公开(公告)号：US12162951B2

公开(公告)日：2024-12-10

申请号：US17376830

申请日：2021-07-15

Applicant: Janssen Biotech, Inc.

Inventor： Zemeda Ainekulu ,  Qiang Chen ,  Ellen Chi ,  Wilson Edwards ,  Matt Husovsky ,  Ann Lacombe ,  Quynh Nguyen ,  Paul H. Kim ,  H. Mimi Zhou ,  John T. Lee

IPC: G01N33/53 ,  C07H21/04 ,  C07K1/22 ,  C07K16/42 ,  C12N5/02 ,  C12N15/00 ,  C12P21/06 ,  G01N33/68

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.

公开(公告)号：US20240384002A1

公开(公告)日：2024-11-21

申请号：US18792966

申请日：2024-08-02

Applicant: Janssen Biotech, Inc.

Inventor： Vadim Dudkin ,  Shalom Goldberg ,  Michael J. McCauley ,  Kristen Wiley

IPC: C07K16/30 ,  A61K47/54 ,  A61K47/62 ,  A61K47/68 ,  C07K1/107

Abstract: Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.

公开(公告)号：US20240360421A1

公开(公告)日：2024-10-31

申请号：US18630620

申请日：2024-04-09

Applicant: JANSSEN BIOTECH, INC.

Inventor： Iqbal S GREWAL ,  Rajkumar GANESAN ,  Sanjaya SINGH

IPC: C12N5/074 ,  A61K35/545 ,  C12N15/86

CPC classification number: C12N5/0696 ,  A61K35/545 ,  C12N15/86 ,  C12N2501/2315 ,  C12N2501/999 ,  C12N2502/1114

Abstract: Provided here in are methods of producing induced pluripotent stem cells (iPSCs) and isolated population of produced induced pluripotent stem cells (iPSCs). Also provided herein are methods of treating a subject in need thereof using the produced iPSCs or pharmaceutical compositions comprising the produced iPSCs.

公开(公告)号：US12129310B2

公开(公告)日：2024-10-29

申请号：US18122948

申请日：2023-03-17

Applicant: Janssen Biotech, Inc.

Inventor： Sanjaya Singh ,  Rajkumar Ganesan ,  Jun Chen ,  Iqbal S. Grewal

IPC: C07K16/42 ,  G01N33/68

CPC classification number: C07K16/42 ,  G01N33/6857 ,  C07K2317/14 ,  C07K2317/34

Abstract: Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.

公开(公告)号：US20240327869A1

公开(公告)日：2024-10-03

申请号：US18744565

申请日：2024-06-14

Applicant: JANSSEN BIOTECH, INC.

Inventor： William Lloyd PERRY, III ,  Brian TOMKOWICZ

IPC: C12N15/86 ,  C12N7/00

CPC classification number: C12N15/86 ,  C12N7/00 ,  C12N2750/14121 ,  C12N2750/14151 ,  C12N2800/50 ,  C12N2830/36 ,  C12N2830/40 ,  C12N2830/42 ,  C12N2830/50

Abstract: Recombinant constructs, cells and means for improved production of Adeno-Associated Viruses (AAVs) are described. Also described are methods of using the constructs and cells to produce recombinant AAVs.

公开(公告)号：US12098210B2

公开(公告)日：2024-09-24

申请号：US18052174

申请日：2022-11-02

Applicant: JANSSEN BIOTECH, INC.

Inventor： Jenna Goldberg ,  Jagoda Jasielec ,  Raluca Verona ,  Brendan Weiss

IPC: C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC classification number: C07K16/2878 ,  A61K31/454 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39558 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/30 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/31

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of BCMAxCD3 bispecific antibodies. In particular, methods are disclosed of using a BCMAxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers, particularly relapsed or refractory multiple myeloma.

公开(公告)号：US20240294884A1

公开(公告)日：2024-09-05

申请号：US18663981

申请日：2024-05-14

Applicant: Janssen Biotech, Inc.

Inventor： Ricardo ATTAR ,  Jason DEHART ,  Selina KHAN ,  Vinod KRISHNA ,  Jenifer LUM ,  Christian MAINE ,  Barbara SANDERS ,  Manuel Alejandro SEPULVEDA ,  Patrick WILKINSON ,  Roland ZAHN

IPC: C12N7/00 ,  A61K39/00 ,  A61K45/06 ,  C12N15/86

CPC classification number: C12N7/00 ,  A61K45/06 ,  C12N15/86 ,  A61K2039/505 ,  C12N2750/14111

Abstract: Provided are vaccines, polypeptides and polynucleotides based on mutant CALR and JAK2 sequences, vectors, host cells, viruses, and methods of making and using them. The disclosure also provides methods of inducing an immune response and methods of treating, preventing, reducing a risk of onset or delaying the onset of a clinical condition characterized by an expression of JAK2V617F or CALR exon 9 mutant, or both JAK2V617F and CALR exon 9 mutant, wherein the method comprises a plurality of administrations of any of the compositions comprising polynucleotides, polypeptides or vectors disclosed herein.

公开(公告)号：US12076413B2

公开(公告)日：2024-09-03

申请号：US17512195

申请日：2021-10-27

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar Ganesan ,  Iqbal S. Grewal ,  Sanjaya Singh ,  Michael Riis Hansen

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/00

CPC classification number: A61K47/6897 ,  C07K16/2809 ,  A61K39/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73

Abstract: Provided herein, in certain aspects, are antibodies that bind to T cell receptor (TCR) Vγ9 (TRGV9), TCR Vδ2 (TRDV2), or the TCR gamma/delta constant region (TRGDC), as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making and using the antibodies are also provided.

公开(公告)号：US12065488B2

公开(公告)日：2024-08-20

申请号：US17516082

申请日：2021-11-01

Applicant: Janssen Biotech, Inc. ,  Applied Molecular Evolution, Inc.

Inventor： Yan Chen ,  Debra Gardner ,  David M. Knight ,  Michael W. Lark ,  Bailin Liang ,  David M. Marquis ,  David J. Shealy ,  Eric Michael Smith ,  Xiao-yu R. Song ,  Vedrana Stojanovic-Susulic ,  Raymond Sweet ,  Susan Tam ,  Alain P. Vasserot ,  Sheng-Jiun Wu ,  Jing Yang

IPC: C07K16/24 ,  A61K39/00

CPC classification number: C07K16/248 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.

公开(公告)号：US20240226893A1

公开(公告)日：2024-07-11

申请号：US18559029

申请日：2022-05-12

Applicant: IMEC VZW ,  Janssen Biotech Inc.

Inventor： Peter Peumans ,  Olivier Henry ,  Willem Van Roy ,  Tim Stakenborg ,  Alexander Graham Irwin Tulloch

IPC: B01L3/00

CPC classification number: B01L3/502761 ,  B01L3/502715 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/086 ,  B01L2400/088

Abstract: A device for sorting biological cells comprises a flow channel configured to pass a flow of liquid carrying the biological cells. The flow channel comprises at least one zone associated with a cell category. Each zone of the flow channel comprises at least one surface coated with molecules having an affinity to the cell category associated with the zone, the at least one surface of the zone being configured to modify, by the molecules of the surface, a movement of a cell belonging to the associated cell category of the zone as the cell passes the zone. The device comprises a detector configured to detect a cell exhibiting at least one modified movement in one zone of the flow channel, and to transmit a trigger signal based on the detection of the cell. The device further comprises an actuator configured to divert the detected cell based on the trigger signal.