公开(公告)号：US20080241207A1

公开(公告)日：2008-10-02

申请号：US11985996

申请日：2007-11-19

Applicant: Y. Tom Tang ,  Ivan Labat ,  Radoje T. Drmanac ,  Nancy Mize ,  Mitsuo Nishikawa ,  Cheng-Chi Chao

Inventor： Y. Tom Tang ,  Ivan Labat ,  Radoje T. Drmanac ,  Nancy Mize ,  Mitsuo Nishikawa ,  Cheng-Chi Chao

IPC: A61L27/54 ,  C12Q1/68 ,  C07K16/22 ,  C12N5/02 ,  G01N33/53 ,  C40B40/08 ,  A61P43/00 ,  A61K35/12 ,  A61K38/18 ,  A61K31/711 ,  C12N5/00 ,  C12N5/22

CPC classification number: C07K14/475 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K16/00 ,  C07K2319/00 ,  C12N9/16 ,  C12N9/6432 ,  C12Y304/21006 ,  Y10S435/81 ,  Y10S435/975

Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

Abstract translation: 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列 （Hyseq克隆鉴定号13804756,13687487,13804756）。 本发明的其它方面包括含有生产新型人类干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US07317099B2

公开(公告)日：2008-01-08

申请号：US10168365

申请日：2000-12-23

Applicant: Ivan Labat ,  Y. Tom Tang ,  Radoje T. Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy K. Mize ,  John Childs ,  Cheng-Chi Chao

Inventor： Ivan Labat ,  Y. Tom Tang ,  Radoje T. Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy K. Mize ,  John Childs ,  Cheng-Chi Chao

IPC: C07H21/04 ,  C12N15/00 ,  C12N5/10 ,  C12N1/15 ,  C12N15/21

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/475

Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

Abstract translation: 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的干细胞生长因子样多肽的突变体或其变体。 这些多核苷酸包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US20060074044A1

公开(公告)日：2006-04-06

申请号：US11283290

申请日：2005-11-18

Applicant: Ivan Labat ,  Y. Tang ,  Radoje Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy Mize ,  John Childs ,  Cheng-Chi Chao

Inventor： Ivan Labat ,  Y. Tang ,  Radoje Drmanac ,  Chenghua Liu ,  Juhi Lee ,  Nancy Mize ,  John Childs ,  Cheng-Chi Chao

IPC: A61K48/00 ,  C07H21/04 ,  C12P21/06 ,  C07K14/475

CPC classification number: C07K14/475 ,  A61K38/00

Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof the correspond to a novel human secreted stem cell growth factor-like polypeptide. These polypeptides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invertion include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

Abstract translation: 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其突变体或变体对应于新的人分泌的干细胞生长因子样多肽。 这些多肽包含从人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，淋巴细胞，肺成纤维细胞，胎儿脑和睾丸制备的cDNA文库中分离的核酸序列。 逆转的其他方面包括含有产生新的人分泌干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US20080241882A1

公开(公告)日：2008-10-02

申请号：US11985824

申请日：2007-11-16

Applicant: Y. Tom Tang ,  Ivan Labat ,  Radoje T. Drmanac ,  Nancy Mize ,  Mitsuo Nishikawa ,  Cheng-Chi Chao

Inventor： Y. Tom Tang ,  Ivan Labat ,  Radoje T. Drmanac ,  Nancy Mize ,  Mitsuo Nishikawa ,  Cheng-Chi Chao

IPC: C12P21/00 ,  C07H21/04 ,  C12N15/63 ,  C12N5/06

CPC classification number: C07K14/475 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K16/00 ,  C07K2319/00 ,  C12N9/16 ,  C12N9/6432 ,  C12Y304/21006 ,  Y10S435/81 ,  Y10S435/975

Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695), from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes fro producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

Abstract translation: 本发明提供由对应于新的人类干细胞生长因子样蛋白质的这种多核苷酸及其突变体或变体编码的新型多核苷酸和多肽。 这些多核苷酸包含从人胎儿皮肤（Hyseq克隆鉴定号15375176），成年脾（Hyseq克隆鉴定号14856094）和人内皮细胞的人睾丸细胞（Hyseq克隆鉴定号2880984和2881695）的cDNA文库中分离的核酸序列 （Hyseq克隆鉴定号13804756,13687487,13804756）。 本发明的其它方面包括含有产生新型人干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US06964868B1

