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公开(公告)号：US06787357B2
公开(公告)日：2004-09-07
申请号：US09970651
申请日：2001-10-05
申请人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Philippe Lam , Marcus E. Carr , Helen Fillmore
发明人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Philippe Lam , Marcus E. Carr , Helen Fillmore
IPC分类号： C12N502
CPC分类号： A61L27/3834 , A61K35/12 , A61L15/32 , A61L27/225 , A61L27/3616 , A61L2400/04 , B29C41/006 , C07K14/75 , C12N5/0062 , C12N5/0068 , C12N5/0622 , C12N2503/00 , C12N2510/00 , C12N2533/56
摘要： The invention is directed to use of fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or “organ-like” tissue. A preferred embodiment is a plasma-derived fibrin matrix containing cells.
摘要翻译： 本发明涉及使用纤维蛋白作为细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括特定器官或“器官样”组织的合成制造。 优选的实施方案是含有细胞的血浆衍生的纤维蛋白基质。
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公开(公告)号：US20100310658A1
公开(公告)日：2010-12-09
申请号：US12796207
申请日：2010-06-08
IPC分类号： A61K9/00 , C07K14/435 , A61K38/36 , A61K35/00 , A61K38/18 , A61K35/12 , C12Q1/02 , A61P17/02 , A61P7/00 , C25D9/02
CPC分类号： C12N5/0622 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/041 , A61L2400/04 , B29C41/006 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , C08L89/00
摘要： The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrite to form the tissues and organs.
摘要翻译： 本发明涉及形成和使用电加工的纤维蛋白作为细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电加工的纤维蛋白也可以与其它分子组合以将分子递送到电加工的纤维蛋白的施用位点或植入。 将纤维蛋白或纤维蛋白/细胞悬浮液电沉积到一个亚晶体上以形成组织和器官。
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公开(公告)号：US07759082B2
公开(公告)日：2010-07-20
申请号：US10764691
申请日：2004-01-26
IPC分类号： C12Q1/56
CPC分类号： C12N5/0622 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/38 , A61L31/041 , A61L2400/04 , B29C41/006 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , C08L89/00
摘要： The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.
摘要翻译： 本发明涉及形成和使用电加工的纤维蛋白作为细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电加工的纤维蛋白也可以与其它分子组合以将分子递送到电加工的纤维蛋白的施用位点或植入。 将纤维蛋白或纤维蛋白/细胞悬浮液电沉积在基质上以形成组织和器官。
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公开(公告)号：US08586345B2
公开(公告)日：2013-11-19
申请号：US13052778
申请日：2011-03-21
申请人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
发明人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
CPC分类号： B29C67/0007 , A61F2/08 , A61K38/00 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/507 , A61L31/041 , A61L2430/30 , B29C41/006 , C07K14/78 , C12N5/0012 , C12N5/0068 , C12N2533/40 , C12N2533/54 , D01D5/0038 , D01F1/10 , D01F4/00 , Y10T428/298 , Y10T442/2525 , Y10T442/60 , Y10T442/614 , C08L67/04 , C08L89/00 , C08L89/06
摘要： The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
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公开(公告)号：US20100291058A1
公开(公告)日：2010-11-18
申请号：US12758360
申请日：2010-04-12
申请人： Gary L. Bowlin , David G. Simpson , Gary E. Wnek , Marcus E. Carr, JR. , Peter J. Stevens , Gary Cadd , I. Kelman Cohen
发明人： Gary L. Bowlin , David G. Simpson , Gary E. Wnek , Marcus E. Carr, JR. , Peter J. Stevens , Gary Cadd , I. Kelman Cohen
CPC分类号： A61L24/102 , A61F2/105 , A61F2013/00314 , A61F2013/00472 , A61K38/363 , A61K38/39 , A61L24/106 , C07K14/78 , Y10T428/298 , A61K2300/00
摘要： The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants.
摘要翻译： 本发明涉及用于皮肤和其它组织的密封剂。 密封剂包括电加工材料。 密封剂可能含有多于一种的电处理材料，并且可能含有其他物质。 本发明还涉及制造和使用这种密封剂的方法。
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公开(公告)号：US07615373B2
公开(公告)日：2009-11-10
申请号：US10447670
申请日：2003-05-28
申请人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
发明人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
CPC分类号： B29C67/0007 , A61F2/08 , A61K38/00 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/507 , A61L31/041 , A61L2430/30 , B29C41/006 , C07K14/78 , C12N5/0012 , C12N5/0068 , C12N2533/40 , C12N2533/54 , D01D5/0038 , D01F1/10 , D01F4/00 , Y10T428/298 , Y10T442/2525 , Y10T442/60 , Y10T442/614 , C08L67/04 , C08L89/00 , C08L89/06
摘要： The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
摘要翻译： 本发明涉及电加工胶原的形成和使用，包括用作细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电处理胶原蛋白也可以与其他分子组合，以将物质递送到电加工胶原的施用部位或植入。 将胶原或胶原/细胞悬浮液电沉积在基质上以形成组织和器官。
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公开(公告)号：US20110288026A1
公开(公告)日：2011-11-24
申请号：US13052778
申请日：2011-03-21
申请人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
发明人： David G. Simpson , Gary L. Bowlin , Gary E. Wnek , Peter J. Stevens , Marcus E. Carr , Jamil A. Matthews , Saravanamoorthy Rajendran
CPC分类号： B29C67/0007 , A61F2/08 , A61K38/00 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/507 , A61L31/041 , A61L2430/30 , B29C41/006 , C07K14/78 , C12N5/0012 , C12N5/0068 , C12N2533/40 , C12N2533/54 , D01D5/0038 , D01F1/10 , D01F4/00 , Y10T428/298 , Y10T442/2525 , Y10T442/60 , Y10T442/614 , C08L67/04 , C08L89/00 , C08L89/06
摘要： The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.
