公开(公告)号：US20100234786A1

公开(公告)日：2010-09-16

申请号：US12705054

申请日：2010-02-12

Applicant: Barry Neil Fulkerson ,  James R. Braig

Inventor： Barry Neil Fulkerson ,  James R. Braig

IPC: A61M1/14

CPC classification number: A61M1/3653 ,  A61M1/3639 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2230/06

Abstract: The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.

Abstract translation: 本发明涉及一种具有断开监视器的透析系统，用于确定与患者的血液线路连接是否已断开。 它包括与患者流体连通的血液回路和透析电路，用于产生指示血液回路中脉冲信号的信号的压力传感器，用于产生指示患者脉搏和断开的信号的心脏参考信号发生器 监控。 断开监视器包括：压力传感器数据接收器，用于接收指示血液回路中的脉冲信号的信号;心脏参考信号接收器，用于接收指示患者脉搏的信号;以及处理器，用于将指示 脉搏信号和指示患者脉搏的信号，以产生指示与患者的血液线路连接断开的数据。

公开(公告)号：US08535522B2

公开(公告)日：2013-09-17

申请号：US12705054

申请日：2010-02-12

Applicant: Barry Neil Fulkerson ,  James R. Braig

Inventor： Barry Neil Fulkerson ,  James R. Braig

IPC: B01D61/32 ,  B01D61/28 ,  B01D61/30 ,  A61M1/14

CPC classification number: A61M1/3653 ,  A61M1/3639 ,  A61M1/3656 ,  A61M1/3659 ,  A61M2230/06

Abstract: The present invention is directed to a dialysis system with a disconnection monitor for determining if a blood line connection to a patient has been disconnected. It includes a blood circuit in fluid communication with a patient and a dialysis circuit, a pressure transducer for generating a signal indicative of a pulse signal in the blood circuit, a cardiac reference signal generator for generating a signal indicative of the patient's pulse and a disconnection monitor. The disconnection monitor includes a pressure transducer data receiver for receiving the signal indicative of the pulse signal in the blood circuit, a cardiac reference signal receiver for receiving the signal indicative of the patient's pulse, and a processor for cross-correlating the signal indicative of the pulse signal in the blood circuit and the signal indicative of the patient's pulse to generate data indicative of a disconnection of the blood line connection to the patient.

Abstract translation: 本发明涉及一种具有断开监视器的透析系统，用于确定与患者的血液线路连接是否已断开。 它包括与患者流体连通的血液回路和透析电路，用于产生指示血液回路中脉冲信号的信号的压力传感器，用于产生指示患者脉搏和断开的信号的心脏参考信号发生器 监控。 断开监视器包括：压力传感器数据接收器，用于接收指示血液回路中的脉冲信号的信号;心脏参考信号接收器，用于接收指示患者脉搏的信号;以及处理器，用于将指示 脉搏信号和指示患者脉搏的信号，以产生指示与患者的血液线路连接断开的数据。

公开(公告)号：US09848821B2

公开(公告)日：2017-12-26

申请号：US13162315

申请日：2011-06-16

Applicant: Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

Inventor： Peter Rule ,  James R. Braig ,  Richard Keenan ,  David N. Callicoat

IPC: A61B5/00 ,  B65D33/00 ,  B65D81/00 ,  A61D5/00 ,  A61M1/00 ,  A61M27/00 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15 ,  A61B5/153 ,  A61B5/157 ,  A61M5/14 ,  A61M5/172 ,  A61M5/145 ,  A61M5/142

CPC classification number: A61B5/4839 ,  A61B5/14532 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/157 ,  A61B5/6866 ,  A61M5/1415 ,  A61M5/1452 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/201

Abstract: Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.

公开(公告)号：US09414782B2

公开(公告)日：2016-08-16

申请号：US13619825

申请日：2012-09-14

Applicant: James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

Inventor： James R. Braig ,  Richard Keenan ,  Peter Rule ,  Gil Rivas ,  Mahesh Seetharaman

IPC: A61M5/172 ,  A61B5/00 ,  A61B5/155 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  G06F19/00 ,  A61M5/168 ,  A61M5/14 ,  A61M5/142

CPC classification number: A61B5/4839 ,  A61B5/1427 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1495 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150786 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/412 ,  A61B5/7475 ,  A61M5/16827 ,  A61M5/1723 ,  A61M2005/1404 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2205/12 ,  A61M2205/3303 ,  A61M2209/084 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468

Abstract: Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

公开(公告)号：US08936755B2

公开(公告)日：2015-01-20

申请号：US13423077

申请日：2012-03-16

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00 ,  A61B5/15 ,  A61B5/155 ,  A61B5/145 ,  A61M5/172 ,  A61B5/1455 ,  A61B5/157 ,  A61B10/00 ,  A61M5/142 ,  A61M5/168 ,  A61M5/36 ,  A61M5/38 ,  G01N21/03

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14525 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/251 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

Abstract translation: 公开了一种用于分析体液组成的装置。 该装置可以包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端和与流体处理网络可操作地接合的泵单元。 泵单元可以具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中，泵单元可操作以从体外抽取体液样本 患者通过病人结束。 该装置可以包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。

公开(公告)号：US08491501B2

公开(公告)日：2013-07-23

申请号：US13046611

申请日：2011-03-11

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00 ,  B65D81/00 ,  A61M37/00 ,  G01N35/00 ,  G01N9/30

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150358 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  G06F19/00 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.

