公开(公告)号：US20240150509A1

公开(公告)日：2024-05-09

申请号：US18408005

申请日：2024-01-09

Applicant: McMaster University

Inventor： Sarah Alison Stewart ,  Harald Donald Helmut Stover ,  Michael Bradley Coulson

IPC: C08F222/06 ,  C08F8/34 ,  C08J3/075 ,  C08J3/24

CPC classification number: C08F222/06 ,  C08F8/34 ,  C08J3/075 ,  C08J3/24 ,  C08J2300/14

Abstract: A novel synthetic functionalized backbone polymer is provided which is a polyanionic side-chain functionalized backbone polymer comprising a hydrophilic backbone polymer functionalized with an activated alkene or epoxy group. The functionalized backbone polymer may be combined with a free or protected thiol-containing compound to form a crosslinked hydrogel having biomedical application, and may additionally be combined with a hydrogel matrix to yield a hydrogel system useful for in vivo delivery of cells and other therapeutic agents.

公开(公告)号：US11935404B2

公开(公告)日：2024-03-19

申请号：US17211390

申请日：2021-03-24

Applicant: Toyota Motor Engineering & Manufacturing North America, Inc. ,  McMaster University

Inventor： Baik Hoh ,  Hao Yang ,  Seyhan Ucar ,  Kentaro Oguchi

IPC: G08G1/0967 ,  G08G1/01

CPC classification number: G08G1/096725 ,  G08G1/0133

Abstract: A method of operating a traffic management system may comprise identifying a vehicle queue in a first lane of a road based on sensor data from one or more connected vehicles traveling along the road, determining driving instructions for a connected vehicle within a queue management region in a second lane, adjacent to the first lane, to create a gap in front of the connected vehicle for a vehicle in the vehicle queue to change lanes into the gap, and transmitting the driving instructions to the connected vehicle.

公开(公告)号：US20230405042A1

公开(公告)日：2023-12-21

申请号：US18198154

申请日：2023-05-16

Applicant: McMaster University

Inventor： Jonathan Schertzer ,  Fernando Forato Anhe ,  Han Fang

IPC: A61K31/765 ,  A61K38/44 ,  A61K38/26 ,  A61K31/155 ,  A61K35/741 ,  A61P3/10

CPC classification number: A61K31/765 ,  A61K38/443 ,  A61P3/10 ,  A61K31/155 ,  A61K35/741 ,  A61K38/26

Abstract: The present application relates to methods of lowering at least one of blood glucose, liver fat, liver glycogen, insulin or insulin resistance in a mammal, for example, mammals who are obese, or have metabolic disease, fatty liver disease, pre-diabetes or type 2 diabetes. In an embodiment, a method comprises administering to a mammal a polymer comprising L-lactate monomer, or a functionally equivalent derivative or fragment thereof, which inhibits or at least reduces D-lactate transport across the intestinal barrier. Compositions useful in the methods are also provided.

公开(公告)号：US11841599B2

公开(公告)日：2023-12-12

申请号：US17451711

申请日：2021-10-21

Applicant: McMaster University

Inventor： Chang-qing Xu ,  Liam Flannigan ,  Joshua Kneller

IPC: G02F1/39 ,  G02F1/35 ,  H01S3/109 ,  H01S3/108

CPC classification number: G02F1/39 ,  G02F1/3534 ,  G02F1/3548 ,  H01S3/109 ,  H01S3/1083

Abstract: Optical transmitters and optical receivers utilizing long wave infrared light for use with an earth-orbiting satellite communication system, and a structure including an intracavity optical nonlinear process, are described herein. The transmitters include a pumping laser diode with a fast-axis collimating lens and a pumping wavelength λ0, operating in a continuous wavelength (CW) mode. The transmitters also include a laser cavity having a beam combiner or a dichroic mirror, a laser crystal with a lasing wavelength λ1 and a difference frequency generation orientation patterned semiconductor to generate long wave-IR light. The transmitters also include a second laser at a wavelength λ2, operating in a modulation mode. The receivers have a similar structure to the transmitters, utilizing a sum frequency generation orientation patterned semiconductor to convert long wave-IR light into the short wave-IR.

公开(公告)号：US11788057B2

公开(公告)日：2023-10-17

申请号：US16178172

申请日：2018-11-01

Applicant: McMaster University

Inventor： Abdel Rahman Abdel Fattah ,  Rakesh Prasad Sahu ,  Fei Geng ,  Sarah Mishriki ,  Elvira Meleca ,  Ishwar K. Puri ,  Suvojit Ghosh

IPC: C12N5/00 ,  G01N33/50 ,  C12Q1/6876

CPC classification number: C12N5/0062 ,  C12Q1/6876 ,  G01N33/5032 ,  G01N33/5082 ,  C12N2513/00 ,  C12N2527/00 ,  C12Q2600/136

Abstract: A novel macroscale, contactless, label-free method to print in situ three-dimensional (3D) particle assemblies of different morphologies and sizes is demonstrated using non-adherent (blood) and adherent (MCF-7 and HUVEC) cells. This method of manipulating particles such as cells or biological moleules does not necessarily require the use of nozzles that can contaminate the cell suspension, or to which cells can adhere. Instead, the intrinsic diamagnetic properties of particles such as cells are used to magnetically manipulate them in situ in a nontoxic paramagnetic medium, creating various shapes such as (a) rectangular bar, (b) three-pointed star, and (c) spheroids of varying sizes. A normal distribution of 3D cell structures is produced when formed through magnetic assembly. The use of this method in co-culturing of different cell lines is also demonstrated. The technique is envisioned to be transferable to other cell lines or diamagnetic biological molecules, with potential applications in tissue engineering, medical diagnostics and drug screening.

