公开(公告)号：US20140294871A1

公开(公告)日：2014-10-02

申请号：US14346562

申请日：2012-10-01

申请人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia

发明人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia

IPC分类号： A61K39/39 ,  A23K1/16 ,  C07K14/46

CPC分类号： A61K39/39 ,  A23K20/147 ,  A61K38/00 ,  C07K14/461

摘要： The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia (Oreochromis niloticus) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions to for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.

摘要翻译： 本发明涉及从罗非鱼（Oreochromis niloticus）鳃提取物中分离和纯化的抗微生物肽。 这样的肽可以通过化学合成或通过常规分子生物学技术在异源系统如细菌和酵母中表达产生。 这些肽显示出对各种生物体的抗菌活性，包括革兰氏阳性菌，革兰氏阴性菌，真菌和病毒。 本发明还包括用于控制包含这些抗微生物肽的病原体的组合物。 疫苗制剂中作为分子佐剂使用这些肽也是本发明的一部分。

公开(公告)号：US08691234B2

公开(公告)日：2014-04-08

申请号：US12430534

申请日：2009-04-27

申请人： Santiago Duenas Carrera ,  Juan Morales Grillo ,  Liz Alvarez-Lajonchere Ponce de Leon ,  Alexis Musacchio Lasa ,  Rolando Pajon Feyt ,  Ariel Vina Rodriguez ,  Julio C. Alvarez Obregon ,  Nelson Acosta Rivero ,  Gillian Martinez Donato

发明人： Santiago Duenas Carrera ,  Juan Morales Grillo ,  Liz Alvarez-Lajonchere Ponce de Leon ,  Alexis Musacchio Lasa ,  Rolando Pajon Feyt ,  Ariel Vina Rodriguez ,  Julio C. Alvarez Obregon ,  Nelson Acosta Rivero ,  Gillian Martinez Donato

IPC分类号： A61K39/00

CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K39/292 ,  A61K2039/53 ,  A61K2039/55505 ,  A61K2039/70 ,  C12N2730/10134 ,  C12N2770/24234

摘要： Formulation of vaccine antigens, containing as main components: a—) one or several DNA expressing one or several proteins in the immunized individuals and b—) a viral antigen, in appropriate proportions. Development of new formulations, minimizing the number of components that enhance and diversify the spectrum of immune response against different pathogenic entities and generating combined vaccines against pathogens.These formulations can be applied in the pharmaceutical industry for preventive and-or therapeutic use in human.

摘要翻译： 包含作为主要成分的疫苗抗原的制剂：a-）在免疫个体中表达一种或几种蛋白质的一种或几种DNA，和b-以适当比例的病毒抗原。 开发新的配方，最大限度地减少增加和多样化针对不同病原体的免疫反应谱的组分数量，并产生抗病原体的联合疫苗。 这些制剂可以应用于制药工业中用于预防和/或治疗人类。

公开(公告)号：US20140086829A1

公开(公告)日：2014-03-27

申请号：US13976060

申请日：2011-12-26

申请人： Humberto Lamdan Ordas ,  Jorge Victor Gavilondo Cowley ,  Marta Ayala Avila ,  Yasmiana Munoz Pozo ,  Amaury Pupo Merino ,  Gertrudis Rojas Dorantes ,  Lincidio Perez Sanchez

发明人： Humberto Lamdan Ordas ,  Jorge Victor Gavilondo Cowley ,  Marta Ayala Avila ,  Yasmiana Munoz Pozo ,  Amaury Pupo Merino ,  Gertrudis Rojas Dorantes ,  Lincidio Perez Sanchez

IPC分类号： C07K16/22 ,  A61K51/10

CPC分类号： C07K16/22 ,  A61K51/1021 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention reveals human recombinant antibodies that recognize the human Vascular Endothelium Growth Factor A (VEGF-A), block its interaction with the VEGFR2 receptor, and interfere with its proliferative effect in vitro and pro-angiogenic effect in vivo. The antibodies identify an epitope on human VEGF-A different from any other previously reported, and were obtained by combining one immunoglobulin light chain variable region with other three heavy chain ones. The antibodies were obtained by human immunoglobulin variable region mutagenesis, and can be employed for the immunotherapy of pathological entities associated with to an increase in vasculature, such as age-related macular degeneration, cancer, and others.

摘要翻译： 本发明揭示识别人血管内皮生长因子A（VEGF-A）的人重组抗体，阻断其与VEGFR2受体的相互作用，并且干扰其在体内的增殖作用和促血管生成作用。 抗体鉴定了与之前报道的任何其它VEGF不同的人VEGF-A上的表位，并且通过将一个免疫球蛋白轻链可变区与其他三个重链可变区组合获得。 通过人免疫球蛋白可变区诱变获得抗体，并且可用于与脉管系统增加相关的病理实体的免疫治疗，例如年龄相关性黄斑变性，癌症等。

公开(公告)号：US08409562B2

公开(公告)日：2013-04-02

申请号：US12280055

申请日：2007-02-28

申请人： Jorge Roberto Toledo Alonso ,  Oliberto Sánchez Ramos ,  Maritza Isidra Barrera Valle ,  Nancy Elena Figueroa Baile ,  Yanet Prieto Carratala ,  Maria Pilar Rodriguez Molto ,  Maria Teresa Frias Lepoureau ,  Carlos Guillermo Borroto Nordelo

