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公开(公告)号：US08372860B2
公开(公告)日：2013-02-12
申请号：US12715651
申请日：2010-03-02
申请人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
发明人： Young-Choon Moon , Liangxian Cao , Nadarajan Tamilarasu , Hongyan Qi , Soongyu Choi , William Joseph Lennox , Donald Thomas Corson , Seongwoo Hwang , Thomas Davis
IPC分类号： A61K31/437 , C07D471/04
CPC分类号： A61K31/337 , A61K31/4353 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/5513 , G01N2333/475 , G01N2333/515 , A61K2300/00
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血浆和/或肿瘤VEGF水平的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。
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12.发明申请公开(公告)号：US20120136154A1
公开(公告)日：2012-05-31
申请号：US13321262
申请日：2010-05-27
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Provided herein are improved processes for the synthesis of substituted tetrahydro beta-carboline derivatives. In particular, provided herein are improved processes useful for the preparation of (S)-4-chlorophenyl 6-chloro-1-(4-methoxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indole-2(9H)-carboxylate. Formula (I)
摘要翻译： 本文提供了用于合成取代的四氢β-咔啉衍生物的改进方法。 特别地，本文提供的是用于制备（S）-4-氯苯基6-氯-1-（4-甲氧基苯基）-3,4-二氢-1H-吡啶并[3,4-b] 2（9H） - 羧酸酯。 式（I）
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公开(公告)号：US20120009142A1
公开(公告)日：2012-01-12
申请号：US13158653
申请日：2011-06-13
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Christine Espiritu , Concetta Freund , Zhengxian Gu , Takashi Komatsu
IPC分类号： A61K38/20 , C07D401/10 , C07D409/06 , C07D403/10 , A61P31/14 , A61K31/454 , A61K31/4178 , A61K38/21 , A61K31/7056 , C07D209/40 , A61K31/404
CPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , Y02A50/465
摘要： In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.
摘要翻译： 根据本发明，已经鉴定了抑制病毒复制的化合物，优选丙型肝炎病毒（HCV）复制，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于治疗或预防病毒感染的化合物。 在本发明的另一方面，提供了可用于治疗或预防HCV感染的化合物。
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公开(公告)号：US07973069B2
公开(公告)日：2011-07-05
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Jin Zhu , Xiaoyan Zhang
IPC分类号： C07D209/10 , A61K31/404
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20110160190A1
公开(公告)日：2011-06-30
申请号：US13040614
申请日：2011-03-04
申请人： Young-Choon MOON , Liangxian CAO , Nadarajan TAMILARASU , Hongyan QI , Soongyu CHOI , William Joseph LENNOX , Donald Thomas CORSON , Seongwoo HWANG , Thomas DAVIS
发明人： Young-Choon MOON , Liangxian CAO , Nadarajan TAMILARASU , Hongyan QI , Soongyu CHOI , William Joseph LENNOX , Donald Thomas CORSON , Seongwoo HWANG , Thomas DAVIS
IPC分类号： A61K31/551 , A61K31/497 , A61K31/437 , A61K31/506 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P35/00
CPC分类号： A61K31/337 , A61K31/4353 , A61K31/437 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/541 , A61K31/5513 , G01N2333/475 , G01N2333/515 , A61K2300/00
摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.
摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血浆和/或肿瘤VEGF水平的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。
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16.发明申请UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE 有权UREIDO替代苯甲酸化合物及其用于非感染抑制和疾病治疗的用途公开(公告)号：US20110130391A1
公开(公告)日：2011-06-02
申请号：US12980495
申请日：2010-12-29
IPC分类号： A61K31/549 , C07D233/38 , C07D401/10 , C07D403/10 , C07D285/16 , C07D285/06 , C07D233/72 , C07C275/42 , A61K31/4172 , A61K31/454 , A61K31/433 , A61K31/195 , A61P31/04 , A61P35/00 , A61P37/02 , A61P3/10 , A61P7/00 , A61P9/00 , A61P25/00 , A61P11/00 , A61P29/00
CPC分类号： C07D285/16 , A61K31/17 , A61K31/4166 , A61K31/4172 , A61K31/4196 , A61K31/421 , A61K31/426 , C07C275/42 , C07D233/32 , C07D233/42 , C07D233/72 , C07D401/04 , C07D401/10 , C07D405/04 , C07D405/06 , C07D409/04
摘要： The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.