公开(公告)号：US20230320647A1

公开(公告)日：2023-10-12

申请号：US18208170

申请日：2023-06-09

Applicant: McMaster University

Inventor： John Francis Connolly ,  Kyle Ingram Ruiter ,  Rober Boshra

IPC: A61B5/291 ,  A61B5/16 ,  G06N20/00 ,  A61B5/316 ,  A61B5/377

CPC classification number: A61B5/291 ,  A61B5/168 ,  G06N20/00 ,  A61B5/316 ,  A61B5/377 ,  A61B5/162 ,  G06N3/08

Abstract: An improved system for assessing cognitive function is described that uses tracked electrical activity of the brain of the individuals in response to a specific sequence of stimuli in generating data sets, which, for example, can be encapsulated as a data structure. The data sets can include tracked specific response types, at different times and amplitudes, including, but not limited to, event related potential signal components. Brainwave features including, event related potentials, are tracked in relation to both pre-attentive brain responses and consciously controlled attention responses.

公开(公告)号：US20230280410A1

公开(公告)日：2023-09-07

申请号：US18118231

申请日：2023-03-07

Applicant: The Trustees of Columbia University in the City of New York ,  McMaster University

Inventor： Ephram Chemali ,  Matthias Preindl

IPC: G01R31/392 ,  G01R31/382 ,  H01M10/48 ,  H02J7/00 ,  G06N3/045

CPC classification number: G01R31/392 ,  G01R31/382 ,  H01M10/486 ,  H02J7/0048 ,  G06N3/045 ,  G06N3/08

Abstract: An approach to control or monitoring of battery operation makes use of an artificial neural network (ANN), which receives one or more battery attributes for a Lithium ion (Li-ion) battery, and determines, based on the received one or more battery attributes, a state-of-charge (SOC) and/or a state-of-health (SOH) estimate for the Li-ion battery. The ANN includes at least one of a recurrent neural network (RNN) and a convolutional neural network (CNN), and the series of values of the battery attributes includes at one of battery voltage values, battery current values, and battery temperature values.

公开(公告)号：US20230250430A1

公开(公告)日：2023-08-10

申请号：US18010878

申请日：2021-06-15

Applicant: McMaster University

Inventor： John Brennan ,  Yingfu Li ,  Jimmy Gu

IPC: C12N15/113 ,  C12Q1/6825 ,  C12Q1/70 ,  C12Q1/6883

CPC classification number: C12N15/1131 ,  C12Q1/6825 ,  C12Q1/701 ,  C12Q1/6883 ,  C12Q2600/118

Abstract: This disclosure relates to recognition moieties, biosensors, biosensor systems and kits thereof, and the methods for their use in detecting a target nucleic acid molecule in a test sample, including viral RNA and methods for determining whether a subject has a viral infection. The methods disclosed herein include detecting a viral infection in a subject comprising testing a sample from the subject for the presence of a target nucleic acid using a biosensor system, wherein presence of a target nucleic acid indicates that the subject has a viral infection.

公开(公告)号：US11719707B2

公开(公告)日：2023-08-08

申请号：US16863023

申请日：2020-04-30

Applicant: McMaster University

Inventor： David Alexander Clark ,  Warren George Foster

IPC: G01N33/68 ,  G01N33/563

CPC classification number: G01N33/6893 ,  G01N33/563 ,  G01N2333/705

Abstract: The present invention relates to methods of detecting CD200L in a female subject from a secretory phase biological sample. Increased levels of CD200L have been determined to be associated with endometriosis. CD200L is therefore a useful biomarker for the diagnosis of endometriosis and a useful target for therapeutic intervention.

公开(公告)号：US20230174909A1

公开(公告)日：2023-06-08

申请号：US17997991

申请日：2021-05-06

Applicant: MCMASTER UNIVERSITY

Inventor： Boyang ZHANG ,  Shravanthi RAJASEKAR ,  Dawn song YI LIN

IPC: C12M1/32 ,  C12M1/00 ,  C12M1/12

CPC classification number: C12M23/12 ,  C12M29/10 ,  C12M25/14

Abstract: Described herein is a cell culture system for constructing a perfusable network of self-assembled cells comprising a multi-well plate embedded with microchannels connecting a central well with at least one inlet well and at least one outlet well, the central well for culturing seeded cells within an extracellular matrix, wherein the perfusable network allows perfusion through the microchannels connecting the central well with at least one inlet well and at least one outlet well. The cell culture system allows the array of perfusable networks formed, connected, and perfused inside the multi-well plate to be accessible and/or extractable from the top of the central well. In aspect, the cell culture system can improve the experimental throughputs of organ-on-a-chip systems and expand the application of microphysiological systems to regenerative cell therapy. A perfusable network of self-assembled cells and method of making thereof using the cell culture system described herein are also provided.