发明人： Jorge Roberto Toledo Alonso ,  Oliberto Sánchez Ramos ,  Maritza Isidra Barrera Valle ,  Nancy Elena Figueroa Baile ,  Yanet Prieto Carratala ,  Maria Pilar Rodriguez Molto ,  Maria Teresa Frias Lepoureau ,  Carlos Guillermo Borroto Nordelo

IPC分类号： A61K38/21 ,  A61P31/12

CPC分类号： C07K14/005 ,  A01K2267/01 ,  A61K39/12 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/6031 ,  C07K14/70575 ,  C07K16/1081 ,  C07K2317/76 ,  C07K2319/21 ,  C07K2319/74 ,  C12N2710/10343 ,  C12N2770/24322 ,  C12N2770/24334

摘要： The current invention describes chimeric vaccine antigens against the virus that causes the Classic Swine Fever (CSFV). Such vaccine antigens are based on viral subunits coupled to proteins able to stimulate cellular and humoral immune system. Chimeric antigens can be produced in expression systems that guarantee a correct tertiary structure folding of the chimeric molecules, which constitute the essence of the current invention. The vaccine formulations containing such chimeric antigens induce an early and potent immune response on vaccinated pigs and confer full protection against CSFV. Moreover, the resultant vaccine formulations prevent the viral transmission from sows to their offspring. The chimeric antigens, as well as the resultant vaccine formulations, can be applied in animal health as vaccines for preventive use in swine.

摘要翻译： 本发明描述了针对导致经典猪瘟（CSFV）的病毒的嵌合疫苗抗原。 这种疫苗抗原基于与能够刺激细胞和体液免疫系统的蛋白质偶联的病毒亚基。 嵌合抗原可以在保证构成本发明精华的嵌合分子的正确三级结构折叠的表达系统中产生。 含有这种嵌合抗原的疫苗制剂在接种疫苗的猪上诱导早期有效的免疫应答并赋予对CSFV的完全保护。 此外，所得疫苗制剂防止病毒从母猪传播到其后代。 嵌合抗原以及得到的疫苗制剂可以作为预防用于猪的疫苗用于动物健康。

公开(公告)号：US08324164B2

公开(公告)日：2012-12-04

申请号：US12649687

申请日：2009-12-30

申请人： Maria del Carmen Domínguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marin ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vázquez Bonachea ,  José Suárez Alba

发明人： Maria del Carmen Domínguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marin ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vázquez Bonachea ,  José Suárez Alba

IPC分类号： A61P19/02 ,  A61P29/00 ,  A61K38/17 ,  C07K14/47

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。

公开(公告)号：US08007776B2

公开(公告)日：2011-08-30

申请号：US10529923

申请日：2003-10-08

申请人： Alicia Santos Savio ,  Ricardo Silva Rodriguez ,  Yanelis Morera Diaz ,  Armando Alexei Rodriquez Alfonso ,  Jose Rafael Martinez Castillo ,  Haydee Geronimo Perez ,  Alejandro Moro Soria ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ricardo Silva Rodriguez ,  Yanelis Morera Diaz ,  Armando Alexei Rodriquez Alfonso ,  Jose Rafael Martinez Castillo ,  Haydee Geronimo Perez ,  Alejandro Moro Soria ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/20

CPC分类号： A61K39/0005

摘要： Vaccine composition containing IL-15 for active immunization to treatment diseases related to over-expression of this cytokine. The technical aim pursued in this invention is to inhibit IL-15 activity through development of a therapeutic vaccine which elicits IL-15 neutralizing antibodies in the immunized host.IL-15 can be presented in this vaccine composition either alone or coupled to a carrier such as the P64k protein with a vaccine adjuvant such as Aluminum hydroxide.Besides, this invention is related to the use of this vaccine for treatment of Rheumatoid arthritis and other IL-15 over-expressing related diseases, and leukemia, where this cytokine acts as a growth factor.

摘要翻译： 含有IL-15的疫苗组合物用于主动免疫治疗与该细胞因子的过表达有关的疾病。 在本发明中追求的技术目的是通过开发在免疫宿主中引发IL-15中和抗体的治疗性疫苗来抑制IL-15活性。 IL-15可以单独存在于该疫苗组合物中，也可以与诸如氢氧化铝等疫苗佐剂的载体例如P64k蛋白偶联。 此外，本发明涉及该疫苗用于治疗类风湿性关节炎和其它IL-15过表达相关疾病和白血病，其中该细胞因子作为生长因子。

公开(公告)号：US07919463B2

公开(公告)日：2011-04-05

申请号：US11989088

申请日：2006-06-23

申请人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia ,  Yamila Carpio Gonzalez ,  Reynold Morales Fernandez

发明人： Jannel Acosta Alba ,  Mario Pablo Estrada Garcia ,  Yamila Carpio Gonzalez ,  Reynold Morales Fernandez

IPC分类号： A61K38/27 ,  C07K14/61

CPC分类号： C07K14/61 ,  A23K20/147 ,  A23K50/80 ,  C07K14/461 ,  C12N15/81

摘要： The present invention is related to polypeptides derived from tilapia growth hormone.

