公开(公告)日：2019-03-07
申请号：US16121329
申请日：2018-09-04
Inventor： Shawn S. Adibi
IPC: A61B5/00
Abstract: A bruxnostic device includes a plastic channel configured to be received over a plurality of teeth of an individual. The bruxnostic device further comprises a layer of pressure-indicating material enclosed within the plastic channel in a position to be disposed between maxillary teeth and mandibular teeth of the individual when the plastic channel is received over the plurality of teeth. The pressure-indicating layer produces a color indication in response to pressure between the maxillary teeth and the mandibular teeth.
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公开(公告)号：US20190060446A1
公开(公告)日：2019-02-28
申请号：US16081911
申请日：2017-03-02
Inventor： Jinming GAO , Zhijian CHEN , Min LUO , Zhaohui WANG , Hua WANG , Haocheng CAI , Gang HUANG , Yang-Xin FU
IPC: A61K39/39 , A61K39/00 , A61K9/51 , A61K39/145
Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.
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公开(公告)号：US20190039934A1
公开(公告)日：2019-02-07
申请号：US16051703
申请日：2018-08-01
Inventor： Arturo Alejandro Fuentes , Kamal Sarkar , Stephen Crown , Horacio Vasquez
Abstract: Described herein is a method of preparing glass structures having tunable material properties. By varying process conditions, physical, thermal, optical, electrical, and mechanical properties of the glass particles can be altered in a predictable manner. By varying porosity, density, and pore structures, for example, a wide range of physical, thermal, optical, electrical, and mechanical characteristics of micron and nanometer sized glass particles can be achieved and/or modified.
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164.发明授权公开(公告)号：US10192099B2
公开(公告)日：2019-01-29
申请号：US15215157
申请日：2016-07-20
Inventor： Sos S. Agaian , Clara M. Mosquera Lopez , Ali Almuntashri , Richard Metzler
IPC: G06K9/00 , G16H50/30 , G16H50/70 , G16H50/20 , A61B5/00 , G01N15/14 , G06T7/00 , G06T7/13 , G06T7/181 , G06T7/90 , G06F19/00 , G06K9/46 , G06K9/62 , G06T5/00 , G06T5/20 , A61B10/02
Abstract: Systems and methods for detection, grading, scoring and tele-screening of cancerous lesions are described. A complete scheme for automated quantitative analysis and assessment of human and animal tissue images of several types of cancers is presented. Various aspects of the invention are directed to the detection, grading, prediction and staging of prostate cancer on serial sections/slides of prostate core images, or biopsy images. Accordingly, the invention includes a variety of sub-systems, which could be used separately or in conjunction to automatically grade cancerous regions. Each system utilizes a different approach with a different feature set. For instance, in the quantitative analysis, textural-based and morphology-based features may be extracted at image- and (or) object-levels from regions of interest.
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公开(公告)号：US20190008727A1
公开(公告)日：2019-01-10
申请号：US16067796
申请日：2016-12-16
Inventor： James SEAWARD , Alex KANE , Rami HALLAC
Abstract: A feeding apparatus includes a nipple shield, a deformable nipple defining a chamber, an inlet through which fluid can flow into the chamber, and an outlet through which fluid can exit the nipple, a first portion of the nipple having a first stiffness and a second portion of the nipple having a second stiffness that is lower than the first stiffness, the first portion disposed on a first side of a longitudinal plane bisecting the nipple and the second portion disposed on a second side of the plane, and a check valve disposed in the nipple to divide the chamber into a first portion between the check valve and the outlet, and a second portion between the check valve and the inlet, wherein the check valve is configured to admit fluid into the first portion but prevent fluid from leaving the first portion through the check valve.
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Patent Agency Ranking
166.发明授权公开(公告)号：US10167258B2
公开(公告)日：2019-01-01
申请号：US15103619
申请日：2014-12-12
Inventor： David T. Chuang , Shih-Chia Tso , Xiangbing Qi , Wen-Jun Gui , Cheng-Yang Wu , Jacinta L. Chuang , Uttam K. Tambar , R. Max Wynn
IPC: C07D209/44 , C07D401/14 , C07D401/06 , C07D401/12 , C07D487/08
Abstract: The present disclosure relates to the identification of PDK inhibitors and their use in the treatment of diseases such as diabetes, cardiovascular disease and cancer. The invention relates to the development of robust PDK inhibitors that can be used to improve glucose metabolism and correct metabolic dysfunction in vivo. Based on the unique structural features present in the ATP-binding pocket of PDK2, a single functional-group change was made in a known Hsp90 inhibitor that binds to the corresponding pocket of the latter protein from the GHKL family. This approach efficiently converted the Hsp90 inhibitor to a highly specific inhibitor for all PDK isoforms. These final PDK inhibitors of this series robustly augments PDC activity with reduced phosphorylation in tissues.
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公开(公告)号：US20180369424A1
公开(公告)日：2018-12-27
申请号：US16114187
申请日：2018-08-27
Inventor： Jinming GAO , Gang HUANG , Tian ZHAO , Xinpeng MA , Yiguang WANG , Yang LI , Baran D. SUMER
IPC: A61K49/00 , C09B69/10 , G01N33/84 , G01N33/58 , G01N21/64 , C08F8/42 , C08F8/34 , C08F8/32 , C08F8/30
Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.
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公开(公告)号：US20180360806A1
公开(公告)日：2018-12-20
申请号：US16063312
申请日：2016-12-19
Inventor： Jerrie S. REFUERZO , Biana GODIN , Monica LONGO
IPC: A61K31/405 , A61K38/11 , A61K9/127 , A61K47/69 , A61P15/00
Abstract: Methods and compositions are provided for treating and preventing preterm labor using liposome encapsulated tocolytic agents, such as indomethacin. In certain aspects, targeted liposomes are provided that allow delivery of tocolytic agents directly to the uterus, such as by targeting to the oxytocin receptor.
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169.发明申请公开(公告)号：US20180354909A1
公开(公告)日：2018-12-13
申请号：US16060913
申请日：2016-12-09
Inventor： Jef DE BRABANDER , Luis F. PARADA , S. Kyun LIM , Qiren LIANG , Hua-yu WANG , Yufeng SHI
IPC: C07D235/18 , C07D235/16 , C07D405/04 , C07D401/04 , C07D487/04 , C07D471/04 , A61P35/00
CPC classification number: C07D235/18 , A61P35/00 , C07D235/16 , C07D401/04 , C07D405/04 , C07D471/04 , C07D487/04
Abstract: Provided herein are compounds of the formula:(I) wherein: R1, R2, R3, R4, R5, X, A1, A2, A3, and A4 are as defined herein. In some aspects, these compounds may be used to treat cancer and other hyperproliferative disease. In some aspects, compositions, methods of treatment, and methods of synthesis are also provided herein.
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公开(公告)号：US20180353622A1
公开(公告)日：2018-12-13
申请号：US16003683
申请日：2018-06-08
Inventor： Lawrence LUM , Rubina TULADHAR , Tae Hyun HWANG , Yunku YEU , John Tyler PIAZZA , Quinn BARRETT
CPC classification number: A61K48/0066 , A61K38/465 , C12N15/11 , C12N2310/20
Abstract: Disclosed herein are methods for gene inactivation or rescue by cutting genomic DNA at regions of putative exon splicing enhancers with CRISPR-type enzymes.
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