公开(公告)号：US08497275B2

公开(公告)日：2013-07-30

申请号：US12492518

申请日：2009-06-26

Applicant: Brian E. Green ,  David D. Anderson ,  Todd D. Bosse ,  Curt S. Cooper ,  Larry L. Klein ,  Allan C. Krueger ,  Daniel P. Larson ,  Dachun Liu ,  Keith F. McDaniel ,  Christopher E. Motter ,  John K. Pratt ,  Todd W. Rockway ,  Teresa A. Rosenberg ,  Ming C. Yeung ,  Hui-Ju Chen ,  Jason P. Shanley

Inventor： Brian E. Green ,  David D. Anderson ,  Todd D. Bosse ,  Curt S. Cooper ,  Larry L. Klein ,  Allan C. Krueger ,  Daniel P. Larson ,  Dachun Liu ,  Keith F. McDaniel ,  Christopher E. Motter ,  John K. Pratt ,  Todd W. Rockway ,  Teresa A. Rosenberg ,  Ming C. Yeung ,  Hui-Ju Chen ,  Jason P. Shanley

IPC: A61K31/4965 ,  A61K31/40 ,  A61K38/00 ,  A61K38/05

CPC classification number: C07D403/12 ,  C07D207/16 ,  C07D241/24 ,  C07D403/14 ,  C07D409/14 ,  C07K7/02

Abstract: This invention relates to: (a) compounds of formula I and salts thereof that, inter alia, are useful as hepatitis C virus (HCV) inhibitors; (b) intermediates useful for the preparation of such compounds and salts; (c) pharmaceutical compositions comprising such compounds and salts; and (d) methods of use of such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）式I化合物及其盐，其特别可用作丙型肝炎病毒（HCV）抑制剂; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的药物组合物; 和（d）使用这些化合物，盐和组合物的方法。

公开(公告)号：US20120295842A1

公开(公告)日：2012-11-22

申请号：US13339448

申请日：2011-12-29

Applicant: Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  David J. Grampovnik ,  Brian Green ,  Timothy Middleton ,  Todd Hopkins ,  Yat Sun Or

Inventor： Keith F. McDaniel ,  Hui-Ju Chen ,  Jason P. Shanley ,  David J. Grampovnik ,  Brian Green ,  Timothy Middleton ,  Todd Hopkins ,  Yat Sun Or

IPC: C07K7/56 ,  C07K1/113 ,  A61P31/12 ,  A61K38/12

CPC classification number: C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：US20120172291A1

公开(公告)日：2012-07-05

申请号：US13339440

申请日：2011-12-29

Applicant: Keith F. McDaniel ,  Hui-Ju Chen ,  Ming Yeung ,  Timothy Middleton ,  Liangjun Lu ,  Kevin Kurtz

Inventor： Keith F. McDaniel ,  Hui-Ju Chen ,  Ming Yeung ,  Timothy Middleton ,  Liangjun Lu ,  Kevin Kurtz

IPC: A61K38/06 ,  A61P31/14 ,  C07K5/02

CPC classification number: C07K5/02 ,  A61K38/00 ,  C07K5/0804 ,  C07K5/0827

Abstract: The present invention relates to novel fluorinated macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的氟化大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：US08193227B2

公开(公告)日：2012-06-05

申请号：US11009841

申请日：2004-12-10

Applicant: Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

Inventor： Charles A. Flentge ,  Hui-Ju Chen ,  David A. DeGoey ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Dale J. Kempf ,  Larry L. Klein ,  Allan C. Krueger ,  Darold L. Madigan ,  John T. Randolph ,  Minghua Sun ,  Ming C. Yeung ,  Chen Zhao

