公开(公告)号：US07048931B1

公开(公告)日：2006-05-23

申请号：US10129909

申请日：2000-11-09

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Yasir A. W. Skeiky ,  Aijun Wang

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Steven G. Reed ,  Michael D. Kalos ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Yasir A. W. Skeiky ,  Aijun Wang

IPC分类号： A61K39/00 ,  A61K38/00 ,  C12Q1/68 ,  C07H21/02 ,  A01N43/04

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07H21/02 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/80

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as prostate cancer, are disclosed. Compositions may comprise one or more prostate-specific proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a prostate-specific protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as prostate cancer. Diagnostic methods based on detecting a prostate-specific protein, or mRNA encoding such a protein, in a sample are also provided.

公开(公告)号：US06894146B1

公开(公告)日：2005-05-17

申请号：US09657279

申请日：2000-09-06

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick ,  Darrick Carter ,  Samuel X. Li ,  Aijun Wang ,  Yasir A. W. Skeiky ,  William T. Hepler ,  Robert A. Henderson

IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  C07K14/11 ,  C07K14/47 ,  C07K14/705 ,  C12N9/64 ,  C07K5/00 ,  C07K14/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2035/124 ,  A61K2039/5156 ,  A61K2039/53 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16022

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是前列腺癌的组合物和方法。 说明性组合物包含一种或多种前列腺特异性多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是前列腺癌的诊断，预防和/或治疗。

公开(公告)号：US06858710B2

公开(公告)日：2005-02-22

申请号：US10198053

申请日：2002-07-17

申请人： Chaitanya S. Bangur ,  Marc W. Retter ,  Gary R. Fanger ,  Paul Hill

发明人： Chaitanya S. Bangur ,  Marc W. Retter ,  Gary R. Fanger ,  Paul Hill

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K16/30 ,  A61K35/14 ,  A61K39/395 ,  A61K51/00 ,  C07K1/00 ,  C07K16/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2319/00

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

公开(公告)号：US06858204B2

公开(公告)日：2005-02-22

申请号：US10017754

申请日：2001-10-29

申请人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

发明人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68 ,  A01N63/00 ,  A61K39/00 ,  A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

公开(公告)号：US06746846B1

公开(公告)日：2004-06-08

申请号：US09658824

申请日：2000-09-08

申请人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

发明人： Tongtong Wang ,  Chaitanya S. Bangur ,  Michael J. Lodes ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Darrick Carter ,  Marc W. Retter ,  Jane Mannion ,  Liqun Fan

IPC分类号： G01N33574

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K2319/00 ,  C12Q1/6886 ,  C12Q2600/158

摘要： Compositions and methods for the therapy and diagnosis of cancer, such as lung cancer, are disclosed. Compositions may comprise one or more lung tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a lung tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as lung cancer. Diagnostic methods based on detecting a lung tumor protein, or mRNA encoding such a protein, in a sample are also provide.

摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如肺癌。 组合物可以包含一种或多种肺肿瘤蛋白，其免疫原性部分，或编码这些部分的多核苷酸。 或者，治疗组合物可以包含表达肺肿瘤蛋白的抗原呈递细胞，或表达这种蛋白质的细胞特异的T细胞。 这样的组合物可以用于例如预防和治疗诸如肺癌的疾病。 还提供了基于在样品中检测肺肿瘤蛋白或编码这种蛋白的mRNA的诊断方法。

公开(公告)号：US06656480B2

公开(公告)日：2003-12-02

申请号：US09429755

申请日：1999-10-28

申请人： Marc W. Retter ,  Davin C. Dillon

发明人： Marc W. Retter ,  Davin C. Dillon

IPC分类号： A61K3900

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/5154 ,  A61K2039/53 ,  A61K2039/57 ,  C07K14/47 ,  C07K14/82 ,  C07K2319/00 ,  C12N2740/10022 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10S436/813 ,  Y10S530/806 ,  Y10S530/828

摘要： Compositions and methods for the detection and therapy of breast cancer are disclosed. The compounds provided include nucleotide sequences that are preferentially expressed in breast tumor tissue, as well as polypeptides encoded by such nucleotide sequences. Vaccines and pharmaceutical compositions comprising such compounds are also provided and may be used, for example, for the prevention and treatment of breast cancer. The polypeptides may also be used for the production of antibodies, which are useful for diagnosing and monitoring the progression of breast cancer in a patient.