公开(公告)号：US20120232362A1

公开(公告)日：2012-09-13

申请号：US13423077

申请日：2012-03-16

Applicant: Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

Inventor： Jennifer H. Gable ,  James R. Braig ,  Kenneth I. Li ,  Mark Wechsler ,  Peng Zheng ,  Richard Keenan

IPC: A61B5/00

CPC classification number: A61B5/157 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/1411 ,  A61B5/1427 ,  A61B5/1451 ,  A61B5/14517 ,  A61B5/14525 ,  A61B5/14532 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150267 ,  A61B5/150755 ,  A61B5/150992 ,  A61B5/4839 ,  A61B10/0064 ,  A61B2560/0443 ,  A61M5/14212 ,  A61M5/14232 ,  A61M5/16854 ,  A61M5/1723 ,  A61M5/365 ,  A61M5/38 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2230/20 ,  A61M2230/201 ,  G01N21/03 ,  G01N21/251 ,  G01N21/3577 ,  G01N2021/3595 ,  G01N2201/02 ,  G01N2201/061 ,  Y10T137/4478 ,  Y10T137/7722 ,  Y10T137/86485 ,  Y10T436/111666 ,  Y10T436/2575

Abstract: Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

Abstract translation: 公开了一种用于分析体液组成的装置。 该装置可以包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端和与流体处理网络可操作地接合的泵单元。 泵单元可以具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中，泵单元可操作以从体外抽取体液样本 患者通过病人结束。 该装置可以包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。

公开(公告)号：US20100249547A1

公开(公告)日：2010-09-30

申请号：US12815372

申请日：2010-06-14

Applicant: James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

Inventor： James R. Braig ,  Peter Rule ,  Phillip C. Hartstein ,  Bernhard B. Sterling ,  Jennifer H. Gable ,  Kenneth I. Li

IPC: A61B5/15

CPC classification number: A61B5/157 ,  A61B5/01 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150083 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150458 ,  A61B5/150503 ,  A61B5/150618 ,  A61B5/150717 ,  A61B5/15087 ,  A61B5/151 ,  A61B5/15107 ,  A61B5/15136 ,  A61B5/1514 ,  A61B5/15194 ,  A61B5/6826 ,  A61B5/6838 ,  A61B10/0045 ,  A61B2562/0295 ,  A61B2562/12 ,  G01N21/03 ,  G01N21/0332 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/3581 ,  G01N33/49 ,  G01N33/66 ,  G01N2021/0389 ,  G01N2201/02 ,  G01N2201/068

Abstract: A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

Abstract translation: 能够在患者附近部署的无试剂全血分析物检测系统具有能够发射包括光谱带的辐射束的源。 全血系统还具有光束的光路中的检测器。 全血系统还具有容纳源和检测器的壳体。 全血系统还具有位于束的光路中的样品元件。 样品元件具有不消除光谱带中的辐射束的透射率的样品池和样品池壁。

公开(公告)号：US07785258B2

公开(公告)日：2010-08-31

申请号：US11316523

申请日：2005-12-21

Applicant: James R. Braig ,  Peter Rule

Inventor： James R. Braig ,  Peter Rule

IPC: A61B5/00 ,  A61B5/05 ,  C12M1/34 ,  C12M3/00 ,  C12M1/36 ,  C12M1/00

CPC classification number: G06F19/3468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14557 ,  A61B5/1486 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150862 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B5/4839 ,  A61M5/14212 ,  A61M2230/20 ,  G01N21/274 ,  G01N21/35 ,  G01N2201/1293 ,  G06F19/00

Abstract: In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.

Abstract translation: 在某些实施例中，维持患者健康的方法使用分析物检测系统。 分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。 该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。 该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

公开(公告)号：US07593108B2

公开(公告)日：2009-09-22

申请号：US11841878

申请日：2007-08-20

Applicant: Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Philip C. Hartstein ,  Robert D. Gaffney

Inventor： Bernhard B. Sterling ,  James R. Braig ,  Daniel S. Goldberger ,  Philip C. Hartstein ,  Robert D. Gaffney

IPC: G01N33/48 ,  G01N21/00 ,  A61B5/00

CPC classification number: A61B5/14546 ,  A61B5/14532 ,  G01N21/03 ,  G01N21/314 ,  G01N21/35

Abstract: A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.

Abstract translation: 一种方法确定样品中的分析物浓度。 样品包括分析物和物质。 该方法包括提供样品的吸收数据。 该方法还包括提供该物质的参考吸收数据。 该方法还包括计算吸收数据的物质贡献。 该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。