摘要翻译： 本发明涉及来源于罗非鱼生长激素的多肽。

公开(公告)号：US20100144642A1

公开(公告)日：2010-06-10

申请号：US12649687

申请日：2009-12-30

申请人： María del Carmen Domínguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marín ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Díaz ,  Nelson J. Merino García ,  Ariel Vázquez Bonachea ,  José Suárez Alba

发明人： María del Carmen Domínguez Horta ,  Gabriel Ramón Padrón Palomares ,  Nelia López Marín ,  Norailys Lorenzo Perez ,  Ariana Barberá Betancourt ,  Ariadna Hernández Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Díaz ,  Nelson J. Merino García ,  Ariel Vázquez Bonachea ,  José Suárez Alba

IPC分类号： A61K38/16 ,  C07K14/00 ,  A61P29/00 ,  A61P19/02

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。

公开(公告)号：US20090136511A1

公开(公告)日：2009-05-28

申请号：US11662844

申请日：2005-09-16

申请人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

发明人： Alicia Santos Savio ,  Ania Cabrales Rico ,  Osvaldo Reyes Acosta ,  Haydee Geronimo Perez ,  Celia Aurora Arrieta Aguero ,  Silvio Ernesto Perea Rodriguez

IPC分类号： A61K38/08 ,  C07K7/06 ,  A61K39/00 ,  A61K39/395 ,  A61P19/02 ,  A61P17/06 ,  C07K16/00 ,  C07H21/00

CPC分类号： C07K14/5443 ,  A61K38/00 ,  A61K39/00 ,  C07K16/244

摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor α subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.

摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示该肽在结合IL15受体α亚基（IL15Rα）和TNFα介导的细胞凋亡时抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的若干病理学的用途。

公开(公告)号：US20080312139A1

公开(公告)日：2008-12-18

申请号：US12197001

申请日：2008-08-22

申请人： Jorge Berlanga Acosta ,  Jose I. Fernandez Montequin ,  Calixto Valdes Perez ,  Neobalis Franco Perez ,  Ingrid Rojas Constantin ,  Hector Santana Milian ,  Larissa Chacon Corvea ,  Gerardo E. Guillen Nieto ,  Luis Herrera Martinez ,  Leonardo Canan-Haden Frias ,  Haydee Geronimo Perez ,  Jorge Sotolongo Pena

发明人： Jorge Berlanga Acosta ,  Jose I. Fernandez Montequin ,  Calixto Valdes Perez ,  Neobalis Franco Perez ,  Ingrid Rojas Constantin ,  Hector Santana Milian ,  Larissa Chacon Corvea ,  Gerardo E. Guillen Nieto ,  Luis Herrera Martinez ,  Leonardo Canan-Haden Frias ,  Haydee Geronimo Perez ,  Jorge Sotolongo Pena

IPC分类号： A61K38/39 ,  C07K14/485 ,  A61P9/10 ,  A61K38/18

CPC分类号： A61K38/1808

摘要： The invention relates to the use of Epidermal Growth Factor (EGF) in a preferably-Injectable pharmaceutical composition which is administered by means of infiltration into and around chronic cutaneous ischaemic lesions in order to prevent diabetic foot amputation. Said composition can be administered to recently-created surgical surfaces damaged by the effect of acute reperfusion with oxygenated blood following prolonged ischaemia, thereby preventing further surgical procedures and favouring the preservation of the extremity. The aforementioned composition can be used to improve (i) the cell microenvironment, thereby increasing the reparative and defensive capacity and viability of the is tissues and (ii) the cicatrisation of cutaneous ischaemic lesions, thereby stimulating cell proliferation. The invention is suitable for use in human, veterinary and experimental medicine, specifically in vascular angiology and surgery, dermatology, burn treatment and reconstructive surgery and geriatric medicine. Said composition can be used for recalcitrant ulcers which are associated with lesions in the macro and/or microvasculature, patients with inadequate lymphatic and/or venous return and ulcers or other lesions which are difficult to cicatrise and/or heal.

摘要翻译： 本发明涉及在优选可注射的药物组合物中使用表皮生长因子（EGF），其通过渗入慢性皮肤缺血性损伤中及其周围而被施用，以防止糖尿病足部截肢。 所述组合物可以施用于由于长时间缺血引起的急性再灌注与氧合血液的影响而损伤的近期产生的手术表面，从而防止进一步的外科手术并有利于肢体的保存。 上述组合物可用于改善（i）细胞微环境，从而增加组织的修复和防御能力和活力，和（ii）皮肤缺血性损伤的瘢痕化，从而刺激细胞增殖。 本发明适用于人类，兽医和实验医学，特别适用于血管病变和手术，皮肤病学，烧伤治疗和重建手术以及老年医学。 所述组合物可用于与宏观和/或微血管系统中的病变相关的顽固性溃疡，淋巴和/或静脉回流不足的患者以及难以发rise和/或愈合的溃疡或其它病变。