摘要翻译： 本发明涉及电加工胶原的形成和使用，包括用作细胞外基质，并与细胞一起用于形成工程化组织。 工程组织可以包括可以植入受体的特定器官或组织的合成制造。 电处理胶原蛋白也可以与其他分子组合，以将物质递送到电加工胶原的施用部位或植入。 将胶原或胶原/细胞悬浮液电沉积在基质上以形成组织和器官。
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公开(公告)号：US06592623B1
公开(公告)日：2003-07-15
申请号：US09386273
申请日：1999-08-31
申请人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Louis Terracio
发明人： Gary L. Bowlin , Gary Wnek , David G. Simpson , Louis Terracio
IPC分类号： A61F208
CPC分类号： A61L27/383 , A61F2/08 , A61L27/18 , A61L27/24 , A61L27/34 , A61L27/3817 , A61L27/3826 , A61L27/3873 , A61L27/507 , A61L2430/30 , C08L67/04 , C08L89/06
摘要： A muscle implant includes an extracellular matrix, tendon and muscle cells. The extracellular matrix is made of a matrix of electrospun polymer fibers. The tendon is made of extruded collagen fibers and the muscle cells are disposed on the extracellular matrix in such a manner that the combination of components will functionally and structurally act as normal muscle tissue. Cardiac and smooth muscles may be similarly formed without tendons but including the extracellular matrix and muscle cells.
摘要翻译： 肌肉植入物包括细胞外基质，肌腱和肌肉细胞。 细胞外基质由电纺聚合物纤维基质制成。 肌腱由挤出的胶原纤维制成，并且肌细胞以这样的方式设置在细胞外基质上，使得组分的组合将在功能上和结构上作为正常肌肉组织起作用。 心肌和平滑肌可以类似地形成，没有肌腱，但包括细胞外基质和肌肉细胞。
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公开(公告)号：US20110280841A1
公开(公告)日：2011-11-17
申请号：US13008329
申请日：2011-01-18
申请人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
发明人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
IPC分类号： A61K35/36 , A61K31/65 , A61K35/39 , B05D1/04 , A61P19/08 , A61P3/10 , A61P31/00 , A61P17/00 , A61K38/18 , A61K35/32
CPC分类号： C12N5/0622 , A61F2/08 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/38 , A61L27/3847 , A61L27/507 , A61L31/041 , A61L2400/04 , A61L2430/30 , B29C41/006 , B29C67/0007 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , Y10S514/801 , C08L89/00 , C08L67/04 , C08L89/06
摘要： The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.
摘要翻译： 本发明涉及包含电处理材料和物质的新型组合物，其形成和用途。 电加工材料可以例如是一种或多种天然材料，一种或多种合成材料或其组合。 该物质可以是一种或多种治疗或化妆物质或其它化合物，分子，细胞，囊泡。 组合物可用于物质递送，包括通过例如释放物质或含有释放物质的细胞在生物体内的药物递送。 组合物可以用于其它目的，例如假体或类似的植入物。
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10.发明授权Electroprocessed material made by simultaneously electroprocessing a natural protein polymer and two synthetic polymers 失效通过同时电加工天然蛋白质聚合物和两种合成聚合物制备的电加工材料公开(公告)号：US07374774B2
公开(公告)日：2008-05-20
申请号：US10668085
申请日：2003-09-22
申请人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
发明人： Gary L. Bowlin , Gary E. Wnek , David G. Simpson
CPC分类号： C12N5/0622 , A61F2/08 , A61K35/12 , A61K2035/126 , A61L15/32 , A61L27/18 , A61L27/225 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/38 , A61L27/3847 , A61L27/507 , A61L31/041 , A61L2400/04 , A61L2430/30 , B29C41/006 , B29C67/0007 , C07K14/75 , C07K14/78 , C12N5/0012 , C12N5/0062 , C12N5/0068 , C12N2503/00 , C12N2510/00 , C12N2533/40 , C12N2533/54 , C12N2533/56 , Y10S514/801 , C08L89/00 , C08L67/04 , C08L89/06
摘要： The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.
摘要翻译： 本发明涉及包含电处理材料和物质的新型组合物，其形成和用途。 电加工材料可以例如是一种或多种天然材料，一种或多种合成材料或其组合。 该物质可以是一种或多种治疗或化妆物质或其它化合物，分子，细胞，囊泡。 组合物可用于物质递送，包括通过例如释放物质或含有释放物质的细胞在生物体内的药物递送。 组合物可以用于其它目的，例如假体或类似的植入物。
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