公开(公告)日：2005-11-15

申请号：US09297648

申请日：1999-01-28

Applicant: Lewis T. Williams ,  Jaime Escobedo ,  Michael A. Innis ,  Pablo Dominguez Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia C. Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee William Jones ,  Birgit Stache-Crain

Inventor： Lewis T. Williams ,  Jaime Escobedo ,  Michael A. Innis ,  Pablo Dominguez Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia C. Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee William Jones ,  Birgit Stache-Crain

IPC: C07K14/47 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63

CPC classification number: C07K14/4748

Abstract: This invention relates to novel human polynucleotides and variants thereof, their encoded polypeptides and variants thereof, to genes corresponding to these polynucleotides and to proteins expressed by the genes. The invention also relates to diagnostic and therapeutic agents employing such novel human polynucleotides, their corresponding genes or gene products, e.g., these genes and proteins, including probes, antisense constructs, and antibodies.

Abstract translation: 本发明涉及对应于这些多核苷酸的基因和由该基因表达的蛋白质的新型人多核苷酸及其变体，其编码的多肽及其变体。 本发明还涉及使用这种新型人多核苷酸的诊断和治疗剂，其相应的基因或基因产物，例如这些基因和蛋白质，包括探针，反义构建体和抗体。

公开(公告)号：US20050227917A1

公开(公告)日：2005-10-13

申请号：US10779543

申请日：2004-02-12

Applicant: Lewis Williams ,  Jaime Escobedo ,  Michael Innis ,  Pablo Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Zhijun He ,  Elizabeth Scott ,  Guozhong Zhang ,  Theresa May ,  Doreen Sakamoto ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee Jones ,  Birgit Stache-Crain

Inventor： Lewis Williams ,  Jaime Escobedo ,  Michael Innis ,  Pablo Garcia ,  Julie Sudduth-Klinger ,  Christoph Reinhard ,  Klaus Giese ,  Filippo Randazzo ,  Giulia Kennedy ,  David Pot ,  Altaf Kassam ,  George Lamson ,  Zhijun He ,  Elizabeth Scott ,  Guozhong Zhang ,  Theresa May ,  Doreen Sakamoto ,  Radoje Drmanac ,  Radomir Crkvenjakov ,  Mark Dickson ,  Snezana Drmanac ,  Ivan Labat ,  Dena Leshkowitz ,  David Kita ,  Veronica Garcia ,  Lee Jones ,  Birgit Stache-Crain

IPC: A61K38/17 ,  C07H21/04 ,  C07K14/47 ,  C12Q1/68 ,  G01N33/574

CPC classification number: A61K38/1709 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/574

Abstract: The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

Abstract translation: 本发明提供在癌细胞中差异表达的多核苷酸以及由此编码的多肽。 这些多核苷酸可用于各种诊断和治疗方法。 本发明还提供减少癌细胞生长的方法。 这些方法可用于治疗癌症。

公开(公告)号：US06673904B2

公开(公告)日：2004-01-06

申请号：US09912935

申请日：2001-07-24

Applicant: Mitsuo Nishikawa ,  Ivan Labat ,  Radoje T. Drmanac ,  Y. Tom Tang ,  Cheng-Chi Chao ,  Nancy Mize ,  John Childs

Inventor： Mitsuo Nishikawa ,  Ivan Labat ,  Radoje T. Drmanac ,  Y. Tom Tang ,  Cheng-Chi Chao ,  Nancy Mize ,  John Childs

IPC: A61K3800

CPC classification number: C07K14/475 ,  A61K38/00 ,  A61K2039/53 ,  Y10S435/81 ,  Y10S435/975

Abstract: The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human and mouse secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from mouse bone marrow and human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, placental, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

Abstract translation: 本发明提供由对应于新型人和小鼠分泌的干细胞生长因子样多肽的这种多核苷酸和突变体或其变体编码的新型多核苷酸和多肽。 这些多核苷酸包括从小鼠骨髓和人胎肝脾，卵巢，成人脑，肺肿瘤，脊髓，子宫颈，卵巢，内皮细胞，脐带，胎盘，淋巴细胞，肺成纤维细胞，胎儿中制备的cDNA文库中分离的核酸序列 大脑和睾丸。 本发明的其它方面包括含有用于产生新的人分泌的干细胞生长因子样多肽的方法的载体和对这些多肽特异的抗体。