Abstract:
The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
Abstract:
A generalized grain ruler incorporating a plurality of uniform patches representing a range of granularities, each patch being a perceptually distinct representation of graininess spaced at perceptually uniform intervals and recorded in an increasing sequence of graininess. A method for producing a generalized grain ruler for the measurement, by comparison of, grain in a reference imaging system generated image, comprising, the steps of: a) generating a set of random numbers for each image component; b) filtering each set of random numbers to alter the Wiener spectrum to result in a filtered set of random numbers that look as if they were generated by the reference photographic system; and c) delivering the filtered set of random numbers to an output device that renders them into an image which is the generalized grain ruler.
Abstract:
A ratiometric method for using optical sensors is provided to measure dissolved oxygen in a fluid sample. The sensor is formulated so as to contain an oxygen permeable membrane of a cured perfluorinated urethane polymer and, incorporated therein, an oxygen-sensitive indicator component and a reference dye component. The emission spectrum from the indicator component is calibrated by comparison with that of the reference dye, which is substantially less sensitive to oxygen-quenching and which has a photodecomposition rate similar to the indicator component. Methods for making and using the membrane and sensor are provided as well.
Abstract:
An AC TFEL device includes a front electrode set deposited on a transparent substrate and a rear electrode set, the electrode sets enclosing a thin film laminate which includes a pair of insulating layers sandwiching an alkaline earth thiogallate thin film phosphor doped with a rare earth activator. The thiogallate phosphor layer is capable of producing blue light of sufficient intensity to create a full color TFEL panel.
Abstract:
A method for annealing a deposited material on a substrate structure, where the annealing temperature of the deposited material is greater than the melting temperature of the substrate structure, including the step of inserting the substrate structure into an oven preheated to a temperature above the annealing temperature. The substrate structure is kept in the oven for a time interval wherein the mean temperature of the deposited material is above the annealing temperature and the mean temperature of the substrate structure is below its melting temperature. The substrate structure may be actively cooled while in the oven, thus increasing the time interval the mean temperature of the deposited material can be maintained above the annealing temperature.
Abstract:
A display having a filter disposed on, or in, a portion of the substrate is described. The filter is generally a red filter such that light passing through the filter will produce a red colored light. The filter is comprised of cadmium sulfoselenide in a 62/38 composition (CdS.sub..62 Se.38). The light is generated by a phosphor element which will emit a compatible color light. Other light emitting phosphors, such as green and blue, are also utilized without a filter to provide a multi-colored display.
Abstract:
An optical probe is presented for use in measuring pH and oxygen content in blood in a blood vessel within a living body. An elongated flexible optical fiber means is provided which has a proximal end and a distal end. The distal end is adapted to be inserted into a blood vessel. A membrane is secured to the distal end of the optical fiber and receives light from the distal end of the fiber and returns light therethrough to the proximal end. The membrane is constructed of hydrophilic porous material containing a pH sensitive dye. A plurality of microspheres are embedded in and carried by the membrane. These microspheres are constructed hydrophobic material and each carries a fluorescent dye quenchable with oxygen. Consequently, when light is supplied to the proximal end of the optical fiber, it is conveyed to the membrane. This causes the pH sensitive dye to react and light is conveyed through the optical fiber having an intensity level indicative of the pH level in the blood. The oxygen sensitive dye fluoresces and light is transmitted to the proximal end of an intensity which varies with the partial pressure of oxygen.
Abstract:
A photodetector including a light transmissive electrically conducting layer having a textured surface with a semiconductor body thereon. This layer traps incident light thereby enhancing the absorption of light by the semiconductor body. A photodetector comprising a textured light transmissive electrically conducting layer of SnO.sub.2 and a body of hydrogenated amorphous silicon has a conversion efficiency about fifty percent greater than that of comparative cells. The invention also includes a method of fabricating the photodetector of the invention.
Abstract:
A lenticular array suitable for CCD stripe filters is made by anisotropically etching a V-shaped groove in a 100 silicon wafer wherein the walls of the V-grooves are made by intersecting 111 planes, replicating the V-grooves in metal to form an inverted V-master and spin coating a hardenable resin thereon to form a uniform array of lenses between the peaks.
Abstract:
A recording blank, composed of at least one diffraction grating substrate, such as nickel, covered with a layer of photoresist is used to produce an embossing master by exposing the photoresist to picture information composed of respective white and non-white manifesting regions; developing the exposed photoresist to reveal the grating portions underlying solely the white manifesting regions; electroplating and/or etching the revealed portions to level and obliterate the revealed grating portions, and then removing the remainder of the photoresist.