摘要翻译： 本发明包括脲基取代的苯甲酸化合物，包含该化合物的组合物和通过施用这些化合物或组合物来治疗或预防与无义突变mRNA相关的疾病的方法。
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公开(公告)号：US20100305100A1
公开(公告)日：2010-12-02
申请号：US12828597
申请日：2010-07-01
申请人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary Mitchell Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey Allen Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/55 , C07D209/04 , C07D417/06 , C07D405/12 , C07D271/10 , C07D403/04 , C07D263/30 , C07D401/12 , C07D239/10 , C07D215/00 , C07D223/16 , A61K31/405 , A61K31/40 , A61K31/4155 , A61K31/4245 , A61K31/427 , A61K31/42 , A61K31/4439 , A61K31/497 , A61K31/4725 , A61P31/14 , A61P31/12
CPC分类号： C07D209/30 , C07D209/14 , C07D209/42 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
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公开(公告)号：US20100292187A1
公开(公告)日：2010-11-18
申请号：US12814755
申请日：2010-06-14
申请人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
发明人： Gary M. Karp , Peter Seongwoo Hwang , James J. Takasugi , Hongyu Ren , Richard Gerald Wilde , Anthony A. Turpoff , Alexander Arefolov , Guangming Chen , Jeffrey A. Campbell , Chunshi Li , Steven Paget , Nanjing Zhang , Xiaoyan Zhang , Jin Zhu
IPC分类号： A61K31/675 , A61K31/541 , A61K31/53 , A61K31/497 , A61K31/506 , A61K31/454 , A61K31/4439 , A61K31/433 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4196 , A61K31/4155 , A61K31/407 , A61K31/404 , C07D417/12 , C07D413/12 , C07D401/12 , C07D413/04 , C07D417/10 , C07D413/10 , C07F9/572 , C07D491/14 , C07D403/10 , C07D209/14 , C07D403/12 , C07D407/12 , C07D417/04 , C07D403/04 , C07D401/04 , A61P31/12
CPC分类号： C07D209/30 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/12 , C07D413/12 , C07D417/10 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.
摘要翻译： 本发明提供化合物，药物组合物和使用这些化合物或组合物治疗病毒感染或影响病毒IRES活性的方法。
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19.发明申请公开(公告)号：US20100121070A1
公开(公告)日：2010-05-13
申请号：US12691005
申请日：2010-01-21
申请人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
发明人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC分类号： C07D271/06
CPC分类号： A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
摘要： Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了1,2,4-恶二唑苯甲酸衍生物，1,2,4-恶二唑苯甲酸衍生物的使用方法和药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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20.发明授权公开(公告)号：US07683082B2
公开(公告)日：2010-03-23
申请号：US11724408
申请日：2007-03-14
申请人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
发明人： Gary Mitchell Karp , Seongwoo Hwang , Guangming Chen , Neil Gregory Almstead , Young-Choon Moon
IPC分类号： A61K31/4245 , C07D271/06
CPC分类号： A61K31/4245 , A61K9/0053 , A61K9/12 , A61K9/48 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/655 , A61K45/06 , A61P27/02 , C07D271/06 , C07D271/12 , C07D285/14 , C07D413/02 , C07D413/04 , C07D413/10
摘要： Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.
摘要翻译： 公开了新的1,2,4-恶二唑苯甲酸化合物，使用方法和包含1,2,4-恶二唑苯甲酸衍生物的药物组合物。 所述方法包括治疗或预防通过调节过早翻译终止或无义介导的mRNA衰变而改善的疾病或改善与其相关的一种或多种症状的方法。
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