公开(公告)号：US3908015A

公开(公告)日：1975-09-23

申请号：US48538674

申请日：1974-07-03

Applicant: ROUSSEL UCLAF

Inventor： HAINAUT DANIEL ,  DEMOUTE JEAN-PIERRE

IPC: A01N37/42 ,  A01N43/20 ,  A01N9/24 ,  A01N9/28

CPC classification number: A01N37/42

Abstract: Novel insecticidal compositions and method wherein the active ingredient is an unsaturated Beta -keto ester of the formula

wherein A is selected from the group consisting of chlorine and bromine, B is hydroxy and A and B together form an epoxide, X and Y are hydrogen or indicate another bond between the carbon atoms to which they are attached, AlK is alkyl of 1 to 8 carbon atoms and m is 3,4 or 5 with the proviso that X and Y are hydrogen when A and B form an epoxide.

Abstract translation: 新型杀虫剂组合物和方法，其中活性成分是式O的不饱和β-酮酯共聚物CH 3 - （CH 2）m -CH-CH-C = C-（CH 2）2 -C-CH 2 COOAlK I ||| ABXY 其中A选自氯和溴，B是羟基，A和B一起形成环氧化物，X和Y是氢或表示它们连接的碳原子之间的另一个键，AlK是1至 8个碳原子，m为3,4或5，条件是当A和B形成环氧化物时，X和Y为氢。

公开(公告)号：US3905965A

公开(公告)日：1975-09-16

申请号：US29777672

申请日：1972-10-16

Applicant: ROUSSEL UCLAF

Inventor： MARTEL JACQUES ,  HEYMES RENE

IPC: C07D513/04 ,  C07D279/04

CPC classification number: C07D501/46 ,  C07D513/04

Abstract: WHEREIN X'' IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL AND PHENYL LOWER ALKYL, R'' is selected from the group consisting of hydrogen, lower alkyl, phenyl, phenyl lower alkyl, lower alkyl phenyl, and Z'' is selected from the group consisting of amino and tritylamino. These compounds are useful as intermediates in the preparation of cephalosporin compounds.

A 1,3-thiazine compound having the formula

Abstract translation: 具有式WHEREIN X'的1,3-噻嗪化合物选自氢，低级烷基和苯基低级烷基，R'选自氢，低级烷基，苯基，苯基低级烷基，低级 烷基苯基，Z'选自氨基和三苯甲基氨基。

公开(公告)号：US3891636A

公开(公告)日：1975-06-24

申请号：US40799573

申请日：1973-10-19

Applicant: ROUSSEL UCLAF

Inventor： DERIBLE PIERRE HENRI ,  LAVAUX JEAN-PAUL

IPC: C07D417/06 ,  C07D279/26 ,  C07D279/28

CPC classification number: C07D417/06

Abstract: WHEREIN X is selected from the group consisting of hydrogen, chlorine, -CF3, -OCH3 and SCH3, B and R are individually selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, Z'' is selected from the group consisting of hydrogen and alkyl of 1 to 10 carbon atoms, p is 0 or 1, n is 0, 1 or 2 and A is selected from the group consisting of hydrogen, -COOR2 and COR1, R2 is linear alkyl of 1 to 15 carbon atoms and R1 is selected from the group consisting of alkyl of 1 to 18 carbon atoms optionally containing a double bond or -0- and a polymethoxyphenyl and their non-toxic, pharmaceutically acceptable acid addition salts having neuroleptic, analgesic, spasmolytic and antihistaminic activity and their preparation and novel intermediates.
Novel 10-(piperidino-alkyl)-phenothiazines of the formula

Abstract translation: 式WHEREIN X的新颖的10-（哌啶子基 - 烷基） - 吩噻嗪选自氢，氯，-CF 3，-OCH 3和SCH 3，B和R各自独立地选自氢和烷基的1 至4个碳原子，Z'选自氢和1至10个碳原子的烷基，p为0或1，n为0,1或2，A选自氢，-COOR 2 和-COR 1，R 2是1至15个碳原子的直链烷基，并且R 1选自任选含有双键的碳原子数1〜18的烷基或-O-和多甲氧基苯基及其无毒的药学上可接受的 具有止痛，止痛，解痉和抗组胺活性的酸加成盐及其制备和新型中间体。

公开(公告)号：US3873530A

公开(公告)日：1975-03-25

申请号：US37217173

申请日：1973-06-21

Applicant: ROUSSEL UCLAF

Inventor： VIEHE HEINZ GUNTER ,  VAN VYVE THERESE ,  JANOUSEK ZDENEK

IPC: C07D239/42 ,  C07C67/00 ,  C07C241/00 ,  C07C257/02 ,  C07D231/38 ,  C07D231/56 ,  C07D239/70 ,  C07D239/94 ,  C07D295/14 ,  C07D401/06 ,  C09B23/00

CPC classification number: C07D231/38 ,  C07D231/56 ,  C07D239/94 ,  C07D295/14 ,  C07D401/06

Abstract: WHEREIN R and R1 are individually selected from the group consisting of lower alkyl, phenyl optionally substituted with halogen and benzyl and taken together are selected from the group consisting of lower alkylene, -CH2-CH2-O-CH2-CH2- and

WHERE R4 is alkyl of 1 to 5 carbon atoms, R2 and R3 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl and taken together are selected from the group consisting of alkylene of 3 to 5 carbon atoms and benzoalkylene of 7 to 10 carbon atoms, X is halogen and Y is selected from the group consisting of dilower alkylamino wherein the alkyl have 1 to 5 carbon atoms, morpholino, piperidino and 1-pyrrolidinyl.

