公开(公告)号：US08354114B2

公开(公告)日：2013-01-15

申请号：US12090435

申请日：2006-10-17

Applicant: Bin Lu ,  Hong Jin

Inventor： Bin Lu ,  Hong Jin

IPC: A61K39/145 ,  A61K39/285

CPC classification number: C12N7/00 ,  A61K35/76 ,  A61K38/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/295 ,  A61K2039/5254 ,  C07K14/005 ,  C12N15/86 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16151 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16243 ,  C12N2760/16251

Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics.

Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。

公开(公告)号：US20120282673A1

公开(公告)日：2012-11-08

申请号：US13474409

申请日：2012-05-17

Applicant: Hong JIN ,  Robert Brazas ,  Bin Lu

Inventor： Hong JIN ,  Robert Brazas ,  Bin Lu

IPC: C12N7/01

CPC classification number: C12N7/045 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/543 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2800/40 ,  G01N33/56983 ,  G01N2469/20 ,  G01N2500/00

Abstract: The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.

Abstract translation: 本发明提供具有减毒表型并且包含病毒P，M2-1和/或M2-2蛋白中的一个或多个突变的重组呼吸道合胞病毒，以及包含这样的病毒的活减毒疫苗和编码这种病毒的核酸 病毒 描述了重组RSV P，M2-1和M2-2蛋白。 还提供了产生减毒重组RSV的方法，以及定量利用副粘病毒科重组病毒的中和抗体的方法。

公开(公告)号：US20120280645A1

公开(公告)日：2012-11-08

申请号：US13551973

申请日：2012-07-18

Applicant: Eric Jon Olsson ,  Bin Lu ,  Ting Yan ,  Steven John Fredette ,  Charles John Luebke

Inventor： Eric Jon Olsson ,  Bin Lu ,  Ting Yan ,  Steven John Fredette ,  Charles John Luebke

IPC: H02P27/04

CPC classification number: H02P23/02 ,  H02P23/0077 ,  H02P23/14 ,  H02P27/047

Abstract: A system and method for controlling an AC motor drive includes a control system programmed with an algorithm configured to optimize operation of the motor drive. Specifically, the control system is programmed to input an initial voltage-frequency command to the drive. The initial voltage-frequency command includes a voltage reference and a frequency reference corresponding to an operating point of an initial voltage/frequency (V/Hz) curve. The control system monitors a real-time output of the drive, modifies the voltage reference based on the real-time output of the drive, and transmits a modified voltage-frequency command to the drive. The modified voltage-frequency command corresponds to an operating point of a modified V/Hz curve defined by the modified voltage reference and the initial V/Hz curve.

Abstract translation: 用于控制AC电动机驱动器的系统和方法包括用配置成优化电动机驱动器的操作的算法来编程的控制系统。 具体地，控制系统被编程为向驱动器输入初始电压 - 频率命令。 初始电压 - 频率指令包括对应于初始电压/频率（V / Hz）曲线的工作点的电压基准和频率基准。 控制系统监控驱动器的实时输出，根据驱动器的实时输出修改参考电压，并向驱动器发送修改的电压 - 频率指令。 修改的电压 - 频率指令对应于由修改的电压基准和初始V / Hz曲线定义的修改的V / Hz曲线的工作点。

公开(公告)号：US08264788B2

公开(公告)日：2012-09-11

申请号：US12390592

申请日：2009-02-23

Applicant: Kaizhong Gao ,  Michael Allen Seigler ,  Xuhui Jin ,  Ganping Ju ,  Bin Lu

Inventor： Kaizhong Gao ,  Michael Allen Seigler ,  Xuhui Jin ,  Ganping Ju ,  Bin Lu

IPC: G11B5/02

CPC classification number: G11B5/314 ,  B82Y10/00 ,  G11B5/743 ,  G11B5/855 ,  G11B2005/001 ,  G11B2005/0021

Abstract: An apparatus includes a recording media including a substrate, a plurality of tracks of magnetic material on the substrate, and a non-magnetic material between the tracks; a recording head having an air bearing surface positioned adjacent to the recording media, and including a magnetic pole, an optical transducer, and a near-field transducer, wherein the near-field transducer directs electromagnetic radiation onto tracks to heat portions of the tracks and a magnetic field from the magnetic pole is used to create magnetic transitions in the heated portions of the tracks; and a plasmonic material positioned adjacent to the magnetic material to increase coupling between the electromagnetic radiation and the magnetic material.