IPC: A61K31/415 ,  C07D233/00

CPC classification number: C07D417/12 ,  C07C311/18 ,  C07C311/29 ,  C07C311/41 ,  C07C311/47 ,  C07C317/18 ,  C07D209/14 ,  C07D213/30 ,  C07D213/40 ,  C07D233/36 ,  C07D233/64 ,  C07D233/72 ,  C07D277/24 ,  C07D277/28 ,  C07D307/14 ,  C07D307/20 ,  C07D307/52 ,  C07D333/20 ,  C07D401/06 ,  C07D403/06 ,  C07D405/06 ,  C07D405/10 ,  C07D409/06 ,  C07D409/10 ,  C07D417/06 ,  C07D417/10 ,  C07D471/04 ,  C07D493/04

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US20120101031A1

公开(公告)日：2012-04-26

申请号：US13154721

申请日：2011-06-07

Applicant: Hui-Ju Chen ,  Keith F. McDaniel ,  Brian E. Green ,  Jason P. Shanley ,  Albert W. Kruger ,  Jorge Gandarilla ,  Dennie S. Welch ,  Russell D. Cink ,  Steven C. Cullen ,  Yonghua Gai ,  Guoqiang Wang ,  Yat Sun Or

Inventor： Hui-Ju Chen ,  Keith F. McDaniel ,  Brian E. Green ,  Jason P. Shanley ,  Albert W. Kruger ,  Jorge Gandarilla ,  Dennie S. Welch ,  Russell D. Cink ,  Steven C. Cullen ,  Yonghua Gai ,  Guoqiang Wang ,  Yat Sun Or

IPC: A61K38/12 ,  A61P31/12 ,  C07K5/087

CPC classification number: C07K5/081 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：US07696226B2

公开(公告)日：2010-04-13

申请号：US11010177

申请日：2004-12-10

Applicant: John T. Randolph ,  Hui-Ju Chen ,  David A. DeGoey ,  Charles A. Flentge ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf ,  Larry L. Klein ,  Ming C. Yeung

Inventor： John T. Randolph ,  Hui-Ju Chen ,  David A. DeGoey ,  Charles A. Flentge ,  William J. Flosi ,  David J. Grampovnik ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf ,  Larry L. Klein ,  Ming C. Yeung

IPC: A61K31/4709 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4436 ,  C07D401/14

CPC classification number: C07C271/22 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14

Abstract: A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

Abstract translation: 公开了式的化合物作为HIV蛋白酶抑制剂。 还公开了用于抑制HIV感染的方法和组合物。

公开(公告)号：US20050233376A1

公开(公告)日：2005-10-20

申请号：US11166238

申请日：2005-06-27

Applicant: Jiann-Hua Wang ,  Hui-Ju Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

Inventor： Jiann-Hua Wang ,  Hui-Ju Chen ,  Tzu-Chiang Wu ,  Chien-Ho Chuang ,  Tsung-Kai Chuang

IPC: C12M1/34 ,  C12Q1/68 ,  G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/6452 ,  G01N21/6456

Abstract: A biochip scanner device includes a light source for emitting a light beam; a light processing unit for focusing the light beam onto the biochip to excite fluorescence from a sample spot on the biochip; a filter for filtering off the light beam from the light source and the scattered light from the surface on the biochip; a photomultiplier tube (PMT) for detecting and converting the fluorescence into a current signal; and an output device for outputting/displaying the current signal detected by the PMT. The output device controls the platform to match the pattern of the biochip. No conversion of the output signal of the output device into image data is needed. A real-time analysis proceeds while samples are being scanned on the biochip. The biochip scanner device of the present invention reads the current signal from PMT directly without processing it into image data and setting lens before the PMT is no longer needed. As a result, the structure of the device is simplified and the cost for production is reduced.