Novel intermediates useful for organic synthesis which are immonium salts of the formula

Abstract translation: 用于有机合成的新型中间体，其为式WHEREIN R和R 1的亚铵盐分别选自低级烷基，任选被卤素和苄基取代的苯基，并且一起选自低级亚烷基，-CH 2 -CH 2 -O-CH 2 -CH 2 - 和WHERE R 4是1至5个碳原子的烷基，R 2和R 3分别选自氢，1至5个碳原子的烷基和苯基，并且一起选自 由3至5个碳原子的亚烷基和7至10个碳原子的苯并亚烷基组成的组，X是卤素，Y选自二烷基氨基，其中烷基具有1至5个碳原子，吗啉代，哌啶子基和1-吡咯烷基 。

公开(公告)号：US3857838A

公开(公告)日：1974-12-31

申请号：US28839372

申请日：1972-09-12

Applicant: ROUSSEL UCLAF

Inventor： PERRONNET J ,  POITTEVIN A

IPC: A01N57/08 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6561 ,  C07D51/46

CPC classification number: C07D471/04 ,  C07D487/04 ,  C07F9/6561

Abstract: An organophosphate ester having the formula

WHEREIN A represents a divalent radical selected from the group consisting of alkylene having three to five carbon atoms, aza substitued alkylene having three to five carbon atoms in the chain and thia substituted alkylene having three to five carbon atoms in the chain, Y'' represents a member selected from the group consisting of hydrogen, alkyl having one to six carbon atoms, cyano, halo and alkylthio having one to six carbon atoms, X represents a member selected from the group consisting of sulfur and oxygen, R1'''' represents an alkyl having one to four carbon atoms, R2'''' represents a member selected from the group consisting of alkyl having one to four carbon atoms, alkoxy having one to four carbon atoms, alkoxyalkoxy having one to four carbon atoms in each alk, and

WHERE R1'' and R2'' are members selected from the group consisting of hydrogen and alkyl having one to three carbon atoms; as well as the process of producing said organophosphate esters. The compounds have insecticidal and acaricidal properties.

Abstract translation: 具有下式的有机磷酸酯取代为WHEREIN A表示选自具有3-5个碳原子的亚烷基的二价基团，链中具有3-5个碳原子的氮杂取代的亚烷基和具有3至5个碳原子的取代的亚烷基 该链Y表示选自氢，碳原子数1〜6的烷基，氰基，卤代和碳原子数1〜6的烷硫基，X表示选自硫和氧的成员， R 1“表示碳原子数为1〜4的烷基，R 2”表示选自碳原子数1〜4的烷基，碳原子数1〜4的烷氧基，碳原子数1〜4的烷氧基烷氧基， 烷基和其中R 1'和R 2'是选自氢和具有1至3个碳原子的烷基的成员; 以及生产所述有机磷酸酯的方法。 这些化合物具有杀虫和杀螨的特性。

公开(公告)号：US3856967A

公开(公告)日：1974-12-24

申请号：US27237572

申请日：1972-07-17

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS A ,  NOMINE G

IPC: C07D209/08 ,  C07D209/12 ,  A61K27/00

CPC classification number: C07D209/12 ,  C07D209/08

Abstract: WHEREIN A is a divalent aliphatic hydrocarbon derived from a linear or branched alkyl, R is selected from the group consisting of cyclohexyl and an aromatic radical, R'' is selected from the group consisting of halogen, trifluoromethyl, lower alkyl, lower alkoxy and N,N-dilower-alkylamino and R1 is selected from the group consisting of hydrogen and lower alkyl and a cation of a nontoxic, therapeutically acceptable base which possess antiinflammatory and analgesic activity and their preparation.

1-CARBOXYALKYL-2-METHYL-INDOLES OF THE FORMULA

Abstract translation: 式中的1-羧甲基-2-甲基吲哚A是衍生自直链或支链烷基的二价脂族烃，R选自环己基和芳族基，R'选自 卤素，三氟甲基，低级烷基，低级烷氧基和N，N-二 - 低级烷基氨基，R 1选自氢和低级烷基，以及具有抗炎和止痛活性的无毒性，治疗上可接受的碱的阳离子， 制备。

公开(公告)号：US3855293A

公开(公告)日：1974-12-17

申请号：US38545273

申请日：1973-08-03

Applicant: ROUSSEL UCLAF

Inventor： VIEHE H ,  JANOUSEK Z

IPC: C07C67/00 ,  C07C239/00 ,  C07C275/00 ,  C07D249/08 ,  C07D249/14 ,  C07C123/00

CPC classification number: C07D249/14 ,  C07C275/00 ,  C07D249/08

Abstract: Novel amine compounds of the formula WHEREIN R, R1, Y and Y1 are individually alkyl of 1 to 5 carbon atoms and X is a halogen and the dotted lines represent 2 conjugated double bonds which are useful intermediates in organic synthesis and particularly for the preparation of 1,2,4triazoles.