Abstract translation: 一种设备包括：记录介质，包括基板，多个基板上的磁性材料轨迹，以及轨道之间的非磁性材料; 记录头，其具有邻近记录介质定位的空气轴承表面，并且包括磁极，光学换能器和近场换能器，其中近场换能器将电磁辐射引导到轨道上以加热轨道的部分， 来自磁极的磁场用于在轨道的加热部分中产生磁转变; 以及与磁性材料相邻定位的等离子体元件，以增加电磁辐射与磁性材料之间的耦合。

公开(公告)号：US20120156311A1

公开(公告)日：2012-06-21

申请号：US13393284

申请日：2010-09-01

Applicant: Qing-Bin Lu

Inventor： Qing-Bin Lu

IPC: A61K33/24 ,  C07C211/51 ,  A61K35/00 ,  C07D403/06

CPC classification number: A61K45/06 ,  A61K31/122 ,  A61K31/136 ,  A61K31/282 ,  A61K31/404 ,  A61K31/555 ,  A61K33/24 ,  A61K2300/00

Abstract: The combination of a biocompatible electron donor and a platinum-based antineoplastic agent exhibits improved efficacy in treating cancer This improved activity appears to be the result of electron transfer from the aforementioned donor compound to the platinum-based antineoplastic agent As the electron donor alone has no chemotherapeutic utility in treating cancer, the resulting combinations appear to be synergistic in nature In select preferred embodiments, the biocompatible electron donor is an amine (such as N,N,N′,N′-tetramethyl-p-phenylene diamine or indocyanine green), a phenolic compound (such as a flavanol or catechin), or a quinone (such as an aromatic quinone), while the antineoplastic is cisplatin.

Abstract translation: 生物相容性电子给体和铂类抗肿瘤剂的组合在治疗癌症中表现出改进的功效。这种改善的活性似乎是从上述供体化合物向铂基抗肿瘤药物的电子转移的结果。由于电子给体单独没有 生物相容性电子给体是一种胺（如N，N，N'，N'-四甲基 - 对苯二胺或吲哚菁绿），其特征在于， ，酚类化合物（例如黄烷醇或儿茶素）或醌（如芳香醌），而抗肿瘤药是顺铂。

公开(公告)号：US20120063032A1

公开(公告)日：2012-03-15

申请号：US12879791

申请日：2010-09-10

Applicant: Eric Meloche ,  Bin Lu ,  Lixin Jia ,  Jianhua Xue ,  John David Westwood ,  Mark Anthony Gubbins ,  Alexandru Cazacu

Inventor： Eric Meloche ,  Bin Lu ,  Lixin Jia ,  Jianhua Xue ,  John David Westwood ,  Mark Anthony Gubbins ,  Alexandru Cazacu

IPC: G11B5/127

CPC classification number: G11B5/11 ,  G11B5/1278 ,  G11B5/3116 ,  G11B5/315

Abstract: Data storage systems having barriers that may reduce erasure flux and increase write-ability are provided. Data storage systems include a writing element. The writing element has a write pole with a flare region. A magnetic flux barrier is located along the write pole flare region. The magnetic flux barrier is illustratively made from an in-plane magnetically anisotropic material that has an easy plane of magnetization. In another embodiment, a data storage system includes a writing element having an air bearing surface and a shield at the air bearing surface. The shield has a magnetic permeability of approximately zero. The shield illustratively includes alternating layers of positive and negative permeabilities. The shield optionally includes a plurality of shields that may include top, bottom, and side shields.

Abstract translation: 提供了具有可能减少擦除通量并增加写入能力的障碍的数据存储系统。 数据存储系统包括写入元件。 写入元件具有带闪光区域的写入极。 磁通势垒位于写磁极耀斑区域。 磁通势垒示意性地由具有易磁化平面的面内磁各向异性材料制成。 在另一个实施例中，数据存储系统包括具有空气轴承表面和在空气支承表面处的屏蔽的书写元件。 屏蔽具有大约零的磁导率。 屏蔽件示例性地包括正和负磁导率的交替层。 屏蔽件可选地包括可以包括顶部，底部和侧部屏蔽件的多个屏蔽件。

公开(公告)号：US08114415B2

公开(公告)日：2012-02-14

申请号：US12254131

申请日：2008-10-20

Applicant: Erich Hoffmann ,  Hong Jin ,  Bin Lu ,  Gregory Duke ,  George Kemble ,  Zhongying Chen

Inventor： Erich Hoffmann ,  Hong Jin ,  Bin Lu ,  Gregory Duke ,  George Kemble ,  Zhongying Chen

IPC: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  C12P21/04

CPC classification number: C12N15/86 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16162 ,  C12N2760/16222 ,  C12N2760/16234 ,  C12N2760/16243 ,  C12N2760/16262 ,  C12N2840/20

Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.

Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。 另外，本发明提供了生产能够在含胚鸡蛋和/或细胞（例如Vero和/或MDCK）中复制的流感病毒的方法，并进一步提供具有增强的复制特征的流感病毒。 还提供了生产在例如25℃下有效复制的冷适应（ca）流感病毒的方法（和包含其的免疫原性组合物）。

公开(公告)号：US08063306B2

公开(公告)日：2011-11-22

申请号：US12444071

申请日：2007-09-21

Applicant: Jingwen Zhong ,  Pierre Bonvallat ,  Zhiyong Xu ,  Bin Lu

Inventor： Jingwen Zhong ,  Pierre Bonvallat ,  Zhiyong Xu ,  Bin Lu

IPC: H02G15/113

CPC classification number: H02G15/046 ,  H02G15/113

Abstract: A re-enterable enclosure for a cable splice includes a first cover member and a second cover member configured for engagement with each other, and movable between an open position and a closed position. The first and second cover members form a cavity for enclosing the cable splice when the cover members are in the closed position. Internal walls in at least one of the first and second cover members are configured to define a sealant containment space that at least partially surrounds the cavity. At least one latch is configured to maintain the first and second cover members in the closed position, the at least one latch configured to exert a compression force along a line extending through the sealant containment space.

Abstract translation: 用于电缆接头的可重新进入的外壳包括第一盖构件和第二盖构件，第二盖构件和第二盖构件被构造成彼此接合并可在打开位置和关闭位置之间移动。 当盖构件处于关闭位置时，第一和第二盖构件形成用于封闭电缆接头的空腔。 第一和第二盖构件中的至少一个中的内壁构造成限定至少部分地围绕空腔的密封剂容纳空间。 至少一个闩锁构造成将第一和第二盖构件保持在关闭位置，所述至少一个闩锁构造成沿着延伸穿过密封剂容纳空间的线施加压缩力。

公开(公告)号：US08012736B2

公开(公告)日：2011-09-06

申请号：US10423828

申请日：2003-04-25

Applicant: Erich Hoffman ,  Hong Jin ,  Bin Lu ,  Greg Duke ,  George Kemble

Inventor： Erich Hoffman ,  Hong Jin ,  Bin Lu ,  Greg Duke ,  George Kemble

IPC: C12N7/02

CPC classification number: A61K39/145 ,  A61K2039/5254 ,  C07K14/005 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N15/87 ,  C12N2760/16122 ,  C12N2760/16143 ,  C12N2760/16162 ,  C12N2760/16222 ,  C12N2760/16243 ,  C12N2760/16262

Abstract: Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.

Abstract translation: 提供了用于在细胞培养中生产适合作为重组流感疫苗的流感病毒的载体和方法。 提供了用于多质粒流感病毒表达系统的双向表达载体。

公开(公告)号：US07829208B2

公开(公告)日：2010-11-09

申请号：US11947288

申请日：2007-11-29

Applicant: Yingguo Peng ,  Bin Lu

Inventor： Yingguo Peng ,  Bin Lu

IPC: G11B5/66

CPC classification number: G11B5/732 ,  C23C14/0036 ,  C23C14/0641 ,  G11B5/7325 ,  G11B5/82 ,  G11B5/8404

Abstract: A magnetic recording media with a multilayer structure and methods for forming the media are described. The magnetic recording media includes a substrate, an underlayer on top of the substrate and a magnetic layer over the underlayer. The underlayer includes a CrN film formed by sputter depositing chromium in the presence of nitrogen or nitrogen containing compounds.

Abstract translation: 描述了具有多层结构的磁记录介质和用于形成介质的方法。 磁记录介质包括衬底，衬底顶部的底层和衬底上的磁性层。 底层包括在氮或含氮化合物存在下溅射沉积铬形成的CrN膜。