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11.发明公开公开(公告)号：US20240166984A1
公开(公告)日：2024-05-23
申请号：US18283748
申请日：2022-03-23
发明人： Caitlin O'MAHONY-BARTNETT , Barry J. MC CARTHY , Christopher W. RODE , Ronan HAYES , Fiona MADDEN , Jingjie MO , Francis C. MASLANKA , Kevin CLARK , Daniel A. TROUT , Pushpraj RANA , Emmanouela GRATSIA , Carl RAFFERTY , Karin M. BALSS , Olav LYNGBERG
摘要： Methods for determining glycation on a molecule and/or a glycan structure on a glycosylated molecule through the use of a combination of spectroscopic analysis and chemometric modeling are described. In addition, methods and systems for producing a molecule with a desired level of glycation, including a non-glycated molecule, and/or a desired level of a glycan structure on a glycosylated molecule are described.
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公开(公告)号：US20240166737A1
公开(公告)日：2024-05-23
申请号：US18493367
申请日：2023-10-24
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , C12N15/63 , G01N33/574
CPC分类号： C07K16/28 , A61P35/00 , C07K16/2809 , C12N15/63 , G01N33/57407 , A61K2039/505 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present disclosure provides MSLN binding agents in the monospecific and multispecific formats, including bispecific MSLN×CD3 binding proteins, and related compositions and methods of use.
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公开(公告)号：US20240166720A1
公开(公告)日：2024-05-23
申请号：US18549795
申请日：2022-03-11
发明人： Ninkka TAMOT , Paul B. HARVILLA , Douglas YAMADA , Manuel Alejandro SEPULVEDA , Rajkumar GANESAN , Sanjaya SINGH
IPC分类号： C07K14/705 , A61K39/00 , A61K39/39 , A61P37/04
CPC分类号： C07K14/70575 , A61K39/39 , A61P37/04 , A61K2039/55516 , C07K2319/00 , C07K2319/30
摘要： Provided herein are bioengineered immunomodulatory fusion proteins and uses thereof for modulating immune responses, as well as uses for improving a response of a subject to a vaccine, or uses for treating a disease or disorder, such as cancer or a pathogen infection. Provided herein is a single chain trimeric CD40L Fc fusion protein comprising (a) three CD40 ligand CD40L subunits covalently linked to one another by peptide linkers (CD40L trimer); and (b) an Fc monomer peptide.
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公开(公告)号：US20240158499A1
公开(公告)日：2024-05-16
申请号：US18549665
申请日：2022-03-11
发明人： Songmao Zheng , John Emery , Jennifer F. Nemeth , Fang Shen , Pankaj Seth
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/565 , C07K2317/622
摘要： The invention provides antigen binding domains that bind Cluster of Differentiation 79B protein (CD79B) protein comprising the antigen binding domains that bind CD79b, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US11981932B2
公开(公告)日：2024-05-14
申请号：US17349328
申请日：2021-06-16
发明人： Iqbal S. Grewal , Rajkumar Ganesan , Sanjaya Singh
IPC分类号： C12N5/074 , A61K35/545 , C12N15/86
CPC分类号： C12N5/0696 , A61K35/545 , C12N15/86 , C12N2501/2315 , C12N2501/999 , C12N2502/1114
摘要： Provided here in are methods of producing induced pluripotent stem cells (iPSCs) and isolated population of produced induced pluripotent stem cells (iPSCs). Also provided herein are methods of treating a subject in need thereof using the produced iPSCs or pharmaceutical compositions comprising the produced iPSCs.
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16.发明公开公开(公告)号：US20240150405A1
公开(公告)日：2024-05-09
申请号：US18492612
申请日：2023-10-23
发明人： Chengzao SUN , Brian Troy FREDERICK , Sandeep SOMANI , Gregory Thomas BOURNE , Raymond PATCH , Ashok BHANDARI , Raffaele INGENITO , Roberto COSTANTE , Danila BRANCA , Elisabetta BIANCHI
IPC分类号： C07K7/64
摘要： The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel diseases.
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公开(公告)号：US20240132835A1
公开(公告)日：2024-04-25
申请号：US17769373
申请日：2020-10-15
摘要： Materials and methods to control a nutrient feed in a cell culture process is provided. A sample is received from a bioreactor comprising a cell culture. A viable cell density and a residual nutrient measurement are determined from the received sample. A daily nutrient feeding target is calculated based on the viable cell density and the residual nutrient measurement. The nutrient is fed to the bioreactor according to the calculated daily nutrient feeding target.
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公开(公告)号：US11965024B2
公开(公告)日：2024-04-23
申请号：US17472198
申请日：2021-09-10
IPC分类号： C07K16/28 , A61K39/00 , A61P35/00 , C07K16/30 , C12N5/0783
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/28 , C07K16/2866 , C07K16/2878 , C07K16/3069 , C12N5/0636 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/565 , C07K2317/92
摘要： Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US11956362B2
公开(公告)日：2024-04-09
申请号：US17586644
申请日：2022-01-27
发明人： Khurram Mahmood , Eric Matthew Bell , Stuart Maxwell Altman , Jeremy Alan Dunn , Sambasiva R. Pedapalli , Christopher Prado Dunn , Nerses Ohanyan , Anand Kothari , Ryan Jeffrey Southwick , Richard Brewster Wickersham, III
CPC分类号： H04L9/3213 , G16H20/00 , H04L9/0637 , H04L63/102 , H04L9/50
摘要： The subject disclosure relates to systems, devices, and methods for executing operations related to procurement of individualized medicine therapies. Also disclosed are embodiments systems, methods, and devices for accessing a wide range of individualized medicine platform modules. Furthermore, disclosed herein are individualized medicine platform systems, methods and devices communicatively coupled to blockchain computing systems comprising several nodes. The disclosed systems, methods, and devices also generate chain of custody and chain of identity event data.
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20.发明公开公开(公告)号：US20240101697A1
公开(公告)日：2024-03-28
申请号：US18208361
申请日：2023-06-12
CPC分类号： C07K16/2896 , A61K45/06 , A61P35/00 , A61P35/02 , C07K16/2809 , C07K16/2878 , C07K16/30 , C07K16/468 , A61K2039/505 , C07K2317/21 , C07K2317/31
摘要： Disclosed are methods of treating cancers and enhancing efficacy of T cell redirecting therapeutics.
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