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    Enzymatic modification of the surface of a polyester fiber or article
    15.
    发明授权
    Enzymatic modification of the surface of a polyester fiber or article 有权
    聚酯纤维或制品的表面的酶改性

    公开(公告)号：US06254645B1

    公开(公告)日：2001-07-03

    申请号：US09435083

    申请日：1999-11-05

    Applicant: James T. Kellis, Jr. ,  Ayrookaran J. Poulose ,  Mee-Young Yoon

    Inventor： James T. Kellis, Jr. ,  Ayrookaran J. Poulose ,  Mee-Young Yoon

    IPC: C09B6700

    CPC classification number: D06P3/522 ,  D06M16/003 ,  D06M2101/32 ,  D06M2200/00 ,  D06P1/0004 ,  D06P5/22 ,  Y10S8/04

    Abstract: A method is provided for improving the uptake of a cationic compound onto a polyester article starting material, comprising the steps of: (a) obtaining a polyesterase enzyme; (b) contacting said polyesterase enzyme with said polyester article starting material under conditions and for a time suitable for said polyesterase to produce surface modification of said polyester article starting material and produce a surface modified polyester; (c) contacting said modified polyester article, subsequently or simultaneously with said step (b) with a cationic compound whereby adherence of said cationic compound to said modified polyester is increased compared to said polyester starting material. Also disclosed is a method for increasing the hydrophilicity of a polyester to improve fabric characteristics such as stain resistance, wettability and/or dyeability.

    Abstract translation: 提供了一种改善阳离子化合物在聚酯制品原料上的吸收的方法，包括以下步骤：（a）获得聚酯酶; （b）使所述聚酯酶与所述聚酯制品起始材料在适于所述聚酯酶的条件下进行接触以产生所述聚酯制品原料的表面改性并制备表面改性聚酯; （c）随后或与所述步骤（b）同时地将所述改性聚酯制品与阳离子化合物接触，由此所述阳离子化合物与所述改性聚酯的粘合比所述聚酯起始材料增加。 还公开了提高聚酯的亲水性以提高织物特性如耐污染性，润湿性和/或染色性的方法。

    Multiply-Substituted Protease Variants
    19.
    发明申请
    Multiply-Substituted Protease Variants 审中-公开
    多重取代的蛋白酶变体

    公开(公告)号：US20110091958A1

    公开(公告)日：2011-04-21

    申请号：US12776921

    申请日：2010-05-10

    Applicant: AYROOKARAN J. POULOSE ,  DAVID A. ESTELL ,  JAMES T. KELLIS, JR. ,  RICHARD R. BOTT

    Inventor： AYROOKARAN J. POULOSE ,  DAVID A. ESTELL ,  JAMES T. KELLIS, JR. ,  RICHARD R. BOTT

    IPC: C12N9/48 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21

    CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38609 ,  C12Y304/21062

    Abstract: Novel enzyme variants including protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue correspond to positions 27, 45, 170, 181, 251 and 271 of Bacillus amyloliquefaciens subtilisin. Additional variants comprising at least one additional substituion at a positon selected from 1, 14, 49, 61, 87, 100, 102, 118, 128, 204 and 258 of Bacillus amyloliquefaciens subtilisin are also described.

    Abstract translation: 公开了包含衍生自天然或重组非人蛋白酶的DNA序列的蛋白酶变体的新型酶变体。 一般来说，变体蛋白酶通过体外修饰编码天然存在或重组蛋白酶的前体DNA序列获得，以产生前体蛋白酶的氨基酸序列中的多个氨基酸残基的取代。 这种变体蛋白酶具有与前体蛋白酶不同的性质，例如改变的洗涤性能。 取代的氨基酸残基对应于解淀粉芽孢杆菌枯草杆菌蛋白酶的位置27,45,170,181,251和271。 还描述了在解淀粉芽孢杆菌枯草杆菌蛋白酶的1,4,14,69,61,87,100,102,118,128,204和258的选择位置中至少包含一个另外的取代基的另外的变体。

    Methods for Improving Protein Properties
    20.
    发明申请
    Methods for Improving Protein Properties 审中-公开
    改善蛋白质性质的方法

    公开(公告)号：US20100233780A1

    公开(公告)日：2010-09-16

    申请号：US12602989

    申请日：2008-06-06

    Applicant: Wolfgang Aehle ,  Luis Gustavo Cascao-Pereira ,  James T. Kellis, JR. ,  Andrew Shaw

    Inventor： Wolfgang Aehle ,  Luis Gustavo Cascao-Pereira ,  James T. Kellis, JR. ,  Andrew Shaw

    IPC: C12N9/48 ,  C07K14/00 ,  C12N9/00 ,  C12N9/26 ,  C12N9/42 ,  C12N9/18 ,  C12N9/20 ,  C12N9/88 ,  C12N9/02 ,  C12N9/10 ,  C12N9/08

    CPC classification number: C12N9/54 ,  C11D3/386 ,  C11D3/38681 ,  C12N9/2411 ,  C12N9/2417 ,  C12N15/1034 ,  C12Y302/01001 ,  C12Y304/21062

    Abstract: The present invention provides methods for engineering proteins to optimize their performance under certain environmental conditions of interest. In some embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity under particular environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their catalytic activity and/or stability under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for engineering enzymes to optimize their storage stability, particularly under adverse environmental conditions. In some preferred embodiments, the present invention provides methods for altering the net surface charge and/or surface charge distribution of enzymes (e.g., metalloproteases) to obtain enzyme variants that demonstrate improved performance and/or stability in detergent formulations as compared to the starting or parent enzyme.

    Abstract translation: 本发明提供了在某些感兴趣的环境条件下工程化蛋白质以优化其性能的方法。 在一些实施方案中，本发明提供了工程化酶以在特定环境条件下优化其催化活性的方法。 在一些优选实施方案中，本发明提供了工程化酶以在不利的环境条件下优化其催化活性和/或稳定性的方法。 在一些优选的实施方案中，本发明提供了工程化酶优化其储存稳定性的方法，特别是在不利的环境条件下。 在一些优选的实施方案中，本发明提供了用于改变酶（例如金属蛋白酶）的净表面电荷和/或表面电荷分布以获得酶变体的方法，所述酶变体与洗涤剂配方相比起始或以后可以改善洗涤剂配方的性能和/或稳定性 亲本酶。

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