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    FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY
    181.
    发明申请
    FIBERS COMPRISING POLYESTERAMIDE COPOLYMERS FOR DRUG DELIVERY 审中-公开

    公开(公告)号：US20200087819A1

    公开(公告)日：2020-03-19

    申请号：US16689569

    申请日：2019-11-20

    Applicant: DSM IP Assets B.V.

    Inventor： Mirian Hendrika Jacoba GILLISSEN-VAN DER VIGHT ,  Jens Christoph THIES ,  Gueorgui MIHOV

    IPC: D01F6/82 ,  C08G69/44 ,  A61K9/70 ,  C08L77/12 ,  A61K9/00 ,  A61K47/34

    Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (iv), wherein −m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, −m+p+q=1 whereby m or p could be 0, −n is about 5 to about 300; (pref. 50-200), -Ri in independently selected from the group consisting of (C2-C20) alkykene or (C2-C20) alkenylene and combinations thereof; —R and R in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, ()alkyl, ()alkenyl, (C-C)alkynyl, (C-Cio)aryl, —(CH2)SH, —(CH2)2S(CH), —CH2OH, —CH(OH)CH, —(CH2)NH3, —(CH2)NHC(—NH2—)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH—CH2—CH(CH), (CH)2—CH—CH2—, H2N—(CH2), Ph-CH2—, CH—C—CH2—, HO-p-Ph-CH2—, (CH)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—; —R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol, —R is selected from bicyclic-fragments of 1,4,3,6-dianhydrohexitols of structural formula (III); —R is selected from the group consisting of (C6-Cio)aryl, (GCeJalkyl, —R is —(CH2)4—; whereby a is at least 0.05 and b is at least 0.05 and a+b−.

    Process for preparing nylon salt and its polymerization
    183.
    发明授权
    Process for preparing nylon salt and its polymerization 有权

    公开(公告)号：US10590238B2

    公开(公告)日：2020-03-17

    申请号：US15329404

    申请日：2015-07-24

    Applicant: DSM IP ASSETS B.V.

    Inventor： Bas Van Laarhoven ,  Eric Grolman ,  Michiel Muyris

    IPC: C08G69/26 ,  C08G69/30 ,  C08G69/28 ,  C08J3/12

    Abstract: The present invention relates to a process for preparing a granular nylon salt material, wherein an aqueous mixture, comprising at least 65 wt. % of salt components, and at most 35 wt. % of an aqueous medium, the weight percentages (wt. %) being relative to the total weight of the aqueous mixture, is flashed from a pressure vessel via a flash valve into a flash chamber, thereby evaporating the aqueous medium in an amount sufficient to result in a residual moisture content of at most 7.5 wt. %, and forming a granular nylon salt material. The invention also relates to a process for preparing a nylon polymer, comprising direct solid state polymerization of the granular salt material prepared by flash granulation.

    PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS
    188.
    发明申请
    PROCESS FOR ENZYMATIC HYDROLYSIS OF LIGNOCELLULOSIC MATERIAL AND FERMENTATION OF SUGARS 审中-公开

    公开(公告)号：US20200048669A1

    公开(公告)日：2020-02-13

    申请号：US16528191

    申请日：2019-07-31

    Applicant: DSM IP ASSETS B.V.

    Inventor： Bertus NOORDAM ,  Michael Petrus Jozef BERKHOUT

    IPC: C12P19/02 ,  C13K13/00 ,  D21C3/26 ,  C13K1/02 ,  C12P19/14

    Abstract: The invention relates to a process for the preparation of a fermentation product from lignocellulosic material, comprising the following steps: a) optionally, pre-treatment of the lignocellulosic material, b) optionally, washing of the optionally pretreated lignocellulosic material, c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material using an enzyme composition comprising at least two cellulases and whereby the enzyme composition at least comprises LPMO, and optionally purifying the hydrolysed lignocellulosic material, d) fermentation of the hydrolysed lignocellulosic material to produce a fermentation product, and e) optionally, recovery of a fermentation product, wherein oxygen is consumed in amounts corresponding to between 20 and 5000 mmol molecular oxygen per kg glucan present in the lignocellulosic material, the oxygen is added after the pretreatment and before and/or during the enzymatic hydrolysis of the lignocellulosic material, preferably in an amount corresponding to at least 30 mmol molecular oxygen per kg glucan present in the lignocellulosic material, more preferably in an amount corresponding to at least 40 mmol molecular oxygen per kg glucan present in the lignocellulosic material, and most preferably in an amount corresponding to at least 50 mmol molecular oxygen per kg glucan present in the lignocellulosic material is consumed.

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