Abstract translation: 式WHEREIN R，R1，Y和Y1的新型胺化合物分别是1至5个碳原子的烷基，X是卤素，虚线代表2个共轭双键，它们是有机合成中有用的中间体，特别是制备 1,2,4-三唑。

公开(公告)号：US3829585A

公开(公告)日：1974-08-13

申请号：US34677073

申请日：1973-04-02

Applicant: ROUSSEL UCLAF

Inventor： ALLAIS A ,  MEIER J ,  DUBE J

IPC: C07C69/738 ,  A61K31/215 ,  A61K31/25 ,  A61K31/335 ,  A61K31/357 ,  A61P25/04 ,  A61P29/00 ,  C07C49/813 ,  C07C51/08 ,  C07C59/88 ,  C07C65/36 ,  C07C67/00 ,  C07C245/14 ,  C07C313/00 ,  C07C323/62 ,  C07D317/24 ,  C07F3/00 ,  A61K27/00

CPC classification number: C07F3/00 ,  C07C49/813 ,  C07C51/08 ,  C07C59/88 ,  C07C65/36 ,  C07C245/14 ,  C07D317/24

Abstract: P and Q being alkyl of 1 to 5 carbon atoms and the two benzene rings may be optionally substituted with at least one member of the group consisting of chlorine, fluorine, bromine, trifluoromethyl and alkyl and alkoxy and alkylthio of 1 to 7 carbon atoms, intermediates and process for their preparation and their use as analgesics and antiinflammatory agents.

WHEREIN R is selected from the group consisting of hydrogen and alkyl of 1 to 7 carbon atoms, R1 and R2 are hydrogen or taken together are

Racemates and optically active isomers of benzoylphenyl-acetic acid esters of the formula

公开(公告)号：US3825664A

公开(公告)日：1974-07-23

申请号：US10451671

申请日：1971-01-06

Applicant: ROUSSEL UCLAF

Inventor： HAGEMANN G ,  CLEMENCE F

IPC: A61K31/195 ,  A61K27/00

CPC classification number: A61K31/195

Abstract: COMPOSITIONS FOR TREATING MICROBIC INFECTIONS HAVING AS THE ACTIVE INGREDIENT RACEMIC OR OPTICALLY ACTIVE ISOMERS OF N-SUCCINYL-GLUTAMIC ACID AND ITS NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE SALTS WITH MINERAL OR ORGANIC BASES AND A METHOD OF COMBATTING INFECTIONS IN WARM-BLOODED ANIMALS.

公开(公告)号：US3808216A

公开(公告)日：1974-04-30

申请号：US24140572

申请日：1972-04-05

Applicant: ROUSSEL UCLAF

Inventor： CEREDE J ,  ALLAIS A ,  MEIER J

IPC: C07D409/12 ,  A61K31/47 ,  C07D417/12 ,  C07D33/60

CPC classification number: A61K31/47

Abstract: NOVEL 4-AMINO-QUINOLINES OF THE FORMULA

4-(X-OOC-Y-NH-),R,R1-QUINOLINE

WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, -CF3, LOWER ALKYL, LOWER ALKOXY, LOWER ALKYLSULFONYLOXY, LOWER ALKYLTHIO, NITRO, LOWER ALKYLAMINO, LOWER ACYLAMINO AND CYANO, R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, CHLORINE AND METHYL, Y IS SELECTED FROM THE GROUP CONSISTING OF 2,3 AND 3,4-DISUBSTITUTED THIOPHENES OF THE FORMULA

R2-THIEN-2,3-YLENE AND R2-THIEN-3,4-YLENE

AND 4,5-DISUBSTITUTED THIAZOLES OF THE FORMULA

2-Q-THIAZOL-4,5-YLENE

WHEREIN R2 AND Q ARE SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND LOWER ALKYL AD X IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, LOWER ALKYL, A PHENYL, DILOWERALKYLAMINO LOWER ALKYLENE, N-MORPHOLINO LOWER ALKYLENE,

-CH2-CH(-O-R3)-CH2-O-R4, 2-P2-1,3-DIOXAN-5-YL, AND

-(CH2)N-N(+)(-M'')2-M Z(-),

R3 AND R4 BEING HYDROGEN AND TAKEN TOGETHER FORM

-C(-P)(-P1)-

P AND P1 ARE LOWER ALKYL, P2 IS SELECTED FROM THE GROUP CONSISTING OF LOWER ALKYL AND MONOCYCLIC ARYL, M AND M'' ARE LOWER ALKYL, Z IS HALOGEN AND N IS AN INTEGER FROM 1 TO 6, AND THEIR NON-TOXIC, PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS HAVING ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY AND THEIR PREPARATION. LOWER ALKYL MEANS HAVING 1 TO 6 CARBON ATOMS.