公开(公告)号：US07202938B2

公开(公告)日：2007-04-10

申请号：US10918700

申请日：2004-08-16

Applicant: Theodorus M. Modderman ,  Gerrit J. Nijmeijer ,  Nicholaas A. A. J. van Asten ,  Frederik T. E. Heuts ,  Richard J. H. Du Croo de Jongh ,  Marcus E. J. Boonman ,  Jacob F. F. Klinkhamer

Inventor： Theodorus M. Modderman ,  Gerrit J. Nijmeijer ,  Nicholaas A. A. J. van Asten ,  Frederik T. E. Heuts ,  Richard J. H. Du Croo de Jongh ,  Marcus E. J. Boonman ,  Jacob F. F. Klinkhamer

IPC: G03B27/52 ,  G03B27/42 ,  G03B27/32

CPC classification number: G03F9/7026 ,  G03F9/70 ,  G03F9/7034 ,  G03F9/7049 ,  G03F9/7096

Abstract: In an off-axis levelling procedure a height map of the substrate is generated at a measurement station. The height map is referenced to a physical reference surface of the substrate table. The physical reference surface may be a surface in which is inset a transmission image sensor. At the exposure station the height of the physical reference surface is measured and related to the focal plane of the projection lens. The height map can then be used to determine the optimum height and/or tilt of substrate table to position the exposure area on the substrate in best focus during exposure. The same principles can be applied to (reflective) masks.

公开(公告)号：US07192726B1

公开(公告)日：2007-03-20

申请号：US10049374

申请日：2000-08-11

Applicant: Marcus E. Carr, Jr. ,  Ashok Krischnaswami ,  Erika Martin

Inventor： Marcus E. Carr, Jr. ,  Ashok Krischnaswami ,  Erika Martin

IPC: C12Q1/56

CPC classification number: G01N33/86 ,  G01N2800/224 ,  G01N2800/226 ,  G01N2800/323 ,  G01N2800/52

Abstract: Platelet contractile force and/or clot elastic modulus measurements are used to identify patients at risk for atherosclerosis or for bleeding during surgical procedures or other applications. Measurements which are elevated are indicative of atherosclerosis, and measurements which are reduced are indicative of a bleeding risk.

Abstract translation: 血小板收缩力和/或凝块弹性模量测量用于鉴定在外科手术或其他应用中有动脉粥样硬化或出血风险的患者。 升高的测量指示动脉粥样硬化，并且减少的测量指示出血风险。

公开(公告)号：US07115042B2

公开(公告)日：2006-10-03

申请号：US10618528

申请日：2003-07-11

Applicant: Thomas Gulan ,  Marcus E. Frankovitch ,  Michael G. Simon ,  Anthony Perun

Inventor： Thomas Gulan ,  Marcus E. Frankovitch ,  Michael G. Simon ,  Anthony Perun

IPC: A63B69/36

CPC classification number: A63B69/3632 ,  A63B15/005 ,  A63B60/04

Abstract: Disclosed are apparatus and method for a golf swing training club. The golf swing training club may include, a shaft, a grip connected to one end of the shaft, a clubhead connected to the other end of the shaft, and a weight coupled to the shaft, where the weight slides along the shaft during the golf swing. The club may include a release mechanism that is connected to the shaft. The release mechanism releases the weight when a centrifugal force is applied on the club. The method for using the golf swing training club may include swinging the club, and causing the weight to slide along the shaft during the golf swing. The method may include releasing the weight from the release mechanism when the centrifugal force is applied to the club.