Abstract translation: 生物芯片扫描器装置包括用于发射光束的光源; 光处理单元，用于将光束聚焦到生物芯片上以从生物芯片上的样品点激发荧光; 用于滤除来自光源的光束的滤光器和来自生物芯片上的表面的散射光; 用于检测并将荧光转换成电流信号的光电倍增管（PMT）; 以及用于输出/显示由PMT检测的电流信号的输出装置。 输出设备控制平台以匹配生物芯片的图案。 不需要将输出设备的输出信号转换为图像数据。 在生物芯片上扫描样品时，进行实时分析。 本发明的生物芯片扫描器装置在PMT不再需要之前直接从PMT读取当前信号而不将其处理成图像数据和设置透镜。 结果，简化了装置的结构，降低了生产成本。

公开(公告)号：US20170119196A1

公开(公告)日：2017-05-04

申请号：US15407269

申请日：2017-01-17

Applicant: Hui-Ju Chen ,  Hsiu-Lan Chen Lu ,  Han Tsung Chen ,  Wei Fu Chen

Inventor： Hui-Ju Chen ,  Hsiu-Lan Chen Lu ,  Han Tsung Chen ,  Wei Fu Chen

IPC: A47J31/06 ,  A47J31/00

CPC classification number: A47J31/005 ,  A47J31/0605 ,  A47J41/02

Abstract: A thermo tea maker includes a tea cup and a tea infuser. The exterior of the tea cup has a first isolation gap in a vacuum state to block the heat conduction from an inner part to an outer part of the cup part. The exterior of the tea infuser has a second isolation gap in a vacuum state to block the heat conduction from an inner segment to an outer segment of the tea infuser. The tea cup and the tea infuser are able to keep the tea warm. When the tea infuser is turned, the tea infuser will not scald the user's hand.

公开(公告)号：US08748374B2

公开(公告)日：2014-06-10

申请号：US13154721

申请日：2011-06-07

Applicant: Hui-Ju Chen ,  Keith F. McDaniel ,  Brian E. Green ,  Jason P. Shanley ,  Albert W. Kruger ,  Jorge Gandarllla ,  Dennie S. Welch ,  Russell D. Cink ,  Steven C. Cullen ,  Yonghua Gai ,  Guoqiang Wang ,  Yat Sun Or

Inventor： Hui-Ju Chen ,  Keith F. McDaniel ,  Brian E. Green ,  Jason P. Shanley ,  Albert W. Kruger ,  Jorge Gandarllla ,  Dennie S. Welch ,  Russell D. Cink ,  Steven C. Cullen ,  Yonghua Gai ,  Guoqiang Wang ,  Yat Sun Or

IPC: A61K38/00

CPC classification number: C07K5/081 ,  C07D487/04

Abstract: The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.

Abstract translation: 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。

公开(公告)号：US20130131085A1

公开(公告)日：2013-05-23

申请号：US13713903

申请日：2012-12-13

Applicant: Larry L. Klein ,  Hui-Ju Chen ,  Ming C. Yeung ,  Charles A. Flentge ,  John T. Randolph ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf

Inventor： Larry L. Klein ,  Hui-Ju Chen ,  Ming C. Yeung ,  Charles A. Flentge ,  John T. Randolph ,  Peggy P. Huang ,  Douglas K. Hutchinson ,  Dale J. Kempf

IPC: C07D417/12 ,  C07D213/79 ,  C07D277/593

CPC classification number: A61K31/5377 ,  A61K31/4164 ,  A61K31/4178 ,  A61K31/4439 ,  A61K31/4525 ,  A61K31/496 ,  A61K31/506 ,  A61K45/06 ,  C07D213/79 ,  C07D277/24 ,  C07D277/30 ,  C07D277/593 ,  C07D417/12

Abstract: The present invention features compounds of formula I or pharmaceutically acceptable salts, solvates or prodrugs thereof, and methods of using the same to inhibit the metabolizing activities of CYP enzymes. The present invention also features methods of using these compounds, salts, solvates or prodrugs to improve the pharmacokinetics of drugs that are metabolized by CYP enzymes.

Abstract translation: 本发明的特征在于式I化合物或其药学上可接受的盐，溶剂合物或前药，以及使用该化合物抑制CYP酶代谢活性的方法。 本发明还涉及使用这些化合物，盐，溶剂合物或前药来改善由CYP酶代谢的药物的药代动力学的方法。