公开(公告)号：US07006857B2

公开(公告)日：2006-02-28

申请号：US10426160

申请日：2003-04-28

Applicant: James R. Braig ,  Charles E. Kramer ,  Bernhard B. Sterling ,  Daniel S. Goldberger ,  Peng Zheng ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard A. King ,  Casper W. Barnes

Inventor： James R. Braig ,  Charles E. Kramer ,  Bernhard B. Sterling ,  Daniel S. Goldberger ,  Peng Zheng ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard A. King ,  Casper W. Barnes

IPC: A61B5/00 ,  G01N21/71

CPC classification number: A61B5/0059 ,  G01N21/35

Abstract: A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

公开(公告)号：US06944486B2

公开(公告)日：2005-09-13

申请号：US10456109

申请日：2003-06-06

Applicant: James R. Braig ,  Charles E. Kramer ,  Bernhard B. Sterling ,  Daniel S. Goldberger ,  Peng Zheng ,  Arthur M. Shulenberger ,  Rick Trembino ,  Richard A. King ,  Casper W. Barnes

Inventor： James R. Braig ,  Charles E. Kramer ,  Bernhard B. Sterling ,  Daniel S. Goldberger ,  Peng Zheng ,  Arthur M. Shulenberger ,  Rick Trembino ,  Richard A. King ,  Casper W. Barnes

IPC: A61B5/00 ,  G01N21/35

CPC classification number: A61B5/0059 ,  G01N21/35

Abstract: A method and apparatus of determining the analyte concentration of a test sample is described. A temperature gradient is introduced into the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. The modulation of the temperature gradient is controlled by a surface temperature modulation. A transfer function is determined that relates the surface temperature modulation to the modulation of the measured infrared radiation. Reference and analytical signals are detected. In the presence of the selected analyte, phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated and processed to determine analyte concentration in the sample.

Abstract translation: 描述了测定试样的分析物浓度的方法和装置。 将温度梯度引入测试样品，红外辐射检测器测量所选分析物的吸收峰和参考波长的辐射。 温度梯度的调制由表面温度调制控制。 确定将表面温度调制与所测量的红外辐射的调制相关联的传递函数。 检测参考和分析信号。 在所选分析物的存在下，检测到传递函数中的相位和幅度差异。 测量，相关和处理与分析物浓度关系的这些相位和幅度差异，以确定样品中的分析物浓度。

公开(公告)号：US06771993B2

公开(公告)日：2004-08-03

申请号：US10219996

申请日：2002-08-15

Applicant: Peter Rule ,  James R. Braig ,  Philip C. Hartstein ,  Jennifer H. Gable

Inventor： Peter Rule ,  James R. Braig ,  Philip C. Hartstein ,  Jennifer H. Gable

IPC: A61B500

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1491

Abstract: An adapter presents a sample of bodily fluid, such as whole blood, including an analyte to an analyzer window of a non-invasive monitor. The adapter comprises a base material that comprises a first side and a second side. The adapter also comprises a sample accommodating volume extending between an opening in the second side of the base material and an opening in the first side of the base material.

Abstract translation: 适配器将诸如全血的体液样品（包括分析物）提供给非侵入性监测器的分析器窗口。 适配器包括包括第一侧和第二侧的基材。 适配器还包括在基材的第二侧的开口和基材的第一侧中的开口之间延伸的样品容纳体积。

公开(公告)号：US06198949B1

公开(公告)日：2001-03-06

申请号：US09265195

申请日：1999-03-10

Applicant: James R. Braig ,  Bernhard B. Sterling ,  Daniel S. Goldberger ,  Joan C. Godfrey ,  Julian Cortella ,  David J. Correia ,  Arthur M. Shulenberger ,  Charles E. Kramer

Inventor： James R. Braig ,  Bernhard B. Sterling ,  Daniel S. Goldberger ,  Joan C. Godfrey ,  Julian Cortella ,  David J. Correia ,  Arthur M. Shulenberger ,  Charles E. Kramer

IPC: A61B500

CPC classification number: A61B5/01 ,  A61B5/14532 ,  G01J3/02 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/42 ,  G01J5/061

Abstract: A solid-state spectrometer for the non-invasive generation and capture of thermal gradient spectra from human or animal tissue. The spectrometer includes an infrared transmissive thermal mass window for inducing a transient temperature gradient in the tissue by means of conductive heat transfer with the tissue, and a cooling element in operative combination with the thermal mass window for cooling the thermal mass window. Also provided is an infrared sensor for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the tissue, and for providing output signals proportional to the detected infrared emissions. A data capture element is provided for sampling the output signals received from the infrared sensor as the transient temperature gradient progresses into the tissue.