Abstract translation: 公开了一种用于高尔夫挥杆训练俱乐部的装置和方法。 高尔夫挥杆训练球杆可以包括：轴，连接到轴的一端的手柄，连接到轴的另一端的杆头，以及联接到轴的重物，其中重量在高尔夫球期间沿轴滑动 摇摆。 球杆可以包括连接到轴的释放机构。 当离心力施加在球杆上时，释放机构释放重量。 使用高尔夫挥杆训练杆的方法可以包括摆动球杆，并且在高尔夫挥杆期间使重物沿着轴滑动。 该方法可以包括当离心力施加到球杆时从释放机构释放重物。

公开(公告)号：US06787357B2

公开(公告)日：2004-09-07

申请号：US09970651

申请日：2001-10-05

Applicant: Gary L. Bowlin ,  Gary Wnek ,  David G. Simpson ,  Philippe Lam ,  Marcus E. Carr ,  Helen Fillmore

Inventor： Gary L. Bowlin ,  Gary Wnek ,  David G. Simpson ,  Philippe Lam ,  Marcus E. Carr ,  Helen Fillmore

IPC: C12N502

CPC classification number: A61L27/3834 ,  A61K35/12 ,  A61L15/32 ,  A61L27/225 ,  A61L27/3616 ,  A61L2400/04 ,  B29C41/006 ,  C07K14/75 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0622 ,  C12N2503/00 ,  C12N2510/00 ,  C12N2533/56

Abstract: The invention is directed to use of fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or “organ-like” tissue. A preferred embodiment is a plasma-derived fibrin matrix containing cells.

Abstract translation: 本发明涉及使用纤维蛋白作为细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括特定器官或“器官样”组织的合成制造。 优选的实施方案是含有细胞的血浆衍生的纤维蛋白基质。

公开(公告)号：US06762335B1

公开(公告)日：2004-07-13

申请号：US09515314

申请日：2000-02-29

Applicant: Kelli E. Prince ,  Marcus E. Ledoux ,  Honn Tudor ,  L. Mark Gremillion

Inventor： Kelli E. Prince ,  Marcus E. Ledoux ,  Honn Tudor ,  L. Mark Gremillion

IPC: C07C532

CPC classification number: B01J8/0214 ,  B01J2208/00707 ,  B01J2208/00725 ,  B01J2208/00849 ,  B01J2219/00024 ,  C07C5/333 ,  Y10S585/921 ,  Y10S585/922 ,  C07C15/46

Abstract: The present invention discloses a process and apparatus for improving the catalyst life and efficiency in a gas flow catalyst bed reactor assembly. The reactor comprises an outer reaction vessel, an inner displacement cylinder, and an annular catalyst bed surrounding the displacement cylinder having a top half and a bottom half. Fluid flow improvement is achieved by adding at least one baffle to the top half of the displacement cylinder to improve uniformity of fluid flow in the reaction vessel and across the catalyst bed. Also disclosed is a process for improving fluid flow uniformity in a gas phase reactor comprising an outer reaction vessel, an inner displacement vessel having a top half and a bottom half and a reaction outer surface and an inert inner space, and an annular catalyst bed. The process comprises conducting fluid flow simulations using actual reactor conditions. During simulation, baffles are added on the outer reaction surface of the displacement reactor to improve simulated fluid flow. The baffles are added to the displacement cylinder by entering the inner inert space of the cylinder and attaching the baffles to the reaction outer surface from the inner inert space. The process allows the modification of existing reactors without disassembling the reactor.

Abstract translation: 本发明公开了一种改善气流催化剂床反应器组件的催化剂寿命和效率的方法和装置。 反应器包括外反应容器，内排量圆筒和围绕位移圆筒的环形催化剂床，其具有上半部和下半部。 通过将至少一个挡板添加到排量缸的上半部分来实现流体流动改善，以改善反应容器中和穿过催化剂床的流体流动的均匀性。 还公开了一种用于改善气相反应器中的流体流动均匀性的方法，其包括外部反应容器，具有上半部分和下半部分的内部容积容器以及反应外表面和惰性内部空间以及环形催化剂床。 该方法包括使用实际的反应器条件进行流体流动模拟。 在模拟期间，挡板被添加到位移反应器的外部反应表面上以改善模拟的流体流动。 挡板通过进入气缸的内部惰性空间并将挡板从内部惰性空间连接到反作用外表面而被添加到排量缸中。 该方法允许在不拆卸反应器的情况下修改现有反应器。

