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22 条记录 (耗时 0.02 秒)

    Pressurized flat conformal tank
    11.
    发明申请
    Pressurized flat conformal tank 审中-公开
    加压扁平保形槽

    公开(公告)号：US20060021987A1

    公开(公告)日：2006-02-02

    申请号：US10909114

    申请日：2004-07-29

    申请人： John Smolik

    发明人： John Smolik

    IPC分类号： F17C1/00

    CPC分类号： F17C1/00 ,  F17C2201/0133 ,  F17C2201/0157 ,  F17C2201/0166 ,  F17C2201/056 ,  F17C2203/013 ,  F17C2203/0629 ,  F17C2203/0636 ,  F17C2223/0123 ,  F17C2223/013 ,  F17C2223/035 ,  F17C2260/013 ,  F17C2260/018 ,  F17C2270/0168 ,  F17C2270/0189 ,  F17C2270/0194

    摘要： A vessel for containing a fluid under pressure comprises essentially flat parallel surfaces connected by hemispherical edge closures. Internal tension members are connected between the parallel surfaces to distribute the pressure of the fluid in the vessel. The shape of the vessel can be generally square, triangular, toroidal, or other variation to conform to an available space. The skin of the vessel, the hemispheric edge closures, and the internal tension members are typically fabricated from a high strength lightweight material, such as titanium.

    摘要翻译： 用于容纳压力的流体的容器包括通过半球形边缘封闭连接的基本平坦的平行表面。 内部张力构件连接在平行表面之间以分配容器中的流体的压力。 容器的形状可以是大致正方形，三角形，环形或其他变化以符合可用空间。 容器的皮肤，半球形边缘封闭件和内部拉伸构件通常由诸如钛的高强度轻质材料制成。

    Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins
    12.
    发明授权
    Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins 有权
    增强蛋白质稳定化和生产可用于生产这种稳定化蛋白质的细胞系的方法

    公开(公告)号：US06468777B2

    公开(公告)日：2002-10-22

    申请号：US09803634

    申请日：2001-03-09

    申请人： H. Craig Dees ,  John Smolik

    发明人： H. Craig Dees ,  John Smolik

    IPC分类号： C12N701

    CPC分类号： C07K14/47 ,  C12N7/00 ,  C12N2760/18451

    摘要： A method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products. The present invention is also directed to methods for selection or engineering of cell lines yielding such enhanced stabilized products. More specifically, example embodiments of the present invention are directed to methods for enhancing production of a viral agent, production of cell lines exhibiting permanent genetic modification, production of permissive eucaryotic cell lines, enhancing functional recombinant product yield, and the products of such methods.

    摘要翻译： 通过应激蛋白和产生的蛋白质产物增强蛋白质生产的控制和稳定来增加病毒，病毒蛋白质和其他相关生物材料的产量的方法。 本发明还涉及用于选择或工程化产生这种增强的稳定化产物的细胞系的方法。 更具体地，本发明的示例性实施方案涉及用于增强病毒剂的产生，显示永久遗传修饰的细胞系的产生，允许的真核细胞系的产生，增强功能重组产物产量以及这些方法的产物的方法。

    Intracorporeal Medicaments for High Energy Phototherapeutic Treatment of Disease
    13.
    发明申请
    Intracorporeal Medicaments for High Energy Phototherapeutic Treatment of Disease 审中-公开
    体内高能量光疗治疗疾病的药物

    公开(公告)号：US20100076246A1

    公开(公告)日：2010-03-25

    申请号：US12543653

    申请日：2009-08-19

    申请人： H. Craig Dees ,  Timothy C. Scott ,  Eric A. Wachter ,  Walter G. Fisher ,  John Smolik

    发明人： H. Craig Dees ,  Timothy C. Scott ,  Eric A. Wachter ,  Walter G. Fisher ,  John Smolik

    IPC分类号： A61N5/10 ,  A61K31/352 ,  A61P35/04

    CPC分类号： A61K31/352 ,  A61B2017/22062 ,  A61B2017/22087 ,  A61K9/0019 ,  A61K41/0038 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/1098 ,  C07D311/82

    摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

    摘要翻译： 描述了新的体内放射碘化物药物和用于治疗人或动物组织的这种高能光疗药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤化呫吨衍生物。 卤化呫吨构成了一种有效的放射增敏剂，其在用电离辐射照射治疗部位时变得光活化。 在本发明的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官的各种病症， 循环系统和相关器官，头颈部，内分泌和淋巴系统及相关器官，各种其他组织，例如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。 在另一个实施方案中，这些药物是以包括液体，半固体，固体或气溶胶输送载体在内的各种制剂生产的。

    Topical Medicaments and Methods for Photodynamic Treatment of Disease
    15.
    发明申请
    Topical Medicaments and Methods for Photodynamic Treatment of Disease 有权
    光动力治疗疾病的专题药物和方法

    公开(公告)号：US20080118578A1

    公开(公告)日：2008-05-22

    申请号：US11936963

    申请日：2007-11-08

    申请人： H. Craig Dees ,  Timothy C. Scott ,  John Smolik ,  Eric A. Wachter ,  Walter G. Fisher

    发明人： H. Craig Dees ,  Timothy C. Scott ,  John Smolik ,  Eric A. Wachter ,  Walter G. Fisher

    IPC分类号： A61K33/14 ,  A61P43/00

    CPC分类号： A61K31/352 ,  A61K33/14 ,  A61K41/00 ,  A61K2300/00

    摘要： New photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene. The halogenated xanthenes constitute a family of potent photosensitizers that become photoactivated upon illumination of the treatment site with visible wavelengths of light. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs; the mouth and digestive tract and related organs; the urinary and reproductive tracts and related organs; the respiratory tract and related organs; various other internal or external tissue surfaces, such as tissue surfaces exposed during surgery; and for treatment of a variety of conditions related to microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid or aerosol delivery vehicles.

    摘要翻译： 描述了用于治疗人或动物组织的新的光动力学，局部适用药物和这种光动力药物的某些医学用途，其中这种药物的主要活性成分是卤代呫吨。 卤化呫吨构成了一系列有效的光敏剂，在用可见光波长照射治疗部位时变得光活化。 在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官的各种病症; 口腔和消化道及相关器官; 泌尿生殖道及相关器官; 呼吸道及相关器官; 各种其他内部或外部组织表面，例如在手术期间暴露的组织表面; 并用于治疗与微生物或寄生虫感染有关的各种病症。 在另一个优选的实施方案中，这种药物是以包括液体，半固体或气溶胶递送载体在内的各种制剂生产的。