Abstract translation: 一种用于非侵入性生成和捕获来自人或动物组织的热梯度光谱的固态光谱仪。 光谱仪包括用于通过与组织的导电热传递在组织中诱导瞬时温度梯度的红外透射热质窗口，以及与用于冷却热质量窗口的热质量窗口可操作组合的冷却元件。 还提供了一种红外传感器，用于当瞬态温度梯度进入组织时检测从组织发出的红外辐射，并提供与检测到的红外发射成比例的输出信号。 提供数据采集元件，用于对瞬态温度梯度进入组织中的红外传感器接收的输出信号进行采样。

公开(公告)号：US6072180A

公开(公告)日：2000-06-06

申请号：US816723

申请日：1997-03-12

Applicant: Charles E. Kramer ,  Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard A. King

Inventor： Charles E. Kramer ,  Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Arthur M. Shulenberger ,  Rick Trebino ,  Richard A. King

IPC: G01N21/35 ,  A61B5/00 ,  A61B5/01 ,  G01J3/42 ,  G01N21/71 ,  G01N25/72

CPC classification number: G01J3/42 ,  A61B5/14532 ,  A61B5/1455 ,  G01N21/71 ,  G01N25/72 ,  G01N21/35

Abstract: A spectrometer for the non-invasive generation and capture of thermal gradient spectra from human or animal tissue. The spectrometer includes an infrared transmissive thermal mass for inducing a transient temperature gradient in the tissue by means of conductive heat transfer with the tissue, and cooling means in operative combination with the thermal mass for cooling the thermal mass. Also provided is an infrared sensor means for detecting infrared emissions emanating from the tissue as the transient temperature gradient progresses into the tissue, and for providing output signals proportional to the detected infrared emissions. Data capture means is provided for sampling the output signals received from the infrared sensor means as the transient temperature gradient progresses into the tissue.

Abstract translation: 用于非侵入性生成和捕获来自人或动物组织的热梯度光谱的光谱仪。 光谱仪包括红外透射热物质，用于通过与组织的导电热传递来诱导组织中的瞬态温度梯度，以及与用于冷却热质量的热质量操作组合的冷却装置。 还提供了一种红外传感器装置，用于当瞬态温度梯度进入组织时检测从组织发出的红外辐射，并提供与检测到的红外发射成比例的输出信号。 提供数据捕获装置，用于当瞬态温度梯度进入组织时对从红外传感器装置接收的输出信号进行采样。

公开(公告)号：US5095913A

公开(公告)日：1992-03-17

申请号：US522208

申请日：1990-05-11

Applicant: Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

Inventor： Mark Yelderman ,  Daniel S. Goldberger ,  James R. Braig

IPC: A61B5/083 ,  G01J1/24 ,  G01J5/12 ,  G01N21/31 ,  G01N21/35

CPC classification number: G01N21/3504 ,  A61B5/083 ,  G01J1/24 ,  G01J5/12 ,  G01N2021/3166 ,  G01N2201/126

Abstract: Methods and apparatus for constructing optically stabilized, shutterless infrared capnographs are disclosed. The capnographs of the present invention provide the absolute concentration of the constituents of the respiratory airstream of a patient, without the thermal drift problems normally associated with thermopile detectors, thereby providing a device with a high degree of accuracy. The present invention eliminates the need for a mechanical shutter to modulate the incident infrared beam and the need for a modulated source, thereby increasing the reliability and response time of the devices disclosed. Capnographs which are substantially unaffected by changes in the ambient temperature at which they operate are provided by connecting pairs of optically filtered thermopiles in series and processing the resulting differential pair.

Abstract translation: 公开了用于构造光学稳定的无闸门红外捕集仪的方法和装置。 本发明的血氧监护仪提供了患者的呼吸气流的成分的绝对浓度，而没有通常与热电堆检测器相关的热漂移问题，从而提供高精度的装置。 本发明不需要机械快门来调制入射的红外光束和调制源的需要，从而增加所公开的设备的可靠性和响应时间。 基本上不受其工作环境温度变化影响的测井仪通过串联连接成对的光学过滤的热电堆并处理所得的差分对来提供。

公开(公告)号：US08535522B2

公开(公告)日：2013-09-17

申请号：US12705054

申请日：2010-02-12

Applicant: Barry Neil Fulkerson ,  James R. Braig

Inventor： Barry Neil Fulkerson ,  James R. Braig

IPC: B01D61/32 ,  B01D61/28 ,  B01D61/30 ,  A61M1/14

CPC classification number: A61M1/3653 ,  A61M1/3639 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2230/06

Abstract: The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.

Abstract translation: 本发明涉及一种具有断开监视器的透析系统，用于确定与患者的血液线路连接是否已断开。 它包括与患者流体连通的血液回路和透析电路，用于产生指示血液回路中脉冲信号的信号的压力传感器，用于产生指示患者脉搏和断开的信号的心脏参考信号发生器 监控。 断开监视器包括：压力传感器数据接收器，用于接收指示血液回路中的脉冲信号的信号;心脏参考信号接收器，用于接收指示患者脉搏的信号;以及处理器，用于将指示 脉搏信号和指示患者脉搏的信号，以产生指示与患者的血液线路连接断开的数据。

公开(公告)号：US20120330115A1

公开(公告)日：2012-12-27

申请号：US13423029

申请日：2012-03-16

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/157

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US08197770B2

公开(公告)日：2012-06-12

申请号：US12359874

申请日：2009-01-26

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: B01L3/00

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing and a first fluid passageway extending from the module housing. The first fluid passageway has a patient end remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell is configured to hold at least a portion of the first component.

Abstract translation: 流体处理模块被配置为可移除地与可重复使用的主流体处理装置接合。 模块包括模块壳体和从模块壳体延伸的第一流体通道。 第一流体通道具有远离壳体的患者端。 第一流体通道被配置为提供与患者体内的体液的流体连通。 流体组分分离器与第一流体通道流体连通。 流体组分分离器构造成将至少一种组分与从患者抽出的体液的一部分分离。 光谱样品池被配置为保持第一组分的至少一部分。

公开(公告)号：US08139207B2

公开(公告)日：2012-03-20

申请号：US13210347

申请日：2011-08-15

Applicant: James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Philip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: G01N33/48

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。