公开(公告)号：US06573104B2

公开(公告)日：2003-06-03

申请号：US09852149

申请日：2001-05-10

Applicant: Marcus E. Carr, Jr. ,  Mark Licata

Inventor： Marcus E. Carr, Jr. ,  Mark Licata

IPC: G01N3386

CPC classification number: G01N33/4905 ,  G01N33/86 ,  Y10T436/10

Abstract: Blood clot analysis instrumentation used to evaluate platelet function and clot structure by monitoring force development during clot retraction or upon application of a known amount of force can have a calibration check automatically performed by using a top member with a known amount of mass which is detachable from the instrumentation, and preferably is a disposable component. The calibration check is performed by monitoring force or displacement on a holding member with and without the top member attached. If the difference measured is within a preferred tolerance range, then the instrumentation can be deemed to be within the specifications deemed best suited for the instrument. The top member may also be modified to allow for mixing reagents with the clot, thereby avoiding the need to pre-mix blood with reagents before measurement. This can be accomplished by providing the top member with a rotation mechanism, such as an air driven fin assembly, that permits the top member to rotate forwards and/or backwards relative to the receptacle which holds the blood sample. The top member may also carry on board one or more reagents used for the diagnostic tests to be performed on the blood sample. Different top members might be used to perform different tests by being capable of dispensing different reagents. Moreover, a bar code or other indicia may be used to have the instrumentation automatically identify the test being performed, and this can also be used to provide information useful in regulating the mixing operation to be performed by the top member. Furthermore, a disposable liner may also be positionable within the receptacle such that the entire test can be performed with disposable components, thereby reducing clean up time, improving performance of the instrumentation, and enhancing the safety for the clinicians. Finally, the shape of the top and bottom members are configured in such a way as to have the evaporation force vector perpendicular to the clot retraction force vector.

公开(公告)号：US06406907B1

公开(公告)日：2002-06-18

申请号：US09513007

申请日：2000-02-25

Applicant: Michael J. Taylor ,  Marcus E. Kehrli, Jr. ,  Eun-Kyung Lee

Inventor： Michael J. Taylor ,  Marcus E. Kehrli, Jr. ,  Eun-Kyung Lee

IPC: C07H2104

CPC classification number: C07K14/70575

Abstract: The invention relates to nucleic acid sequences encoding a bovine tumor necrosis factor receptor-I (TNF-RI). Also within the invention is a soluble bovine TNF-RI, which is a potent inhibitor of bovine tumor necrosis factor-&agr; (TNF-&agr;). The invention demonstrates that soluble bovine TNF-RI has therapeutic value as an inhibitor of TNF in cattle suffering from coliform mastitis or other inflammatory disease.

Abstract translation: 本发明涉及编码牛肿瘤坏死因子受体-I（TNF-RI）的核酸序列。 本发明还有一种可溶性牛TNF-RI，其是牛肿瘤坏死因子-α（TNF-α）的有效抑制剂。 本发明表明，可溶性牛TNF-RI具有作为大肠杆菌性乳腺炎或其它炎性疾病的牛的TNF抑制剂的治疗价值。

公开(公告)号：US06234958B1

公开(公告)日：2001-05-22

申请号：US09201016

申请日：1998-11-30

Applicant: Phillip Jack Snoke ,  Randall J. Hasslinger ,  Marcus E. Finch ,  Michael J. Mark

Inventor： Phillip Jack Snoke ,  Randall J. Hasslinger ,  Marcus E. Finch ,  Michael J. Mark

IPC: A61B100

CPC classification number: A61B1/00082 ,  A61B1/015 ,  A61B1/018 ,  A61B1/303 ,  A61B17/3431 ,  A61B17/3439 ,  A61B17/4241 ,  A61B2017/3445 ,  A61B2017/345 ,  A61B2017/3466 ,  A61B2090/036 ,  A61M25/0147 ,  A61M25/0662