公开(公告)号：US07888477B2

公开(公告)日：2011-02-15

申请号：US10860790

申请日：2004-06-02

申请人： Chaitanya S Bangur ,  Marc W Retter ,  Gary R Fanger ,  Paul Hill

发明人： Chaitanya S Bangur ,  Marc W Retter ,  Gary R Fanger ,  Paul Hill

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C07K16/3069 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2319/00 ,  Y02A50/472

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly ovarian cancer, are disclosed. Illustrative compositions comprise one or more ovarian tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly ovarian cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是卵巢癌的组合物和方法。 说明性组合物包含一个或多个卵巢肿瘤多肽，其免疫原性部分，编码此类多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达此类多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是卵巢癌的诊断，预防和/或治疗。

公开(公告)号：US20100303817A1

公开(公告)日：2010-12-02

申请号：US12633498

申请日：2009-12-08

申请人： Gary R. FANGER ,  Neil FANGER ,  David KING ,  Marc W. RETTER ,  Kenneth L. ROCK

发明人： Gary R. FANGER ,  Neil FANGER ,  David KING ,  Marc W. RETTER ,  Kenneth L. ROCK

IPC分类号： A61K39/395 ,  C12N5/02 ,  A61P35/04

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732

摘要： Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell.

摘要翻译： 公开了用于治疗癌症，特别是黑素瘤，骨髓瘤，小细胞肺癌，胸腺淋巴瘤，T细胞淋巴瘤，B细胞淋巴瘤，骨肉瘤和急性T细胞白血病的组合物和方法。 说明性组合物包括一种或多种编码这种抗神经节苷脂抗体的抗神经节苷脂抗体和多核苷酸。 这些抗体可以是例如仓鼠抗体，嵌合人/仓鼠抗体或人源化抗体。 所公开的组合物可用于例如治疗癌症，并可用于诱导癌细胞中的细胞凋亡。

公开(公告)号：US20080219988A1

公开(公告)日：2008-09-11

申请号：US11928383

申请日：2007-10-30

申请人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

发明人： Jiangchun Xu ,  Davin C. Dillon ,  Jennifer L. Mitcham ,  Susan L. Harlocker ,  Yuqiu Jiang ,  Robert A. Henderson ,  Michael D. Kalos ,  Gary R. Fanger ,  Marc W. Retter ,  John A. Stolk ,  Craig H. Day ,  Thomas S. Vedvick

IPC分类号： A61K39/395 ,  C07K7/06 ,  C07H21/00 ,  C12N15/63 ,  C12N1/00 ,  C07K16/00 ,  A61K35/12 ,  A61P35/00 ,  A61K38/16 ,  G01N33/574 ,  C07K14/00 ,  C12N5/00 ,  A61K38/08 ,  A61K31/7052

CPC分类号： C07K14/005 ,  A01K2227/105 ,  A01K2267/0331 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5156 ,  A61K2039/53 ,  A61K2039/55566 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/705 ,  C07K16/3069 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2319/00 ,  C12N9/6424 ,  C12N2760/16222 ,  G01N33/57434

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly prostate cancer, are disclosed. Illustrative compositions comprise one or more prostate-specific polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly prostate cancer.

公开(公告)号：US20080171690A1

公开(公告)日：2008-07-17

申请号：US11929579

申请日：2007-10-30

申请人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

发明人： Robert A. Henderson ,  Tongtong Wang ,  Yoshihiro Watanabe ,  Michael D. Kalos ,  Paul R. Sleath ,  Jeffrey C. Johnson ,  Marc W. Retter ,  Margarita Durham ,  Darrick Carter ,  Gary R. Fanger ,  Thomas S. Vedvick ,  Chaitanya S. Bangur ,  Andria McNabb

IPC分类号： A61K38/00 ,  C07K4/00 ,  C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  C07K14/47 ,  C07K16/3023 ,  C07K2317/34 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57423

摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.

摘要翻译： 公开了用于治疗和诊断癌症，特别是肺癌的组合物和方法。 说明性组合物包含一种或多种肺肿瘤多肽，其免疫原性部分，编码这种多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如疾病，特别是肺癌的诊断，预防和/或治疗。