Abstract: A medical device introduction system, a medical introducer, and related methods are provided. The medical device introduction system preferably includes a medical introducer having an introducer body and a plurality of lumen formed therein, an imaging device positioned in a predetermined one of the plurality of lumen of the medical introducer so that the imaging device is separately controllable independent of the medical introducer, and a separate steerable working channel device positioned in at least one other of the plurality of lumen of the medical introducer so that the separate steerable working channel device and the imaging device are separately controllable by a user thereof independent of each other. The separate steerable working channel device preferably includes an elongate tube portion having at least one lumen formed therein which defines the working channel and steering means associated with the elongate tube portion for steering the elongate tube portion.

Abstract translation: 提供医疗器械引入系统，医疗引导器和相关方法。 医疗器械引入系统优选地包括具有引导器主体和形成在其中的多个内腔的医疗引导器，成像装置定位在医疗引入器的多个内腔中的预定的一个内腔中，使得成像装置独立于 医疗引导器和位于医疗引导器的多个内腔中的至少另一个内的单独的可操纵工作通道装置，使得独立的可操纵工作通道装置和成像装置可以彼此独立地由用户独立地控制。 单独的可操纵工作通道装置优选地包括细长管部分，其具有形成在其中的至少一个内腔，其限定工作通道和与细长管部分相关联的转向装置，用于转向细长管部分。

公开(公告)号：US5466604A

公开(公告)日：1995-11-14

申请号：US208020

申请日：1994-03-08

Applicant: Xin Yang ,  Jaw E. Lee ,  William Armiger ,  Sergey K. Maneshin ,  Marcus E. Kolb

Inventor： Xin Yang ,  Jaw E. Lee ,  William Armiger ,  Sergey K. Maneshin ,  Marcus E. Kolb

IPC: C02F3/00 ,  G01N33/18 ,  G05D21/02 ,  C12M1/34

CPC classification number: G05D21/02 ,  C02F3/006 ,  C02F2209/22 ,  C02F2209/36 ,  C02F2209/44 ,  Y02W10/15 ,  Y10S435/81

Abstract: Apparatus which monitors and controls biological activity of mixed liquor under anaerobic, anoxic and aerobic conditions by measuring the change of intracellular NAD(P)H of the microorganisms. A wastewater treatment system is controlled in accordance with the results generated by the monitoring system.

Abstract translation: 通过测量微生物的细胞内NAD（P）H的变化来监测和控制在厌氧，缺氧和需氧条件下混合液体的生物活性的装置。 废水处理系统根据监控系统产生的结果进行控制。

公开(公告)号：US5118182A

公开(公告)日：1992-06-02

申请号：US593680

申请日：1990-10-05

Applicant: Marcus E. Carr, Jr.

Inventor： Marcus E. Carr, Jr.

IPC: C12Q1/56 ,  G01N15/02 ,  G01N21/59

CPC classification number: C12Q1/56 ,  G01N15/0205 ,  G01N21/59 ,  G01N2333/75 ,  G01N2333/974

Abstract: Experiments have been conducted which demonstrate that gel optical density is a linear function of the fibrin fiber mass/length ratio (.mu.) and that the slope of the linear function is dependent on the concentration of fibrinogen in the sample. Once the linear function is known, knowledge of a gel optical density at one wavelength is adequate to determine .mu.. Such measurements allow quantitative monitoring of fibrin structure, and are clinically relevant.

Abstract translation: 已经进行了实验，其证明凝胶光密度是纤维蛋白纤维质量/长度比（μ）的线性函数，并且线性函数的斜率取决于样品中纤维蛋白原的浓度。 一旦已知线性函数，在一个波长处的凝胶光密度的知识足以确定mu。 这些测量可以定量监测纤维蛋白结构，并且在临床上是相关的。